{"id":"https://openalex.org/W2153907290","doi":null,"title":"Ionizing radiation inhibits the PLK cell cycle gene in a G2 checkpoint-dependent manner.","display_name":"Ionizing radiation inhibits the PLK cell cycle gene in a G2 checkpoint-dependent manner.","publication_year":2004,"publication_date":"2004-03-01","ids":{"openalex":"https://openalex.org/W2153907290","mag":"2153907290","pmid":"https://pubmed.ncbi.nlm.nih.gov/15160994"},"language":"en","primary_location":{"id":"pmid:15160994","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15160994","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053482931","display_name":"Anne Hansen Ree","orcid":"https://orcid.org/0000-0002-8264-3223","observed_orcids":["https://orcid.org/0000-0002-8264-3223"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Anne Hansen Ree","raw_affiliation_strings":["Department of Tumor Biology, The Norwegian Radium Hospital, 0310 Oslo, Norway. a.h.ree@labmed.uio.no","University of Oslo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tumor Biology, The Norwegian Radium Hospital, 0310 Oslo, Norway. a.h.ree@labmed.uio.no","institution_ids":[]},{"raw_affiliation_string":"University of Oslo","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084611810","display_name":"\u00c5se Bratland","orcid":"https://orcid.org/0009-0009-9789-7961","observed_orcids":["https://orcid.org/0009-0009-9789-7961"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Ase Bratland","raw_affiliation_strings":["University of Oslo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oslo","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075079620","display_name":"Kirsti Solberg Landsverk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Kirsti Solberg Landsverk","raw_affiliation_strings":["University of Oslo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oslo","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113522568","display_name":"\u00d8ystein Fodstad","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oystein Fodstad","raw_affiliation_strings":["Institute for Cancer Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cancer Research","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0974,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.35453193,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"24","issue":"2B","first_page":"555","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.39969998598098755,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.39969998598098755,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.30149999260902405,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.12080000340938568,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/plk1","display_name":"PLK1","score":0.9639999866485596},{"id":"https://openalex.org/keywords/g2-checkpoint","display_name":"G2 checkpoint","score":0.8330000042915344},{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.8769999742507935},{"id":"https://openalex.org/keywords/tp53","display_name":"TP53","score":0.8309999704360962},{"id":"https://openalex.org/keywords/breast-cancer-cell-lines","display_name":"breast cancer cell lines","score":0.7289999723434448},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.7310000061988831},{"id":"https://openalex.org/keywords/p21-cdkn1a","display_name":"CDKN1A/p21","score":0.7630000114440918},{"id":"https://openalex.org/keywords/fractionated-irradiation","display_name":"fractionated irradiation","score":0.7739999890327454},{"id":"https://openalex.org/keywords/dna-damage-checkpoint","display_name":"DNA damage checkpoint","score":0.6510000228881836},{"id":"https://openalex.org/keywords/hcc1937","display_name":"HCC1937","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.7785011529922485},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.6533271074295044},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.582876443862915},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5657631754875183},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.47152575850486755},{"id":"https://openalex.org/C50001416","wikidata":"https://www.wikidata.org/wiki/Q17861750","display_name":"CHEK1","level":5,"score":0.42147207260131836},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.41324102878570557},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40765875577926636},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36589932441711426},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32521575689315796},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.21793672442436218},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15002942085266113},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.14363324642181396}],"mesh":[{"descriptor_ui":"D000097869","descriptor_name":"Polo-Like Kinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D016195","descriptor_name":"G2 Phase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016195","descriptor_name":"G2 Phase","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:15160994","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15160994","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2153907290","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15160994","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1481731879","https://openalex.org/W1520947267","https://openalex.org/W1537737236","https://openalex.org/W1661087247","https://openalex.org/W1682348115","https://openalex.org/W1755597336","https://openalex.org/W1757178672","https://openalex.org/W1886278373","https://openalex.org/W1969308341","https://openalex.org/W1976960697","https://openalex.org/W1985407849","https://openalex.org/W1986926802","https://openalex.org/W1987353686","https://openalex.org/W1988876917","https://openalex.org/W1994162200","https://openalex.org/W2004981153","https://openalex.org/W2017697398","https://openalex.org/W2020339838","https://openalex.org/W2022811243","https://openalex.org/W2028521239","https://openalex.org/W2034317592","https://openalex.org/W2034577150","https://openalex.org/W2053738387","https://openalex.org/W2057949133","https://openalex.org/W2076906857","https://openalex.org/W2077381664","https://openalex.org/W2082087067","https://openalex.org/W2106436159","https://openalex.org/W2142904932","https://openalex.org/W2143916467","https://openalex.org/W2145579904","https://openalex.org/W2147688002","https://openalex.org/W2164916497","https://openalex.org/W2167003908","https://openalex.org/W2168225429"],"related_works":["https://openalex.org/W1987353686","https://openalex.org/W1964503671","https://openalex.org/W2010052397","https://openalex.org/W3132816076","https://openalex.org/W2065631558","https://openalex.org/W2090303332","https://openalex.org/W2382673631","https://openalex.org/W392410600","https://openalex.org/W1986203874","https://openalex.org/W2788661926"],"abstract_inverted_index":{"Tumor":[0],"cell":[1,6,51,57,96,118,136,156,177,183,187,220,239,246],"cycle":[2,7,52,157,188],"arrest":[3,189,212],"at":[4,203,213],"the":[5,16,25,35,40,45,93,109,116,134,138,142,154,166,175,200,204,214,218,223,235,242],"G2/M":[8,215],"boundary":[9,206],"after":[10,129,190],"ionizing":[11,230],"radiation":[12,99,231],"involves":[13],"inhibition":[14],"of":[15,29,63,82,104,115,125,147,197,225],"Polo-like":[17],"kinase":[18],"1":[19],"(Plk1).":[20],"We":[21],"recently":[22],"found":[23],"that":[24,254],"mechanism":[26],"comprised":[27],"repression":[28,103],"its":[30],"gene,":[31],"PLK,":[32],"mediated":[33],"by":[34,229],"tumor-suppressor":[36],"protein":[37],"BRCA1.":[38],"In":[39,92,131],"present":[41],"study":[42],"we":[43,252],"examined":[44],"regulatory":[46,161,256],"responses":[47],"on":[48,163],"PLK":[49,105,126,164,226],"and":[50,241],"phases":[53],"in":[54,165,174,217,234],"breast":[55],"carcinoma":[56],"lines":[58],"exposed":[59],"to":[60,89,133,172,208,211],"various":[61],"modes":[62],"therapeutic":[64],"irradiation.":[65,130],"The":[66,160],"tumor":[67],"cells,":[68,168,199],"harboring":[69],"different":[70],"DNA":[71],"damage":[72],"checkpoint":[73,263],"defects,":[74],"were":[75,170],"irradiated":[76],"with":[77,122,249],"either":[78],"a":[79],"single":[80],"dose":[81],"8.0":[83,90],"Gy":[84],"or":[85],"fractionated":[86],"doses":[87],"accumulating":[88],"Gy.":[91],"BRCA1-/-":[94,244],"HCC1937":[95,135,182,245],"line":[97,119,184,240,247],"both":[98],"regimens":[100],"caused":[101],"moderate":[102],"mRNA":[106,127,151,227],"expression,":[107],"whereas":[108,180],"reconstituted":[110,248],"wild-type":[111],"(wt)":[112],"BRCA1":[113],"genotype":[114],"HCC1937/BRCA1wt":[117,176],"was":[120,232],"associated":[121],"significant":[123],"down-regulation":[124,224],"expression":[128,152,228],"contrast":[132],"lines,":[137],"MCF7/LCC2":[139,167,219,238],"cells":[140],"displayed":[141,185],"characteristic":[143],"wt":[144,236,250],"TP53":[145,237],"constitution":[146],"persistent,":[148],"radiation-induced":[149,201],"CDKN1A":[150],"(encoding":[153],"G1":[155],"inhibitor":[158],"p21(Waf1/Cip1/Sdi1)).":[159],"effects":[162],"however,":[169],"identical":[171,233],"those":[173],"line.":[178,221],"Moreover,":[179],"neither":[181],"G1/S":[186,205],"irradiation":[191],"but,":[192],"instead,":[193],"an":[194,260],"apparent":[195],"accumulation":[196],"G2/M-phase":[198],"delay":[202],"seemed":[207],"be":[209],"superior":[210],"transition":[216],"Since":[222],"TP53-mutated":[243],"BRCA1,":[251],"conclude":[253],"this":[255],"effect":[257],"solely":[258],"requires":[259],"intact":[261],"G2":[262],"effector":[264],"mechanism.":[265]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}