{"id":"https://openalex.org/W2153990740","doi":"https://doi.org/10.1255/ejms.340","title":"The Use of Accurate Mass Measurement by Orthogonal Time-of-Flight Mass Spectrometry in Pharmaceuticals Research","display_name":"The Use of Accurate Mass Measurement by Orthogonal Time-of-Flight Mass Spectrometry in Pharmaceuticals Research","publication_year":2000,"publication_date":"2000-04-01","ids":{"openalex":"https://openalex.org/W2153990740","doi":"https://doi.org/10.1255/ejms.340","mag":"2153990740"},"language":"en","primary_location":{"id":"doi:10.1255/ejms.340","doi":"https://doi.org/10.1255/ejms.340","is_oa":false,"landing_page_url":"https://doi.org/10.1255/ejms.340","pdf_url":null,"source":{"id":"https://openalex.org/S4210216295","display_name":"European Journal of Mass Spectrometry","issn_l":"1356-1049","issn":["1356-1049","1469-0667","1747-3705","1751-6838"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Mass Spectrometry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084139086","display_name":"Frank H. Cottee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frank Cottee","raw_affiliation_strings":["SmithKline Beecham Pharmaceuticals, Analytical Sciences, The Old Powder Mills, Leigh, Tonbridge, Kent, TN11 9AN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SmithKline Beecham Pharmaceuticals, Analytical Sciences, The Old Powder Mills, Leigh, Tonbridge, Kent, TN11 9AN, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110718785","display_name":"Neville J. Haskins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neville Haskins","raw_affiliation_strings":["SmithKline Beecham Pharmaceuticals, Analytical Sciences, NFSP (N), Harlow, Essex, CM19 5AW, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SmithKline Beecham Pharmaceuticals, Analytical Sciences, NFSP (N), Harlow, Essex, CM19 5AW, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111969498","display_name":"Duncan K. Bryant","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Duncan Bryant","raw_affiliation_strings":["SmithKline Beecham Pharmaceuticals, Analytical Sciences, NFSP (N), Harlow, Essex, CM19 5AW, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SmithKline Beecham Pharmaceuticals, Analytical Sciences, NFSP (N), Harlow, Essex, CM19 5AW, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006722857","display_name":"Christine Eckers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine Eckers","raw_affiliation_strings":["SmithKline Beecham Pharmaceuticals, Analytical Sciences, NFSP (N), Harlow, Essex, CM19 5AW, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SmithKline Beecham Pharmaceuticals, Analytical Sciences, NFSP (N), Harlow, Essex, CM19 5AW, UK","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036282155","display_name":"Soraya Mont\u00e9","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Soraya Mont\u00e9","raw_affiliation_strings":["SmithKline Beecham Pharmaceuticals, Analytical Sciences, NFSP (N), Harlow, Essex, CM19 5AW, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SmithKline Beecham Pharmaceuticals, Analytical Sciences, NFSP (N), Harlow, Essex, CM19 5AW, UK","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":1.8541,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.84190715,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"2","first_page":"219","last_page":"224"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/accurate-mass-measurement","display_name":"accurate mass measurement","score":0.9879999756813049},{"id":"https://openalex.org/keywords/structure-elucidation","display_name":"structure elucidation","score":0.7490000128746033},{"id":"https://openalex.org/keywords/drug-substances","display_name":"drug substances","score":0.6029999852180481},{"id":"https://openalex.org/keywords/drug-degradation","display_name":"drug degradation","score":0.6520000100135803},{"id":"https://openalex.org/keywords/minor-components","display_name":"minor components","score":0.8820000290870667},{"id":"https://openalex.org/keywords/drug-quantification","display_name":"pharmaceutical analysis","score":0.625},{"id":"https://openalex.org/keywords/organic-mass-spectrometry","display_name":"organic mass spectrometry","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.8457852602005005},{"id":"https://openalex.org/C16291436","wikidata":"https://www.wikidata.org/wiki/Q874402","display_name":"Time-of-flight mass spectrometry","level":4,"score":0.5257426500320435},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4932195544242859},{"id":"https://openalex.org/C98960154","wikidata":"https://www.wikidata.org/wiki/Q3983322","display_name":"Time of flight","level":2,"score":0.4555574059486389},{"id":"https://openalex.org/C3017610826","wikidata":"https://www.wikidata.org/wiki/Q5755916","display_name":"High mass","level":2,"score":0.44388219714164734},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.41000908613204956},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3647148013114929},{"id":"https://openalex.org/C21880701","wikidata":"https://www.wikidata.org/wiki/Q2144042","display_name":"Process engineering","level":1,"score":0.34470492601394653},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.27940914034843445},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.21111392974853516},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1544663906097412},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1298103630542755},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.11551854014396667},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.0795077383518219},{"id":"https://openalex.org/C44870925","wikidata":"https://www.wikidata.org/wiki/Q37547","display_name":"Astrophysics","level":1,"score":0.06803980469703674},{"id":"https://openalex.org/C198291218","wikidata":"https://www.wikidata.org/wiki/Q190382","display_name":"Ionization","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1255/ejms.340","doi":"https://doi.org/10.1255/ejms.340","is_oa":false,"landing_page_url":"https://doi.org/10.1255/ejms.340","pdf_url":null,"source":{"id":"https://openalex.org/S4210216295","display_name":"European Journal of Mass Spectrometry","issn_l":"1356-1049","issn":["1356-1049","1469-0667","1747-3705","1751-6838"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Mass Spectrometry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W622501371","https://openalex.org/W2012239358","https://openalex.org/W2033599685","https://openalex.org/W2035814955","https://openalex.org/W2056295045","https://openalex.org/W2070919225","https://openalex.org/W2135842532","https://openalex.org/W2144432721"],"related_works":["https://openalex.org/W2749460201","https://openalex.org/W2069722002","https://openalex.org/W1271893754","https://openalex.org/W2144432721","https://openalex.org/W2095950597","https://openalex.org/W2011213858","https://openalex.org/W1974698408","https://openalex.org/W2166078857","https://openalex.org/W1996010134","https://openalex.org/W2594896410"],"abstract_inverted_index":{"Allan":[0],"Maccoll":[1],"was":[2],"the":[3,10,15,21,31,62,79,85,102],"founding":[4],"editor":[5],"of":[6,17,23,33,46,66,72,104,135],"Organic":[7],"Mass":[8],"Spectrometry,":[9],"first":[11],"journal":[12],"dedicated":[13],"to":[14,20,95,100,124],"application":[16,45],"mass":[18,47,93,98,120],"spectrometry":[19,48],"analysis":[22],"organic":[24,67],"structures.":[25],"Many":[26],"papers":[27],"in":[28,51,84,127,132],"OMS":[29],"described":[30],"elucidation":[32],"structures":[34,103],"from":[35,118],"natural":[36],"and":[37,64,111],"synthetic":[38],"sources.":[39],"This":[40],"is":[41,122],"still":[42],"a":[43,70,129,133],"major":[44],"today,":[49],"especially":[50,89],"those":[52],"fine":[53],"chemical":[54],"industries":[55],"such":[56],"as":[57],"Pharmaceuticals":[58],"which":[59],"depend":[60],"on":[61],"discovery":[63],"development":[65],"compounds":[68],"for":[69],"variety":[71],"applications.":[73],"In":[74],"this":[75],"paper":[76],"we":[77,81],"describe":[78],"advances":[80],"have":[82],"made":[83],"last":[86],"few":[87],"years,":[88],"utilising":[90],"time-of-flight":[91],"(ToF)":[92],"spectrometers,":[94],"use":[96],"accurate":[97,119],"measurement":[99,121],"determine":[101],"minor":[105],"components":[106],"contained":[107],"within":[108],"drug":[109],"substance":[110],"degraded":[112],"samples.":[113],"The":[114],"additional":[115],"information":[116],"obtained":[117],"shown":[123],"be":[125],"critical":[126],"assigning":[128],"particular":[130],"structure":[131],"number":[134],"examples.":[136]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
