{"id":"https://openalex.org/W2153680683","doi":null,"title":"Nitric oxide synthase is expressed in human macrophages during foreign body inflammation.","display_name":"Nitric oxide synthase is expressed in human macrophages during foreign body inflammation.","publication_year":1997,"publication_date":"1997-03-01","ids":{"openalex":"https://openalex.org/W2153680683","mag":"2153680683","pmid":"https://pubmed.ncbi.nlm.nih.gov/9060826","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1857881"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:1532741","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1857881","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1857881","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000639183","display_name":"Eeva Moilanen","orcid":"https://orcid.org/0000-0002-8577-0316","observed_orcids":["https://orcid.org/0000-0002-8577-0316"]},"institutions":[{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"E Moilanen","raw_affiliation_strings":["Wellcome Research Laboratories, Beckenham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Research Laboratories, Beckenham, United Kingdom","institution_ids":["https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056249217","display_name":"Teemu P.S. Moilanen","orcid":"https://orcid.org/0000-0003-4899-1301","observed_orcids":["https://orcid.org/0000-0003-4899-1301"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Moilanen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109060953","display_name":"Richard G. Knowles","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Knowles","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054595285","display_name":"Ian G. Charles","orcid":"https://orcid.org/0000-0002-2423-1167","observed_orcids":["https://orcid.org/0000-0002-2423-1167"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Charles","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Y Kadoya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Kadoya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009495769","display_name":"Najat Al-Saffar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N al-Saffar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109224530","display_name":"Peter A. Revell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P A Revell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5005357835","display_name":"Salvador Moncada","orcid":"https://orcid.org/0000-0001-9538-5801","observed_orcids":["https://orcid.org/0000-0001-9538-5801"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Moncada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":11.3197,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.98991845,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"150","issue":"3","first_page":"881","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.03220000118017197,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.012600000016391277,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9430000185966492},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.777999997138977},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9350000023841858},{"id":"https://openalex.org/keywords/aseptic-loosening","display_name":"aseptic loosening","score":0.7940000295639038},{"id":"https://openalex.org/keywords/hip-prosthesis","display_name":"hip prosthesis","score":0.6700000166893005},{"id":"https://openalex.org/keywords/knee-prosthesis","display_name":"knee prosthesis","score":1.0},{"id":"https://openalex.org/keywords/revision-arthroplasty","display_name":"revision arthroplasty","score":0.8289999961853027},{"id":"https://openalex.org/keywords/osteolysis","display_name":"osteolysis","score":0.777999997138977},{"id":"https://openalex.org/keywords/vascular-endothelial-cells","display_name":"vascular endothelial cells","score":0.8240000009536743},{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.6990000009536743},{"id":"https://openalex.org/keywords/citrulline","display_name":"citrulline","score":0.9419999718666077}],"concepts":[{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.7438969016075134},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6933140158653259},{"id":"https://openalex.org/C2779129087","wikidata":"https://www.wikidata.org/wiki/Q408641","display_name":"Citrulline","level":4,"score":0.6742293834686279},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.554607093334198},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5502552390098572},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5233649015426636},{"id":"https://openalex.org/C108657112","wikidata":"https://www.wikidata.org/wiki/Q3332118","display_name":"Foreign-body giant cell","level":2,"score":0.5091032385826111},{"id":"https://openalex.org/C2777652487","wikidata":"https://www.wikidata.org/wiki/Q575064","display_name":"Synovial membrane","level":3,"score":0.4400979280471802},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4054937958717346},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.39598536491394043},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36863428354263306},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27520257234573364},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27271783351898193},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.2576395571231842},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24200475215911865},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.10277312994003296},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06875559687614441},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005549","descriptor_name":"Foreign-Body Reaction","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005549","descriptor_name":"Foreign-Body Reaction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007595","descriptor_name":"Joint Prosthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008262","descriptor_name":"Macrophage Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011475","descriptor_name":"Prosthesis Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012086","descriptor_name":"Reoperation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D013583","descriptor_name":"Synovial Membrane","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013583","descriptor_name":"Synovial Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true}],"locations_count":6,"locations":[{"id":"pmh:oai:europepmc.org:1532741","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1857881","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:9060826","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9060826","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1857881","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1857881/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:101553","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/101553/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Pathology , 150 (3) pp. 881-887. (1997)","raw_type":"Article"},{"id":"pmh:oai:opus.lib.uts.edu.au:10453/13775","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10453/13775","pdf_url":null,"source":{"id":"https://openalex.org/S4377196279","display_name":"OPUS - Open Publications of UTS Scholars (University of Technology Sydney)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114017466","host_organization_name":"University of Technology Sydney","host_organization_lineage":["https://openalex.org/I114017466"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"mag:2153680683","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9060826","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1532741","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1857881","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.766700029373169,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1486705747","https://openalex.org/W1764308599","https://openalex.org/W1966198985","https://openalex.org/W1973535328","https://openalex.org/W1975587041","https://openalex.org/W1979388174","https://openalex.org/W1981598802","https://openalex.org/W1989219781","https://openalex.org/W1996058483","https://openalex.org/W2020638356","https://openalex.org/W2040873162","https://openalex.org/W2053490208","https://openalex.org/W2055354965","https://openalex.org/W2056262838","https://openalex.org/W2062083637","https://openalex.org/W2063580118","https://openalex.org/W2068263425","https://openalex.org/W2073573464","https://openalex.org/W2091429164","https://openalex.org/W2093195099","https://openalex.org/W2106554511","https://openalex.org/W2113694345","https://openalex.org/W2135166538","https://openalex.org/W2152611825","https://openalex.org/W2160997491","https://openalex.org/W2170320784","https://openalex.org/W2187116198","https://openalex.org/W2228466038","https://openalex.org/W4291287216"],"related_works":["https://openalex.org/W1638064197","https://openalex.org/W1512618897","https://openalex.org/W1999398465","https://openalex.org/W7099162159","https://openalex.org/W174965442","https://openalex.org/W2003473706","https://openalex.org/W2010599717","https://openalex.org/W2020063866","https://openalex.org/W2119108876","https://openalex.org/W2417992426"],"abstract_inverted_index":{"Although":[0],"nitric":[1],"oxide":[2],"(NO)":[3],"is":[4],"a":[5],"well":[6],"documented":[7],"effector":[8],"molecule":[9],"in":[10,15,43,80,128,137],"rodent":[11],"macrophages,":[12],"its":[13],"significance":[14],"human":[16],"mononuclear":[17],"phagocytic":[18],"cells":[19],"has":[20],"been":[21],"controversial.":[22],"The":[23,73],"foreign":[24],"body":[25],"inflammatory":[26,142],"reaction":[27],"around":[28],"loosened":[29,60],"joint":[30],"replacement":[31],"implants":[32],"leads":[33],"to":[34,92],"formation":[35],"of":[36,50,58,68,75,82,108,115,140],"an":[37,134],"osteolytic":[38,144],"granulomatous":[39],"pseudo-synovial":[40],"membrane":[41,52],"rich":[42],"activated":[44],"macrophages.":[45],"We":[46],"studied":[47],"13":[48],"specimens":[49],"interface":[51,130],"tissue":[53,87,131],"collected":[54],"from":[55,110],"revision":[56],"surgery":[57],"aseptically":[59],"hip":[61],"and":[62,94,112,143],"knee":[63],"prostheses":[64],"for":[65],"the":[66,86,105,113,129,138,141],"presence":[67,74,114],"inducible":[69],"NO":[70,126],"synthase":[71],"(iNOS).":[72],"iNOS":[76,98,116],"was":[77,90,100,118],"demonstrated":[78,101,119],"immunohistochemically":[79],"10":[81],"these":[83],"specimens.":[84],"Within":[85],"this":[88],"enzyme":[89],"confined":[91],"macrophages":[93],"vascular":[95],"endothelial":[96],"cells.":[97],"activity":[99],"biochemically":[102],"by":[103],"measuring":[104],"calcium-independent":[106],"generation":[107],"citrulline":[109],"L-arginine,":[111],"mRNA":[117],"using":[120],"reverse":[121],"transcriptase":[122],"polymerase":[123],"chain":[124],"reaction.":[125],"synthesis":[127],"may":[132],"be":[133],"important":[135],"factor":[136],"maintenance":[139],"processes.":[145]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
