{"id":"https://openalex.org/W2153756155","doi":"https://doi.org/10.2174/1381612023394890","title":"Genomics Strategies for Antifungal Drug Discovery - From Gene Discovery to Compound Screening","display_name":"Genomics Strategies for Antifungal Drug Discovery - From Gene Discovery to Compound Screening","publication_year":2002,"publication_date":"2002-06-01","ids":{"openalex":"https://openalex.org/W2153756155","doi":"https://doi.org/10.2174/1381612023394890","mag":"2153756155","pmid":"https://pubmed.ncbi.nlm.nih.gov/12052224"},"language":"en","primary_location":{"id":"doi:10.2174/1381612023394890","doi":"https://doi.org/10.2174/1381612023394890","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1381612023394890","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043504763","display_name":"Debra Aker Willins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Debra Willins","raw_affiliation_strings":["Genome Therapeutics Corp, 100 Beaver Street, Waltham, MA 02453, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Therapeutics Corp, 100 Beaver Street, Waltham, MA 02453, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113634611","display_name":"Marco M. Kessler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marco Kessler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063931983","display_name":"Scott S. Walker","orcid":"https://orcid.org/0000-0002-3076-439X","observed_orcids":["https://orcid.org/0000-0002-3076-439X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott Walker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111465482","display_name":"Gregory R. Reyes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gregory Reyes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5040052318","display_name":"Guillaume Cottarel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guillaume Cottarel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3248,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.81359742,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"8","issue":"13","first_page":"1137","last_page":"1154"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.4487000107765198,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.4487000107765198,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.38839998841285706,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.07029999792575836,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antifungal-drug-discovery","display_name":"antifungal drug discovery","score":0.996999979019165},{"id":"https://openalex.org/keywords/fungal-genomics","display_name":"fungal genomics","score":0.7710000276565552},{"id":"https://openalex.org/keywords/gene-discovery","display_name":"gene discovery","score":0.8550000190734863},{"id":"https://openalex.org/keywords/high-throughput-compound-screening","display_name":"high-throughput compound screening","score":0.9089999794960022},{"id":"https://openalex.org/keywords/essential-genes","display_name":"essential genes","score":0.718999981880188},{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.9010000228881836},{"id":"https://openalex.org/keywords/aspergillus-fumigatus","display_name":"Aspergillus fumigatus","score":1.0}],"concepts":[{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.7077652215957642},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6629933714866638},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6474761366844177},{"id":"https://openalex.org/C2991737395","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal drug","level":3,"score":0.6415352821350098},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.6137058138847351},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5468659996986389},{"id":"https://openalex.org/C2909919671","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal drugs","level":3,"score":0.5145279765129089},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4975309669971466},{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.48936957120895386},{"id":"https://openalex.org/C164614171","wikidata":"https://www.wikidata.org/wiki/Q5204775","display_name":"DECIPHER","level":2,"score":0.464056134223938},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.44030827283859253},{"id":"https://openalex.org/C105176652","wikidata":"https://www.wikidata.org/wiki/Q1147112","display_name":"Comparative genomics","level":5,"score":0.4104447066783905},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36841171979904175},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.23269492387771606}],"mesh":[{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001232","descriptor_name":"Aspergillus fumigatus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015723","descriptor_name":"Gene Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016681","descriptor_name":"Genome, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2174/1381612023394890","doi":"https://doi.org/10.2174/1381612023394890","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1381612023394890","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},{"id":"pmid:12052224","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12052224","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current pharmaceutical design","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.4399999976158142,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2004164443","https://openalex.org/W4281747822","https://openalex.org/W1967019766","https://openalex.org/W2103234337","https://openalex.org/W2020605995","https://openalex.org/W3082221207","https://openalex.org/W7100160727","https://openalex.org/W7099350316","https://openalex.org/W1575161698","https://openalex.org/W2139053514"],"abstract_inverted_index":{"The":[0],"use":[1],"of":[2,46,61,71,77,89,137],"genomics":[3,51],"tools":[4],"to":[5,9,13,17,23,32,41,73,96,128],"discover":[6],"new":[7,44],"genes,":[8],"decipher":[10],"pathways":[11],"or":[12],"assign":[14],"a":[15,18,43,125],"function":[16],"gene":[19,62],"is":[20,94],"just":[21],"beginning":[22],"have":[24,29],"an":[25],"impact.":[26],"Genomics":[27],"approaches":[28,52],"been":[30],"applied":[31],"both":[33],"antibacterial":[34],"and":[35,66,103,135],"antifungal":[36,54],"target":[37,64],"discovery":[38],"in":[39],"order":[40],"identify":[42,74,130],"generation":[45],"antibiotics.":[47],"This":[48],"review":[49],"discusses":[50],"for":[53,85,105,133,145],"drug":[55],"discovery,":[56,63],"focusing":[57],"on":[58],"the":[59,118,138],"areas":[60],"validation,":[65],"compound":[67,147],"screening.":[68,148],"A":[69],"variety":[70],"methods":[72,84],"fungal":[75,116],"genes":[76,131],"interest":[78],"are":[79],"discussed,":[80],"as":[81,83,124],"well":[82],"obtaining":[86],"full-length":[87],"sequences":[88],"these":[90],"genes.":[91],"One":[92],"approach":[93],"well-suited":[95],"organisms":[97,106],"having":[98],"few":[99],"introns":[100,109],"(Candida":[101],"albicans),":[102],"another":[104],"with":[107],"many":[108],"(Aspergillus":[110],"fumigatus).":[111],"To":[112],"validate":[113],"broad":[114],"spectrum":[115],"targets,":[117],"yeast":[119],"Saccharomyces":[120],"cerevisiae":[121],"was":[122],"used":[123],"model":[126],"system":[127],"rapidly":[129],"essential":[132],"growth":[134],"viability":[136],"organism.":[139],"Validated":[140],"targets":[141],"were":[142],"then":[143],"exploited":[144],"high-throughput":[146]},"counts_by_year":[{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}