{"id":"https://openalex.org/W2153756739","doi":"https://doi.org/10.1139/bcb-77-1-11","title":"Molecular dissection of the human multidrug resistance P-glycoprotein","display_name":"Molecular dissection of the human multidrug resistance P-glycoprotein","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2153756739","doi":"https://doi.org/10.1139/bcb-77-1-11","mag":"2153756739","pmid":"https://pubmed.ncbi.nlm.nih.gov/10426282"},"language":"en","primary_location":{"id":"doi:10.1139/bcb-77-1-11","doi":"https://doi.org/10.1139/bcb-77-1-11","is_oa":false,"landing_page_url":"https://doi.org/10.1139/bcb-77-1-11","pdf_url":null,"source":{"id":"https://openalex.org/S159551863","display_name":"Biochemistry and Cell Biology","issn_l":"0829-8211","issn":["0829-8211","1208-6002"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312929","host_organization_name":"Canadian Science Publishing","host_organization_lineage":["https://openalex.org/P4310312929"],"host_organization_lineage_names":["Canadian Science Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry and Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042609718","display_name":"Tip W. Loo","orcid":"https://orcid.org/0000-0003-2108-0188","observed_orcids":["https://orcid.org/0000-0003-2108-0188"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tip W. Loo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5060459035","display_name":"David M. Clarke","orcid":"https://orcid.org/0000-0003-4335-7184","observed_orcids":["https://orcid.org/0000-0003-4335-7184"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David M. Clarke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.3351,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.92719064,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"77","issue":"1","first_page":"11","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.9829999804496765},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.8619999885559082},{"id":"https://openalex.org/keywords/abc-transporters","display_name":"ABC transporters","score":0.9959999918937683},{"id":"https://openalex.org/keywords/drug-transport","display_name":"drug transport","score":0.7639999985694885},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.5799999833106995},{"id":"https://openalex.org/keywords/atpase-activity","display_name":"ATPase activity","score":0.7950000166893005},{"id":"https://openalex.org/keywords/site-directed-mutagenesis","display_name":"site-directed mutagenesis","score":0.9240000247955322},{"id":"https://openalex.org/keywords/disulfide-cross-linking","display_name":"disulfide cross-linking","score":0.996999979019165},{"id":"https://openalex.org/keywords/metal-chelate-chromatography","display_name":"metal chelate chromatography","score":0.8980000019073486},{"id":"https://openalex.org/keywords/protein-structure","display_name":"protein structure","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.8003729581832886},{"id":"https://openalex.org/C2778707650","wikidata":"https://www.wikidata.org/wiki/Q412902","display_name":"P-glycoprotein","level":4,"score":0.7867119312286377},{"id":"https://openalex.org/C44312359","wikidata":"https://www.wikidata.org/wiki/Q286958","display_name":"ATP-binding cassette transporter","level":4,"score":0.6606236696243286},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5300937294960022},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.5288333296775818},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5263998508453369},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.492107093334198},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.46764418482780457},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4423598349094391},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33431434631347656},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24318388104438782},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.17330065369606018},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10888078808784485}],"mesh":[{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018432","descriptor_name":"Drug Resistance, Multiple","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1139/bcb-77-1-11","doi":"https://doi.org/10.1139/bcb-77-1-11","is_oa":false,"landing_page_url":"https://doi.org/10.1139/bcb-77-1-11","pdf_url":null,"source":{"id":"https://openalex.org/S159551863","display_name":"Biochemistry and Cell Biology","issn_l":"0829-8211","issn":["0829-8211","1208-6002"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312929","host_organization_name":"Canadian Science Publishing","host_organization_lineage":["https://openalex.org/P4310312929"],"host_organization_lineage_names":["Canadian Science Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry and Cell Biology","raw_type":"journal-article"},{"id":"doi:10.1139/o99-014","doi":"https://doi.org/10.1139/o99-014","is_oa":false,"landing_page_url":"https://doi.org/10.1139/o99-014","pdf_url":null,"source":{"id":"https://openalex.org/S159551863","display_name":"Biochemistry and Cell Biology","issn_l":"0829-8211","issn":["0829-8211","1208-6002"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312929","host_organization_name":"Canadian Science Publishing","host_organization_lineage":["https://openalex.org/P4310312929"],"host_organization_lineage_names":["Canadian Science Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry and Cell Biology","raw_type":"journal-article"},{"id":"pmid:10426282","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10426282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry and cell biology = Biochimie et biologie cellulaire","raw_type":"Lecture"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":102,"referenced_works":["https://openalex.org/W24492042","https://openalex.org/W42293926","https://openalex.org/W80727568","https://openalex.org/W86821847","https://openalex.org/W101324336","https://openalex.org/W1530290881","https://openalex.org/W1542671610","https://openalex.org/W1545285984","https://openalex.org/W1551948893","https://openalex.org/W1561829393","https://openalex.org/W1564063900","https://openalex.org/W1564476874","https://openalex.org/W1565284520","https://openalex.org/W1571215201","https://openalex.org/W1577612357","https://openalex.org/W1578072993","https://openalex.org/W1578745312","https://openalex.org/W1587030064","https://openalex.org/W1588246354","https://openalex.org/W1591356314","https://openalex.org/W1594196316","https://openalex.org/W1596954277","https://openalex.org/W1598654033","https://openalex.org/W1599794366","https://openalex.org/W1608154971","https://openalex.org/W1678477795","https://openalex.org/W1768645045","https://openalex.org/W1776236658","https://openalex.org/W1778855378","https://openalex.org/W1858200607","https://openalex.org/W1865504766","https://openalex.org/W1963552073","https://openalex.org/W1964470226","https://openalex.org/W1975553252","https://openalex.org/W1977254345","https://openalex.org/W1979590194","https://openalex.org/W1981267478","https://openalex.org/W1983343128","https://openalex.org/W1984038333","https://openalex.org/W1988867706","https://openalex.org/W1989023531","https://openalex.org/W1990043592","https://openalex.org/W1992531404","https://openalex.org/W1995776268","https://openalex.org/W1996653201","https://openalex.org/W1996845076","https://openalex.org/W1997538023","https://openalex.org/W2003448477","https://openalex.org/W2003464317","https://openalex.org/W2003623971","https://openalex.org/W2006677268","https://openalex.org/W2007644784","https://openalex.org/W2007965142","https://openalex.org/W2010623159","https://openalex.org/W2011163792","https://openalex.org/W2012021913","https://openalex.org/W2013540958","https://openalex.org/W2018022126","https://openalex.org/W2018652769","https://openalex.org/W2019113077","https://openalex.org/W2019702811","https://openalex.org/W2025603165","https://openalex.org/W2026537707","https://openalex.org/W2028533496","https://openalex.org/W2029185839","https://openalex.org/W2029302957","https://openalex.org/W2033526989","https://openalex.org/W2039864751","https://openalex.org/W2042316019","https://openalex.org/W2045689507","https://openalex.org/W2045831118","https://openalex.org/W2046197513","https://openalex.org/W2047949724","https://openalex.org/W2048010223","https://openalex.org/W2049683781","https://openalex.org/W2050917153","https://openalex.org/W2060914976","https://openalex.org/W2072208750","https://openalex.org/W2076031566","https://openalex.org/W2078877172","https://openalex.org/W2079466396","https://openalex.org/W2080271815","https://openalex.org/W2082064626","https://openalex.org/W2086602165","https://openalex.org/W2090910729","https://openalex.org/W2091803979","https://openalex.org/W2102286060","https://openalex.org/W2112001901","https://openalex.org/W2131403498","https://openalex.org/W2144648087","https://openalex.org/W2150097377","https://openalex.org/W2153712534","https://openalex.org/W2167621975","https://openalex.org/W2168959672","https://openalex.org/W2170560435","https://openalex.org/W2170734806","https://openalex.org/W2172134989","https://openalex.org/W2240907549","https://openalex.org/W2340306303","https://openalex.org/W2413545665","https://openalex.org/W2414829702","https://openalex.org/W2512279504"],"related_works":["https://openalex.org/W4233641679","https://openalex.org/W2049195759","https://openalex.org/W2028331415","https://openalex.org/W2083808039","https://openalex.org/W2078151716","https://openalex.org/W2027439716","https://openalex.org/W2088391278","https://openalex.org/W1990043592","https://openalex.org/W4253789696","https://openalex.org/W2493271536"],"abstract_inverted_index":{"The":[0,36],"human":[1],"multidrug":[2,48],"resistance":[3,49],"P-glycoprotein":[4],"is":[5],"an":[6],"ATP-dependent":[7],"drug":[8,81],"pump":[9],"that":[10],"extrudes":[11],"a":[12],"broad":[13],"range":[14],"of":[15,47,58],"cytotoxic":[16,34],"agents":[17],"from":[18,30],"the":[19,28,45,59],"cell.":[20],"Its":[21],"physiological":[22],"role":[23],"may":[24],"be":[25],"to":[26,44],"protect":[27],"body":[29],"endogenous":[31],"and":[32,66,74],"exogenous":[33],"agents.":[35],"protein":[37,67],"has":[38],"clinical":[39],"importance":[40],"because":[41],"it":[42],"contributes":[43],"phenomenon":[46],"during":[50],"chemotherapy.":[51],"In":[52],"this":[53,72],"review,":[54],"we":[55],"discuss":[56],"some":[57],"results":[60],"obtained":[61],"by":[62],"using":[63],"molecular":[64],"biology":[65],"chemistry":[68],"techniques":[69],"for":[70],"studying":[71],"important":[73],"intriguing":[75],"protein.Key":[76],"words:":[77],"P-glycoprotein,":[78],"ABC":[79],"transporters,":[80],"transport,":[82],"dibromobimane,":[83],"mutagenesis,":[84],"disulfide":[85],"crosslinking,":[86],"metal-chelate":[87],"chromatography,":[88],"ATPase":[89],"activity.":[90]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
