{"id":"https://openalex.org/W2154148361","doi":"https://doi.org/10.1359/jbmr.1998.13.10.1594","title":"The Effects of Twelve Weeks of Bed Rest on Bone Histology, Biochemical Markers of Bone Turnover, and Calcium Homeostasis in Eleven Normal Subjects","display_name":"The Effects of Twelve Weeks of Bed Rest on Bone Histology, Biochemical Markers of Bone Turnover, and Calcium Homeostasis in Eleven Normal Subjects","publication_year":1998,"publication_date":"1998-10-01","ids":{"openalex":"https://openalex.org/W2154148361","doi":"https://doi.org/10.1359/jbmr.1998.13.10.1594","mag":"2154148361","pmid":"https://pubmed.ncbi.nlm.nih.gov/9783548"},"language":"en","primary_location":{"id":"doi:10.1359/jbmr.1998.13.10.1594","doi":"https://doi.org/10.1359/jbmr.1998.13.10.1594","is_oa":false,"landing_page_url":"https://doi.org/10.1359/jbmr.1998.13.10.1594","pdf_url":null,"source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2154148361"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111758666","display_name":"Joseph E. Zerwekh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joseph E. Zerwekh","raw_affiliation_strings":["Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, U.S.A","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083986756","display_name":"Lisa A. Ruml","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa A. Ruml","raw_affiliation_strings":["Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, U.S.A","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040421908","display_name":"Frank Gottschalk","orcid":"https://orcid.org/0000-0002-2467-1437","observed_orcids":["https://orcid.org/0000-0002-2467-1437"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank Gottschalk","raw_affiliation_strings":["Department of Orthopedic Surgery, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, U.S.A","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113668156","display_name":"Charles Y.C. Pak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Y. C. Pak","raw_affiliation_strings":["Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, U.S.A","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111758666"],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":{"value":3780,"currency":"USD","value_usd":3780},"apc_paid":null,"fwci":4.608,"has_fulltext":false,"cited_by_count":389,"citation_normalized_percentile":{"value":0.95487614,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"13","issue":"10","first_page":"1594","last_page":"1601"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.04010000079870224,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bed-rest","display_name":"bed rest","score":0.9610000252723694},{"id":"https://openalex.org/keywords/skeletal-unloading","display_name":"skeletal unloading","score":0.9079999923706055},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.6129999756813049},{"id":"https://openalex.org/keywords/bone-turnover-markers","display_name":"bone turnover markers","score":0.6480000019073486},{"id":"https://openalex.org/keywords/calcium-homeostasis","display_name":"calcium homeostasis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":0.8920000195503235},{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d","display_name":"1,25-dihydroxyvitamin D","score":0.9829999804496765},{"id":"https://openalex.org/keywords/bone-histology","display_name":"bone histology","score":0.8659999966621399},{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":0.7139999866485596},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.8169999718666077},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.7749999761581421},{"id":"https://openalex.org/keywords/osteocalcin","display_name":"osteocalcin","score":0.7070000171661377},{"id":"https://openalex.org/keywords/bone-specific-alkaline-phosphatase","display_name":"bone-specific alkaline phosphatase","score":0.8930000066757202},{"id":"https://openalex.org/keywords/urinary-deoxypyridinoline","display_name":"urinary deoxypyridinoline","score":0.7990000247955322},{"id":"https://openalex.org/keywords/urinary-n-telopeptide","display_name":"urinary N-telopeptide","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.8602221012115479},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.7359654903411865},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.6947336196899414},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.6593338251113892},{"id":"https://openalex.org/C87975464","wikidata":"https://www.wikidata.org/wiki/Q910704","display_name":"Calcium metabolism","level":3,"score":0.6520470976829529},{"id":"https://openalex.org/C77265313","wikidata":"https://www.wikidata.org/wiki/Q879844","display_name":"Rest (music)","level":2,"score":0.6392011046409607},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5572293996810913},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5408876538276672},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45250025391578674},{"id":"https://openalex.org/C189701845","wikidata":"https://www.wikidata.org/wiki/Q382952","display_name":"Isotopes of calcium","level":3,"score":0.4432685673236847}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001510","descriptor_name":"Bed Rest","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007408","descriptor_name":"Intestinal Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016474","descriptor_name":"Weight-Bearing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016723","descriptor_name":"Bone Remodeling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1359/jbmr.1998.13.10.1594","doi":"https://doi.org/10.1359/jbmr.1998.13.10.1594","is_oa":false,"landing_page_url":"https://doi.org/10.1359/jbmr.1998.13.10.1594","pdf_url":null,"source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},{"id":"pmid:9783548","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9783548","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G1067666716","display_name":null,"funder_award_id":"R01-16061","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G1867400065","display_name":"GENERAL CLINICAL RESEARCH CENTER","funder_award_id":"M01RR000633","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320306101","display_name":"National Aeronautics and Space Administration","ror":"https://ror.org/027ka1x80"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337376","display_name":"NIH Clinical Center","ror":"https://ror.org/04vfsmv21"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W38486948","https://openalex.org/W94140509","https://openalex.org/W851686870","https://openalex.org/W1718909266","https://openalex.org/W1955559333","https://openalex.org/W1967260783","https://openalex.org/W1968738869","https://openalex.org/W1972705221","https://openalex.org/W1973830769","https://openalex.org/W1986014616","https://openalex.org/W2006712324","https://openalex.org/W2007108920","https://openalex.org/W2007172615","https://openalex.org/W2010218431","https://openalex.org/W2040436635","https://openalex.org/W2045167548","https://openalex.org/W2052204645","https://openalex.org/W2055658787","https://openalex.org/W2082806185","https://openalex.org/W2087378917","https://openalex.org/W2093659135","https://openalex.org/W2131098491","https://openalex.org/W2145453088","https://openalex.org/W2167999248","https://openalex.org/W2312380669","https://openalex.org/W2318291687","https://openalex.org/W2422495554","https://openalex.org/W2427901126","https://openalex.org/W2908629052","https://openalex.org/W2992959682","https://openalex.org/W6601595989","https://openalex.org/W6623559703","https://openalex.org/W6771149549"],"related_works":["https://openalex.org/W2005193615","https://openalex.org/W1994664721","https://openalex.org/W2992959682","https://openalex.org/W2030106417","https://openalex.org/W2158918394","https://openalex.org/W1986214667","https://openalex.org/W1981060853","https://openalex.org/W2096846696","https://openalex.org/W1868682","https://openalex.org/W2746030826"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2,60],"undertaken":[3],"to":[4,122,169,194,209,224,240,321,323],"examine":[5],"the":[6,72,80,87,145,312,317],"effects":[7],"of":[8,11,16,26,41,53,65,119,160,250,273,280,290,314],"12":[9,51,63],"weeks":[10,52],"skeletal":[12],"unloading":[13,324],"on":[14],"parameters":[15],"calcium":[17,99,112],"homeostasis,":[18],"calcitropic":[19],"hormones,":[20],"bone":[21,27,155,165,178,251,274,291,332,340],"histology,":[22],"and":[23,78,100,135,176,183,257,278,328,334],"biochemical":[24,248,271],"markers":[25,249,272],"turnover":[28],"in":[29,97,108,154,331,339],"11":[30,39],"normal":[31,150,307],"subjects":[32,49],"(9":[33],"men,":[34],"2":[35],"women;":[36],"34":[37],"+/-":[38,167,171,192,196,207,211,222,226,238,242],"years":[40],"age).":[42],"Following":[43],"an":[44],"ambulatory":[45],"control":[46],"evaluation,":[47],"all":[48,297],"underwent":[50],"bed":[54,130,142,268,302],"rest.":[55,131,269],"An":[56],"additional":[57],"metabolic":[58],"evaluation":[59],"performed":[61],"after":[62],"days":[64],"reambulation.":[66,309],"Bone":[67],"mineral":[68],"density":[69],"declined":[70,139,305],"at":[71,79],"spine":[73],"(-2.9%,":[74],"p":[75,83,173,213,244],"=":[76,84,174,199,214,229,245],"0.092)":[77],"hip":[81],"(-3.8%,":[82],"0.002":[85],"for":[86,163,180],"trochanter).":[88],"Bed":[89],"rest":[90,117,303],"prompted":[91],"a":[92,105,115,158,287,326,335],"rapid,":[93],"sustained,":[94],"significant":[95,106,299],"increase":[96,107,330],"urinary":[98],"phosphorus":[101],"as":[102,104,124,126,201,284,286],"well":[103,285],"serum":[109,136,288],"calcium.":[110],"Urinary":[111,270],"increased":[113,177,189,219],"from":[114,190,220],"pre-bed":[116],"value":[118],"5.3":[120],"mmol/day":[121,128],"values":[123,147],"high":[125],"73":[127],"during":[129,141,267,301,308],"Immunoreactive":[132],"parathyroid":[133],"hormone":[134],"1,25-dihydroxyvitamin":[137],"D":[138],"significantly":[140,266],"rest,":[143],"although":[144],"mean":[146,232],"remained":[148],"within":[149],"limits.":[151],"Significant":[152],"changes":[153],"histology":[156],"included":[157],"suppression":[159],"osteoblastic":[161],"surface":[162,188,205,218,235],"cancellous":[164,182],"(3.1":[166],"1.3%":[168],"1.9":[170],"1.5%,":[172],"0.0142)":[175],"resorption":[179,275,292,333],"both":[181],"cortical":[184],"bone.":[185],"Cortical":[186],"eroded":[187,217],"3.5":[191],"1.1%":[193,223],"7.3":[195],"4.0%":[197],"(p":[198,228],"0.018)":[200],"did":[202,263],"active":[203,233],"osteoclastic":[204,234],"(0.2":[206,237],"0.3%":[208],"0.7":[210],"0.7%,":[212],"0.021).":[215],"Cancellous":[216],"2.1":[221],"4.7":[225],"2.2%":[227],"0.002),":[230],"while":[231],"doubled":[236],"0.2%":[239],"0.4":[241],"0.3%,":[243],"0.020).":[246],"Serum":[247],"formation":[252],"(osteocalcin,":[253],"bone-specific":[254],"alkaline":[255],"phosphatase,":[256],"type":[258,281],"I":[259,282,294],"procollagen":[260],"extension":[261],"peptide)":[262],"not":[264],"change":[265],"(hydroxyproline,":[276],"deoxypyridinoline,":[277],"N-telopeptide":[279],"collagen)":[283],"marker":[289],"(type":[293],"collagen":[295],"carboxytelopeptide)":[296],"demonstrated":[298],"increases":[300],"which":[304],"toward":[306],"Thus,":[310],"under":[311],"conditions":[313],"this":[315],"study,":[316],"human":[318],"skeleton":[319],"appears":[320],"respond":[322],"by":[325],"rapid":[327],"sustained":[329],"more":[336],"subtle":[337],"decrease":[338],"formation.":[341]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":24},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":17}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}