{"id":"https://openalex.org/W2153952243","doi":"https://doi.org/10.1002/pros.23093","title":"Epigenomic profiling of DNA methylation in paired prostate cancer versus adjacent benign tissue","display_name":"Epigenomic profiling of DNA methylation in paired prostate cancer versus adjacent benign tissue","publication_year":2015,"publication_date":"2015-09-18","ids":{"openalex":"https://openalex.org/W2153952243","doi":"https://doi.org/10.1002/pros.23093","mag":"2153952243","pmid":"https://pubmed.ncbi.nlm.nih.gov/26383847","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4928710"},"language":"en","primary_location":{"id":"doi:10.1002/pros.23093","doi":"https://doi.org/10.1002/pros.23093","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pros.23093","pdf_url":null,"source":{"id":"https://openalex.org/S197000376","display_name":"The Prostate","issn_l":"0270-4137","issn":["0270-4137","1097-0045"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4928710","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108833393","display_name":"Milan S. Geybels","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Milan S. Geybels","raw_affiliation_strings":["Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, the Netherlands","Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, the Netherlands","institution_ids":["https://openalex.org/I34352273"]},{"raw_affiliation_string":"Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003926666","display_name":"Shanshan Zhao","orcid":"https://orcid.org/0000-0002-5828-4881","observed_orcids":["https://orcid.org/0000-0002-5828-4881"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shanshan Zhao","raw_affiliation_strings":["Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington","National Institute of Environmental Health Sciences, Biostatistics and Computational Biology Branch, Research Triangle Park, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"National Institute of Environmental Health Sciences, Biostatistics and Computational Biology Branch, Research Triangle Park, North Carolina","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108298473","display_name":"Chao-Jen Wong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chao-Jen Wong","raw_affiliation_strings":["Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030012584","display_name":"Marina V. Bibikova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I178645029","display_name":"Illumina (United States)","ror":"https://ror.org/05k34t975","country_code":"US","type":"company","lineage":["https://openalex.org/I178645029"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marina Bibikova","raw_affiliation_strings":["Illumina, Inc., San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Illumina, Inc., San Diego, California","institution_ids":["https://openalex.org/I178645029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090638156","display_name":"Brandy Klotzle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I178645029","display_name":"Illumina (United States)","ror":"https://ror.org/05k34t975","country_code":"US","type":"company","lineage":["https://openalex.org/I178645029"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandy Klotzle","raw_affiliation_strings":["Illumina, Inc., San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Illumina, Inc., San Diego, California","institution_ids":["https://openalex.org/I178645029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000129649","display_name":"Michael C. Wu","orcid":"https://orcid.org/0000-0002-3357-6570","observed_orcids":["https://orcid.org/0000-0002-3357-6570"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Wu","raw_affiliation_strings":["Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045178497","display_name":"Elaine A. Ostrander","orcid":"https://orcid.org/0000-0001-6075-9738","observed_orcids":["https://orcid.org/0000-0001-6075-9738"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elaine A. Ostrander","raw_affiliation_strings":["Cancer Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042998865","display_name":"Jian\u2010Bing Fan","orcid":"https://orcid.org/0000-0002-7852-8097","observed_orcids":["https://orcid.org/0000-0002-7852-8097"]},"institutions":[{"id":"https://openalex.org/I178645029","display_name":"Illumina (United States)","ror":"https://ror.org/05k34t975","country_code":"US","type":"company","lineage":["https://openalex.org/I178645029"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian-Bing Fan","raw_affiliation_strings":["Illumina, Inc., San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Illumina, Inc., San Diego, California","institution_ids":["https://openalex.org/I178645029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058030955","display_name":"Ziding Feng","orcid":"https://orcid.org/0000-0003-3051-8882","observed_orcids":["https://orcid.org/0000-0003-3051-8882"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ziding Feng","raw_affiliation_strings":["MD Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054491363","display_name":"Janet L. Stanford","orcid":"https://orcid.org/0000-0001-5062-4784","observed_orcids":["https://orcid.org/0000-0001-5062-4784"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Janet L. Stanford","raw_affiliation_strings":["Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington","Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington","institution_ids":["https://openalex.org/I4210089486"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5054491363"],"corresponding_institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210089486"],"apc_list":{"value":4600,"currency":"USD","value_usd":4600},"apc_paid":null,"fwci":3.0362,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.92341798,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"75","issue":"16","first_page":"1941","last_page":"1950"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/differentially-methylated-cpg-sites","display_name":"differentially methylated CpG sites","score":0.9129999876022339},{"id":"https://openalex.org/keywords/promoter-hypermethylation","display_name":"promoter hypermethylation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/epigenetic-profiling","display_name":"epigenetic profiling","score":0.781000018119812},{"id":"https://openalex.org/keywords/scgb3a1","display_name":"SCGB3A1","score":0.8870000243186951},{"id":"https://openalex.org/keywords/hif-3alpha","display_name":"HIF-3\u03b1","score":1.0},{"id":"https://openalex.org/keywords/aox1","display_name":"AOX1","score":1.0},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.781000018119812},{"id":"https://openalex.org/keywords/epigenetic-biomarkers","display_name":"epigenetic biomarkers","score":0.8700000047683716},{"id":"https://openalex.org/keywords/radical-prostatectomy","display_name":"radical prostatectomy","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.8706508278846741},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.7551689743995667},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6861571073532104},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6499269604682922},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.598850429058075},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5819581747055054},{"id":"https://openalex.org/C154253233","wikidata":"https://www.wikidata.org/wiki/Q14862240","display_name":"Differentially methylated regions","level":5,"score":0.5418468713760376},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.4732561409473419},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.46275943517684937},{"id":"https://openalex.org/C116114238","wikidata":"https://www.wikidata.org/wiki/Q6823960","display_name":"Methylated DNA immunoprecipitation","level":5,"score":0.4366021156311035},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4016270935535431},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3471931219100952},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3437916934490204},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32731732726097107},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2992987632751465},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24190714955329895}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1002/pros.23093","doi":"https://doi.org/10.1002/pros.23093","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pros.23093","pdf_url":null,"source":{"id":"https://openalex.org/S197000376","display_name":"The Prostate","issn_l":"0270-4137","issn":["0270-4137","1097-0045"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"journal-article"},{"id":"pmid:26383847","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26383847","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"Journal Article"},{"id":"pmh:oai:cris.maastrichtuniversity.nl:openaire_cris_publications/2d8b2d91-79c5-471d-b9dd-a817acca8ca0","doi":null,"is_oa":false,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/2d8b2d91-79c5-471d-b9dd-a817acca8ca0","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Geybels, M S, Zhao, S, Wong, C-J, Bibikova, M, Klotzle, B, Wu, M, Ostrander, E A, Fan, J-B, Feng, Z & Stanford, J L 2015, 'Epigenomic profiling of DNA methylation in paired prostate cancer versus adjacent benign tissue', Prostate, vol. 75, no. 16, pp. 1941-1950. https://doi.org/10.1002/pros.23093","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:europepmc.org:4054128","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4928710","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4928710","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4928710","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Prostate","raw_type":"Text"},{"id":"pmh:um:oai:cris.maastrichtuniversity.nl:publications/2d8b2d91-79c5-471d-b9dd-a817acca8ca0","doi":null,"is_oa":false,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/2d8b2d91-79c5-471d-b9dd-a817acca8ca0","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Prostate, 75(16), 1941 - 1950. Wiley","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4054128","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4928710","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1269383123","display_name":null,"funder_award_id":"BUIT 20146645","funder_id":"https://openalex.org/F4320322777","funder_display_name":"KWF Kankerbestrijding"},{"id":"https://openalex.org/G186534930","display_name":"PROSTATE CANCER IN RELATION TO VASECTOMY","funder_award_id":"R01CA056678","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4021351988","display_name":"Aggressive Prostate Cancer: Linking Epigenomics and Genetics for Prevention","funder_award_id":"K05CA175147","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6444713482","display_name":"NSAIDS and Other Medications in Prostate Cancer Etiology","funder_award_id":"R01CA092579","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000878657","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016672","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000881195","display_name":"The Pacific Northwest Prostate Cancer SPORE","funder_award_id":"P50CA097186","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306163","display_name":"Prostate Cancer Foundation","ror":"https://ror.org/01npwtv09"},{"id":"https://openalex.org/F4320308793","display_name":"Fred Hutchinson Cancer Research Center","ror":"https://ror.org/007ps6h72"},{"id":"https://openalex.org/F4320322777","display_name":"KWF Kankerbestrijding","ror":"https://ror.org/0368jnd28"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1562429056","https://openalex.org/W1964278453","https://openalex.org/W1964895626","https://openalex.org/W1969422002","https://openalex.org/W1974033268","https://openalex.org/W1998500203","https://openalex.org/W2011670486","https://openalex.org/W2018483968","https://openalex.org/W2021341344","https://openalex.org/W2022052582","https://openalex.org/W2024858951","https://openalex.org/W2026431475","https://openalex.org/W2029341502","https://openalex.org/W2034215593","https://openalex.org/W2035289590","https://openalex.org/W2040257851","https://openalex.org/W2055986128","https://openalex.org/W2056040742","https://openalex.org/W2056866491","https://openalex.org/W2059724367","https://openalex.org/W2070166913","https://openalex.org/W2101870168","https://openalex.org/W2103115232","https://openalex.org/W2105488327","https://openalex.org/W2107665951","https://openalex.org/W2111927725","https://openalex.org/W2112376388","https://openalex.org/W2113830858","https://openalex.org/W2114884175","https://openalex.org/W2127821100","https://openalex.org/W2128130893","https://openalex.org/W2132180848","https://openalex.org/W2132778659","https://openalex.org/W2135305351","https://openalex.org/W2135455143","https://openalex.org/W2136004131","https://openalex.org/W2141410747","https://openalex.org/W2146512944","https://openalex.org/W2150127222","https://openalex.org/W2154525266","https://openalex.org/W2156168853","https://openalex.org/W2163454545","https://openalex.org/W2164218164","https://openalex.org/W2168759949","https://openalex.org/W2182914031","https://openalex.org/W2319969389","https://openalex.org/W2346636110"],"related_works":["https://openalex.org/W2498735961","https://openalex.org/W4412193379","https://openalex.org/W4313562172","https://openalex.org/W6939734944","https://openalex.org/W2034215593","https://openalex.org/W2029341502","https://openalex.org/W2114884175","https://openalex.org/W2991067453","https://openalex.org/W2090979034","https://openalex.org/W2083551673"],"abstract_inverted_index":{"BACKGROUND:":[0],"Aberrant":[1],"DNA":[2,11,119],"methylation":[3,12,120,137],"may":[4,230],"promote":[5],"prostate":[6,15],"carcinogenesis.":[7],"We":[8],"investigated":[9],"epigenome-wide":[10],"profiles":[13,121],"in":[14,100,150,165,223],"cancer":[16],"(PCa)":[17],"compared":[18],"to":[19,23,70],"adjacent":[20,36,103,213],"benign":[21,37,104,127,168,214],"tissue":[22,38,105,128,144,215],"identify":[24],"differentially":[25,84,94,172,218],"methylated":[26,85,95,173,219],"CpG":[27,73,86,96],"sites.":[28],"METHODS:":[29],"The":[30,170,195],"study":[31,61,209],"included":[32,147,175],"paired":[33,60],"PCa":[34,101,125,166,211],"and":[35,63,126,185,191,221,224],"samples":[39],"from":[40],"20":[41],"radical":[42],"prostatectomy":[43],"patients.":[44],"Epigenetic":[45],"profiling":[46],"was":[47],"done":[48],"using":[49],"the":[50,59,79,82,109,235],"Infinium":[51],"HumanMethylation450":[52],"BeadChip.":[53],"Linear":[54],"models":[55],"that":[56,178],"accounted":[57],"for":[58,154,204,234],"design":[62],"False":[64],"Discovery":[65],"Rate":[66],"Q-values":[67],"were":[68,88,98,113,163,179],"used":[69,233],"evaluate":[71],"differential":[72],"methylation.":[74],"mRNA":[75],"expression":[76],"levels":[77],"of":[78,111,139,159,194,210,237],"genes":[80,156,174,177],"with":[81,181],"most":[83],"sites":[87,97],"analyzed.":[89],"RESULTS:":[90],"In":[91],"total,":[92],"2,040":[93],"identified":[99],"versus":[102,167,212],"(Q-value":[106],"<":[107],"0.001),":[108],"majority":[110],"which":[112,146,229],"hypermethylated":[114,132,164],"(n":[115],"=":[116],"1,946;":[117],"95%).":[118],"accurately":[122],"distinguished":[123],"between":[124,143],"samples.":[129],"Twenty-seven":[130],"top-ranked":[131,171],"CpGs":[133,149,162,220],"had":[134],"a":[135],"mean":[136],"difference":[138],"at":[140],"least":[141],"40%":[142],"types,":[145],"25":[148],"17":[151],"genes.":[152],"Furthermore,":[153],"10":[155],"over":[157],"50%":[158],"promoter":[160,183,227],"region":[161],"tissue.":[169],"three":[176],"associated":[180],"both":[182],"hypermethylation":[184],"reduced":[186],"gene":[187,226],"expression:":[188],"SCGB3A1,":[189],"HIF3A,":[190],"AOX1.":[192],"Analysis":[193],"Cancer":[196],"Genome":[197],"Atlas":[198],"(TCGA)":[199],"data":[200],"provided":[201],"confirmatory":[202],"evidence":[203],"our":[205],"findings.":[206],"CONCLUSIONS:":[207],"This":[208],"showed":[216],"many":[217],"regions":[222],"outside":[225],"regions,":[228],"potentially":[231],"be":[232],"development":[236],"future":[238],"epigenetic-based":[239],"diagnostic":[240],"tests":[241],"or":[242],"as":[243],"therapeutic":[244],"targets.":[245]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}