{"id":"https://openalex.org/W2153595680","doi":"https://doi.org/10.1096/fasebj.1.4.2820823","title":"The peripheral\u2010type benzodiazepine receptor: a protein of mitochondrial outer membranes utilizing porphyrins as endogenous ligands","display_name":"The peripheral\u2010type benzodiazepine receptor: a protein of mitochondrial outer membranes utilizing porphyrins as endogenous ligands","publication_year":1987,"publication_date":"1987-10-01","ids":{"openalex":"https://openalex.org/W2153595680","doi":"https://doi.org/10.1096/fasebj.1.4.2820823","mag":"2153595680","pmid":"https://pubmed.ncbi.nlm.nih.gov/2820823"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.1.4.2820823","doi":"https://doi.org/10.1096/fasebj.1.4.2820823","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.1.4.2820823","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020208893","display_name":"Solomon H. Snyder","orcid":"https://orcid.org/0000-0002-6818-7022","observed_orcids":["https://orcid.org/0000-0002-6818-7022"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Solomon H. Snyder","raw_affiliation_strings":["Departments of Neuroscience, Pharmacology and Molecular Sciences, Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neuroscience, Pharmacology and Molecular Sciences, Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013477531","display_name":"Ajay Mark Verma","orcid":"https://orcid.org/0000-0002-6432-3357","observed_orcids":["https://orcid.org/0000-0002-6432-3357"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ajay Verma","raw_affiliation_strings":["Departments of Neuroscience, Pharmacology and Molecular Sciences, Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neuroscience, Pharmacology and Molecular Sciences, Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109994361","display_name":"Rosario Rich Trifiletti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rosario R. Trifiletti","raw_affiliation_strings":["Departments of Neuroscience, Pharmacology and Molecular Sciences, Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neuroscience, Pharmacology and Molecular Sciences, Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5020208893"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":3.9943,"has_fulltext":false,"cited_by_count":158,"citation_normalized_percentile":{"value":0.94913685,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"1","issue":"4","first_page":"282","last_page":"288"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.801800012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.801800012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13047","display_name":"Pharmacological Receptor Mechanisms and Effects","score":0.0731000006198883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.02500000037252903,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/translocator-protein-tspo","display_name":"translocator protein (TSPO)","score":0.9909999966621399},{"id":"https://openalex.org/keywords/outer-mitochondrial-membrane","display_name":"mitochondrial outer membrane","score":0.8889999985694885},{"id":"https://openalex.org/keywords/porin","display_name":"porin","score":0.8650000095367432},{"id":"https://openalex.org/keywords/porphyrins","display_name":"porphyrins","score":0.9419999718666077},{"id":"https://openalex.org/keywords/endogenous-ligands","display_name":"endogenous ligands","score":0.921999990940094},{"id":"https://openalex.org/keywords/adrenal-cortex","display_name":"adrenal cortex","score":0.5759999752044678},{"id":"https://openalex.org/keywords/leydig-cells","display_name":"Leydig cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.734000027179718},{"id":"https://openalex.org/keywords/photoaffinity-labeling","display_name":"photoaffinity labeling","score":0.8370000123977661},{"id":"https://openalex.org/keywords/flunitrazepam","display_name":"flunitrazepam","score":0.8529999852180481},{"id":"https://openalex.org/keywords/diazepam","display_name":"diazepam","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C2776791281","wikidata":"https://www.wikidata.org/wiki/Q2385013","display_name":"Translocator protein","level":4,"score":0.8112914562225342},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.7047775983810425},{"id":"https://openalex.org/C2778173252","wikidata":"https://www.wikidata.org/wiki/Q83871","display_name":"Benzodiazepine","level":3,"score":0.5623823404312134},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.5590721368789673},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.5575371384620667},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5525389909744263},{"id":"https://openalex.org/C2778581200","wikidata":"https://www.wikidata.org/wiki/Q16943198","display_name":"Photoaffinity labeling","level":3,"score":0.5191159248352051},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.49774888157844543},{"id":"https://openalex.org/C2781442855","wikidata":"https://www.wikidata.org/wiki/Q62947","display_name":"Flunitrazepam","level":4,"score":0.4872661828994751},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.48705700039863586},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34041130542755127},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3390037417411804},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.0},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004702","descriptor_name":"Endocrine Glands","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007425","descriptor_name":"Intracellular Membranes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011166","descriptor_name":"Porphyrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1096/fasebj.1.4.2820823","doi":"https://doi.org/10.1096/fasebj.1.4.2820823","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.1.4.2820823","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},{"id":"pmid:2820823","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2820823","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","raw_type":"Journal Article"},{"id":"mag:2261510462","doi":null,"is_oa":false,"landing_page_url":"http://www.osti.gov/scitech/biblio/6974835-peripheral-type-benzodiazepine-receptor-protein-mitochondrial-outer-membranes-utilizing-porphyrins-endogenous-ligands","pdf_url":null,"source":{"id":"https://openalex.org/S4306510388","display_name":"Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1615557336","display_name":null,"funder_award_id":"DA 00074","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G2137558941","display_name":null,"funder_award_id":"NS16375","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G58031844","display_name":null,"funder_award_id":"DA.00266","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1604272930","https://openalex.org/W1635203761","https://openalex.org/W1960932156","https://openalex.org/W1965976632","https://openalex.org/W1967412073","https://openalex.org/W1968332855","https://openalex.org/W1968463314","https://openalex.org/W1969814314","https://openalex.org/W1970013901","https://openalex.org/W1981454650","https://openalex.org/W1982904143","https://openalex.org/W1984044317","https://openalex.org/W1993811512","https://openalex.org/W2009571951","https://openalex.org/W2010336982","https://openalex.org/W2014349643","https://openalex.org/W2026276973","https://openalex.org/W2027593690","https://openalex.org/W2034127921","https://openalex.org/W2039194467","https://openalex.org/W2042232934","https://openalex.org/W2056442441","https://openalex.org/W2064969949","https://openalex.org/W2068462317","https://openalex.org/W2071215725","https://openalex.org/W2085492035","https://openalex.org/W2085946323","https://openalex.org/W2151946938","https://openalex.org/W2231557771","https://openalex.org/W2403725722","https://openalex.org/W2414961437","https://openalex.org/W2415549287","https://openalex.org/W2437070473"],"related_works":["https://openalex.org/W1604272930","https://openalex.org/W2085492035","https://openalex.org/W1998220351","https://openalex.org/W1981182127","https://openalex.org/W1977093059","https://openalex.org/W2072700306","https://openalex.org/W643289512","https://openalex.org/W2033498298","https://openalex.org/W2068462317","https://openalex.org/W2398585490"],"abstract_inverted_index":{"The":[0,28,100],"peripheral-type":[1,29],"benzodiazepine":[2,23,30],"receptor":[3,24,31,85,141],"is":[4],"a":[5,68,120],"site":[6],"identified":[7],"by":[8,43],"its":[9,144],"nanomolar":[10,133],"affinity":[11,17],"for":[12,20,125,149],"[3H]diazepam,":[13],"similar":[14],"to":[15,104],"the":[16,21,26,51,54,62,72,75,83,108,126,139],"of":[18,50,61,71,78,82,94,115,129,136,153],"diazepam":[19],"central-type":[22],"in":[25,33,53,58],"brain.":[27],"occurs":[32],"many":[34,150],"peripheral":[35,117],"tissues":[36,118],"but":[37],"has":[38],"discrete":[39,90],"localizations":[40],"as":[41],"indicated":[42],"autoradiographic":[44],"studies":[45,66],"showing":[46],"uniquely":[47],"high":[48],"densities":[49],"receptors":[52,73],"adrenal":[55],"cortex":[56],"and":[57,96,147],"Leydig":[59],"cells":[60],"testes.":[63],"Subcellular":[64],"localization":[65],"reveal":[67],"selective":[69],"association":[70],"with":[74,86,107,138],"outer":[76],"membrane":[77],"mitochondria.":[79],"Photoaffinity":[80],"labeling":[81],"mitochondrial":[84,140],"[3H]flunitrazepam":[87],"reveals":[88,119],"two":[89],"labeled":[91],"protein":[92,112],"bands":[93],"30":[95],"35":[97],"kDa,":[98],"respectively.":[99],"35-kDa":[101],"band":[102],"appears":[103],"be":[105],"identical":[106],"voltage-dependent":[109],"anion":[110],"channel":[111],"porin.":[113],"Fractionation":[114],"numerous":[116],"single":[121],"principal":[122],"endogenous":[123],"ligand":[124],"receptor,":[127],"consisting":[128],"porphyrins,":[130],"which":[131],"display":[132],"affinity.":[134],"Interactions":[135],"porphyrins":[137],"may":[142],"clarify":[143],"physiological":[145],"role":[146],"account":[148],"pharmacological":[151],"actions":[152],"benzodiazepines.":[154]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}