{"id":"https://openalex.org/W2154157930","doi":"https://doi.org/10.1111/j.1600-0854.2004.00216.x","title":"Temperature\u2010Sensitive Random Insulin Granule Diffusion is a Prerequisite for Recruiting Granules for Release","display_name":"Temperature\u2010Sensitive Random Insulin Granule Diffusion is a Prerequisite for Recruiting Granules for Release","publication_year":2004,"publication_date":"2004-08-18","ids":{"openalex":"https://openalex.org/W2154157930","doi":"https://doi.org/10.1111/j.1600-0854.2004.00216.x","mag":"2154157930","pmid":"https://pubmed.ncbi.nlm.nih.gov/15355511"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0854.2004.00216.x","doi":"https://doi.org/10.1111/j.1600-0854.2004.00216.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1600-0854.2004.00216.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0854.2004.00216.x","source":{"id":"https://openalex.org/S174148068","display_name":"Traffic","issn_l":"1398-9219","issn":["1398-9219","1600-0854"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Traffic","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0854.2004.00216.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084333273","display_name":"Rosita Ivarsson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Rosita Ivarsson","raw_affiliation_strings":["The Diabetes Programme at Lund University, Department of Physiological Sciences, BMC B11, SE-221 84 Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Diabetes Programme at Lund University, Department of Physiological Sciences, BMC B11, SE-221 84 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041786438","display_name":"Stefanie Oberm\u00fcller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Stefanie Oberm\u00fcller","raw_affiliation_strings":["The Diabetes Programme at Lund University, Department of Physiological Sciences, BMC B11, SE-221 84 Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Diabetes Programme at Lund University, Department of Physiological Sciences, BMC B11, SE-221 84 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015737554","display_name":"Guy A. Rutter","orcid":"https://orcid.org/0000-0001-6360-0343","observed_orcids":["https://orcid.org/0000-0001-6360-0343"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Guy A. Rutter","raw_affiliation_strings":["Henry Wellcome Laboratories for Integrated Cell Signalling and Department of Biochemistry, University of Bristol, Bristol BS8 1TD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry Wellcome Laboratories for Integrated Cell Signalling and Department of Biochemistry, University of Bristol, Bristol BS8 1TD, UK","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053125173","display_name":"Juris Galvanovskis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Juris Galvanovskis","raw_affiliation_strings":["The Diabetes Programme at Lund University, Department of Physiological Sciences, BMC B11, SE-221 84 Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Diabetes Programme at Lund University, Department of Physiological Sciences, BMC B11, SE-221 84 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019916793","display_name":"Erik Renstr\u00f6m","orcid":"https://orcid.org/0000-0002-4065-4485","observed_orcids":["https://orcid.org/0000-0002-4065-4485"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Erik Renstr\u00f6m","raw_affiliation_strings":["The Diabetes Programme at Lund University, Department of Physiological Sciences, BMC B11, SE-221 84 Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Diabetes Programme at Lund University, Department of Physiological Sciences, BMC B11, SE-221 84 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5019916793"],"corresponding_institution_ids":["https://openalex.org/I187531555"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":1.4522,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.83359754,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"5","issue":"10","first_page":"750","last_page":"762"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.8008000254631042,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.8008000254631042,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.19539999961853027,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/random-diffusion","display_name":"random diffusion","score":0.8349999785423279},{"id":"https://openalex.org/keywords/temperature-response","display_name":"temperature sensitivity","score":0.7229999899864197},{"id":"https://openalex.org/keywords/second-phase-insulin-secretion","display_name":"second-phase insulin secretion","score":0.7879999876022339},{"id":"https://openalex.org/keywords/exocytosis","display_name":"exocytosis","score":0.9480000138282776},{"id":"https://openalex.org/keywords/ins-1-cells","display_name":"INS-1 cells","score":0.8640000224113464},{"id":"https://openalex.org/keywords/activation-energy","display_name":"activation energy","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C49760210","wikidata":"https://www.wikidata.org/wiki/Q5596727","display_name":"Granule (geology)","level":2,"score":0.8731662631034851},{"id":"https://openalex.org/C175969161","wikidata":"https://www.wikidata.org/wiki/Q323426","display_name":"Exocytosis","level":3,"score":0.8459924459457397},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.7311603426933289},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6572641134262085},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4779148995876312},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4667641818523407},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3498116433620453},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.3420998454093933},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.29129716753959656},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005089","descriptor_name":"Exocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D022142","descriptor_name":"Secretory Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1600-0854.2004.00216.x","doi":"https://doi.org/10.1111/j.1600-0854.2004.00216.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1600-0854.2004.00216.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0854.2004.00216.x","source":{"id":"https://openalex.org/S174148068","display_name":"Traffic","issn_l":"1398-9219","issn":["1398-9219","1600-0854"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Traffic","raw_type":"journal-article"},{"id":"pmid:15355511","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15355511","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Traffic (Copenhagen, Denmark)","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.514.2580","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.514.2580","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"pmh:oai:lup.lub.lu.se:31e5f1bd-a4e6-4a4d-9882-e8e6db59f82f","doi":null,"is_oa":true,"landing_page_url":"https://lup.lub.lu.se/record/127530","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1398-9219","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1111/j.1600-0854.2004.00216.x","doi":"https://doi.org/10.1111/j.1600-0854.2004.00216.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1600-0854.2004.00216.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0854.2004.00216.x","source":{"id":"https://openalex.org/S174148068","display_name":"Traffic","issn_l":"1398-9219","issn":["1398-9219","1600-0854"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Traffic","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320870","display_name":"European Foundation for the Study of Diabetes","ror":"https://ror.org/05tgz4m05"},{"id":"https://openalex.org/F4320321761","display_name":"Crafoordska Stiftelsen","ror":"https://ror.org/02hwwbr17"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2154157930.pdf","grobid_xml":"https://content.openalex.org/works/W2154157930.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W106267973","https://openalex.org/W591832344","https://openalex.org/W1571457734","https://openalex.org/W1594664435","https://openalex.org/W1984540625","https://openalex.org/W1996514721","https://openalex.org/W1999716446","https://openalex.org/W2000084192","https://openalex.org/W2002757608","https://openalex.org/W2004564781","https://openalex.org/W2014410123","https://openalex.org/W2017270830","https://openalex.org/W2018505091","https://openalex.org/W2033004791","https://openalex.org/W2050076638","https://openalex.org/W2054181228","https://openalex.org/W2055454610","https://openalex.org/W2065011201","https://openalex.org/W2068803404","https://openalex.org/W2074850592","https://openalex.org/W2076428562","https://openalex.org/W2080730085","https://openalex.org/W2092172320","https://openalex.org/W2106997862","https://openalex.org/W2111301709","https://openalex.org/W2124971376","https://openalex.org/W2128167237","https://openalex.org/W2133217243","https://openalex.org/W2134052238","https://openalex.org/W2136358674","https://openalex.org/W2150728321","https://openalex.org/W2339049224","https://openalex.org/W2341678080","https://openalex.org/W4300720602"],"related_works":["https://openalex.org/W1551951867","https://openalex.org/W776363937","https://openalex.org/W2325249200","https://openalex.org/W2055454610","https://openalex.org/W2332540094","https://openalex.org/W2313394625","https://openalex.org/W2338004252","https://openalex.org/W2018472858","https://openalex.org/W2074850592","https://openalex.org/W1963181827"],"abstract_inverted_index":{"Glucose-evoked":[0],"insulin":[1,23,45,115,175,192,200,206],"secretion":[2,176],"exhibits":[3,158],"a":[4,65,80,159,188],"biphasic":[5,160],"time":[6],"course":[7],"and":[8,41,168,195],"is":[9,118,177,187],"associated":[10],"with":[11,25],"accelerated":[12],"intracellular":[13],"granule":[14,46,105,116,134,153,193],"movement.":[15],"We":[16,181],"combined":[17],"live":[18],"confocal":[19],"imaging":[20],"of":[21,28,44,72,88,91,96,103,114,145,152,199],"EGFP-labelled":[22],"granules":[24,201],"capacitance":[26],"measurements":[27],"exocytosis":[29,157],"in":[30,69,166],"clonal":[31],"INS-1":[32],"cells":[33],"to":[34,60,120,163],"explore":[35],"the":[36,54,70,89,104,140,143,150,170,197],"relation":[37],"between":[38],"distinct":[39],"random":[40,133,184],"directed":[42,73,77,92,146,191],"modes":[43],"movement,":[47],"as":[48,50],"well":[49],"exocytotic":[51],"capacity.":[52],"Reducing":[53],"temperature":[55,86],"from":[56],"34":[57],"degrees":[58,62],"C":[59,63],"24":[61],"caused":[64],"dramatic":[66],"81%":[67],"drop":[68],"frequency":[71,90],"events,":[74],"but":[75],"reduced":[76,124],"velocities":[78,106],"by":[79,136,179],"mere":[81],"25%.":[82],"The":[83],"much":[84],"stronger":[85],"sensitivity":[87],"events":[93,147],"(estimated":[94],"energy":[95],"activation":[97],"approximately":[98,137],"135":[99],"kJ/mol)":[100,109],"than":[101,123],"that":[102,111,164,183],"(approximately":[107],"22":[108],"suggests":[110],"cooling-induced":[112],"suppression":[113],"movement":[117,186],"attributable":[119],"factors":[121],"other":[122],"motor":[125],"protein":[126],"adenosine":[127],"5'-triphosphatase":[128],"activity.":[129],"Indeed,":[130],"cooling":[131],"suppresses":[132],"diffusion":[135],"50%.":[138],"In":[139],"single":[141],"cell,":[142],"number":[144],"depends":[148],"on":[149],"extent":[151],"diffusion.":[154],"Finally,":[155],"single-cell":[156],"pattern":[161],"corresponding":[162],"observed":[165],"vivo,":[167],"only":[169],"component":[171],"reflecting":[172],"2nd":[173,204],"phase":[174,205],"affected":[178],"cooling.":[180],"conclude":[182],"diffusive":[185],"prerequisite":[189],"for":[190,196],"transport":[194],"recruitment":[198],"released":[202],"during":[203],"secretion.":[207]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}