{"id":"https://openalex.org/W2154203858","doi":"https://doi.org/10.1007/s00262-004-0653-2","title":"Tumor antigen-specific T helper cells in cancer immunity and immunotherapy","display_name":"Tumor antigen-specific T helper cells in cancer immunity and immunotherapy","publication_year":2005,"publication_date":"2005-01-26","ids":{"openalex":"https://openalex.org/W2154203858","doi":"https://doi.org/10.1007/s00262-004-0653-2","mag":"2154203858","pmid":"https://pubmed.ncbi.nlm.nih.gov/16010587","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11032889"},"language":"en","primary_location":{"id":"doi:10.1007/s00262-004-0653-2","doi":"https://doi.org/10.1007/s00262-004-0653-2","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00262-004-0653-2","pdf_url":null,"source":{"id":"https://openalex.org/S203303425","display_name":"Cancer Immunology Immunotherapy","issn_l":"0340-7004","issn":["0340-7004","1432-0851"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology, Immunotherapy","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11032889","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031005364","display_name":"Keith L. Knutson","orcid":"https://orcid.org/0000-0001-9932-4467","observed_orcids":["https://orcid.org/0000-0001-9932-4467"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"K. L. Knutson","raw_affiliation_strings":["Department of Immunology, Mayo Clinic College of Medicine, 342C Guggenheim Bldg., 200 First St. SW, Rochester, MN 55906, USA. knutson.keith@mayo.edu","Department of Immunology, Mayo Clinic College of Medicine, 342C Guggenheim Bldg., 200 First St. SW, Rochester, MN, 55906, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Mayo Clinic College of Medicine, 342C Guggenheim Bldg., 200 First St. SW, Rochester, MN 55906, USA. knutson.keith@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Immunology, Mayo Clinic College of Medicine, 342C Guggenheim Bldg., 200 First St. SW, Rochester, MN, 55906, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039848435","display_name":"Mary Lenora Disis","orcid":"https://orcid.org/0000-0001-7653-4648","observed_orcids":["https://orcid.org/0000-0001-7653-4648"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. L. Disis","raw_affiliation_strings":["Tumor Vaccine Group, Oncology, University of Washington, 1959 NE Pacific Street, Box 356527, Seattle, WA, 98195-6527, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Vaccine Group, Oncology, University of Washington, 1959 NE Pacific Street, Box 356527, Seattle, WA, 98195-6527, USA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031005364"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":3.0423,"has_fulltext":false,"cited_by_count":673,"citation_normalized_percentile":{"value":0.94606742,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"54","issue":"8","first_page":"721","last_page":"728"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.014000000432133675,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd4-t-helper-cells","display_name":"CD4+ T helper cells","score":0.7950000166893005},{"id":"https://openalex.org/keywords/th1-cells","display_name":"Th1 cells","score":0.7390000224113464},{"id":"https://openalex.org/keywords/th2-cells","display_name":"Th2 cells","score":1.0},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.8619999885559082},{"id":"https://openalex.org/keywords/cross-priming","display_name":"cross-priming","score":0.7900000214576721},{"id":"https://openalex.org/keywords/mhc-class-ii-presentation","display_name":"MHC class II presentation","score":0.6890000104904175},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.7670000195503235},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9879999756813049},{"id":"https://openalex.org/keywords/antigen-presenting-cells","display_name":"antigen-presenting cells","score":0.7200000286102295},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.7720000147819519},{"id":"https://openalex.org/keywords/cancer-vaccines","display_name":"cancer vaccines","score":0.5580000281333923},{"id":"https://openalex.org/keywords/epitope-spreading","display_name":"epitope spreading","score":0.9449999928474426},{"id":"https://openalex.org/keywords/cytokine-environment","display_name":"cytokine environment","score":0.328000009059906}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.7272902727127075},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6118135452270508},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5797812938690186},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5687727928161621},{"id":"https://openalex.org/C147969180","wikidata":"https://www.wikidata.org/wiki/Q5014579","display_name":"CTL*","level":4,"score":0.5552154779434204},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5242257714271545},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.5236955881118774},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.4918372631072998},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4564826488494873},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.44512930512428284},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.3031264841556549},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07492384314537048},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017951","descriptor_name":"Antigen Presentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1007/s00262-004-0653-2","doi":"https://doi.org/10.1007/s00262-004-0653-2","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00262-004-0653-2","pdf_url":null,"source":{"id":"https://openalex.org/S203303425","display_name":"Cancer Immunology Immunotherapy","issn_l":"0340-7004","issn":["0340-7004","1432-0851"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology, Immunotherapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11032889","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11032889","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunol Immunother","raw_type":"Text"},{"id":"pmid:16010587","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16010587","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer immunology, immunotherapy : CII","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11032889","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11032889","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunol Immunother","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4081782440","display_name":"A Cancer Vaccine for Ovarian and Breast Cancer","funder_award_id":"R41CA107590","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7865177195","display_name":"MIDCAREER INVESTIGATOR AWARD IN PATIENT ORIENTED RESEARC","funder_award_id":"K24CA085218","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8882381471","display_name":" Tumor rejection antigens induced via epitope spreading","funder_award_id":"5r21ca105270-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G944679409","display_name":null,"funder_award_id":"R21 CA105270","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306109","display_name":"Avon Foundation for Women","ror":"https://ror.org/02eqe7f55"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W196287517","https://openalex.org/W1508865104","https://openalex.org/W1511272968","https://openalex.org/W1572789270","https://openalex.org/W1595826760","https://openalex.org/W1823881321","https://openalex.org/W1874580585","https://openalex.org/W1944657476","https://openalex.org/W1971272821","https://openalex.org/W1979154086","https://openalex.org/W1989064979","https://openalex.org/W1991148746","https://openalex.org/W1993149812","https://openalex.org/W1994048581","https://openalex.org/W1999502843","https://openalex.org/W2009256715","https://openalex.org/W2009648532","https://openalex.org/W2013064448","https://openalex.org/W2015886648","https://openalex.org/W2016213018","https://openalex.org/W2018236996","https://openalex.org/W2021002908","https://openalex.org/W2021137893","https://openalex.org/W2022680838","https://openalex.org/W2025195329","https://openalex.org/W2025240311","https://openalex.org/W2029478340","https://openalex.org/W2030317951","https://openalex.org/W2031477951","https://openalex.org/W2042953790","https://openalex.org/W2045097625","https://openalex.org/W2045801459","https://openalex.org/W2058591930","https://openalex.org/W2059853480","https://openalex.org/W2069634988","https://openalex.org/W2072710870","https://openalex.org/W2074222872","https://openalex.org/W2078885983","https://openalex.org/W2080956086","https://openalex.org/W2091387892","https://openalex.org/W2092992894","https://openalex.org/W2100677570","https://openalex.org/W2105216614","https://openalex.org/W2111041097","https://openalex.org/W2122797958","https://openalex.org/W2123987776","https://openalex.org/W2125506721","https://openalex.org/W2131739944","https://openalex.org/W2135951804","https://openalex.org/W2138376629","https://openalex.org/W2138733343","https://openalex.org/W2138982922","https://openalex.org/W2139640891","https://openalex.org/W2140404421","https://openalex.org/W2141902217","https://openalex.org/W2148177811","https://openalex.org/W2155778479","https://openalex.org/W2157120289","https://openalex.org/W2159090893","https://openalex.org/W2160259021","https://openalex.org/W2163357710","https://openalex.org/W2171515055","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7209644345","https://openalex.org/W2740027623","https://openalex.org/W7062380678","https://openalex.org/W7099476287","https://openalex.org/W2012853564","https://openalex.org/W2068119757","https://openalex.org/W2145231311","https://openalex.org/W2083500661","https://openalex.org/W3158086066","https://openalex.org/W2011640822"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":24},{"year":2023,"cited_by_count":35},{"year":2022,"cited_by_count":49},{"year":2021,"cited_by_count":42},{"year":2020,"cited_by_count":40},{"year":2019,"cited_by_count":41},{"year":2018,"cited_by_count":34},{"year":2017,"cited_by_count":37},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":34},{"year":2014,"cited_by_count":23},{"year":2013,"cited_by_count":33},{"year":2012,"cited_by_count":35}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
