{"id":"https://openalex.org/W2153592609","doi":"https://doi.org/10.1364/boe.5.002662","title":"In vivo mouse fluorescence imaging for folate-targeted delivery and release kinetics","display_name":"In vivo mouse fluorescence imaging for folate-targeted delivery and release kinetics","publication_year":2014,"publication_date":"2014-07-17","ids":{"openalex":"https://openalex.org/W2153592609","doi":"https://doi.org/10.1364/boe.5.002662","mag":"2153592609","pmid":"https://pubmed.ncbi.nlm.nih.gov/26236559","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4132996"},"language":"en","primary_location":{"id":"doi:10.1364/boe.5.002662","doi":"https://doi.org/10.1364/boe.5.002662","is_oa":true,"landing_page_url":"https://doi.org/10.1364/boe.5.002662","pdf_url":null,"source":{"id":"https://openalex.org/S104118869","display_name":"Biomedical Optics Express","issn_l":"2156-7085","issn":["2156-7085"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315679","host_organization_name":"Optica Publishing Group","host_organization_lineage":["https://openalex.org/P4310315679"],"host_organization_lineage_names":["Optica Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Optics Express","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1364/boe.5.002662","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046305784","display_name":"Esther H. R. Tsai","orcid":"https://orcid.org/0000-0002-5885-6317","observed_orcids":["https://orcid.org/0000-0002-5885-6317"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Esther H. R. Tsai","raw_affiliation_strings":["School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN 47907, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN 47907, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089405489","display_name":"Brian Bentz","orcid":"https://orcid.org/0000-0003-1911-0018","observed_orcids":["https://orcid.org/0000-0003-1911-0018"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Z. Bentz","raw_affiliation_strings":["School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN 47907, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN 47907, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015713099","display_name":"Venkatesh Chelvam","orcid":"https://orcid.org/0000-0001-9593-3759","observed_orcids":["https://orcid.org/0000-0001-9593-3759"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]},{"id":"https://openalex.org/I64295750","display_name":"Indian Institute of Technology Indore","ror":"https://ror.org/01hhf7w52","country_code":"IN","type":"education","lineage":["https://openalex.org/I64295750"]}],"countries":["IN","US"],"is_corresponding":false,"raw_author_name":"Venkatesh Chelvam","raw_affiliation_strings":["Department of Chemistry, Indian Institute of Technology Indore, DAVV-IET Campus, Indore 452017, Madhya Pradesh, India ; Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA","DAVV-IET Campus, Indore 452017, Madhya Pradesh, India","Department of Chemistry, Indian Institute of Technology Indore,","Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Indian Institute of Technology Indore, DAVV-IET Campus, Indore 452017, Madhya Pradesh, India ; Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA","institution_ids":["https://openalex.org/I219193219","https://openalex.org/I64295750"]},{"raw_affiliation_string":"DAVV-IET Campus, Indore 452017, Madhya Pradesh, India","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry, Indian Institute of Technology Indore,","institution_ids":["https://openalex.org/I64295750"]},{"raw_affiliation_string":"Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081631026","display_name":"Vaibhav Gaind","orcid":"https://orcid.org/0000-0003-2511-391X","observed_orcids":["https://orcid.org/0000-0003-2511-391X"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vaibhav Gaind","raw_affiliation_strings":["School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN 47907, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN 47907, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083699462","display_name":"Kevin John Webb","orcid":"https://orcid.org/0000-0001-5834-1631","observed_orcids":["https://orcid.org/0000-0001-5834-1631"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kevin J. Webb","raw_affiliation_strings":["School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN 47907, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN 47907, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012446734","display_name":"Philip Stewart Low","orcid":"https://orcid.org/0000-0001-9042-5528","observed_orcids":["https://orcid.org/0000-0001-9042-5528"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip S. Low","raw_affiliation_strings":["Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5083699462"],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":{"value":1913,"currency":"USD","value_usd":1913},"apc_paid":{"value":1913,"currency":"USD","value_usd":1913},"fwci":2.0739,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.85778588,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"5","issue":"8","first_page":"2662","last_page":"2662"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.4424000084400177,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.4424000084400177,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.41769999265670776,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10532","display_name":"Molecular Sensors and Ion Detection","score":0.0414000004529953,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/folate-targeted-drug-delivery","display_name":"folate-targeted drug delivery","score":0.8209999799728394},{"id":"https://openalex.org/keywords/drug-release-kinetics","display_name":"drug release kinetics","score":0.7099999785423279},{"id":"https://openalex.org/keywords/folate-receptor","display_name":"folate receptor","score":0.7279999852180481},{"id":"https://openalex.org/keywords/near-infrared-fluorophores","display_name":"near-infrared fluorophores","score":0.7350000143051147},{"id":"https://openalex.org/keywords/disulfide-reduction","display_name":"disulfide bond reduction","score":0.9629999995231628},{"id":"https://openalex.org/keywords/in-vivo-fluorescence-imaging","display_name":"in vivo fluorescence imaging","score":0.7490000128746033},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.7580000162124634},{"id":"https://openalex.org/keywords/kb-cells","display_name":"KB cells","score":0.9470000267028809},{"id":"https://openalex.org/keywords/targeted-anticancer-drugs","display_name":"targeted anticancer drugs","score":0.7480000257492065},{"id":"https://openalex.org/keywords/preclinical-drug-development","display_name":"preclinical drug development","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.673640251159668},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.6610814929008484},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.5932273268699646},{"id":"https://openalex.org/C57477423","wikidata":"https://www.wikidata.org/wiki/Q1434196","display_name":"Fluorescence-lifetime imaging microscopy","level":3,"score":0.5595215559005737},{"id":"https://openalex.org/C29331040","wikidata":"https://www.wikidata.org/wiki/Q7239554","display_name":"Preclinical imaging","level":3,"score":0.5264005661010742},{"id":"https://openalex.org/C92630104","wikidata":"https://www.wikidata.org/wiki/Q4115103","display_name":"Optical imaging","level":2,"score":0.44882071018218994},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3959755599498749},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37397605180740356},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3376813530921936},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2817538380622864},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.20354807376861572},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17707088589668274},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08118957281112671},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07934200763702393},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1364/boe.5.002662","doi":"https://doi.org/10.1364/boe.5.002662","is_oa":true,"landing_page_url":"https://doi.org/10.1364/boe.5.002662","pdf_url":null,"source":{"id":"https://openalex.org/S104118869","display_name":"Biomedical Optics Express","issn_l":"2156-7085","issn":["2156-7085"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315679","host_organization_name":"Optica Publishing Group","host_organization_lineage":["https://openalex.org/P4310315679"],"host_organization_lineage_names":["Optica Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Optics Express","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4132996","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4132996","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomed Opt Express","raw_type":"Text"},{"id":"pmid:26236559","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26236559","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical optics express","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1364/boe.5.002662","doi":"https://doi.org/10.1364/boe.5.002662","is_oa":true,"landing_page_url":"https://doi.org/10.1364/boe.5.002662","pdf_url":null,"source":{"id":"https://openalex.org/S104118869","display_name":"Biomedical Optics Express","issn_l":"2156-7085","issn":["2156-7085"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315679","host_organization_name":"Optica Publishing Group","host_organization_lineage":["https://openalex.org/P4310315679"],"host_organization_lineage_names":["Optica Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Optics Express","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5186338787","display_name":"Towards Deep Tissue Imaging of Fluorescence Resonance Energy Transfer Parameters","funder_award_id":"0854249","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5873716790","display_name":"CIF: Small: Optical Diffusion Tomography, with Application to in Vivo Fluorescence Resonance Energy Transfer Imaging","funder_award_id":"0915966","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6829875104","display_name":"CIF: Small: Fast In Vivo Optical Imaging in the Heavily and Weakly Scattering Regimes","funder_award_id":"1218909","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8061667383","display_name":"Optical Imaging of Targeted Anti-Cancer Drug Delivery Kinetics","funder_award_id":"R21CA182235","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332172","display_name":"Directorate for Mathematical and Physical Sciences","ror":"https://ror.org/029b7h395"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1919555085","https://openalex.org/W1967362555","https://openalex.org/W1978498174","https://openalex.org/W1988959629","https://openalex.org/W1991354544","https://openalex.org/W1994337577","https://openalex.org/W1995980440","https://openalex.org/W1996311294","https://openalex.org/W2017096549","https://openalex.org/W2019207861","https://openalex.org/W2025312995","https://openalex.org/W2027163628","https://openalex.org/W2033106066","https://openalex.org/W2039026859","https://openalex.org/W2040626002","https://openalex.org/W2040798835","https://openalex.org/W2043818471","https://openalex.org/W2045936365","https://openalex.org/W2050973816","https://openalex.org/W2051252098","https://openalex.org/W2051763142","https://openalex.org/W2060459188","https://openalex.org/W2067848116","https://openalex.org/W2078602456","https://openalex.org/W2085780709","https://openalex.org/W2094517427","https://openalex.org/W2095634557","https://openalex.org/W2105347172","https://openalex.org/W2112579958","https://openalex.org/W2112999913","https://openalex.org/W2116725368","https://openalex.org/W2119603765","https://openalex.org/W2125773640","https://openalex.org/W2131060408","https://openalex.org/W2136956182","https://openalex.org/W2147607085","https://openalex.org/W2149875392","https://openalex.org/W2150451572","https://openalex.org/W2151904753","https://openalex.org/W2163108870"],"related_works":["https://openalex.org/W2014866541","https://openalex.org/W2334587091","https://openalex.org/W2029916977","https://openalex.org/W2016623780","https://openalex.org/W2035891863","https://openalex.org/W2890516004","https://openalex.org/W2765393984","https://openalex.org/W2946987020","https://openalex.org/W2013919931","https://openalex.org/W2101288636"],"abstract_inverted_index":{"Many":[0],"cancer":[1],"cells":[2,71],"over-express":[3],"folate":[4],"receptors,":[5],"and":[6,16,34,39,61,94],"this":[7],"provides":[8],"an":[9,25,100],"opportunity":[10],"for":[11,31,50,103],"both":[12],"folate-targeted":[13],"fluorescence":[14],"imaging":[15,27],"the":[17,32,51,92],"development":[18],"of":[19,36,96],"targeted":[20],"anti-cancer":[21],"drugs.":[22],"We":[23],"present":[24],"optical":[26],"modality":[28],"that":[29],"allows":[30],"monitoring":[33],"evaluation":[35],"drug":[37,107],"delivery":[38],"release":[40],"through":[41],"disulfide":[42],"bond":[43],"reduction":[44],"inside":[45],"a":[46,65,73],"tumor":[47,67],"in":[48,72,77,84,88,106],"vivo":[49,78],"first":[52],"time.":[53],"A":[54],"near-infrared":[55],"folate-targeting":[56],"fluorophore":[57],"pair":[58],"was":[59],"synthesized":[60],"used":[62],"to":[63,82],"image":[64],"xenograft":[66],"grown":[68],"from":[69],"KB":[70],"live":[74],"mouse.":[75],"The":[76],"results":[79],"are":[80],"shown":[81],"be":[83],"agreement":[85],"with":[86],"previous":[87],"vitro":[89],"studies,":[90],"confirming":[91],"validity":[93],"feasibility":[95],"our":[97],"method":[98],"as":[99],"effective":[101],"tool":[102],"preclinical":[104],"studies":[105],"development.":[108]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
