{"id":"https://openalex.org/W2153953124","doi":"https://doi.org/10.1182/blood.v90.3.1101","title":"The Pattern of Interleukin-1\u03b2 (IL-1\u03b2) and Its Modulating Agents IL-1 Receptor Antagonist and IL-1 Soluble Receptor Type II in Acute Meningococcal Infections","display_name":"The Pattern of Interleukin-1\u03b2 (IL-1\u03b2) and Its Modulating Agents IL-1 Receptor Antagonist and IL-1 Soluble Receptor Type II in Acute Meningococcal Infections","publication_year":1997,"publication_date":"1997-08-01","ids":{"openalex":"https://openalex.org/W2153953124","doi":"https://doi.org/10.1182/blood.v90.3.1101","mag":"2153953124","pmid":"https://pubmed.ncbi.nlm.nih.gov/9242541"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v90.3.1101","doi":"https://doi.org/10.1182/blood.v90.3.1101","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v90.3.1101","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059446029","display_name":"Marcel van Deuren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]},{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Marcel van Deuren","raw_affiliation_strings":["From the Departments of Internal Medicine, Intensive Care, Laboratory of Endocrinology and Reproduction, University Hospital Nijmegen, Nijmegen; the Department of Internal Medicine, Eemland Hospital Amersfoort, Amersfoort, The Netherlands; New England Medical Center, Boston, MA; and the Division of Infectious Diseases, University of Colorado Health Science Center, Denver","New England Medical Center, Boston, MA","the Department of Internal Medicine, Eemland Hospital Amersfoort, Amersfoort, The Netherlands","the Division of Infectious Diseases, University of Colorado Health Science Center, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Internal Medicine, Intensive Care, Laboratory of Endocrinology and Reproduction, University Hospital Nijmegen, Nijmegen; the Department of Internal Medicine, Eemland Hospital Amersfoort, Amersfoort, The Netherlands; New England Medical Center, Boston, MA; and the Division of Infectious Diseases, University of Colorado Health Science Center, Denver","institution_ids":["https://openalex.org/I145872427"]},{"raw_affiliation_string":"New England Medical Center, Boston, MA","institution_ids":["https://openalex.org/I1290900354"]},{"raw_affiliation_string":"the Department of Internal Medicine, Eemland Hospital Amersfoort, Amersfoort, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"the Division of Infectious Diseases, University of Colorado Health Science Center, Denver","institution_ids":["https://openalex.org/I4210087413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049681986","display_name":"Johanna van der Ven\u2010Jongekrijg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]},{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Johanna van der Ven-Jongekrijg","raw_affiliation_strings":["From the Departments of Internal Medicine, Intensive Care, Laboratory of Endocrinology and Reproduction, University Hospital Nijmegen, Nijmegen; the Department of Internal Medicine, Eemland Hospital Amersfoort, Amersfoort, The Netherlands; New England Medical Center, Boston, MA; and the Division of Infectious Diseases, University of Colorado Health Science Center, Denver","New England Medical Center, Boston, MA","the Department of Internal Medicine, Eemland Hospital Amersfoort, Amersfoort, The Netherlands","the Division of Infectious Diseases, University of Colorado Health Science Center, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Internal Medicine, Intensive Care, Laboratory of Endocrinology and Reproduction, University Hospital Nijmegen, Nijmegen; the Department of Internal Medicine, Eemland Hospital Amersfoort, Amersfoort, The Netherlands; New England Medical Center, Boston, MA; and the Division of Infectious Diseases, University of Colorado Health Science Center, Denver","institution_ids":["https://openalex.org/I145872427"]},{"raw_affiliation_string":"New England Medical Center, Boston, MA","institution_ids":["https://openalex.org/I1290900354"]},{"raw_affiliation_string":"the Department of Internal Medicine, Eemland Hospital Amersfoort, Amersfoort, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"the Division of Infectious Diseases, University of Colorado Health Science Center, Denver","institution_ids":["https://openalex.org/I4210087413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070134622","display_name":"Edouard G. Vannier","orcid":"https://orcid.org/0000-0001-6654-9053","observed_orcids":["https://orcid.org/0000-0001-6654-9053"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]},{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Edouard Vannier","raw_affiliation_strings":["From the Departments of Internal Medicine, Intensive Care, Laboratory of Endocrinology and Reproduction, University Hospital Nijmegen, Nijmegen; the Department of Internal Medicine, Eemland Hospital Amersfoort, Amersfoort, The Netherlands; New England Medical Center, Boston, MA; and the Division of Infectious Diseases, University of Colorado Health Science Center, Denver","New England Medical Center, Boston, MA","the Department of Internal Medicine, Eemland Hospital Amersfoort, Amersfoort, The Netherlands","the Division of Infectious Diseases, University of Colorado Health Science Center, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Internal Medicine, Intensive Care, Laboratory of Endocrinology and Reproduction, University Hospital Nijmegen, Nijmegen; the Department of Internal Medicine, Eemland Hospital Amersfoort, Amersfoort, The Netherlands; New England Medical Center, Boston, MA; and the Division of Infectious Diseases, University of Colorado Health Science Center, Denver","institution_ids":["https://openalex.org/I145872427"]},{"raw_affiliation_string":"New England Medical Center, Boston, MA","institution_ids":["https://openalex.org/I1290900354"]},{"raw_affiliation_string":"the Department of Internal Medicine, Eemland Hospital Amersfoort, Amersfoort, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"the Division of Infectious Diseases, University of Colorado Health Science Center, Denver","institution_ids":["https://openalex.org/I4210087413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112420952","display_name":"Roelof van Dalen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]},{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Roelof van Dalen","raw_affiliation_strings":["From the Departments of Internal Medicine, Intensive Care, Laboratory of Endocrinology and Reproduction, University Hospital Nijmegen, Nijmegen; the Department of Internal Medicine, Eemland Hospital Amersfoort, Amersfoort, The Netherlands; New England Medical Center, Boston, MA; and the Division of Infectious Diseases, University of Colorado Health Science Center, Denver","New England Medical Center, Boston, MA","the Department of Internal Medicine, Eemland Hospital Amersfoort, Amersfoort, The Netherlands","the Division of Infectious Diseases, University of Colorado Health Science Center, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Internal Medicine, Intensive Care, Laboratory of Endocrinology and Reproduction, University Hospital Nijmegen, Nijmegen; the Department of Internal Medicine, Eemland Hospital Amersfoort, Amersfoort, The Netherlands; New England Medical Center, Boston, MA; and the Division of Infectious Diseases, University of Colorado Health Science Center, Denver","institution_ids":["https://openalex.org/I145872427"]},{"raw_affiliation_string":"New England Medical Center, Boston, MA","institution_ids":["https://openalex.org/I1290900354"]},{"raw_affiliation_string":"the Department of Internal Medicine, Eemland Hospital Amersfoort, Amersfoort, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"the Division of Infectious Diseases, University of Colorado Health Science Center, Denver","institution_ids":["https://openalex.org/I4210087413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111584795","display_name":"Gerard J. Pesman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]},{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Gerard Pesman","raw_affiliation_strings":["From the Departments of Internal Medicine, Intensive Care, Laboratory of Endocrinology and Reproduction, University Hospital Nijmegen, Nijmegen; the Department of Internal Medicine, Eemland Hospital Amersfoort, Amersfoort, The Netherlands; New England Medical Center, Boston, MA; and the Division of Infectious Diseases, University of Colorado Health Science Center, Denver","New England Medical Center, Boston, MA","the Department of Internal Medicine, Eemland Hospital Amersfoort, Amersfoort, The Netherlands","the Division of Infectious Diseases, University of Colorado Health Science Center, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Internal Medicine, Intensive Care, Laboratory of Endocrinology and Reproduction, University Hospital Nijmegen, Nijmegen; the Department of Internal Medicine, Eemland Hospital Amersfoort, Amersfoort, The Netherlands; New England Medical Center, Boston, MA; and the Division of Infectious Diseases, University of Colorado Health Science Center, Denver","institution_ids":["https://openalex.org/I145872427"]},{"raw_affiliation_string":"New England Medical Center, Boston, MA","institution_ids":["https://openalex.org/I1290900354"]},{"raw_affiliation_string":"the Department of Internal Medicine, Eemland Hospital Amersfoort, Amersfoort, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"the Division of Infectious Diseases, University of Colorado Health Science Center, Denver","institution_ids":["https://openalex.org/I4210087413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020434313","display_name":"A. K. M. Bartelink","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]},{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Anton K.M. Bartelink","raw_affiliation_strings":["From the Departments of Internal Medicine, Intensive Care, Laboratory of Endocrinology and Reproduction, University Hospital Nijmegen, Nijmegen; the Department of Internal Medicine, Eemland Hospital Amersfoort, Amersfoort, The Netherlands; New England Medical Center, Boston, MA; and the Division of Infectious Diseases, University of Colorado Health Science Center, Denver","New England Medical Center, Boston, MA","the Department of Internal Medicine, Eemland Hospital Amersfoort, Amersfoort, The Netherlands","the Division of Infectious Diseases, University of Colorado Health Science Center, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Internal Medicine, Intensive Care, Laboratory of Endocrinology and Reproduction, University Hospital Nijmegen, Nijmegen; the Department of Internal Medicine, Eemland Hospital Amersfoort, Amersfoort, The Netherlands; New England Medical Center, Boston, MA; and the Division of Infectious Diseases, University of Colorado Health Science Center, Denver","institution_ids":["https://openalex.org/I145872427"]},{"raw_affiliation_string":"New England Medical Center, Boston, MA","institution_ids":["https://openalex.org/I1290900354"]},{"raw_affiliation_string":"the Department of Internal Medicine, Eemland Hospital Amersfoort, Amersfoort, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"the Division of Infectious Diseases, University of Colorado Health Science Center, Denver","institution_ids":["https://openalex.org/I4210087413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028234430","display_name":"Charles Anthony Dinarello","orcid":"https://orcid.org/0000-0002-5073-8316","observed_orcids":["https://orcid.org/0000-0002-5073-8316"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]},{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Charles A. Dinarello","raw_affiliation_strings":["From the Departments of Internal Medicine, Intensive Care, Laboratory of Endocrinology and Reproduction, University Hospital Nijmegen, Nijmegen; the Department of Internal Medicine, Eemland Hospital Amersfoort, Amersfoort, The Netherlands; New England Medical Center, Boston, MA; and the Division of Infectious Diseases, University of Colorado Health Science Center, Denver","New England Medical Center, Boston, MA","the Department of Internal Medicine, Eemland Hospital Amersfoort, Amersfoort, The Netherlands","the Division of Infectious Diseases, University of Colorado Health Science Center, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Internal Medicine, Intensive Care, Laboratory of Endocrinology and Reproduction, University Hospital Nijmegen, Nijmegen; the Department of Internal Medicine, Eemland Hospital Amersfoort, Amersfoort, The Netherlands; New England Medical Center, Boston, MA; and the Division of Infectious Diseases, University of Colorado Health Science Center, Denver","institution_ids":["https://openalex.org/I145872427"]},{"raw_affiliation_string":"New England Medical Center, Boston, MA","institution_ids":["https://openalex.org/I1290900354"]},{"raw_affiliation_string":"the Department of Internal Medicine, Eemland Hospital Amersfoort, Amersfoort, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"the Division of Infectious Diseases, University of Colorado Health Science Center, Denver","institution_ids":["https://openalex.org/I4210087413"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008373339","display_name":"Jos W. M. van der Meer","orcid":"https://orcid.org/0000-0001-5120-3690","observed_orcids":["https://orcid.org/0000-0001-5120-3690"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]},{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Jos W.M. van der Meer","raw_affiliation_strings":["From the Departments of Internal Medicine, Intensive Care, Laboratory of Endocrinology and Reproduction, University Hospital Nijmegen, Nijmegen; the Department of Internal Medicine, Eemland Hospital Amersfoort, Amersfoort, The Netherlands; New England Medical Center, Boston, MA; and the Division of Infectious Diseases, University of Colorado Health Science Center, Denver","New England Medical Center, Boston, MA","the Department of Internal Medicine, Eemland Hospital Amersfoort, Amersfoort, The Netherlands","the Division of Infectious Diseases, University of Colorado Health Science Center, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Internal Medicine, Intensive Care, Laboratory of Endocrinology and Reproduction, University Hospital Nijmegen, Nijmegen; the Department of Internal Medicine, Eemland Hospital Amersfoort, Amersfoort, The Netherlands; New England Medical Center, Boston, MA; and the Division of Infectious Diseases, University of Colorado Health Science Center, Denver","institution_ids":["https://openalex.org/I145872427"]},{"raw_affiliation_string":"New England Medical Center, Boston, MA","institution_ids":["https://openalex.org/I1290900354"]},{"raw_affiliation_string":"the Department of Internal Medicine, Eemland Hospital Amersfoort, Amersfoort, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"the Division of Infectious Diseases, University of Colorado Health Science Center, Denver","institution_ids":["https://openalex.org/I4210087413"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":3.304,"has_fulltext":false,"cited_by_count":95,"citation_normalized_percentile":{"value":0.91947566,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"90","issue":"3","first_page":"1101","last_page":"1108"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.7714999914169312,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.7714999914169312,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.12099999934434891,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.0575999990105629,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8899999856948853},{"id":"https://openalex.org/keywords/interleukin-1-receptor-antagonist","display_name":"interleukin-1 receptor antagonist","score":0.9559999704360962},{"id":"https://openalex.org/keywords/meningococcal-disease","display_name":"meningococcal disease","score":0.8999999761581421},{"id":"https://openalex.org/keywords/bacterial-meningitis","display_name":"bacterial meningitis","score":0.8679999709129333},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.9860000014305115},{"id":"https://openalex.org/keywords/endotoxin","display_name":"endotoxin","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-cytokines","display_name":"cerebrospinal fluid cytokines","score":0.9100000262260437},{"id":"https://openalex.org/keywords/plasma-cytokine-levels","display_name":"plasma cytokines","score":0.9380000233650208},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cytokine-modulation","display_name":"cytokine modulation","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C149892131","wikidata":"https://www.wikidata.org/wiki/Q14914156","display_name":"Interleukin 1 receptor antagonist","level":5,"score":0.7947907447814941},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.6990628242492676},{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.6619709134101868},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5659840703010559},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.5496328473091125},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.5459210276603699},{"id":"https://openalex.org/C2777977768","wikidata":"https://www.wikidata.org/wiki/Q15996698","display_name":"Interleukin-1 receptor","level":4,"score":0.5403433442115784},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5392964482307434},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5388969779014587},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.5259494781494141},{"id":"https://openalex.org/C11988809","wikidata":"https://www.wikidata.org/wiki/Q412889","display_name":"Interleukin 6","level":3,"score":0.48019516468048096},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47232311964035034},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4624365568161011},{"id":"https://openalex.org/C2781026528","wikidata":"https://www.wikidata.org/wiki/Q48143","display_name":"Meningitis","level":2,"score":0.42357420921325684},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.41221240162849426},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.39861220121383667},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39672327041625977},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.3836906850337982},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.27918875217437744},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.08773991465568542}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004731","descriptor_name":"Endotoxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008585","descriptor_name":"Meningitis, Meningococcal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008585","descriptor_name":"Meningitis, Meningococcal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008585","descriptor_name":"Meningitis, Meningococcal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008589","descriptor_name":"Meningococcal Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008589","descriptor_name":"Meningococcal Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008589","descriptor_name":"Meningococcal Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012795","descriptor_name":"Sialoglycoproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D012795","descriptor_name":"Sialoglycoproteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012795","descriptor_name":"Sialoglycoproteins","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D012795","descriptor_name":"Sialoglycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017472","descriptor_name":"Receptors, Interleukin-1","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017472","descriptor_name":"Receptors, Interleukin-1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D017472","descriptor_name":"Receptors, Interleukin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053574","descriptor_name":"Receptors, Interleukin-1 Type II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053590","descriptor_name":"Interleukin 1 Receptor Antagonist Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood.v90.3.1101","doi":"https://doi.org/10.1182/blood.v90.3.1101","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v90.3.1101","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"doi:10.1182/blood.v90.3.1101.1101_1101_1108","doi":"https://doi.org/10.1182/blood.v90.3.1101.1101_1101_1108","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v90.3.1101.1101_1101_1108","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:9242541","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9242541","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.75,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W36444839","https://openalex.org/W1574290496","https://openalex.org/W1910189841","https://openalex.org/W1966671453","https://openalex.org/W1967413976","https://openalex.org/W1973313699","https://openalex.org/W1973899311","https://openalex.org/W1974495625","https://openalex.org/W1978417778","https://openalex.org/W1984735526","https://openalex.org/W2000378326","https://openalex.org/W2004754577","https://openalex.org/W2005362266","https://openalex.org/W2021045520","https://openalex.org/W2021294973","https://openalex.org/W2027833243","https://openalex.org/W2031960847","https://openalex.org/W2032953982","https://openalex.org/W2036332752","https://openalex.org/W2048022720","https://openalex.org/W2048362161","https://openalex.org/W2053212420","https://openalex.org/W2081441884","https://openalex.org/W2098870010","https://openalex.org/W2099337172","https://openalex.org/W2104492053","https://openalex.org/W2106678289","https://openalex.org/W2115121140","https://openalex.org/W2125499492","https://openalex.org/W2126342903","https://openalex.org/W2129195110","https://openalex.org/W2139963011","https://openalex.org/W2141396178","https://openalex.org/W2142585662","https://openalex.org/W2151144831","https://openalex.org/W2152357679","https://openalex.org/W2152987233","https://openalex.org/W2156885832","https://openalex.org/W2157468464","https://openalex.org/W2162357955","https://openalex.org/W2167184573","https://openalex.org/W2170921103","https://openalex.org/W2333388061","https://openalex.org/W2406312264","https://openalex.org/W2408955877","https://openalex.org/W2419343657","https://openalex.org/W2750312180","https://openalex.org/W3193555215","https://openalex.org/W4388309955","https://openalex.org/W6651340158","https://openalex.org/W6743463356"],"related_works":["https://openalex.org/W4248073078","https://openalex.org/W7014392422","https://openalex.org/W7070478028","https://openalex.org/W2408064203","https://openalex.org/W2152357679","https://openalex.org/W2033575901","https://openalex.org/W2020355720","https://openalex.org/W7096309300","https://openalex.org/W2139963011","https://openalex.org/W1998778729"],"abstract_inverted_index":{"Interleukin-1beta":[0],"(IL-1beta)":[1],"is":[2,18,209],"considered":[3],"an":[4,80],"important":[5],"mediator":[6],"in":[7,44,64,79,89,103,114,121,125,136,147,205,214,237,241,256,289,292],"the":[8,36,51,235,257,261,269,293],"pathogenesis":[9],"of":[10,38,55,83,119,169,194,224,245,253,272],"septic":[11],"shock":[12,66,105,148,162,197],"or":[13],"bacterial":[14],"meningitis.":[15,98,126],"Its":[16],"activity":[17,255],"specifically":[19],"modulated":[20],"by":[21,142,220],"IL-1":[22,27,277],"receptor":[23,29],"antagonist":[24],"(IL-1Ra)":[25],"and":[26,40,67,106,133,161,226,247,260,291],"soluble":[28],"type":[30],"II":[31],"(IL-1sRII).":[32],"We":[33,264],"now":[34],"describe":[35],"time-course":[37],"IL-1beta":[39,60,87,132,246,254],"these":[41],"modulating":[42],"agents":[43],"59":[45],"patients":[46,76,96,163,198],"with":[47,97],"acute":[48,56],"meningococcal":[49,273],"infections,":[50],"prototype":[52],"human":[53],"disease":[54],"endotoxin":[57],"exposure.":[58],"Plasma":[59,99,127],"was":[61,101,201,232],"increased":[62,178],"only":[63],"severe":[65,115],"normalized":[68],"within":[69],"12":[70],"to":[71,95,138,183,189],"24":[72],"hours,":[73],"indicating":[74],"that":[75,211],"were":[77,93,123],"admitted":[78],"early":[81,270],"stage":[82,271],"cytokine":[84],"activation.":[85],"Increased":[86],"values":[88,111],"cerebrospinal":[90],"fluid":[91],"(CSF)":[92],"confined":[94],"IL-1Ra":[100,120,128,275],"elevated":[102,145],"both":[104,159],"nonshock":[107,160,206],"patients,":[108],"extremely":[109],"high":[110],"being":[112],"measured":[113],"shock.":[116],"High":[117],"concentrations":[118,181],"CSF":[122,242,290],"found":[124],"peaked":[129],"shortly":[130],"after":[131,186,192],"decreased":[134],"steeply":[135],"1":[137,188],"2":[139,190],"days,":[140],"followed":[141],"sustained":[143],"moderately":[144],"levels":[146,240],"patients.":[149,207],"Interestingly,":[150],"IL-1sRII":[151,176,216,239,282],"showed":[152],"a":[153,165,221],"completely":[154],"different":[155,251],"pattern.":[156],"At":[157],"admission,":[158,187],"manifested":[164],"similar":[166],"moderate":[167],"increase":[168,200,213],"plasma":[170,175,215,262,294],"IL-1sRII.":[171],"However,":[172],"during":[173,280],"recovery":[174,281],"further":[177],"reaching":[179],"maximal":[180],"3":[182],"5":[184],"days":[185,191],"normalization":[193],"IL-1Ra.":[195,248],"In":[196],"this":[199,212],"more":[202,285],"prominent":[203],"than":[204],"It":[208],"hypothesized":[210],"can":[217],"be":[218,284],"explained":[219],"synergistic":[222],"effect":[223],"dexamethasone":[225],"endotoxin.":[227],"A":[228],"second":[229],"interesting":[230],"observation":[231],"that,":[233],"unlike":[234],"pattern":[236],"plasma,":[238],"paralleled":[243],"those":[244],"This":[249],"suggests":[250],"modulation":[252],"subarachnoid":[258],"space":[259],"compartment.":[263],"conclude":[265],"that:":[266],"(1)":[267],"During":[268],"infections":[274],"modulates":[276],"activity,":[278],"whereas":[279],"may":[283],"important.":[286],"(2)":[287],"Modulation":[288],"compartment":[295],"are":[296],"differentially":[297],"regulated.":[298]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
