{"id":"https://openalex.org/W2153385508","doi":"https://doi.org/10.1083/jcb.127.6.1717","title":"Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis.","display_name":"Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis.","publication_year":1994,"publication_date":"1994-12-15","ids":{"openalex":"https://openalex.org/W2153385508","doi":"https://doi.org/10.1083/jcb.127.6.1717","mag":"2153385508","pmid":"https://pubmed.ncbi.nlm.nih.gov/7798322","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2120296"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.127.6.1717","doi":"https://doi.org/10.1083/jcb.127.6.1717","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.127.6.1717","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2153385508"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2120296/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035495540","display_name":"Steven Estus","orcid":"https://orcid.org/0000-0001-6900-6003","observed_orcids":["https://orcid.org/0000-0001-6900-6003"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Estus","raw_affiliation_strings":["Department of Molecular Biology, Washington University School of Medicine, St. Louis, Missouri 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Washington University School of Medicine, St. Louis, Missouri 63110","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004001853","display_name":"William J. Zaks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W J Zaks","raw_affiliation_strings":["Department of Molecular Biology, Washington University School of Medicine, St. Louis, Missouri 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Washington University School of Medicine, St. Louis, Missouri 63110","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101890647","display_name":"Robert S. Freeman","orcid":"https://orcid.org/0000-0002-4958-8074","observed_orcids":["https://orcid.org/0000-0002-4958-8074"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R S Freeman","raw_affiliation_strings":["Department of Molecular Biology, Washington University School of Medicine, St. Louis, Missouri 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Washington University School of Medicine, St. Louis, Missouri 63110","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040041461","display_name":"M C Gruda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Gruda","raw_affiliation_strings":["Department of Molecular Biology, Washington University School of Medicine, St. Louis, Missouri 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Washington University School of Medicine, St. Louis, Missouri 63110","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107843130","display_name":"Rodrigo Bravo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Bravo","raw_affiliation_strings":["Department of Molecular Biology, Washington University School of Medicine, St. Louis, Missouri 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Washington University School of Medicine, St. Louis, Missouri 63110","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103523426","display_name":"Eugene M. Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E M Johnson","raw_affiliation_strings":["Department of Molecular Biology, Washington University School of Medicine, St. Louis, Missouri 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Washington University School of Medicine, St. Louis, Missouri 63110","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":null,"apc_paid":null,"fwci":19.2152,"has_fulltext":true,"cited_by_count":817,"citation_normalized_percentile":{"value":0.99779904,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"127","issue":"6","first_page":"1717","last_page":"1727"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"programmed cell death","score":0.9269999861717224},{"id":"https://openalex.org/keywords/c-jun","display_name":"c-Jun","score":0.890999972820282},{"id":"https://openalex.org/keywords/c-fos","display_name":"c-fos","score":0.7919999957084656},{"id":"https://openalex.org/keywords/ngf-deprivation","display_name":"NGF deprivation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/sympathetic-neurons","display_name":"sympathetic neurons","score":0.9739999771118164},{"id":"https://openalex.org/keywords/immediate-early-genes","display_name":"immediate early genes","score":0.9380000233650208},{"id":"https://openalex.org/keywords/c-myb","display_name":"MYB","score":0.828000009059906},{"id":"https://openalex.org/keywords/transin","display_name":"transin","score":0.8830000162124634},{"id":"https://openalex.org/keywords/collagenase","display_name":"collagenase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/extracellular-matrix-proteases","display_name":"extracellular matrix proteases","score":0.9110000133514404},{"id":"https://openalex.org/keywords/chromatin-condensation","display_name":"chromatin condensation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.609000027179718},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.42500001192092896},{"id":"https://openalex.org/keywords/fos-family","display_name":"Fos family","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.89151930809021},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.7272318601608276},{"id":"https://openalex.org/C2779555244","wikidata":"https://www.wikidata.org/wiki/Q409638","display_name":"Immediate early gene","level":4,"score":0.6688807010650635},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5646295547485352},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.5321212410926819},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5218093395233154},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5051222443580627},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.48497629165649414},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.48164358735084534},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4502618908882141},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.429721474647522},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.234596848487854},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09069052338600159},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008845","descriptor_name":"Microinjections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009414","descriptor_name":"Nerve Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009500","descriptor_name":"Neutralization Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015513","descriptor_name":"Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015513","descriptor_name":"Oncogene Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016755","descriptor_name":"Proto-Oncogene Proteins c-jun","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016755","descriptor_name":"Proto-Oncogene Proteins c-jun","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016762","descriptor_name":"Genes, fos","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1083/jcb.127.6.1717","doi":"https://doi.org/10.1083/jcb.127.6.1717","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.127.6.1717","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2120296","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2120296/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2120296/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmid:7798322","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7798322","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.274.1234","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.274.1234","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/96/06/J_Cell_Biol_1994_Dec_2_127(6)_1717-1727.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2120296","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2120296/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2120296/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3045978365","display_name":null,"funder_award_id":"HL07275","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3983423450","display_name":"CELL CYCLE GENE EXPRESSION DURING NEURON BIRTH AND DEATH","funder_award_id":"F32NS009294","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G690682852","display_name":null,"funder_award_id":"NS09294","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000921390","display_name":"Diabetes and Related Metabolic Diseases","funder_award_id":"T32DK007120","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2153385508.pdf","grobid_xml":"https://content.openalex.org/works/W2153385508.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W28660586","https://openalex.org/W37384269","https://openalex.org/W81266651","https://openalex.org/W142053782","https://openalex.org/W1500101213","https://openalex.org/W1531209836","https://openalex.org/W1608453530","https://openalex.org/W1648720631","https://openalex.org/W1768423394","https://openalex.org/W1811606715","https://openalex.org/W1833690096","https://openalex.org/W1842375597","https://openalex.org/W1843131799","https://openalex.org/W1849269729","https://openalex.org/W1884284628","https://openalex.org/W1928260425","https://openalex.org/W1969304166","https://openalex.org/W1969628813","https://openalex.org/W1970458627","https://openalex.org/W1975896299","https://openalex.org/W1977686001","https://openalex.org/W1980025084","https://openalex.org/W1980655244","https://openalex.org/W1982622947","https://openalex.org/W1983668432","https://openalex.org/W1983931044","https://openalex.org/W1984695968","https://openalex.org/W1984925149","https://openalex.org/W1985831499","https://openalex.org/W1985956159","https://openalex.org/W1986660515","https://openalex.org/W1987453246","https://openalex.org/W1988920161","https://openalex.org/W1992183658","https://openalex.org/W1993785975","https://openalex.org/W1994666467","https://openalex.org/W1995884552","https://openalex.org/W1997208169","https://openalex.org/W1998448534","https://openalex.org/W1998651839","https://openalex.org/W2000646975","https://openalex.org/W2003054104","https://openalex.org/W2005182680","https://openalex.org/W2011245371","https://openalex.org/W2013464193","https://openalex.org/W2014339903","https://openalex.org/W2027243420","https://openalex.org/W2038813809","https://openalex.org/W2047483221","https://openalex.org/W2047590658","https://openalex.org/W2057621456","https://openalex.org/W2060982272","https://openalex.org/W2069652778","https://openalex.org/W2073786218","https://openalex.org/W2074776278","https://openalex.org/W2080679098","https://openalex.org/W2081948388","https://openalex.org/W2084223366","https://openalex.org/W2089624538","https://openalex.org/W2098412103","https://openalex.org/W2103468507","https://openalex.org/W2115701574","https://openalex.org/W2122716676","https://openalex.org/W2134205510","https://openalex.org/W2134331780","https://openalex.org/W2146346171","https://openalex.org/W2154745705","https://openalex.org/W2167676204","https://openalex.org/W2178615409","https://openalex.org/W2221020875","https://openalex.org/W2467946444"],"related_works":["https://openalex.org/W2048717840","https://openalex.org/W1968015127","https://openalex.org/W1983113381","https://openalex.org/W3163556148","https://openalex.org/W99785206","https://openalex.org/W7063972605","https://openalex.org/W1576438768","https://openalex.org/W2138523588","https://openalex.org/W2057258705","https://openalex.org/W1970458627"],"abstract_inverted_index":{"We":[0],"have":[1],"examined":[2],"the":[3,85,92,104,110,113,151,155,173],"hypothesis":[4],"that":[5,79,128],"neuronal":[6,237],"programmed":[7,238],"cell":[8,105,239],"death":[9,217],"requires":[10],"a":[11,16,44,145,212,232],"genetic":[12,233],"program;":[13],"we":[14,42],"used":[15,43],"model":[17],"wherein":[18],"rat":[19],"sympathetic":[20],"neurons":[21,141,184],"maintained":[22],"in":[23,48,62,78,121,133,222],"vitro":[24],"are":[25],"deprived":[26],"of":[27,52,68,88,94,147,154],"NGF":[28,89],"and":[29,47,56,91,109,118,124,180],"subsequently":[30],"undergo":[31],"apoptosis.":[32,148],"To":[33,149],"evaluate":[34,150],"gene":[35,54,58,107],"expression":[36],"potentially":[37],"necessary":[38,215],"for":[39,169,190,216,236],"this":[40],"process,":[41],"PCR-based":[45],"technique":[46],"situ":[49,122],"hybridization;":[50],"patterns":[51],"general":[53],"repression":[55],"selective":[57],"induction":[59,81,137],"were":[60,76,163],"identified":[61],"NGF-deprived":[63,183],"neurons.":[64,166],"A":[65],"temporal":[66],"cascade":[67,101],"induced":[69,132,206],"genes":[70,111,207],"included":[71,103],"\"immediate":[72],"early":[73],"genes,\"":[74],"which":[75],"remarkable":[77],"their":[80],"occurred":[82],"hours":[83],"after":[84],"initial":[86],"stimulus":[87],"removal":[90],"synthesis":[93],"some":[95],"required":[96],"ongoing":[97],"protein":[98],"synthesis.":[99],"The":[100],"also":[102],"cycle":[106],"c-myb":[108],"encoding":[112],"extracellular":[114],"matrix":[115],"proteases":[116,219],"transin":[117],"collagenase.":[119],"Concurrent":[120],"hybridization":[123],"nuclear":[125],"staining":[126],"revealed":[127],"while":[129],"c-jun":[130],"was":[131,138],"most":[134],"neurons,":[135],"c-fos":[136],"restricted":[139],"to":[140,218],"undergoing":[142],"chromatin":[143],"condensation,":[144],"hallmark":[146],"functional":[152],"role":[153],"proteins":[156,209],"encoded":[157],"by":[158],"these":[159,205,228],"genes,":[160],"neutralizing":[161],"antibodies":[162,188],"injected":[164],"into":[165],"Antibodies":[167],"specific":[168,189],"either":[170],"c-Jun":[171],"or":[172,195],"Fos":[174,177],"family":[175],"(c-Fos,":[176],"B,":[178,192],"Fra-1,":[179],"Fra-2)":[181],"protected":[182],"from":[185,211],"apoptosis,":[186],"whereas":[187],"Jun":[191,193],"D,":[194],"three":[196],"nonimmune":[197],"antibody":[198],"preparations":[199],"had":[200],"no":[201],"protective":[202],"effect.":[203],"Because":[204],"encode":[208],"ranging":[210],"transcription":[213],"factor":[214],"likely":[220],"involved":[221],"tissue":[223],"remodeling":[224],"concurrent":[225],"with":[226],"death,":[227],"data":[229],"may":[230],"outline":[231],"program":[234],"responsible":[235],"death.":[240]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
