{"id":"https://openalex.org/W2154079699","doi":"https://doi.org/10.7326/0003-4819-154-4-201102150-00006","title":"Measuring the Performance of Markers for Guiding Treatment Decisions","display_name":"Measuring the Performance of Markers for Guiding Treatment Decisions","publication_year":2011,"publication_date":"2011-02-15","ids":{"openalex":"https://openalex.org/W2154079699","doi":"https://doi.org/10.7326/0003-4819-154-4-201102150-00006","mag":"2154079699","pmid":"https://pubmed.ncbi.nlm.nih.gov/21320940","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3085402"},"language":"en","primary_location":{"id":"doi:10.7326/0003-4819-154-4-201102150-00006","doi":"https://doi.org/10.7326/0003-4819-154-4-201102150-00006","is_oa":false,"landing_page_url":"https://doi.org/10.7326/0003-4819-154-4-201102150-00006","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3085402","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050864343","display_name":"Holly Janes","orcid":"https://orcid.org/0000-0002-3237-984X","observed_orcids":["https://orcid.org/0000-0002-3237-984X"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]},{"id":"https://openalex.org/I4210101190","display_name":"Cancer Research And Biostatistics","ror":"https://ror.org/01575p865","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210101190"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Holly Janes","raw_affiliation_strings":["From Fred Hutchinson Cancer Research Center, Seattle, Washington; Academic Medical Center, Amsterdam, the Netherlands; and Cancer Research and Biostatistics, Seattle, Washington","Academic Medical Center, Amsterdam, the Netherlands","Cancer Research and Biostatistics, Seattle, Washington","From Fred Hutchinson Cancer Research Center, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Fred Hutchinson Cancer Research Center, Seattle, Washington; Academic Medical Center, Amsterdam, the Netherlands; and Cancer Research and Biostatistics, Seattle, Washington","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I4210089486","https://openalex.org/I4210101190"]},{"raw_affiliation_string":"Academic Medical Center, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I2802928900"]},{"raw_affiliation_string":"Cancer Research and Biostatistics, Seattle, Washington","institution_ids":["https://openalex.org/I4210101190"]},{"raw_affiliation_string":"From Fred Hutchinson Cancer Research Center, Seattle, Washington","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109010710","display_name":"MARGARET SULLIVAN PEPE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]},{"id":"https://openalex.org/I4210101190","display_name":"Cancer Research And Biostatistics","ror":"https://ror.org/01575p865","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210101190"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Margaret S. Pepe","raw_affiliation_strings":["From Fred Hutchinson Cancer Research Center, Seattle, Washington; Academic Medical Center, Amsterdam, the Netherlands; and Cancer Research and Biostatistics, Seattle, Washington","Academic Medical Center, Amsterdam, the Netherlands","Cancer Research and Biostatistics, Seattle, Washington","From Fred Hutchinson Cancer Research Center, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Fred Hutchinson Cancer Research Center, Seattle, Washington; Academic Medical Center, Amsterdam, the Netherlands; and Cancer Research and Biostatistics, Seattle, Washington","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I4210089486","https://openalex.org/I4210101190"]},{"raw_affiliation_string":"Academic Medical Center, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I2802928900"]},{"raw_affiliation_string":"Cancer Research and Biostatistics, Seattle, Washington","institution_ids":["https://openalex.org/I4210101190"]},{"raw_affiliation_string":"From Fred Hutchinson Cancer Research Center, Seattle, Washington","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061726857","display_name":"Patrick M. Bossuyt","orcid":"https://orcid.org/0000-0003-4427-0128","observed_orcids":["https://orcid.org/0000-0003-4427-0128"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]},{"id":"https://openalex.org/I4210101190","display_name":"Cancer Research And Biostatistics","ror":"https://ror.org/01575p865","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210101190"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Patrick M. Bossuyt","raw_affiliation_strings":["From Fred Hutchinson Cancer Research Center, Seattle, Washington; Academic Medical Center, Amsterdam, the Netherlands; and Cancer Research and Biostatistics, Seattle, Washington","Academic Medical Center, Amsterdam, the Netherlands","Cancer Research and Biostatistics, Seattle, Washington","From Fred Hutchinson Cancer Research Center, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Fred Hutchinson Cancer Research Center, Seattle, Washington; Academic Medical Center, Amsterdam, the Netherlands; and Cancer Research and Biostatistics, Seattle, Washington","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I4210089486","https://openalex.org/I4210101190"]},{"raw_affiliation_string":"Academic Medical Center, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I2802928900"]},{"raw_affiliation_string":"Cancer Research and Biostatistics, Seattle, Washington","institution_ids":["https://openalex.org/I4210101190"]},{"raw_affiliation_string":"From Fred Hutchinson Cancer Research Center, Seattle, Washington","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081974715","display_name":"William Eric Barlow","orcid":"https://orcid.org/0000-0003-4651-2282","observed_orcids":["https://orcid.org/0000-0003-4651-2282"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]},{"id":"https://openalex.org/I4210101190","display_name":"Cancer Research And Biostatistics","ror":"https://ror.org/01575p865","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210101190"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"William E. Barlow","raw_affiliation_strings":["From Fred Hutchinson Cancer Research Center, Seattle, Washington; Academic Medical Center, Amsterdam, the Netherlands; and Cancer Research and Biostatistics, Seattle, Washington","Academic Medical Center, Amsterdam, the Netherlands","Cancer Research and Biostatistics, Seattle, Washington","From Fred Hutchinson Cancer Research Center, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Fred Hutchinson Cancer Research Center, Seattle, Washington; Academic Medical Center, Amsterdam, the Netherlands; and Cancer Research and Biostatistics, Seattle, Washington","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I4210089486","https://openalex.org/I4210101190"]},{"raw_affiliation_string":"Academic Medical Center, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I2802928900"]},{"raw_affiliation_string":"Cancer Research and Biostatistics, Seattle, Washington","institution_ids":["https://openalex.org/I4210101190"]},{"raw_affiliation_string":"From Fred Hutchinson Cancer Research Center, Seattle, Washington","institution_ids":["https://openalex.org/I4210089486"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.7771,"has_fulltext":false,"cited_by_count":139,"citation_normalized_percentile":{"value":0.98769423,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"154","issue":"4","first_page":"253","last_page":"259"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.7148000001907349,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.7148000001907349,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10845","display_name":"Advanced Causal Inference Techniques","score":0.24819999933242798,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.9020000100135803},{"id":"https://openalex.org/keywords/treatment-decision-making","display_name":"treatment decision-making","score":0.6729999780654907},{"id":"https://openalex.org/keywords/prognostic-value","display_name":"prognostic value","score":0.7630000114440918}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8031795024871826},{"id":"https://openalex.org/C141341695","wikidata":"https://www.wikidata.org/wiki/Q2368661","display_name":"Surrogate endpoint","level":2,"score":0.6643807888031006},{"id":"https://openalex.org/C2780521871","wikidata":"https://www.wikidata.org/wiki/Q7239671","display_name":"Predictive marker","level":3,"score":0.4849817752838135},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.45681560039520264},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.4472294747829437},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.44556981325149536},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34287554025650024},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.12924346327781677},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.07656067609786987},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.07599899172782898},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002985","descriptor_name":"Clinical Protocols","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D003657","descriptor_name":"Decision Making","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.7326/0003-4819-154-4-201102150-00006","doi":"https://doi.org/10.7326/0003-4819-154-4-201102150-00006","is_oa":false,"landing_page_url":"https://doi.org/10.7326/0003-4819-154-4-201102150-00006","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},{"id":"pmid:21320940","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21320940","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of internal medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/508cbe8f-a79a-4a8f-970f-64593f80e79a","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/508cbe8f-a79a-4a8f-970f-64593f80e79a","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Janes, H, Pepe, M S, Bossuyt, P M & Barlow, W E 2011, 'Measuring the Performance of Markers for Guiding Treatment Decisions', Annals of internal medicine, vol. 154, no. 4, pp. 253-W80. https://doi.org/10.7326/0003-4819-154-4-201102150-00006","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:europepmc.org:2286130","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3085402","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3085402","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3085402","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Ann Intern Med","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.673.7763","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.673.7763","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://annals.org/data/Journals/AIM/20225/0000605-201102150-00006.pdf","raw_type":"text"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/e1e38b88-be68-491a-bc66-bae0ba6513a9","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/measuring-the-performance-of-markers-for-guiding-treatment-decisions(e1e38b88-be68-491a-bc66-bae0ba6513a9).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Annals of internal medicine, 154(4), 253 - W80. American College of Physicians","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2286130","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3085402","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5768896759","display_name":"Statistical Methods for Evaluating Markers for Treatment Selection","funder_award_id":"R01CA152089","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W17456534","https://openalex.org/W1509445416","https://openalex.org/W1539462193","https://openalex.org/W1961026612","https://openalex.org/W1966267239","https://openalex.org/W1972901309","https://openalex.org/W1995945562","https://openalex.org/W2039671563","https://openalex.org/W2053209535","https://openalex.org/W2096489484","https://openalex.org/W2098184866","https://openalex.org/W2106811951","https://openalex.org/W2108284772","https://openalex.org/W2113344831","https://openalex.org/W2113499049","https://openalex.org/W2114850871","https://openalex.org/W2120398882","https://openalex.org/W2121863992","https://openalex.org/W2126503665","https://openalex.org/W2142564546","https://openalex.org/W2146719470","https://openalex.org/W2150540531","https://openalex.org/W2151680906","https://openalex.org/W2155311724","https://openalex.org/W2157995113","https://openalex.org/W2158863975","https://openalex.org/W2160377567","https://openalex.org/W2167539263"],"related_works":["https://openalex.org/W2039671563","https://openalex.org/W1527912572","https://openalex.org/W2551354077","https://openalex.org/W2066648075","https://openalex.org/W2479808300","https://openalex.org/W2151680906","https://openalex.org/W2187636720","https://openalex.org/W1999550436","https://openalex.org/W2108091404","https://openalex.org/W2810543949"],"abstract_inverted_index":{"Treatment":[0],"selection":[1,31],"markers,":[2,6],"sometimes":[3],"called":[4],"predictive":[5],"are":[7,63,133,192,198],"factors":[8],"that":[9,14,72],"help":[10,84],"clinicians":[11],"select":[12,108,166],"therapies":[13],"maximize":[15],"good":[16],"outcomes":[17,21,157],"and":[18,50,59,168,189,208,210],"minimize":[19],"adverse":[20],"for":[22,27,52,173,204],"patients.":[23],"Existing":[24],"statistical":[25,54],"methods":[26,62],"evaluating":[28,38,209],"a":[29,44,53,98,136,152],"treatment":[30,39,89,109,122,149,175,190],"marker":[32,48,57,82,100,106,128,155,164,179],"include":[33],"assessing":[34],"its":[35],"prognostic":[36],"value,":[37,156],"effects":[40,150],"in":[41,185],"patients":[42,85,119,172],"with":[43],"restricted":[45,194],"range":[46],"of":[47,70,97,118,127,154,171],"values,":[49],"testing":[51],"interaction":[55],"between":[56],"value":[58],"treatment.":[60],"These":[61],"inadequate,":[64],"because":[65,146],"they":[66,147],"give":[67],"misleading":[68],"measures":[69],"performance":[71],"do":[73],"not":[74,161,193],"answer":[75],"key":[76],"clinical":[77,183],"questions":[78],"about":[79],"how":[80,88],"the":[81,95,105,113,125,163,169,196,202,206],"might":[83],"choose":[86],"treatment,":[87,167],"decisions":[90],"should":[91],"be":[92],"made":[93],"on":[94,112,124],"basis":[96,126,203],"continuous":[99],"measurement,":[101],"what":[102,116],"effect":[103],"using":[104,159,162],"to":[107,140,165],"would":[110,120],"have":[111,121],"population,":[114],"or":[115,160],"proportion":[117,170],"changes":[123],"measurement.":[129,180],"Marker-by-treatment":[130],"predictiveness":[131],"curves":[132,207],"proposed":[134,200],"as":[135,151,201],"more":[137],"useful":[138],"aid":[139],"answering":[141],"these":[142],"clinically":[143],"relevant":[144],"questions,":[145],"illustrate":[148],"function":[153],"when":[158],"whom":[174],"recommendations":[176],"change":[177],"after":[178],"Randomized":[181],"therapeutic":[182],"trials,":[184],"which":[186],"entry":[187],"criteria":[188],"regimens":[191],"by":[195],"marker,":[197],"also":[199],"constructing":[205],"comparing":[211],"markers.":[212]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}