{"id":"https://openalex.org/W2153580666","doi":"https://doi.org/10.1586/17512433.1.1.145","title":"Challenges and solutions in topical ocular drug-delivery systems","display_name":"Challenges and solutions in topical ocular drug-delivery systems","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2153580666","doi":"https://doi.org/10.1586/17512433.1.1.145","mag":"2153580666","pmid":"https://pubmed.ncbi.nlm.nih.gov/24410518"},"language":"en","primary_location":{"id":"doi:10.1586/17512433.1.1.145","doi":"https://doi.org/10.1586/17512433.1.1.145","is_oa":false,"landing_page_url":"https://doi.org/10.1586/17512433.1.1.145","pdf_url":null,"source":{"id":"https://openalex.org/S102962966","display_name":"Expert Review of Clinical Pharmacology","issn_l":"1751-2433","issn":["1751-2433","1751-2441"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045274371","display_name":"Maryam Ali","orcid":"https://orcid.org/0000-0001-8958-8709","observed_orcids":["https://orcid.org/0000-0001-8958-8709"]},"institutions":[{"id":"https://openalex.org/I82497590","display_name":"Auburn University","ror":"https://ror.org/02v80fc35","country_code":"US","type":"education","lineage":["https://openalex.org/I82497590"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maryam Ali","raw_affiliation_strings":["Auburn University, Biomimetic & Biohybrid Materials, Biomedical Devices, and Drug Delivery Laboratories, Department of Chemical Engineering, Auburn, AL 36849, USA. alimary@auburn.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Auburn University, Biomimetic & Biohybrid Materials, Biomedical Devices, and Drug Delivery Laboratories, Department of Chemical Engineering, Auburn, AL 36849, USA. alimary@auburn.edu","institution_ids":["https://openalex.org/I82497590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033345233","display_name":"Mark Edward Byrne","orcid":"https://orcid.org/0000-0001-7038-7042","observed_orcids":["https://orcid.org/0000-0001-7038-7042"]},"institutions":[{"id":"https://openalex.org/I82497590","display_name":"Auburn University","ror":"https://ror.org/02v80fc35","country_code":"US","type":"education","lineage":["https://openalex.org/I82497590"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Edward Byrne","raw_affiliation_strings":["Auburn University, Biomimetic & Biohybrid Materials, Biomedical Devices, and Drug Delivery Laboratories, Department of Chemical Engineering, Auburn, AL 36849, USA. byrneme@eng.auburn.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Auburn University, Biomimetic & Biohybrid Materials, Biomedical Devices, and Drug Delivery Laboratories, Department of Chemical Engineering, Auburn, AL 36849, USA. byrneme@eng.auburn.edu","institution_ids":["https://openalex.org/I82497590"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I82497590"],"apc_list":null,"apc_paid":null,"fwci":1.7915,"has_fulltext":false,"cited_by_count":83,"citation_normalized_percentile":{"value":0.8281054,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"1","issue":"1","first_page":"145","last_page":"161"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/topical-ocular-drug-delivery","display_name":"topical ocular drug delivery","score":0.9679999947547913},{"id":"https://openalex.org/keywords/ocular-barriers","display_name":"ocular barriers","score":0.843999981880188},{"id":"https://openalex.org/keywords/corneal-epithelium","display_name":"corneal epithelium","score":0.9409999847412109},{"id":"https://openalex.org/keywords/conjunctival-epithelium","display_name":"conjunctival epithelium","score":0.9919999837875366},{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.9990000128746033},{"id":"https://openalex.org/keywords/aqueous-humor","display_name":"aqueous humor","score":0.890999972820282},{"id":"https://openalex.org/keywords/drug-penetration","display_name":"drug penetration","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8540586829185486},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.696558952331543},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6277370452880859},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44390761852264404},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.40794020891189575},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.3206169009208679},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.09930306673049927},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1586/17512433.1.1.145","doi":"https://doi.org/10.1586/17512433.1.1.145","is_oa":false,"landing_page_url":"https://doi.org/10.1586/17512433.1.1.145","pdf_url":null,"source":{"id":"https://openalex.org/S102962966","display_name":"Expert Review of Clinical Pharmacology","issn_l":"1751-2433","issn":["1751-2433","1751-2441"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmid:24410518","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24410518","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert review of clinical pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":101,"referenced_works":["https://openalex.org/W3783758","https://openalex.org/W35122493","https://openalex.org/W46341933","https://openalex.org/W1164915814","https://openalex.org/W1512461245","https://openalex.org/W1576414542","https://openalex.org/W1935413599","https://openalex.org/W1963564206","https://openalex.org/W1966662116","https://openalex.org/W1967521101","https://openalex.org/W1968741570","https://openalex.org/W1969373623","https://openalex.org/W1971360209","https://openalex.org/W1972187956","https://openalex.org/W1972217729","https://openalex.org/W1973751377","https://openalex.org/W1973962716","https://openalex.org/W1979425595","https://openalex.org/W1979565474","https://openalex.org/W1983164716","https://openalex.org/W1985999573","https://openalex.org/W1986180285","https://openalex.org/W1986509489","https://openalex.org/W1987313861","https://openalex.org/W1992242429","https://openalex.org/W1993362861","https://openalex.org/W1995201495","https://openalex.org/W1996540455","https://openalex.org/W1996853317","https://openalex.org/W1996921863","https://openalex.org/W1999718395","https://openalex.org/W2003774675","https://openalex.org/W2004539400","https://openalex.org/W2005173893","https://openalex.org/W2007067975","https://openalex.org/W2009491903","https://openalex.org/W2009568831","https://openalex.org/W2009949312","https://openalex.org/W2011696560","https://openalex.org/W2013242195","https://openalex.org/W2015350369","https://openalex.org/W2017394173","https://openalex.org/W2022637870","https://openalex.org/W2023903257","https://openalex.org/W2026940257","https://openalex.org/W2029446966","https://openalex.org/W2030067645","https://openalex.org/W2034411501","https://openalex.org/W2036524290","https://openalex.org/W2039031017","https://openalex.org/W2040242834","https://openalex.org/W2046158120","https://openalex.org/W2046525386","https://openalex.org/W2054001210","https://openalex.org/W2054431270","https://openalex.org/W2054703112","https://openalex.org/W2055104142","https://openalex.org/W2061955205","https://openalex.org/W2065633657","https://openalex.org/W2068240430","https://openalex.org/W2070795165","https://openalex.org/W2072399777","https://openalex.org/W2075956394","https://openalex.org/W2078628334","https://openalex.org/W2079226662","https://openalex.org/W2080854539","https://openalex.org/W2082276469","https://openalex.org/W2084363217","https://openalex.org/W2085204896","https://openalex.org/W2086357580","https://openalex.org/W2086606866","https://openalex.org/W2088654799","https://openalex.org/W2091149498","https://openalex.org/W2094505929","https://openalex.org/W2095089814","https://openalex.org/W2104838039","https://openalex.org/W2106839778","https://openalex.org/W2109077016","https://openalex.org/W2110125079","https://openalex.org/W2110373623","https://openalex.org/W2115305419","https://openalex.org/W2115495965","https://openalex.org/W2117070871","https://openalex.org/W2119772416","https://openalex.org/W2125367046","https://openalex.org/W2127765589","https://openalex.org/W2138321161","https://openalex.org/W2139013472","https://openalex.org/W2141089465","https://openalex.org/W2141701664","https://openalex.org/W2149282572","https://openalex.org/W2156262826","https://openalex.org/W2156311549","https://openalex.org/W2163597049","https://openalex.org/W2166384232","https://openalex.org/W2168163081","https://openalex.org/W2306464352","https://openalex.org/W2406933516","https://openalex.org/W2537506997","https://openalex.org/W2610469353","https://openalex.org/W4290440818"],"related_works":["https://openalex.org/W2568090626","https://openalex.org/W4381154621","https://openalex.org/W2072399777","https://openalex.org/W4206202146","https://openalex.org/W4321614156","https://openalex.org/W3011214583","https://openalex.org/W7203864584","https://openalex.org/W1985933245","https://openalex.org/W7222384310","https://openalex.org/W4293174779"],"abstract_inverted_index":{"Vision":[0],"significantly":[1],"affects":[2],"quality":[3],"of":[4,9,15,40,45,55,82,91,128,149],"life":[5],"and":[6,30,48,65,68,99],"the":[7,21,36,41,52,63,69,79,85,89,92,96,101,147],"treatment":[8,76],"ocular":[10,27,60,97,134],"disease":[11],"poses":[12],"a":[13,126],"number":[14,127],"unique":[16],"challenges.":[17],"This":[18],"review":[19],"presents":[20],"major":[22],"challenges":[23],"faced":[24],"during":[25],"topical":[26],"drug":[28,93],"administration":[29],"highlights":[31],"strategies":[32,77,111],"used":[33],"to":[34,94,125,157],"overcome":[35],"natural":[37],"transport":[38],"barriers":[39,61,98],"eye.":[42],"The":[43],"circulation":[44],"tear":[46],"fluid":[47],"aqueous":[49],"humor":[50],"decrease":[51],"residence":[53,80],"time":[54,81],"topically":[56],"delivered":[57],"drugs,":[58],"while":[59],"in":[62,84,137],"corneal":[64],"conjuctival":[66],"epithelia":[67],"retinal":[70],"pigment":[71],"epithelium":[72],"limit":[73],"transport.":[74],"Successful":[75],"increase":[78],"drugs":[83],"eye":[86],"and/or":[87],"enhance":[88],"ability":[90],"penetrate":[95],"reach":[100],"target":[102],"tissue.":[103],"In":[104],"this":[105],"review,":[106],"we":[107,140],"discuss":[108],"several":[109],"drug-delivery":[110,135,143,151],"that":[112,131,145],"have":[113],"achieved":[114],"clinical":[115],"success":[116],"or":[117,153],"demonstrate":[118],"high":[119],"potential.":[120],"We":[121],"also":[122],"draw":[123],"attention":[124],"excellent":[129],"reviews":[130],"explore":[132],"various":[133],"techniques":[136,156],"depth.":[138],"Finally,":[139],"highlight":[141],"cutting-edge":[142],"technologies":[144],"improve":[146],"efficacy":[148],"current":[150],"methods":[152],"use":[154],"proven":[155],"deliver":[158],"novel":[159],"therapeutics.":[160]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}