{"id":"https://openalex.org/W2154115960","doi":"https://doi.org/10.1158/2159-8290.cd-12-0521","title":"Mutant and Wild-type Ras: Co-conspirators in Cancer","display_name":"Mutant and Wild-type Ras: Co-conspirators in Cancer","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2154115960","doi":"https://doi.org/10.1158/2159-8290.cd-12-0521","mag":"2154115960","pmid":"https://pubmed.ncbi.nlm.nih.gov/23319767","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3808242"},"language":"en","primary_location":{"id":"doi:10.1158/2159-8290.cd-12-0521","doi":"https://doi.org/10.1158/2159-8290.cd-12-0521","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2159-8290.cd-12-0521","pdf_url":null,"source":{"id":"https://openalex.org/S2486275289","display_name":"Cancer Discovery","issn_l":"2159-8274","issn":["2159-8274","2159-8290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Discovery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3808242","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052928890","display_name":"Tikvah K. Hayes","orcid":"https://orcid.org/0000-0003-0008-5246","observed_orcids":["https://orcid.org/0000-0003-0008-5246"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tikvah K. Hayes","raw_affiliation_strings":["Authors' Affiliations: 1Curriculum in Genetics and Molecular Biology; 2Department of Pharmacology, 3Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: 1Curriculum in Genetics and Molecular Biology; 2Department of Pharmacology, 3Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064063895","display_name":"Channing J. Der","orcid":"https://orcid.org/0000-0002-7751-2747","observed_orcids":["https://orcid.org/0000-0002-7751-2747"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Channing J. Der","raw_affiliation_strings":["Authors' Affiliations: 1Curriculum in Genetics and Molecular Biology; 2Department of Pharmacology, 3Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: 1Curriculum in Genetics and Molecular Biology; 2Department of Pharmacology, 3Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5064063895"],"corresponding_institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"],"apc_list":null,"apc_paid":null,"fwci":0.7533,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.69223688,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"3","issue":"1","first_page":"24","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oncogenic-ras","display_name":"oncogenic Ras","score":0.8299999833106995},{"id":"https://openalex.org/keywords/ras-wild-type","display_name":"RAS wild-type","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tumor-initiation","display_name":"tumor initiation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.9490000009536743},{"id":"https://openalex.org/keywords/oncogenic-signaling","display_name":"oncogenic signaling","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.8423385620117188},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.7566602230072021},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.6422696709632874},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5371535420417786},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5153055191040039},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3683167099952698},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3225530982017517},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22539430856704712}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1158/2159-8290.cd-12-0521","doi":"https://doi.org/10.1158/2159-8290.cd-12-0521","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2159-8290.cd-12-0521","pdf_url":null,"source":{"id":"https://openalex.org/S2486275289","display_name":"Cancer Discovery","issn_l":"2159-8274","issn":["2159-8274","2159-8290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Discovery","raw_type":"journal-article"},{"id":"pmid:23319767","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23319767","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer discovery","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2796104","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3808242","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3808242","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3808242","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Discov","raw_type":"Text"},{"id":"mag:2188505090","doi":null,"is_oa":false,"landing_page_url":"http://cancerdiscovery.aacrjournals.org/content/3/1/24.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2796104","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3808242","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000916247","display_name":"Cancer Cell Biology Training Program","funder_award_id":"T32CA071341","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1606506184","https://openalex.org/W1949819104","https://openalex.org/W1971102429","https://openalex.org/W1971944335","https://openalex.org/W1980323101","https://openalex.org/W2025225219","https://openalex.org/W2146926552","https://openalex.org/W2158608327","https://openalex.org/W2333950962","https://openalex.org/W6640805977","https://openalex.org/W6829858801"],"related_works":["https://openalex.org/W2188505090","https://openalex.org/W1965084174","https://openalex.org/W7099680334","https://openalex.org/W3180597877","https://openalex.org/W2069121183","https://openalex.org/W2464381588","https://openalex.org/W1971944335","https://openalex.org/W7097473285","https://openalex.org/W7096869341","https://openalex.org/W1980323101"],"abstract_inverted_index":{"Abstract":[0],"Summary:":[1],"Although":[2],"the":[3,24],"functional":[4],"interplay":[5],"between":[6],"mutant":[7,59],"and":[8,15,27],"wild-type":[9],"Ras":[10,60],"in":[11,40],"driving":[12],"tumor":[13],"initiation":[14],"growth":[16],"has":[17],"been":[18],"described,":[19],"a":[20],"clear":[21],"picture":[22],"of":[23,29,43],"precise":[25],"ramifications":[26],"mechanisms":[28],"this":[30,41,47],"association":[31],"remains":[32],"elusive,":[33],"sometimes":[34],"with":[35],"conflicting":[36],"conclusions.":[37],"A":[38],"report":[39],"issue":[42],"Cancer":[44,64],"Discovery":[45],"tackles":[46],"question,":[48],"which":[49],"may":[50],"have":[51],"important":[52],"implications":[53],"for":[54,61],"therapeutic":[55],"strategies":[56],"to":[57],"block":[58],"cancer":[62],"treatment.":[63],"Discov;":[65],"3(1);":[66],"24\u20136.":[67],"\u00a92012":[68],"AACR.":[69],"See":[70],"related":[71],"article":[72],"by":[73],"Young":[74],"et":[75],"al.,":[76],"p.":[77],"112":[78]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
