{"id":"https://openalex.org/W2153454681","doi":null,"title":"Future approaches to organ regeneration: microscale environments, stem cell engineering, and self-assembly of living tissues.","display_name":"Future approaches to organ regeneration: microscale environments, stem cell engineering, and self-assembly of living tissues.","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2153454681","mag":"2153454681","pmid":"https://pubmed.ncbi.nlm.nih.gov/19745484"},"language":"en","primary_location":{"id":"pmid:19745484","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19745484","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in health technology and informatics","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036758974","display_name":"Hacking Sa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Adam Hacking","raw_affiliation_strings":["Department of Medicine, Center for Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School and Harvard-MIT Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Center for Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School and Harvard-MIT Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073288182","display_name":"Nezamoddin N. Kachouie","orcid":"https://orcid.org/0000-0001-9397-1807","observed_orcids":["https://orcid.org/0000-0001-9397-1807"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nezamoddin N Kachouie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015493240","display_name":"Won Gu Lee","orcid":"https://orcid.org/0000-0003-1473-0672","observed_orcids":["https://orcid.org/0000-0003-1473-0672"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Won Gu Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5033056518","display_name":"Ali Khademhosseini","orcid":"https://orcid.org/0000-0002-2692-1524","observed_orcids":["https://orcid.org/0000-0002-2692-1524","https://orcid.org/0000-0001-6322-8852"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ali Khademhosseini","raw_affiliation_strings":["Massachusetts Institute Of Technology#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts Institute Of Technology#TAB#","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"149","issue":null,"first_page":"214","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.5425000190734863,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.5425000190734863,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.45509999990463257,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/organ-regeneration","display_name":"organ regeneration","score":0.9940000176429749},{"id":"https://openalex.org/keywords/artificial-organs","display_name":"artificial organs","score":0.7680000066757202},{"id":"https://openalex.org/keywords/stem-cell-differentiation","display_name":"stem cell differentiation","score":0.8169999718666077},{"id":"https://openalex.org/keywords/stem-cell-engineering","display_name":"stem cell engineering","score":0.828000009059906},{"id":"https://openalex.org/keywords/tissue-architecture","display_name":"tissue structure","score":0.7369999885559082},{"id":"https://openalex.org/keywords/nutrient-delivery","display_name":"nutrient delivery","score":0.7459999918937683},{"id":"https://openalex.org/keywords/waste-removal","display_name":"waste removal","score":0.8420000076293945},{"id":"https://openalex.org/keywords/donor-tissue-shortage","display_name":"donor tissue shortage","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C179428855","wikidata":"https://www.wikidata.org/wiki/Q1069216","display_name":"Microscale chemistry","level":2,"score":0.8822369575500488},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.6237659454345703},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6168632507324219},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.5920556783676147},{"id":"https://openalex.org/C2984801823","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Living cell","level":2,"score":0.4756888151168823},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.43972456455230713},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4262341260910034},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3619462251663208},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3099455237388611},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.2475377321243286},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15043339133262634},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C145420912","wikidata":"https://www.wikidata.org/wiki/Q853077","display_name":"Mathematics education","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002468","descriptor_name":"Cell Physiological Phenomena","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:19745484","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19745484","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in health technology and informatics","raw_type":"Journal Article"},{"id":"mag:2153454681","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19745484","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":103,"referenced_works":["https://openalex.org/W44019328","https://openalex.org/W145559274","https://openalex.org/W306749603","https://openalex.org/W348026068","https://openalex.org/W1486455950","https://openalex.org/W1603508604","https://openalex.org/W1606942036","https://openalex.org/W1679037298","https://openalex.org/W1964574792","https://openalex.org/W1966288407","https://openalex.org/W1966594218","https://openalex.org/W1968421448","https://openalex.org/W1969750812","https://openalex.org/W1974365381","https://openalex.org/W1975422671","https://openalex.org/W1979122200","https://openalex.org/W1979608640","https://openalex.org/W1982769493","https://openalex.org/W1989904382","https://openalex.org/W1993313340","https://openalex.org/W1995321764","https://openalex.org/W2000196225","https://openalex.org/W2000453258","https://openalex.org/W2001909877","https://openalex.org/W2002324554","https://openalex.org/W2004435141","https://openalex.org/W2004463118","https://openalex.org/W2010229362","https://openalex.org/W2010353459","https://openalex.org/W2010415067","https://openalex.org/W2011548785","https://openalex.org/W2014726972","https://openalex.org/W2018683165","https://openalex.org/W2019529051","https://openalex.org/W2021928522","https://openalex.org/W2024788494","https://openalex.org/W2027936803","https://openalex.org/W2030299494","https://openalex.org/W2031675589","https://openalex.org/W2033870293","https://openalex.org/W2033926629","https://openalex.org/W2034683890","https://openalex.org/W2037810763","https://openalex.org/W2040165312","https://openalex.org/W2041244672","https://openalex.org/W2041920957","https://openalex.org/W2046322851","https://openalex.org/W2047919277","https://openalex.org/W2047922146","https://openalex.org/W2049222757","https://openalex.org/W2049372016","https://openalex.org/W2052098523","https://openalex.org/W2058461583","https://openalex.org/W2059409877","https://openalex.org/W2062665263","https://openalex.org/W2064186538","https://openalex.org/W2066960006","https://openalex.org/W2068001725","https://openalex.org/W2071628173","https://openalex.org/W2072212761","https://openalex.org/W2072384747","https://openalex.org/W2073759231","https://openalex.org/W2075361086","https://openalex.org/W2076053527","https://openalex.org/W2076766608","https://openalex.org/W2078212435","https://openalex.org/W2081319320","https://openalex.org/W2083940756","https://openalex.org/W2084610464","https://openalex.org/W2089327546","https://openalex.org/W2091099944","https://openalex.org/W2094162187","https://openalex.org/W2097425865","https://openalex.org/W2098569105","https://openalex.org/W2099412187","https://openalex.org/W2101556559","https://openalex.org/W2108265830","https://openalex.org/W2114661172","https://openalex.org/W2115798328","https://openalex.org/W2116397695","https://openalex.org/W2117336213","https://openalex.org/W2119708685","https://openalex.org/W2119738069","https://openalex.org/W2122531454","https://openalex.org/W2122810788","https://openalex.org/W2125987139","https://openalex.org/W2131256178","https://openalex.org/W2131960777","https://openalex.org/W2134208433","https://openalex.org/W2135607345","https://openalex.org/W2137413193","https://openalex.org/W2140715956","https://openalex.org/W2141783259","https://openalex.org/W2142046859","https://openalex.org/W2149893376","https://openalex.org/W2150600914","https://openalex.org/W2161817427","https://openalex.org/W2164406135","https://openalex.org/W2164527416","https://openalex.org/W2166138261","https://openalex.org/W2168684990","https://openalex.org/W2171383148","https://openalex.org/W3149755481"],"related_works":["https://openalex.org/W7099458436","https://openalex.org/W2889668534","https://openalex.org/W2083896892","https://openalex.org/W4229012439","https://openalex.org/W3201166801","https://openalex.org/W2948025468","https://openalex.org/W2800868783","https://openalex.org/W2499400546","https://openalex.org/W59891844","https://openalex.org/W2111166332"],"abstract_inverted_index":{"A":[0],"promising":[1],"means":[2],"to":[3,43],"address":[4],"the":[5,13,34,44,46,57,66,72,80,88,93,96],"limited":[6,28],"supply":[7],"of":[8,15,19,36,40,48,59,63,82,87,98],"donor":[9],"tissue":[10,54,67,90],"is":[11,27],"through":[12],"generation":[14,35,97],"artificial":[16],"organs":[17],"consisting":[18],"cells":[20,41,50],"and":[21,56,61,95],"materials.":[22],"Progress":[23],"towards":[24],"this":[25],"goal":[26],"by":[29,79],"three":[30],"main":[31],"obstacles":[32],"namely":[33],"a":[37,52],"sufficient":[38],"number":[39],"specific":[42],"organ,":[45],"arrangement":[47],"these":[49],"in":[51],"functional":[53],"architecture":[55],"delivery":[58],"nutrients":[60],"removal":[62],"waste":[64],"from":[65],"mass.":[68],"This":[69],"chapter":[70],"describes":[71],"emerging":[73],"approaches":[74],"that":[75],"may":[76],"be":[77],"achieved":[78],"control":[81,86],"stem":[83],"cell":[84,103],"differentiation,":[85],"local":[89],"environment":[91],"on":[92],"microscale,":[94],"complex":[99],"structures":[100],"containing":[101],"multiple":[102],"types.":[104]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
