{"id":"https://openalex.org/W2154191535","doi":"https://doi.org/10.1128/aac.00505-13","title":"Structural Analysis of the Role of Pseudomonas aeruginosa Penicillin-Binding Protein 5 in \u03b2-Lactam Resistance","display_name":"Structural Analysis of the Role of Pseudomonas aeruginosa Penicillin-Binding Protein 5 in \u03b2-Lactam Resistance","publication_year":2013,"publication_date":"2013-04-30","ids":{"openalex":"https://openalex.org/W2154191535","doi":"https://doi.org/10.1128/aac.00505-13","mag":"2154191535","pmid":"https://pubmed.ncbi.nlm.nih.gov/23629710","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3697341"},"language":"en","primary_location":{"id":"doi:10.1128/aac.00505-13","doi":"https://doi.org/10.1128/aac.00505-13","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.00505-13","pdf_url":"https://aac.asm.org/content/aac/57/7/3137.full.pdf","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aac.asm.org/content/aac/57/7/3137.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017969789","display_name":"Jeffrey D. Smith","orcid":"https://orcid.org/0000-0001-8339-628X","observed_orcids":["https://orcid.org/0000-0001-8339-628X"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey D. Smith","raw_affiliation_strings":["Department of Molecular Medicine, University of South Florida, Tampa, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, University of South Florida, Tampa, Florida, USA","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058816305","display_name":"Malika Kumarasiri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Malika Kumarasiri","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066702466","display_name":"Weilie Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weilie Zhang","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069198023","display_name":"Du\u0161an Hesek","orcid":"https://orcid.org/0000-0001-6288-8824","observed_orcids":["https://orcid.org/0000-0001-6288-8824"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dusan Hesek","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017757711","display_name":"Mijoon Lee","orcid":"https://orcid.org/0000-0001-7432-0427","observed_orcids":["https://orcid.org/0000-0001-7432-0427"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mijoon Lee","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109883780","display_name":"M\u00e1rta T\u00f3th","orcid":"https://orcid.org/0000-0002-0442-1553","observed_orcids":["https://orcid.org/0000-0002-0442-1553"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marta Toth","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043351423","display_name":"Sergei B. Vakulenko","orcid":"https://orcid.org/0000-0002-5327-8124","observed_orcids":["https://orcid.org/0000-0002-5327-8124"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sergei Vakulenko","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074738498","display_name":"Jed F. Fisher","orcid":"https://orcid.org/0000-0002-7174-4352","observed_orcids":["https://orcid.org/0000-0002-7174-4352"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jed F. Fisher","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013812375","display_name":"Shahriar Mobashery","orcid":"https://orcid.org/0000-0002-7695-7883","observed_orcids":["https://orcid.org/0000-0002-7695-7883"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shahriar Mobashery","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100402049","display_name":"Yu Chen","orcid":"https://orcid.org/0000-0002-5115-3600","observed_orcids":["https://orcid.org/0000-0002-5115-3600"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Chen","raw_affiliation_strings":["Department of Molecular Medicine, University of South Florida, Tampa, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, University of South Florida, Tampa, Florida, USA","institution_ids":["https://openalex.org/I2613432"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9968,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.83805895,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"57","issue":"7","first_page":"3137","last_page":"3146"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pbp5","display_name":"PBP5","score":0.9789999723434448},{"id":"https://openalex.org/keywords/beta-lactam-resistance","display_name":"beta-lactam resistance","score":0.9070000052452087},{"id":"https://openalex.org/keywords/beta-lactamase-activity","display_name":"beta-lactamase activity","score":0.8740000128746033},{"id":"https://openalex.org/keywords/dd-carboxypeptidase","display_name":"DD-carboxypeptidase","score":0.7910000085830688},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.628000020980835},{"id":"https://openalex.org/keywords/class-a-beta-lactamase","display_name":"class A beta-lactamase","score":0.8949999809265137},{"id":"https://openalex.org/keywords/carbapenemase","display_name":"carbapenemase","score":0.8339999914169312},{"id":"https://openalex.org/keywords/active-site-flexibility","display_name":"active site flexibility","score":0.9229999780654907},{"id":"https://openalex.org/keywords/molecular-dynamics-simulation","display_name":"molecular dynamics simulation","score":0.6850000023841858},{"id":"https://openalex.org/keywords/bifunctional-enzyme","display_name":"bifunctional enzyme","score":0.4129999876022339}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7551823854446411},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.7536911964416504},{"id":"https://openalex.org/C2776653525","wikidata":"https://www.wikidata.org/wiki/Q7162855","display_name":"Penicillin binding proteins","level":4,"score":0.7433914542198181},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.547185480594635},{"id":"https://openalex.org/C2780120296","wikidata":"https://www.wikidata.org/wiki/Q96286","display_name":"Hydrolase","level":3,"score":0.5018532276153564},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.4729059934616089},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.47289907932281494},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.4511031210422516},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.45103344321250916},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4384329617023468},{"id":"https://openalex.org/C174802600","wikidata":"https://www.wikidata.org/wiki/Q12190","display_name":"Penicillin","level":3,"score":0.39003580808639526},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.26681894063949585},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2548268437385559},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22185340523719788},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18022513389587402}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002268","descriptor_name":"Carboxypeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002268","descriptor_name":"Carboxypeptidases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018440","descriptor_name":"beta-Lactam Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046915","descriptor_name":"Penicillin-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D046915","descriptor_name":"Penicillin-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D047090","descriptor_name":"beta-Lactams","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/aac.00505-13","doi":"https://doi.org/10.1128/aac.00505-13","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.00505-13","pdf_url":"https://aac.asm.org/content/aac/57/7/3137.full.pdf","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3697341","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3697341","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:23629710","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23629710","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"},{"id":"pmh:oai:digital.library.adelaide.edu.au:1959.8/157981","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1959.8/157981","pdf_url":null,"source":{"id":"https://openalex.org/S4306401835","display_name":"Adelaide Research & Scholarship (AR&S) (University of Adelaide)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5681781","host_organization_name":"The University of Adelaide","host_organization_lineage":["https://openalex.org/I5681781"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://doi.org/10.1128/AAC.00505-13","raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.1128/aac.00505-13","doi":"https://doi.org/10.1128/aac.00505-13","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.00505-13","pdf_url":"https://aac.asm.org/content/aac/57/7/3137.full.pdf","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4043000042438507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5430742204","display_name":null,"funder_award_id":"AI090348","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6665367320","display_name":"Maturation of Bacterial Cell Wall","funder_award_id":"R01AI090348","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332478","display_name":"U.S. Forest Service","ror":"https://ror.org/03zmjc935"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2154191535.pdf"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W1485555146","https://openalex.org/W1539796472","https://openalex.org/W1548036406","https://openalex.org/W1572369747","https://openalex.org/W1963513281","https://openalex.org/W1973191530","https://openalex.org/W1975943954","https://openalex.org/W1978212838","https://openalex.org/W1984693521","https://openalex.org/W1992789904","https://openalex.org/W1994639967","https://openalex.org/W1996335718","https://openalex.org/W1997284590","https://openalex.org/W1997642184","https://openalex.org/W2001641653","https://openalex.org/W2005977868","https://openalex.org/W2013478603","https://openalex.org/W2018920177","https://openalex.org/W2026219411","https://openalex.org/W2033123159","https://openalex.org/W2034903735","https://openalex.org/W2035416595","https://openalex.org/W2035800315","https://openalex.org/W2046681103","https://openalex.org/W2049334004","https://openalex.org/W2050456292","https://openalex.org/W2057418340","https://openalex.org/W2066946595","https://openalex.org/W2067962590","https://openalex.org/W2068889221","https://openalex.org/W2069198174","https://openalex.org/W2071463329","https://openalex.org/W2073031604","https://openalex.org/W2075287054","https://openalex.org/W2086705273","https://openalex.org/W2088983435","https://openalex.org/W2093983321","https://openalex.org/W2099308633","https://openalex.org/W2099500753","https://openalex.org/W2102821130","https://openalex.org/W2102837962","https://openalex.org/W2105999876","https://openalex.org/W2111957732","https://openalex.org/W2114520383","https://openalex.org/W2117508830","https://openalex.org/W2119538132","https://openalex.org/W2120865397","https://openalex.org/W2120988043","https://openalex.org/W2123677996","https://openalex.org/W2128577323","https://openalex.org/W2131736388","https://openalex.org/W2132086274","https://openalex.org/W2132329502","https://openalex.org/W2139638454","https://openalex.org/W2143982063","https://openalex.org/W2144081223","https://openalex.org/W2148054572","https://openalex.org/W2148325233","https://openalex.org/W2148903381","https://openalex.org/W2152789469","https://openalex.org/W2153583439","https://openalex.org/W2153861364","https://openalex.org/W2161064937","https://openalex.org/W2163341755","https://openalex.org/W2169821755","https://openalex.org/W2330488223","https://openalex.org/W2903140909","https://openalex.org/W4230842383"],"related_works":["https://openalex.org/W2102821130","https://openalex.org/W1971927293","https://openalex.org/W2049334004","https://openalex.org/W2153861364","https://openalex.org/W2898356850","https://openalex.org/W4233093014","https://openalex.org/W2015241610","https://openalex.org/W7098866940","https://openalex.org/W6960782438","https://openalex.org/W2107808275"],"abstract_inverted_index":{"Penicillin-binding":[0],"protein":[1],"5":[2],"(PBP5)":[3],"is":[4,18,52,199],"one":[5],"of":[6,20,35,43,48,58,72,75,87,96,126,166,171,215,224],"the":[7,33,40,44,56,70,73,79,127,141,148,163,172,178,202,213,221,237,242],"most":[8],"abundant":[9],"PBPs":[10],"in":[11,102,162,177,201,218,236],"Pseudomonas":[12],"aeruginosa.":[13],"Although":[14],"its":[15,97,193],"main":[16],"function":[17,197],"that":[19,190,198],"a":[21,84,118,132,196],"cell":[22],"wall":[23],"dd-carboxypeptidase,":[24],"it":[25],"possesses":[26],"sufficient":[27],"\u03b2-lactamase":[28,76,112,231,246],"activity":[29,42,77,232],"to":[30,32,38,69,138,147,220],"contribute":[31],"ability":[34],"P.":[36,62,88,225],"aeruginosa":[37,89,226],"resist":[39],"antibiotic":[41,59],"\u03b2-lactams.":[45],"The":[46],"study":[47],"these":[49],"dual":[50],"activities":[51],"important":[53,65],"for":[54],"understanding":[55,71],"mechanisms":[57],"resistance":[60,223],"by":[61,94,151,241],"aeruginosa,":[63],"an":[64,187],"human":[66],"pathogen,":[67],"and":[68,110,144,156,209,244],"evolution":[74],"from":[78],"PBP":[80,243],"enzymes.":[81],"We":[82],"purified":[83],"soluble":[85],"version":[86],"PBP5":[90,165,205,217],"(designated":[91],"Pa":[92,105,174],"sPBP5)":[93],"deletion":[95],"C-terminal":[98],"membrane":[99],"anchor.":[100],"Under":[101],"vitro":[103],"conditions,":[104],"sPBP5":[106,175],"demonstrates":[107],"both":[108],"dd-carboxypeptidase":[109],"expanded-spectrum":[111],"activities.":[113],"Its":[114],"crystal":[115],"structure":[116],"at":[117],"2.05-\u00c5":[119],"resolution":[120],"shows":[121],"features":[122,159],"closely":[123],"resembling":[124],"those":[125],"class":[128],"A":[129,169],"\u03b2-lactamases,":[130],"including":[131],"shortened":[133],"loop":[134],"spanning":[135],"residues":[136],"74":[137],"78":[139],"near":[140],"active":[142],"site":[143],"with":[145,182],"respect":[146],"conformations":[149],"adopted":[150],"two":[152,173],"active-site":[153,188],"residues,":[154],"Ser101":[155],"Lys203.":[157],"These":[158],"are":[160],"absent":[161,200],"related":[164],"Escherichia":[167],"coli.":[168],"comparison":[170],"monomers":[176],"asymmetric":[179],"unit,":[180],"together":[181],"molecular":[183],"dynamics":[184],"simulations,":[185],"revealed":[186],"flexibility":[189],"may":[191,233],"explain":[192],"carbapenemase":[194],"activity,":[195],"E.":[203],"coli":[204],"enzyme.":[206],"Our":[207],"functional":[208],"structural":[210,238],"characterizations":[211],"underscore":[212],"versatility":[214],"this":[216],"contributing":[219],"\u03b2-lactam":[222],"while":[227],"highlighting":[228],"how":[229],"broader":[230],"be":[234],"encoded":[235],"folds":[239],"shared":[240],"serine":[245],"classes.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
