{"id":"https://openalex.org/W2153482452","doi":"https://doi.org/10.1158/1078-0432.ccr-04-1850","title":"Antiapoptotic Role of Growth Factors in the Myelodysplastic Syndromes: Concordance Between In vitro and In vivo Observations","display_name":"Antiapoptotic Role of Growth Factors in the Myelodysplastic Syndromes: Concordance Between In vitro and In vivo Observations","publication_year":2005,"publication_date":"2005-09-01","ids":{"openalex":"https://openalex.org/W2153482452","doi":"https://doi.org/10.1158/1078-0432.ccr-04-1850","mag":"2153482452","pmid":"https://pubmed.ncbi.nlm.nih.gov/16144933"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-04-1850","doi":"https://doi.org/10.1158/1078-0432.ccr-04-1850","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-04-1850","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088310334","display_name":"Ramin Tehranchi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ramin Tehranchi","raw_affiliation_strings":["1Department of Medicine, Division of Hematology;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medicine, Division of Hematology;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003243714","display_name":"Bengt Fadeel","orcid":"https://orcid.org/0000-0001-5559-8482","observed_orcids":["https://orcid.org/0000-0001-5559-8482"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bengt Fadeel","raw_affiliation_strings":["2Institute of Environmental Medicine, Division of Molecular Toxicology;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Institute of Environmental Medicine, Division of Molecular Toxicology;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110113417","display_name":"Jan Schmidt\u2010Mende","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan Schmidt-Mende","raw_affiliation_strings":["1Department of Medicine, Division of Hematology;","3Institute of Environmental Medicine, Division of Toxicology;","1Department of Medicine, Division of Hematology;; 3Institute of Environmental Medicine, Division of Toxicology;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medicine, Division of Hematology;","institution_ids":[]},{"raw_affiliation_string":"3Institute of Environmental Medicine, Division of Toxicology;","institution_ids":[]},{"raw_affiliation_string":"1Department of Medicine, Division of Hematology;; 3Institute of Environmental Medicine, Division of Toxicology;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108622520","display_name":"Ann\u2010Mari Forsblom","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ann-Mari Forsblom","raw_affiliation_strings":["1Department of Medicine, Division of Hematology;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medicine, Division of Hematology;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025978436","display_name":"Emma K. Emanuelsson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emma Emanuelsson","raw_affiliation_strings":["1Department of Medicine, Division of Hematology;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medicine, Division of Hematology;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011249206","display_name":"Martin J\u00e4dersten","orcid":"https://orcid.org/0000-0001-5217-3235","observed_orcids":["https://orcid.org/0000-0001-5217-3235"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin Jadersten","raw_affiliation_strings":["1Department of Medicine, Division of Hematology;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medicine, Division of Hematology;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039457141","display_name":"Birger Christensson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Birger Christensson","raw_affiliation_strings":["4Department of Laboratory Medicine, Division of Pathology, Karolinska University Hospital Huddinge;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Laboratory Medicine, Division of Pathology, Karolinska University Hospital Huddinge;","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053443688","display_name":"Robert Hast","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Robert Hast","raw_affiliation_strings":["5Department of Medicine, Division of Hematology, Karolinska University Hospital Solna;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Medicine, Division of Hematology, Karolinska University Hospital Solna;","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103392249","display_name":"Robert B. Howe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert B. Howe","raw_affiliation_strings":["7Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050171154","display_name":"Jan Samuelsson","orcid":"https://orcid.org/0000-0003-4834-2360","observed_orcids":["https://orcid.org/0000-0003-4834-2360"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jan Samuelsson","raw_affiliation_strings":["6Department of Medicine, Southern Hospital, Karolinska Institutet, Stockholm, Sweden; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Department of Medicine, Southern Hospital, Karolinska Institutet, Stockholm, Sweden; and","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080920861","display_name":"Boris Zhivotovsky","orcid":"https://orcid.org/0000-0002-2238-3482","observed_orcids":["https://orcid.org/0000-0002-2238-3482"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Boris Zhivotovsky","raw_affiliation_strings":["3Institute of Environmental Medicine, Division of Toxicology;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Institute of Environmental Medicine, Division of Toxicology;","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079746633","display_name":"Eva Hellstr\u00f6m-Lindberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eva Hellstro\u0308m-Lindberg","raw_affiliation_strings":["1Department of Medicine, Division of Hematology;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medicine, Division of Hematology;","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.066,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.91612642,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"11","issue":"17","first_page":"6291","last_page":"6299"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":0.9810000061988831},{"id":"https://openalex.org/keywords/erythropoietin","display_name":"erythropoietin","score":0.968999981880188},{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cytochrome-c-release","display_name":"cytochrome c release","score":0.8610000014305115},{"id":"https://openalex.org/keywords/caspase-activation","display_name":"caspase activation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/g-csf-receptor","display_name":"G-CSF receptor","score":0.8759999871253967},{"id":"https://openalex.org/keywords/erythroid-progenitors","display_name":"erythroid progenitor cells","score":0.6740000247955322},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.8090000152587891},{"id":"https://openalex.org/keywords/5q-syndrome","display_name":"5q- syndrome","score":0.7940000295639038},{"id":"https://openalex.org/keywords/monosomy-7","display_name":"monosomy 7","score":0.9700000286102295},{"id":"https://openalex.org/keywords/trisomy-8","display_name":"trisomy 8","score":0.9959999918937683},{"id":"https://openalex.org/keywords/refractory-anemia","display_name":"refractory anemia","score":0.8600000143051147},{"id":"https://openalex.org/keywords/refractory-anemia-with-ringed-sideroblasts","display_name":"refractory anemia with ringed sideroblasts","score":0.9570000171661377},{"id":"https://openalex.org/keywords/erythroid-maturation","display_name":"erythroid maturation","score":0.5889999866485596},{"id":"https://openalex.org/keywords/clonal-selection","display_name":"clonal selection","score":0.5540000200271606}],"concepts":[{"id":"https://openalex.org/C2778534260","wikidata":"https://www.wikidata.org/wiki/Q218706","display_name":"Erythropoietin","level":2,"score":0.7940852642059326},{"id":"https://openalex.org/C2780817109","wikidata":"https://www.wikidata.org/wiki/Q954625","display_name":"Myelodysplastic syndromes","level":3,"score":0.7297729849815369},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5700174570083618},{"id":"https://openalex.org/C2779703530","wikidata":"https://www.wikidata.org/wiki/Q837174","display_name":"Erythropoiesis","level":3,"score":0.5363506078720093},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5342304706573486},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4920367896556854},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.48093196749687195},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4773312211036682},{"id":"https://openalex.org/C2780365373","wikidata":"https://www.wikidata.org/wiki/Q2454191","display_name":"Trisomy 8","level":5,"score":0.4570103585720062},{"id":"https://openalex.org/C2780844101","wikidata":"https://www.wikidata.org/wiki/Q2380264","display_name":"Ineffective erythropoiesis","level":4,"score":0.4565131664276123},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43098607659339905},{"id":"https://openalex.org/C2777767877","wikidata":"https://www.wikidata.org/wiki/Q419327","display_name":"Granulocyte colony-stimulating factor","level":3,"score":0.4191593527793884},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.41457825899124146},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41111618280410767},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.3805790841579437},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3108375668525696},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25353437662124634},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2378075122833252},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.20540979504585266},{"id":"https://openalex.org/C174475383","wikidata":"https://www.wikidata.org/wiki/Q246128","display_name":"Cytogenetics","level":4,"score":0.1622677445411682},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.14690837264060974},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09712523221969604},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08204302191734314},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000753","descriptor_name":"Anemia, Refractory","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000753","descriptor_name":"Anemia, Refractory","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000756","descriptor_name":"Anemia, Sideroblastic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000756","descriptor_name":"Anemia, Sideroblastic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006021","descriptor_name":"Glycophorins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009006","descriptor_name":"Monosomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014314","descriptor_name":"Trisomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015672","descriptor_name":"Erythroid Precursor Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015672","descriptor_name":"Erythroid Precursor Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016188","descriptor_name":"Receptors, Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045304","descriptor_name":"Cytochromes c","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.ccr-04-1850","doi":"https://doi.org/10.1158/1078-0432.ccr-04-1850","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-04-1850","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:16144933","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16144933","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W3719606","https://openalex.org/W49853543","https://openalex.org/W146301169","https://openalex.org/W157103782","https://openalex.org/W347010909","https://openalex.org/W417406195","https://openalex.org/W1527321128","https://openalex.org/W1541533982","https://openalex.org/W1843432358","https://openalex.org/W1970838494","https://openalex.org/W1976968664","https://openalex.org/W1977998150","https://openalex.org/W1978052815","https://openalex.org/W1981176905","https://openalex.org/W1992207190","https://openalex.org/W2003371248","https://openalex.org/W2016978620","https://openalex.org/W2019350782","https://openalex.org/W2026452824","https://openalex.org/W2028608050","https://openalex.org/W2053503772","https://openalex.org/W2083239534","https://openalex.org/W2101402144","https://openalex.org/W2101423074","https://openalex.org/W2110949925","https://openalex.org/W2117754708","https://openalex.org/W2161854495","https://openalex.org/W2189586120","https://openalex.org/W2208491121","https://openalex.org/W2225322761","https://openalex.org/W2289122463","https://openalex.org/W2322668491","https://openalex.org/W2512906422"],"related_works":["https://openalex.org/W2144253343","https://openalex.org/W1992207190","https://openalex.org/W2133016731","https://openalex.org/W1893537866","https://openalex.org/W1968226137","https://openalex.org/W4241986475","https://openalex.org/W1977998150","https://openalex.org/W2014408999","https://openalex.org/W2118490366","https://openalex.org/W2093924856"],"abstract_inverted_index":{"PURPOSE:":[0],"Erythroid":[1],"apoptosis":[2,47,248],"in":[3,27,30,119,187,202],"low-risk":[4],"myelodysplastic":[5,44,250],"syndrome":[6],"(MDS)":[7],"maybe":[8],"mediated":[9],"via":[10,245,254],"mitochondrial":[11],"release":[12,142,179],"of":[13,33,51,82,93,101,113,121,128,138,175,209,247,249,256],"cytochrome":[14,129],"c":[15,130,178],"and":[16,29,48,64,77,84,95,152,167,180,195,240,253],"subsequent":[17],"caspase":[18,181],"activation.":[19],"In":[20],"the":[21,26,148,156],"present":[22],"study,":[23],"we":[24],"compared":[25],"vitro":[28],"vivo":[31],"effects":[32,92],"proerythroid":[34],"treatment":[35,83,134],"with":[36,53,68,116],"erythropoietin":[37,96,122,154,205,239],"+":[38],"granulocyte":[39],"colony-stimulating":[40],"factor":[41],"(G-CSF)":[42],"on":[43,222],"erythropoiesis":[45],"regarding":[46],"preferential":[49],"growth":[50,112,208,235],"clones":[52],"cytogenetic":[54,117],"abnormalities.":[55],"EXPERIMENTAL":[56],"DESIGN:":[57],"We":[58,232],"enrolled":[59],"15":[60],"refractory":[61,66],"anemia":[62,67],"(RA)":[63],"11":[65],"ringed":[69],"sideroblasts":[70],"(RARS),":[71],"including":[72],"5q-":[73,214],"aberration,":[74],"monosomy":[75,225],"7,":[76],"trisomy":[78,228],"8,":[79],"before":[80,133],"initiation":[81],"followed":[85],"nine":[86],"patients":[87,194],"after":[88],"successful":[89],"treatment.":[90],"The":[91,99,110],"G-CSF":[94,102,146,201,241],"were":[97,183],"assessed.":[98],"expression":[100,174],"receptor":[103],"(G-CSFR)":[104],"was":[105,123,131,143,220],"explored":[106],"during":[107,147,155,170],"erythroid":[108,114,139,251],"maturation.":[109],"relative":[111],"progenitors":[115,188],"aberrations":[118],"presence":[120],"investigated.":[124],"RESULTS:":[125],"Significant":[126],"redistribution":[127],"seen":[132],"at":[135],"all":[136],"stages":[137],"differentiation.":[140],"This":[141],"blocked":[144],"by":[145,153],"whole":[149],"culture":[150],"period":[151],"latter":[157],"phase.":[158],"Both":[159],"freshly":[160],"isolated":[161],"glycophorin":[162],"A+":[163],"bone":[164],"marrow":[165],"cells":[166,212],"intermediate":[168],"erythroblasts":[169,223],"cultivation":[171],"retained":[172],"their":[173],"G-CSFR.":[176],"Cytochrome":[177],"activation":[182],"significantly":[184,206],"less":[185],"pronounced":[186],"obtained":[189],"from":[190,213,224],"successfully":[191],"treated":[192],"nonanemic":[193],"showed":[196],"no":[197,217],"further":[198],"response":[199],"to":[200],"vitro.":[203],"Moreover,":[204],"promoted":[207],"cytogenetically":[210,257],"normal":[211,258],"patients,":[215],"whereas":[216],"such":[218,237],"effect":[219],"observed":[221],"7":[226],"or":[227],"8":[229],"patients.":[230],"CONCLUSION:":[231],"conclude":[233],"that":[234],"factors":[236],"as":[238],"can":[242],"act":[243],"both":[244],"inhibition":[246],"precursors":[252],"selection":[255],"progenitors.":[259]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}