{"id":"https://openalex.org/W2153751798","doi":"https://doi.org/10.1089/zeb.2004.1.239","title":"Ventralized Zebrafish Embryo Rescue by Overexpression of Zic2a","display_name":"Ventralized Zebrafish Embryo Rescue by Overexpression of Zic2a","publication_year":2004,"publication_date":"2004-12-01","ids":{"openalex":"https://openalex.org/W2153751798","doi":"https://doi.org/10.1089/zeb.2004.1.239","mag":"2153751798","pmid":"https://pubmed.ncbi.nlm.nih.gov/18248235"},"language":"en","primary_location":{"id":"doi:10.1089/zeb.2004.1.239","doi":"https://doi.org/10.1089/zeb.2004.1.239","is_oa":false,"landing_page_url":"https://doi.org/10.1089/zeb.2004.1.239","pdf_url":null,"source":{"id":"https://openalex.org/S164728804","display_name":"Zebrafish","issn_l":"1545-8547","issn":["1545-8547","1557-8542"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zebrafish","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://deepblue.lib.umich.edu/bitstream/2027.42/63344/1/zeb.2004.1.239.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086520448","display_name":"Evdokia Dodou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181233156","display_name":"University of Oregon","ror":"https://ror.org/0293rh119","country_code":"US","type":"education","lineage":["https://openalex.org/I181233156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evdokia Dodou","raw_affiliation_strings":["Institute of Neuroscience, University of Oregon, Eugene, Oregon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroscience, University of Oregon, Eugene, Oregon","institution_ids":["https://openalex.org/I181233156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039491508","display_name":"Kate F. Barald","orcid":"https://orcid.org/0000-0002-4851-0603","observed_orcids":["https://orcid.org/0000-0002-4851-0603"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kate F. Barald","raw_affiliation_strings":["Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084768099","display_name":"John H. Postlethwait","orcid":"https://orcid.org/0000-0002-5476-2137","observed_orcids":["https://orcid.org/0000-0002-5476-2137"]},"institutions":[{"id":"https://openalex.org/I181233156","display_name":"University of Oregon","ror":"https://ror.org/0293rh119","country_code":"US","type":"education","lineage":["https://openalex.org/I181233156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John H. Postlethwait","raw_affiliation_strings":["Institute of Neuroscience, University of Oregon, Eugene, Oregon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroscience, University of Oregon, Eugene, Oregon","institution_ids":["https://openalex.org/I181233156"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1953,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.44525334,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"3","first_page":"239","last_page":"256"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroectoderm","display_name":"neuroectoderm","score":0.7570000290870667},{"id":"https://openalex.org/keywords/gastrulation","display_name":"gastrulation","score":0.7110000252723694},{"id":"https://openalex.org/keywords/organizer","display_name":"organizer","score":0.5759999752044678},{"id":"https://openalex.org/keywords/chordin","display_name":"chordin","score":0.8009999990463257},{"id":"https://openalex.org/keywords/ventralization","display_name":"ventralization","score":0.7429999709129333},{"id":"https://openalex.org/keywords/neural-plate","display_name":"neural plate","score":0.5619999766349792},{"id":"https://openalex.org/keywords/forebrain","display_name":"forebrain","score":0.5879999995231628},{"id":"https://openalex.org/keywords/axial-mesoderm","display_name":"axial mesoderm","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C135073763","wikidata":"https://www.wikidata.org/wiki/Q1271432","display_name":"Neuroectoderm","level":5,"score":0.9676221609115601},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9376789331436157},{"id":"https://openalex.org/C129536746","wikidata":"https://www.wikidata.org/wiki/Q1141026","display_name":"Gastrulation","level":4,"score":0.8909189701080322},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.7502612471580505},{"id":"https://openalex.org/C200707615","wikidata":"https://www.wikidata.org/wiki/Q13652744","display_name":"Neuroepithelial cell","level":4,"score":0.6746305823326111},{"id":"https://openalex.org/C197849852","wikidata":"https://www.wikidata.org/wiki/Q2314823","display_name":"Neural plate","level":4,"score":0.6557535529136658},{"id":"https://openalex.org/C83484664","wikidata":"https://www.wikidata.org/wiki/Q24727001","display_name":"Chordin","level":5,"score":0.6238988637924194},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5923930406570435},{"id":"https://openalex.org/C102225024","wikidata":"https://www.wikidata.org/wiki/Q1388375","display_name":"Neurulation","level":5,"score":0.5369154810905457},{"id":"https://openalex.org/C98535976","wikidata":"https://www.wikidata.org/wiki/Q4088022","display_name":"Blastoderm","level":4,"score":0.5302965641021729},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5200067162513733},{"id":"https://openalex.org/C2780915607","wikidata":"https://www.wikidata.org/wiki/Q323438","display_name":"Mesoderm","level":4,"score":0.5136734843254089},{"id":"https://openalex.org/C2779329299","wikidata":"https://www.wikidata.org/wiki/Q272474","display_name":"Ectoderm","level":4,"score":0.4522087275981903},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.422488808631897},{"id":"https://openalex.org/C92375311","wikidata":"https://www.wikidata.org/wiki/Q1484637","display_name":"Epiboly","level":5,"score":0.419097363948822},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.31333112716674805},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.28251931071281433},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.25054335594177246},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14319461584091187},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1089/zeb.2004.1.239","doi":"https://doi.org/10.1089/zeb.2004.1.239","is_oa":false,"landing_page_url":"https://doi.org/10.1089/zeb.2004.1.239","pdf_url":null,"source":{"id":"https://openalex.org/S164728804","display_name":"Zebrafish","issn_l":"1545-8547","issn":["1545-8547","1557-8542"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zebrafish","raw_type":"journal-article"},{"id":"pmid:18248235","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18248235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zebrafish","raw_type":"Journal Article"},{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/63344","doi":null,"is_oa":true,"landing_page_url":"http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18248235&dopt=citation","pdf_url":"http://deepblue.lib.umich.edu/bitstream/2027.42/63344/1/zeb.2004.1.239.pdf","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/63344","doi":null,"is_oa":true,"landing_page_url":"http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18248235&dopt=citation","pdf_url":"http://deepblue.lib.umich.edu/bitstream/2027.42/63344/1/zeb.2004.1.239.pdf","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2077717673","display_name":"Genomic Analysis in Zebrafish Development","funder_award_id":"R01RR010715","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2386706790","display_name":"Signaling Hierarchies in Vertebrate Development","funder_award_id":"P01HD022486","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G2641962263","display_name":null,"funder_award_id":"P01HD22486","funder_id":"https://openalex.org/F4320312726","funder_display_name":"University of Oregon"},{"id":"https://openalex.org/G5044652392","display_name":null,"funder_award_id":"P01HD22486","funder_id":"https://openalex.org/F4320306203","funder_display_name":"M.J. Murdock Charitable Trust"},{"id":"https://openalex.org/G7235994312","display_name":"EXPANSION/IMPROVEMENT OF UNIVERSITY OF OREGON ZEBRAFISH","funder_award_id":"G20RR011724","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8241877127","display_name":null,"funder_award_id":"P01HD22486","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8933020766","display_name":"Renovation of the University of Oregon Zebrafish Facility","funder_award_id":"9602828","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306159","display_name":"W. M. Keck Foundation","ror":"https://ror.org/000dswa46"},{"id":"https://openalex.org/F4320306203","display_name":"M.J. Murdock Charitable Trust","ror":"https://ror.org/02hxgd925"},{"id":"https://openalex.org/F4320312726","display_name":"University of Oregon","ror":"https://ror.org/0293rh119"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2153751798.pdf","grobid_xml":"https://content.openalex.org/works/W2153751798.grobid-xml"},"referenced_works_count":88,"referenced_works":["https://openalex.org/W326368786","https://openalex.org/W1487222554","https://openalex.org/W1520567777","https://openalex.org/W1554593075","https://openalex.org/W1554931738","https://openalex.org/W1556198965","https://openalex.org/W1599717246","https://openalex.org/W1811130017","https://openalex.org/W1811188705","https://openalex.org/W1870931504","https://openalex.org/W1879493681","https://openalex.org/W1888475523","https://openalex.org/W1888989725","https://openalex.org/W1897428854","https://openalex.org/W1923477899","https://openalex.org/W1927171786","https://openalex.org/W1941036671","https://openalex.org/W1966006200","https://openalex.org/W1966435498","https://openalex.org/W1968530627","https://openalex.org/W1969923021","https://openalex.org/W1970562401","https://openalex.org/W1974723367","https://openalex.org/W1974955180","https://openalex.org/W1979062316","https://openalex.org/W1980276935","https://openalex.org/W1983653653","https://openalex.org/W1983828713","https://openalex.org/W1984288177","https://openalex.org/W1984338606","https://openalex.org/W1985628924","https://openalex.org/W1986909055","https://openalex.org/W1990938412","https://openalex.org/W1992038523","https://openalex.org/W2004505240","https://openalex.org/W2005494875","https://openalex.org/W2005849699","https://openalex.org/W2012975927","https://openalex.org/W2014536457","https://openalex.org/W2015633789","https://openalex.org/W2021987019","https://openalex.org/W2025019677","https://openalex.org/W2031502549","https://openalex.org/W2031984950","https://openalex.org/W2033418096","https://openalex.org/W2034529974","https://openalex.org/W2040308393","https://openalex.org/W2040576313","https://openalex.org/W2043188635","https://openalex.org/W2044384686","https://openalex.org/W2055236124","https://openalex.org/W2058008075","https://openalex.org/W2064813976","https://openalex.org/W2069182243","https://openalex.org/W2072716768","https://openalex.org/W2080200696","https://openalex.org/W2084617272","https://openalex.org/W2089611510","https://openalex.org/W2091670449","https://openalex.org/W2097706568","https://openalex.org/W2098650397","https://openalex.org/W2103056085","https://openalex.org/W2103997264","https://openalex.org/W2104051134","https://openalex.org/W2106882534","https://openalex.org/W2116428404","https://openalex.org/W2120960764","https://openalex.org/W2123938765","https://openalex.org/W2124357826","https://openalex.org/W2125068279","https://openalex.org/W2125349610","https://openalex.org/W2127312018","https://openalex.org/W2133158330","https://openalex.org/W2134012523","https://openalex.org/W2141047192","https://openalex.org/W2141614336","https://openalex.org/W2145636711","https://openalex.org/W2152075687","https://openalex.org/W2157444265","https://openalex.org/W2157921963","https://openalex.org/W2158292347","https://openalex.org/W2164386538","https://openalex.org/W2164413753","https://openalex.org/W2168870153","https://openalex.org/W2182498448","https://openalex.org/W2347126938","https://openalex.org/W4241876518","https://openalex.org/W7096920966"],"related_works":["https://openalex.org/W1969923021","https://openalex.org/W2047394496","https://openalex.org/W1599717246","https://openalex.org/W2084617272","https://openalex.org/W2005586114","https://openalex.org/W7097557570","https://openalex.org/W2035853237","https://openalex.org/W1974955180","https://openalex.org/W1970921749","https://openalex.org/W2134012523"],"abstract_inverted_index":{"The":[0],"neuroectoderm":[1,98,207],"arises":[2],"during":[3,99],"gastrulation":[4],"as":[5],"a":[6,53,134,167,186],"population":[7,128,205],"of":[8,28,40,55,92,129,145,151,161,173,191,203,206],"undifferentiated":[9],"proliferating":[10,41,130,152],"neuroepithelial":[11,16,42],"cells.":[12,208],"As":[13],"development":[14],"continues,":[15],"cells":[17],"leave":[18],"the":[19,29,37,56,75,79,86,96,104,117,122,127,142,158,176,180,200,204],"cell":[20],"cycle":[21],"and":[22,26,78,82,101,119,179],"differentiate":[23],"into":[24],"neurons":[25],"glia":[27],"functioning":[30],"central":[31],"nervous":[32,65],"system.":[33],"What":[34],"processes":[35],"establish":[36],"spatial":[38],"distribution":[39],"cells?":[43],"To":[44],"investigate":[45],"this":[46],"question,":[47],"zic2a":[48,71,93,112,137,146,155,189],"was":[49,72],"isolated":[50],"from":[51,141,183],"zebrafish,":[52],"homolog":[54],"Drosophila":[57],"pair-rule":[58],"gene":[59],"odd-paired,":[60],"which":[61,165],"is":[62],"involved":[63],"in":[64,74,89,95,116,121,138,148,175,198],"system":[66],"patterning.":[67],"At":[68],"shield":[69],"stage,":[70],"expressed":[73],"zebrafish":[76,177],"organizer":[77,118,196],"blastoderm":[80],"margin,":[81],"became":[83],"restricted":[84],"to":[85,125],"axial":[87],"mesoderm":[88],"mid-gastrula.":[90],"Expression":[91],"appeared":[94],"prospective":[97],"gastrulation,":[100],"later":[102,120],"demarcated":[103],"presumptive":[105],"forebrain.":[106],"This":[107],"expression":[108,172],"pattern":[109],"suggests":[110],"that":[111],"may":[113],"function":[114,135],"early":[115],"neural":[123],"plate":[124],"demarcate":[126],"neuroectoderm.":[131,153],"Consistent":[132],"with":[133],"for":[136,188],"transducing":[139],"signals":[140],"organizer,":[143,178],"overexpression":[144,156],"resulted":[147],"an":[149],"expansion":[150],"Furthermore,":[154],"rescued":[157],"ventralized":[159],"phenotype":[160,181],"chordino":[162],"mutant":[163],"embryos,":[164],"lack":[166],"functional":[168],"chordin":[169,192],"gene.":[170],"Early":[171],"zic2":[174],"resulting":[182],"overexpression,":[184],"show":[185],"role":[187],"downstream":[190],"or":[193],"other":[194],"secreted":[195],"proteins":[197],"establishing":[199],"initial":[201],"size":[202]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}