{"id":"https://openalex.org/W2153676809","doi":"https://doi.org/10.1210/er.2005-0021","title":"Membrane-Initiated Actions of Estrogens in Neuroendocrinology: Emerging Principles","display_name":"Membrane-Initiated Actions of Estrogens in Neuroendocrinology: Emerging Principles","publication_year":2007,"publication_date":"2007-02-01","ids":{"openalex":"https://openalex.org/W2153676809","doi":"https://doi.org/10.1210/er.2005-0021","mag":"2153676809","pmid":"https://pubmed.ncbi.nlm.nih.gov/17018839"},"language":"en","primary_location":{"id":"doi:10.1210/er.2005-0021","doi":"https://doi.org/10.1210/er.2005-0021","is_oa":false,"landing_page_url":"https://doi.org/10.1210/er.2005-0021","pdf_url":null,"source":{"id":"https://openalex.org/S13493133","display_name":"Endocrine Reviews","issn_l":"0163-769X","issn":["0163-769X","1945-7189"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Reviews","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018883620","display_name":"Nandini Vasudevan","orcid":"https://orcid.org/0000-0003-4326-3938","observed_orcids":["https://orcid.org/0000-0003-4326-3938"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nandini Vasudevan","raw_affiliation_strings":["Department of Biology (N.V.), Pennsylvania State University, University Park, Pennsylvania 16802"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology (N.V.), Pennsylvania State University, University Park, Pennsylvania 16802","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086866710","display_name":"Donald W. Pfaff","orcid":"https://orcid.org/0000-0002-6569-8505","observed_orcids":["https://orcid.org/0000-0002-6569-8505"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald W. Pfaff","raw_affiliation_strings":["Laboratory of Neurobiology and Behavior (D.W.P.), The Rockefeller University, New York, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurobiology and Behavior (D.W.P.), The Rockefeller University, New York, New York 10021","institution_ids":["https://openalex.org/I83399316"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5018883620"],"corresponding_institution_ids":["https://openalex.org/I130769515"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":2.8325,"has_fulltext":true,"cited_by_count":232,"citation_normalized_percentile":{"value":0.93959732,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"28","issue":"1","first_page":"1","last_page":"19"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.5720000267028809},{"id":"https://openalex.org/keywords/nuclear-receptor-signaling","display_name":"nuclear receptor signaling","score":0.609000027179718},{"id":"https://openalex.org/keywords/kinase-activation","display_name":"kinase activation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/calcium-release","display_name":"calcium release","score":0.7310000061988831},{"id":"https://openalex.org/keywords/signaling-crosstalk","display_name":"signaling crosstalk","score":0.6890000104904175},{"id":"https://openalex.org/keywords/neuroendocrinology","display_name":"neuroendocrinology","score":0.75},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.7048448324203491},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6001709699630737},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5252915620803833},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4946536719799042},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4437529444694519},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.440592885017395},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4395248591899872},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.43314746022224426},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23199549317359924},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17267602682113647},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009424","descriptor_name":"Nervous System Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009452","descriptor_name":"Neuroendocrinology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1210/er.2005-0021","doi":"https://doi.org/10.1210/er.2005-0021","is_oa":false,"landing_page_url":"https://doi.org/10.1210/er.2005-0021","pdf_url":null,"source":{"id":"https://openalex.org/S13493133","display_name":"Endocrine Reviews","issn_l":"0163-769X","issn":["0163-769X","1945-7189"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Reviews","raw_type":"journal-article"},{"id":"pmid:17018839","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17018839","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine reviews","raw_type":"Journal Article"},{"id":"pmh:oai:centaur.reading.ac.uk:58931","doi":null,"is_oa":false,"landing_page_url":"https://centaur.reading.ac.uk/58931/1/Vasudevan%20%26%20Pfaff%20Endocrine%20Reviews%2007.pdf","pdf_url":"https://centaur.reading.ac.uk/58931/1/Vasudevan%20%26%20Pfaff%20Endocrine%20Reviews%2007.pdf","source":{"id":"https://openalex.org/S4306402273","display_name":"CentAUR (University of Reading)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71052956","host_organization_name":"University of Reading","host_organization_lineage":["https://openalex.org/I71052956"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.324.6920","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.324.6920","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://edrv.endojournals.org/content/28/1/1.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4043000042438507,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":249,"referenced_works":["https://openalex.org/W8163034","https://openalex.org/W46592252","https://openalex.org/W88146268","https://openalex.org/W103657461","https://openalex.org/W578007426","https://openalex.org/W1502488470","https://openalex.org/W1509103176","https://openalex.org/W1518317724","https://openalex.org/W1520299947","https://openalex.org/W1566992573","https://openalex.org/W1572088692","https://openalex.org/W1602380191","https://openalex.org/W1606667357","https://openalex.org/W1647805770","https://openalex.org/W1661647511","https://openalex.org/W1786781528","https://openalex.org/W1795513906","https://openalex.org/W1809411463","https://openalex.org/W1819608959","https://openalex.org/W1834339553","https://openalex.org/W1930502921","https://openalex.org/W1948173875","https://openalex.org/W1954468845","https://openalex.org/W1955010715","https://openalex.org/W1965322994","https://openalex.org/W1965582720","https://openalex.org/W1966089335","https://openalex.org/W1966475217","https://openalex.org/W1967752257","https://openalex.org/W1968196184","https://openalex.org/W1968998907","https://openalex.org/W1970609355","https://openalex.org/W1971147345","https://openalex.org/W1971656305","https://openalex.org/W1971749886","https://openalex.org/W1972293558","https://openalex.org/W1972523086","https://openalex.org/W1973352944","https://openalex.org/W1973972092","https://openalex.org/W1974184455","https://openalex.org/W1974334424","https://openalex.org/W1975046195","https://openalex.org/W1975290731","https://openalex.org/W1975912787","https://openalex.org/W1976578309","https://openalex.org/W1976603215","https://openalex.org/W1977254575","https://openalex.org/W1979721685","https://openalex.org/W1980185682","https://openalex.org/W1980813865","https://openalex.org/W1981094037","https://openalex.org/W1981467972","https://openalex.org/W1981577043","https://openalex.org/W1981746913","https://openalex.org/W1981851893","https://openalex.org/W1983225187","https://openalex.org/W1983551980","https://openalex.org/W1983621028","https://openalex.org/W1984704631","https://openalex.org/W1985002988","https://openalex.org/W1985571186","https://openalex.org/W1985941840","https://openalex.org/W1985976602","https://openalex.org/W1988941422","https://openalex.org/W1989315787","https://openalex.org/W1989698840","https://openalex.org/W1991393688","https://openalex.org/W1991602904","https://openalex.org/W1994359425","https://openalex.org/W1994411455","https://openalex.org/W1995749463","https://openalex.org/W1996296930","https://openalex.org/W1996729768","https://openalex.org/W1996732665","https://openalex.org/W1997006452","https://openalex.org/W1997173932","https://openalex.org/W1997570118","https://openalex.org/W2000861757","https://openalex.org/W2004051195","https://openalex.org/W2005576254","https://openalex.org/W2005766913","https://openalex.org/W2006431526","https://openalex.org/W2007238907","https://openalex.org/W2007574496","https://openalex.org/W2007980908","https://openalex.org/W2009775232","https://openalex.org/W2010042688","https://openalex.org/W2010142538","https://openalex.org/W2010296464","https://openalex.org/W2010643465","https://openalex.org/W2012892145","https://openalex.org/W2013652259","https://openalex.org/W2014086109","https://openalex.org/W2016425252","https://openalex.org/W2017189350","https://openalex.org/W2017331308","https://openalex.org/W2017949671","https://openalex.org/W2018397818","https://openalex.org/W2019468623","https://openalex.org/W2020665150","https://openalex.org/W2021299976","https://openalex.org/W2021451131","https://openalex.org/W2023728968","https://openalex.org/W2024234796","https://openalex.org/W2024638388","https://openalex.org/W2025361745","https://openalex.org/W2025716332","https://openalex.org/W2027829100","https://openalex.org/W2029151842","https://openalex.org/W2030884639","https://openalex.org/W2031056915","https://openalex.org/W2031329138","https://openalex.org/W2032367586","https://openalex.org/W2032479830","https://openalex.org/W2032488362","https://openalex.org/W2033366396","https://openalex.org/W2034993146","https://openalex.org/W2037133484","https://openalex.org/W2037913174","https://openalex.org/W2038459913","https://openalex.org/W2044787531","https://openalex.org/W2045034712","https://openalex.org/W2045393045","https://openalex.org/W2045465174","https://openalex.org/W2046359774","https://openalex.org/W2047207432","https://openalex.org/W2047461347","https://openalex.org/W2051227097","https://openalex.org/W2051684862","https://openalex.org/W2055071758","https://openalex.org/W2056312478","https://openalex.org/W2058272963","https://openalex.org/W2058903258","https://openalex.org/W2058936346","https://openalex.org/W2060090078","https://openalex.org/W2061055786","https://openalex.org/W2061713372","https://openalex.org/W2065138547","https://openalex.org/W2067099461","https://openalex.org/W2067642579","https://openalex.org/W2068059987","https://openalex.org/W2071716550","https://openalex.org/W2072256242","https://openalex.org/W2072787342","https://openalex.org/W2072808424","https://openalex.org/W2073576669","https://openalex.org/W2073869705","https://openalex.org/W2074667468","https://openalex.org/W2074979859","https://openalex.org/W2075199770","https://openalex.org/W2075243973","https://openalex.org/W2076189206","https://openalex.org/W2083497989","https://openalex.org/W2083600423","https://openalex.org/W2084188625","https://openalex.org/W2084564631","https://openalex.org/W2084915564","https://openalex.org/W2085147305","https://openalex.org/W2087715828","https://openalex.org/W2087892362","https://openalex.org/W2088431185","https://openalex.org/W2088692628","https://openalex.org/W2088993196","https://openalex.org/W2089897988","https://openalex.org/W2090054404","https://openalex.org/W2090980206","https://openalex.org/W2091105506","https://openalex.org/W2091189600","https://openalex.org/W2093108716","https://openalex.org/W2093163249","https://openalex.org/W2093604426","https://openalex.org/W2095577659","https://openalex.org/W2095698264","https://openalex.org/W2095833455","https://openalex.org/W2095926494","https://openalex.org/W2097130643","https://openalex.org/W2097349743","https://openalex.org/W2097808377","https://openalex.org/W2098227474","https://openalex.org/W2098963564","https://openalex.org/W2099406852","https://openalex.org/W2099878230","https://openalex.org/W2101467600","https://openalex.org/W2104370607","https://openalex.org/W2105846317","https://openalex.org/W2107131127","https://openalex.org/W2107695191","https://openalex.org/W2110560495","https://openalex.org/W2110687233","https://openalex.org/W2114942127","https://openalex.org/W2115399218","https://openalex.org/W2119791710","https://openalex.org/W2120809075","https://openalex.org/W2122015809","https://openalex.org/W2122203755","https://openalex.org/W2122368744","https://openalex.org/W2125367143","https://openalex.org/W2126000686","https://openalex.org/W2127188578","https://openalex.org/W2128003724","https://openalex.org/W2130113935","https://openalex.org/W2130457909","https://openalex.org/W2130695898","https://openalex.org/W2132009630","https://openalex.org/W2133850696","https://openalex.org/W2134402538","https://openalex.org/W2135468643","https://openalex.org/W2137272726","https://openalex.org/W2141369673","https://openalex.org/W2141652903","https://openalex.org/W2143006014","https://openalex.org/W2143481850","https://openalex.org/W2144870410","https://openalex.org/W2148188193","https://openalex.org/W2148788638","https://openalex.org/W2149594633","https://openalex.org/W2149713530","https://openalex.org/W2149993703","https://openalex.org/W2150268299","https://openalex.org/W2150405978","https://openalex.org/W2150699733","https://openalex.org/W2150952188","https://openalex.org/W2151463503","https://openalex.org/W2152110038","https://openalex.org/W2152327361","https://openalex.org/W2152420076","https://openalex.org/W2153918480","https://openalex.org/W2154472114","https://openalex.org/W2155391261","https://openalex.org/W2156965301","https://openalex.org/W2157942995","https://openalex.org/W2158251170","https://openalex.org/W2158398694","https://openalex.org/W2158855816","https://openalex.org/W2159984609","https://openalex.org/W2165490077","https://openalex.org/W2166555377","https://openalex.org/W2167978187","https://openalex.org/W2169988894","https://openalex.org/W2170728568","https://openalex.org/W2216094174","https://openalex.org/W2394995650","https://openalex.org/W2416912627","https://openalex.org/W4322703282","https://openalex.org/W6641829967","https://openalex.org/W6653061157","https://openalex.org/W6673552790","https://openalex.org/W6676161785","https://openalex.org/W7099253068"],"related_works":["https://openalex.org/W7097329746","https://openalex.org/W2049111053","https://openalex.org/W2012892145","https://openalex.org/W7009617043","https://openalex.org/W2012450997","https://openalex.org/W2764145798","https://openalex.org/W2026226086","https://openalex.org/W2168605617","https://openalex.org/W2120809075","https://openalex.org/W2025377042"],"abstract_inverted_index":{"Hormonal":[0],"ligands":[1,50],"for":[2],"the":[3,32,65,90,98,104,137,181],"nuclear":[4,121,147],"receptor":[5],"superfamily":[6],"have":[7,70],"at":[8,31,136],"least":[9],"two":[10],"interacting":[11],"mechanisms":[12,41],"of":[13,19,48,62,75,84,93,101,106,110,139,141,169,177,183],"action:":[14],"1)":[15],"classical":[16],"transcriptional":[17,40],"regulation":[18],"target":[20],"genes":[21],"(genomic":[22],"mechanisms);":[23],"and":[24,103,174],"2)":[25],"nongenomic":[26],"actions":[27,47,83,92,109,176],"that":[28,78,89],"are":[29,42,51,79],"initiated":[30],"cell":[33,184],"membrane,":[34],"which":[35,112],"could":[36],"impact":[37],"transcription.":[38,122,166],"Although":[39],"increasingly":[43],"well":[44],"understood,":[45],"membrane-initiated":[46,82,173],"these":[49,114],"incompletely":[52],"understood.":[53],"Historically,":[54],"this":[55],"has":[56],"led":[57],"to":[58,72,81,161],"a":[59],"considerable":[60],"divergence":[61],"thought":[63],"in":[64,128,131,186],"molecular":[66],"endocrine":[67],"field.":[68],"We":[69],"attempted":[71],"uncover":[73],"principles":[74],"hormone":[76],"action":[77],"relevant":[80,143],"estrogens.":[85],"There":[86],"is":[87],"evidence":[88],"membrane-limited":[91],"hormones,":[94],"particularly":[95],"estrogens,":[96,111],"involve":[97],"rapid":[99,115],"activation":[100],"kinases":[102],"release":[105],"calcium.":[107],"Membrane":[108],"activate":[113,159],"signaling":[116,124,185],"cascades,":[117],"can":[118],"also":[119,158],"potentiate":[120],"These":[123],"cascades":[125,160],"may":[126,157],"occur":[127],"parallel":[129],"or":[130,155],"series":[132],"but":[133],"subsequently":[134],"converge":[135],"level":[138],"modification":[140],"transcriptionally":[142],"molecules":[144],"such":[145],"as":[146],"receptors":[148],"and/or":[149],"coactivators.":[150],"In":[151],"addition,":[152],"other":[153],"hormones":[154,178],"neurotransmitters":[156],"crosstalk":[162],"with":[163],"estrogen":[164],"receptor-mediated":[165],"The":[167],"idea":[168],"synergistic":[170],"coupling":[171],"between":[172],"genomic":[175],"fundamentally":[179],"revises":[180],"paradigms":[182],"neuroendocrinology.":[187]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}