{"id":"https://openalex.org/W2153936152","doi":"https://doi.org/10.5281/zenodo.10997576","title":"Duration of the mosquitocidal effect of ivermectin","display_name":"Duration of the mosquitocidal effect of ivermectin","publication_year":2012,"publication_date":"2012-10-23","ids":{"openalex":"https://openalex.org/W2153936152","doi":"https://doi.org/10.5281/zenodo.10997576","mag":"2153936152","pmid":"https://pubmed.ncbi.nlm.nih.gov/38854885","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11153346"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11153346","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11153346","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Malariaworld J","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11153346","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023262714","display_name":"Guido J. H. Bastiaens","orcid":"https://orcid.org/0000-0002-8198-662X","observed_orcids":["https://orcid.org/0000-0002-8198-662X"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Bastiaens, Guido J.H.","raw_affiliation_strings":["Radboud University Nijmegen Medical Centre, Department of Medical Microbiology, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radboud University Nijmegen Medical Centre, Department of Medical Microbiology, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104653604","display_name":"Geert-Jan vanGemert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"van Gemert, Geert-Jan","raw_affiliation_strings":["Radboud University Nijmegen Medical Centre, Department of Medical Microbiology, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radboud University Nijmegen Medical Centre, Department of Medical Microbiology, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026479664","display_name":"Jo Hooghof","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Hooghof, Jo","raw_affiliation_strings":["Radboud University Nijmegen Medical Centre, Department of Medical Microbiology, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radboud University Nijmegen Medical Centre, Department of Medical Microbiology, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043164969","display_name":"Steve W. Lindsay","orcid":"https://orcid.org/0000-0002-3461-9050","observed_orcids":["https://orcid.org/0000-0002-3461-9050"]},"institutions":[{"id":"https://openalex.org/I190082696","display_name":"Durham University","ror":"https://ror.org/01v29qb04","country_code":"GB","type":"education","lineage":["https://openalex.org/I190082696"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lindsay, Steve W.","raw_affiliation_strings":["School of Biological and Biomedical Sciences, Science Laboratories, Durham University, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological and Biomedical Sciences, Science Laboratories, Durham University, UK","institution_ids":["https://openalex.org/I190082696"]}]},{"author_position":"last","author":{"id":null,"display_name":"et al.","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"et al.","raw_affiliation_strings":["Department of Immunology & Infection, London School of Hygiene and Tropical Medicine, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology & Infection, London School of Hygiene and Tropical Medicine, United Kingdom","institution_ids":["https://openalex.org/I4210089966"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2344,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.817621,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"3","issue":null,"first_page":"10","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11065","display_name":"Insect Pest Control Strategies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ivermectin","display_name":"ivermectin","score":1.0},{"id":"https://openalex.org/keywords/malaria-transmission","display_name":"malaria transmission","score":0.5400000214576721},{"id":"https://openalex.org/keywords/mosquito-longevity","display_name":"mosquito longevity","score":0.6589999794960022},{"id":"https://openalex.org/keywords/mosquito-mortality","display_name":"mosquito mortality","score":0.5730000138282776},{"id":"https://openalex.org/keywords/blood-meal","display_name":"blood meal","score":0.3790000081062317},{"id":"https://openalex.org/keywords/drug-combination-therapy","display_name":"drug combination therapy","score":0.4580000042915344},{"id":"https://openalex.org/keywords/antimalarial-drugs","display_name":"antimalarial drugs","score":0.7720000147819519},{"id":"https://openalex.org/keywords/timing-of-drug-administration","display_name":"timing of drug administration","score":0.746999979019165},{"id":"https://openalex.org/keywords/cynomolgus-monkeys","display_name":"Macaca fascicularis","score":0.7350000143051147},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.5239999890327454},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.9340000152587891}],"concepts":[{"id":"https://openalex.org/C2777499811","wikidata":"https://www.wikidata.org/wiki/Q415178","display_name":"Ivermectin","level":2,"score":0.9017307758331299},{"id":"https://openalex.org/C112758219","wikidata":"https://www.wikidata.org/wiki/Q16038819","display_name":"Duration (music)","level":2,"score":0.552559494972229},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3810526728630066},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34638476371765137},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33612459897994995},{"id":"https://openalex.org/C42972112","wikidata":"https://www.wikidata.org/wiki/Q170201","display_name":"Veterinary medicine","level":1,"score":0.3222220540046692},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0448688268661499},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:11153346","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11153346","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Malariaworld J","raw_type":"Text"},{"id":"pmid:38854885","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38854885","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MalariaWorld journal","raw_type":"Journal Article"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/110981","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2066/110981","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.malariaworld.org/sites/default/files/mwjournal/article/MWJ%202012_3_10.pdf","raw_type":"Article / Letter to editor"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/110981","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2066/110981","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Malaria World Journal, 3, 10 - 10","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.5281/zenodo.10997576","doi":"https://doi.org/10.5281/zenodo.10997576","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.10997576","pdf_url":null,"source":{"id":"https://openalex.org/S4393918326","display_name":"MalariaWorld journal","issn_l":"2214-4374","issn":["2214-4374"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.5281/zenodo.10997577","doi":"https://doi.org/10.5281/zenodo.10997577","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.10997577","pdf_url":null,"source":{"id":"https://openalex.org/S4393918326","display_name":"MalariaWorld journal","issn_l":"2214-4374","issn":["2214-4374"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11153346","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11153346","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Malariaworld J","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1970355219","https://openalex.org/W1982491022","https://openalex.org/W1991180849","https://openalex.org/W2015821148","https://openalex.org/W2023978991","https://openalex.org/W2027639485","https://openalex.org/W2031595783","https://openalex.org/W2056933910","https://openalex.org/W2089587242","https://openalex.org/W2091684277","https://openalex.org/W2094585035","https://openalex.org/W2096736440","https://openalex.org/W2104386816","https://openalex.org/W2124102028","https://openalex.org/W2124136203","https://openalex.org/W2137515784","https://openalex.org/W2139477348","https://openalex.org/W2140931333","https://openalex.org/W2166681862","https://openalex.org/W2399178952","https://openalex.org/W3204053182"],"related_works":["https://openalex.org/W1988419562","https://openalex.org/W7098443274","https://openalex.org/W2794814824","https://openalex.org/W4320727152","https://openalex.org/W4396977237","https://openalex.org/W7161977156","https://openalex.org/W4399261222","https://openalex.org/W4379523999","https://openalex.org/W2097679611","https://openalex.org/W2096736440"],"abstract_inverted_index":{"Background:":[0],"Ivermectin":[1],"(IVM)":[2],"reduces":[3,40],"the":[4,48,52,106,123,128,135,159],"lifespan":[5],"of":[6,28,51,55,122,151,161],"malaria-transmitting":[7],"mosquitoes":[8,68,118],"after":[9,98,110,127],"feeding":[10,59,90],"on":[11,47,74,94,120],"humans":[12],"treated":[13],"with":[14],"IVM.":[15],"If":[16],"this":[17,133],"effect":[18,54,137,157],"is":[19],"sufficiently":[20],"long":[21],"and":[22,66,79],"strong,":[23],"IVM":[24,84,99,130,162],"could":[25],"form":[26,166],"part":[27],"a":[29,71,152,167],"drug":[30],"combination":[31],"that":[32,69,82],"not":[33],"only":[34],"treats":[35],"malaria":[36],"patients":[37],"but":[38,144,154],"also":[39],"onward":[41],"transmission.":[42],"Limited":[43],"data":[44],"are":[45,61],"available":[46],"exact":[49],"duration":[50],"mosquitocidal":[53,136,156],"IVM;":[56],"daily":[57],"mosquito":[58],"assays":[60,91],"required":[62],"for":[63],"this.":[64],"Materials":[65],"Methods:":[67],"took":[70],"blood":[72],"meal":[73],"Swiss":[75],"mice,":[76],"Wistar":[77],"rats":[78],"Cynomolgus":[80],"monkeys":[81],"received":[83],"orally":[85],"at":[86],"200-400":[87],"\u03bcg/kg.":[88],"Mosquito":[89,101,113],"were":[92],"performed":[93],"five":[95],"consecutive":[96],"days":[97,126],"administration.":[100,131],"mortality":[102,114],"was":[103,115,138],"determined":[104],"in":[105,141],"first":[107],"72":[108],"hours":[109],"feeding.":[111],"Results:":[112],"70-100%":[116],"when":[117],"fed":[119],"any":[121],"animals":[124,143],"1-2":[125],"last":[129],"After":[132],"time-point":[134],"still":[139],"evident":[140],"some":[142],"became":[145],"more":[146],"variable.":[147],"Conclusions:":[148],"Our":[149],"findings":[150],"pronounced":[153],"short-lived":[155],"makes":[158],"timing":[160],"administration":[163],"crucial":[164],"to":[165,170],"useful":[168],"addition":[169],"anti-malarial":[171],"drugs.":[172]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}