{"id":"https://openalex.org/W2153754152","doi":"https://doi.org/10.1073/pnas.0801227105","title":"Variation in MAPT is associated with cerebrospinal fluid tau levels in the presence of amyloid-beta deposition","display_name":"Variation in MAPT is associated with cerebrospinal fluid tau levels in the presence of amyloid-beta deposition","publication_year":2008,"publication_date":"2008-06-09","ids":{"openalex":"https://openalex.org/W2153754152","doi":"https://doi.org/10.1073/pnas.0801227105","mag":"2153754152","pmid":"https://pubmed.ncbi.nlm.nih.gov/18541914","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2430357"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0801227105","doi":"https://doi.org/10.1073/pnas.0801227105","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0801227105","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2430357","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107876646","display_name":"John S. K. Kauwe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John S. K. Kauwe","raw_affiliation_strings":["Departments of \u2020Psychiatry,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of \u2020Psychiatry,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040490170","display_name":"Carlos Cruchaga","orcid":"https://orcid.org/0000-0002-0276-2899","observed_orcids":["https://orcid.org/0000-0002-0276-2899","https://orcid.org/0000-0002-5261-689X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos Cruchaga","raw_affiliation_strings":["Departments of \u2020Psychiatry,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of \u2020Psychiatry,","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kevin Mayo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin Mayo","raw_affiliation_strings":["Departments of \u2020Psychiatry,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of \u2020Psychiatry,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076480218","display_name":"Chiara Fenoglio","orcid":"https://orcid.org/0000-0001-6332-4721","observed_orcids":["https://orcid.org/0000-0001-6332-4721"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Fenoglio","raw_affiliation_strings":["Department of Neurological Sciences, University of Milan, Instituto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Sciences, University of Milan, Instituto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122 Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I2803066834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007470713","display_name":"Sarah E. Bertelsen","orcid":"https://orcid.org/0000-0002-9498-7963","observed_orcids":["https://orcid.org/0000-0002-9498-7963"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarah Bertelsen","raw_affiliation_strings":["Departments of \u2020Psychiatry,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of \u2020Psychiatry,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065690843","display_name":"Petra Nowotny","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Petra Nowotny","raw_affiliation_strings":["Departments of \u2020Psychiatry,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of \u2020Psychiatry,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081436063","display_name":"Daniela Galimberti","orcid":"https://orcid.org/0000-0002-9284-5953","observed_orcids":["https://orcid.org/0000-0002-9284-5953","https://orcid.org/0000-0002-5010-6167"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniela Galimberti","raw_affiliation_strings":["Department of Neurological Sciences, University of Milan, Instituto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Sciences, University of Milan, Instituto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122 Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I2803066834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023350680","display_name":"Elio Angelo Scarpini","orcid":"https://orcid.org/0000-0002-6395-2119","observed_orcids":["https://orcid.org/0000-0002-6395-2119"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elio Scarpini","raw_affiliation_strings":["Department of Neurological Sciences, University of Milan, Instituto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Sciences, University of Milan, Instituto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122 Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I2803066834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063630764","display_name":"John C. Morris","orcid":"https://orcid.org/0000-0001-9820-5618","observed_orcids":["https://orcid.org/0000-0001-9820-5618","https://orcid.org/0000-0001-8068-9271"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John C. Morris","raw_affiliation_strings":["Alzheimer's Disease Research Center, and","Neurology,","Pathology and Immunology,","Alzheimer's Disease Research Center, and; Neurology,; Pathology and Immunology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer's Disease Research Center, and","institution_ids":[]},{"raw_affiliation_string":"Neurology,","institution_ids":[]},{"raw_affiliation_string":"Pathology and Immunology,","institution_ids":[]},{"raw_affiliation_string":"Alzheimer's Disease Research Center, and; Neurology,; Pathology and Immunology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025837253","display_name":"Anne M. Fagan","orcid":"https://orcid.org/0000-0002-5383-0214","observed_orcids":["https://orcid.org/0000-0002-5383-0214"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4210123851","display_name":"Hope Center for Neurological Disorders","ror":"https://ror.org/035nzyk88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210123851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne M. Fagan","raw_affiliation_strings":["Alzheimer's Disease Research Center, and","Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110; and","Neurology,","Alzheimer's Disease Research Center, and; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110; and; Neurology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer's Disease Research Center, and","institution_ids":[]},{"raw_affiliation_string":"Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110; and","institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4210123851"]},{"raw_affiliation_string":"Neurology,","institution_ids":[]},{"raw_affiliation_string":"Alzheimer's Disease Research Center, and; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110; and; Neurology,","institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4210123851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088998527","display_name":"David M. Holtzman","orcid":"https://orcid.org/0000-0002-3400-0856","observed_orcids":["https://orcid.org/0000-0002-3400-0856"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4210123851","display_name":"Hope Center for Neurological Disorders","ror":"https://ror.org/035nzyk88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210123851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Holtzman","raw_affiliation_strings":["Alzheimer's Disease Research Center, and","Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110; and","Molecular Biology and Pharmacology,","Neurology,","Alzheimer's Disease Research Center, and; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110; and; Molecular Biology and Pharmacology,; Neurology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer's Disease Research Center, and","institution_ids":[]},{"raw_affiliation_string":"Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110; and","institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4210123851"]},{"raw_affiliation_string":"Molecular Biology and Pharmacology,","institution_ids":[]},{"raw_affiliation_string":"Neurology,","institution_ids":[]},{"raw_affiliation_string":"Alzheimer's Disease Research Center, and; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110; and; Molecular Biology and Pharmacology,; Neurology,","institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4210123851"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090202716","display_name":"Alison Goate","orcid":"https://orcid.org/0000-0002-0576-2472","observed_orcids":["https://orcid.org/0000-0002-0576-2472"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4210123851","display_name":"Hope Center for Neurological Disorders","ror":"https://ror.org/035nzyk88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210123851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alison M. Goate","raw_affiliation_strings":["Alzheimer's Disease Research Center, and","Departments of \u2020Psychiatry,","Genetics, and","Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110; and","Neurology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer's Disease Research Center, and","institution_ids":[]},{"raw_affiliation_string":"Departments of \u2020Psychiatry,","institution_ids":[]},{"raw_affiliation_string":"Genetics, and","institution_ids":[]},{"raw_affiliation_string":"Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110; and","institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4210123851"]},{"raw_affiliation_string":"Neurology,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.3375,"has_fulltext":false,"cited_by_count":89,"citation_normalized_percentile":{"value":0.96854699,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"105","issue":"23","first_page":"8050","last_page":"8054"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mapt","display_name":"MAPT","score":0.9760000109672546},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.6690000295639038},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-biomarkers","display_name":"cerebrospinal fluid biomarkers","score":0.8320000171661377},{"id":"https://openalex.org/keywords/amyloid-beta-deposition","display_name":"amyloid-beta deposition","score":0.9039999842643738},{"id":"https://openalex.org/keywords/amyloid-beta-1-42","display_name":"amyloid-beta 42","score":0.8460000157356262},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9399999976158142},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9300000071525574},{"id":"https://openalex.org/keywords/endophenotypes","display_name":"endophenotypes","score":0.8799999952316284},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.8379999995231628},{"id":"https://openalex.org/keywords/age-of-onset","display_name":"age of onset","score":0.8040000200271606},{"id":"https://openalex.org/keywords/tauopathy","display_name":"tauopathy","score":0.7580000162124634},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C187869287","wikidata":"https://www.wikidata.org/wiki/Q2032061","display_name":"Endophenotype","level":3,"score":0.7159844040870667},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.6482869386672974},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6441000699996948},{"id":"https://openalex.org/C2777739294","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tauopathy","level":4,"score":0.6312031745910645},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.6215826272964478},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5581343770027161},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5054159164428711},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4905704855918884},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.4583316445350647},{"id":"https://openalex.org/C2778373026","wikidata":"https://www.wikidata.org/wiki/Q4738819","display_name":"Alzheimer's Disease Neuroimaging Initiative","level":4,"score":0.4119494557380676},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3423624038696289},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3169978857040405},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3068458139896393},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2813901901245117},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.2565974295139313},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.25408780574798584},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24230891466140747},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.20844250917434692},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.0801227105","doi":"https://doi.org/10.1073/pnas.0801227105","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0801227105","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1929950","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2430357","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2430357","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2430357","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:18541914","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18541914","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1929950","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2430357","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.4099999964237213,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G252744684","display_name":null,"funder_award_id":"T32MH14677","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G3591310947","display_name":"Washington University Center for Translational Neuroscience","funder_award_id":"P30NS057105","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4173422570","display_name":"Washington University Institute of Clinical and Translational Sciences (TL1)","funder_award_id":"TL1RR024995","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G4467312596","display_name":null,"funder_award_id":"RR-024992","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G561739401","display_name":null,"funder_award_id":"P 50 AG05681","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6914157503","display_name":"Alzheimer's Disease Research Center","funder_award_id":"P50AG005681","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6990800562","display_name":"Training in the Genetics  and Genomics of Mental Disorders","funder_award_id":"T32MH014677","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G710411779","display_name":null,"funder_award_id":"P01 AG0 3991","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7163257988","display_name":"Healthy Aging and Senile Dementia","funder_award_id":"P01AG003991","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G725115302","display_name":"Washington University Institute of Clinical and Translational Sciences","funder_award_id":"UL1TR000448","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7666698707","display_name":"Washington University Institute of Clinical and Translational Sciences (KL2)","funder_award_id":"KL2RR024994","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G7870180514","display_name":"Washington University Institute of Clinical and Translational Sciences (UL1)","funder_award_id":"UL1RR024992","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8106843359","display_name":"GENOMIC SEARCH FOR SUSCEPTIBILITY TO ALZHEIMER DISEASE","funder_award_id":"R01AG016208","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000072650","display_name":null,"funder_award_id":"AG05681","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000239624","display_name":null,"funder_award_id":"AG 03991","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000271159","display_name":null,"funder_award_id":"RR024992","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000282729","display_name":null,"funder_award_id":"NS057105","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000915971","display_name":"Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study","funder_award_id":"P01AG026276","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G932746212","display_name":null,"funder_award_id":"R01AG16208","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320315284","display_name":"Hope Center for Neurological Disorders","ror":"https://ror.org/035nzyk88"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1513705457","https://openalex.org/W1563659068","https://openalex.org/W1964895626","https://openalex.org/W1972340735","https://openalex.org/W1980842500","https://openalex.org/W1991952617","https://openalex.org/W1993746772","https://openalex.org/W1994722082","https://openalex.org/W2004950789","https://openalex.org/W2006858320","https://openalex.org/W2055629766","https://openalex.org/W2059742736","https://openalex.org/W2081831345","https://openalex.org/W2090220280","https://openalex.org/W2096623085","https://openalex.org/W2105704879","https://openalex.org/W2110888808","https://openalex.org/W2129379145","https://openalex.org/W2130348423","https://openalex.org/W2131830246","https://openalex.org/W2150246483","https://openalex.org/W2150655508","https://openalex.org/W2151288930","https://openalex.org/W2156220037","https://openalex.org/W2162530578","https://openalex.org/W2167141135"],"related_works":["https://openalex.org/W2001571372","https://openalex.org/W2009091375","https://openalex.org/W2897809390","https://openalex.org/W2078080926","https://openalex.org/W2079863513","https://openalex.org/W2461037559","https://openalex.org/W7117158402","https://openalex.org/W2135816796","https://openalex.org/W1989953987","https://openalex.org/W2113990699"],"abstract_inverted_index":{"There":[0],"is":[1],"substantial":[2],"evidence":[3,136,203,212],"that":[4,23,38,99,190,222,233],"cerebrospinal":[5],"fluid":[6],"(CSF)":[7],"levels":[8,36,110,199],"of":[9,51,57,96,137,204,240],"both":[10,24],"Abeta42":[11,109],"and":[12,26,85,120,231,242],"tau/ptau":[13,72,91,105,167],"are":[14,193],"promising":[15],"biomarkers":[16,40],"for":[17,48,87,182,213,237],"Alzheimer's":[18],"disease":[19,244],"(AD).":[20],"We":[21,93],"show":[22,100,189],"Abeta":[25,123,138,206,229],"tau":[27,67,227],"exhibit":[28],"more":[29],"than":[30],"10-fold":[31],"interindividual":[32],"variation":[33,59],"in":[34,60,69,82,125,133,144,154,200,225],"CSF":[35,71,90,104,108,147,166,226],"suggesting":[37],"these":[39,150,191],"may":[41],"also":[42],"be":[43],"effectively":[44],"used":[45,112],"as":[46],"endophenotypes":[47],"genetic":[49],"studies":[50,188],"AD.":[52,183],"To":[53],"test":[54],"the":[55,61,115,126,128,161,238],"role":[56],"common":[58],"gene":[62,186,215],"encoding":[63],"microtubule":[64],"associated":[65,163,169,194],"protein":[66],"(MAPT)":[68],"influencing":[70],"levels,":[73],"we":[74],"genotyped":[75],"21":[76],"MAPT":[77,197],"single":[78],"nucleotide":[79],"polymorphisms":[80],"(SNPs)":[81],"313":[83],"individuals":[84,134,201],"tested":[86],"association":[88,101,129,141],"with":[89,102,119,135,164,170,195,202],"levels.":[92,106],"identified":[94],"alleles":[95,162,192],"several":[97],"SNPs":[98,151],"increased":[103,196],"When":[107,149],"were":[111,152,168],"to":[113],"stratify":[114],"sample":[116],"into":[117],"those":[118],"without":[121],"likely":[122],"deposition":[124,230],"brain":[127,205],"was":[130,142],"only":[131],"observed":[132],"deposition.":[139,207],"This":[140,208],"replicated":[143],"an":[145,171],"independent":[146],"series.":[148],"evaluated":[153],"a":[155,214],"late-onset":[156],"AD":[157],"case":[158],"control":[159],"series":[160],"higher":[165],"earlier":[172],"age":[173],"at":[174],"onset":[175],"but":[176],"had":[177],"no":[178],"effect":[179],"on":[180],"risk":[181],"In":[184],"vivo":[185],"expression":[187],"mRNA":[198],"endophenotype-based":[209],"approach":[210],"provides":[211],"(MAPT":[216],"SNPs)-physiological":[217],"environment":[218],"(Abeta":[219],"deposition)":[220],"interaction":[221,235],"places":[223],"changes":[224],"after":[228],"suggest":[232],"this":[234],"predisposes":[236],"development":[239],"tauopathy":[241],"accelerated":[243],"progression.":[245]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}