{"id":"https://openalex.org/W2153333117","doi":null,"title":"Concentration of interleukin-6 (IL-6), interleukin-8 (IL-8) and interleukin-10 (IL-10) in blood serum of breast cancer patients.","display_name":"Concentration of interleukin-6 (IL-6), interleukin-8 (IL-8) and interleukin-10 (IL-10) in blood serum of breast cancer patients.","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2153333117","mag":"2153333117","pmid":"https://pubmed.ncbi.nlm.nih.gov/14737948"},"language":"en","primary_location":{"id":"pmid:14737948","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14737948","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Roczniki Akademii Medycznej w Bialymstoku (1995)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111735927","display_name":"Leszek Koz\u0142owski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146122375","display_name":"Medical University of Bia\u0142ystok","ror":"https://ror.org/00y4ya841","country_code":"PL","type":"education","lineage":["https://openalex.org/I146122375"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"L Koz\u0142owski","raw_affiliation_strings":["Department of Oncology, Medical University of Bia\u0142ystok, Department of Surgical Oncology, Regional Cancer Center, Bia\u0142ystok, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Medical University of Bia\u0142ystok, Department of Surgical Oncology, Regional Cancer Center, Bia\u0142ystok, Poland","institution_ids":["https://openalex.org/I146122375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071618480","display_name":"Irena Zakrzewska","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Zakrzewska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078493363","display_name":"Piotr Tokajuk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Tokajuk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5007834158","display_name":"Marek Z. Wojtukiewicz","orcid":"https://orcid.org/0000-0002-7604-8188","observed_orcids":["https://orcid.org/0000-0002-7604-8188"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Z Wojtukiewicz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7974,"has_fulltext":false,"cited_by_count":246,"citation_normalized_percentile":{"value":0.84507598,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"48","issue":null,"first_page":"82","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.42329999804496765,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.42329999804496765,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.18569999933242798,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.18320000171661377,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8989999890327454},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":1.0},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":1.0},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9769999980926514},{"id":"https://openalex.org/keywords/serum-cytokine-levels","display_name":"serum cytokine levels","score":0.7910000085830688},{"id":"https://openalex.org/keywords/clinical-stage","display_name":"clinical stage","score":0.8989999890327454},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7829999923706055},{"id":"https://openalex.org/keywords/tumor-immunology","display_name":"tumor immunology","score":0.5789999961853027},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7834988832473755},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7335467338562012},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.5631250143051147},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5234619975090027},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.50689297914505},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4996669292449951},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4839332699775696},{"id":"https://openalex.org/C2777371288","wikidata":"https://www.wikidata.org/wiki/Q410130","display_name":"Interleukin 2","level":3,"score":0.48384180665016174},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.460314005613327},{"id":"https://openalex.org/C187316574","wikidata":"https://www.wikidata.org/wiki/Q423698","display_name":"Interleukin 10","level":3,"score":0.4549212157726288},{"id":"https://openalex.org/C191732599","wikidata":"https://www.wikidata.org/wiki/Q14865947","display_name":"Interleukin 4","level":3,"score":0.43451380729675293},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4307437837123871},{"id":"https://openalex.org/C156730664","wikidata":"https://www.wikidata.org/wiki/Q23308590","display_name":"Interleukin 23","level":4,"score":0.4148094952106476},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4100354015827179},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.40247422456741333},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07114347815513611},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:14737948","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14737948","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Roczniki Akademii Medycznej w Bialymstoku (1995)","raw_type":"Journal Article"},{"id":"mag:2153333117","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14737948","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W48451113","https://openalex.org/W103495436","https://openalex.org/W157721590","https://openalex.org/W218381495","https://openalex.org/W1486621660","https://openalex.org/W1487331723","https://openalex.org/W1505821987","https://openalex.org/W1577568147","https://openalex.org/W1996073048","https://openalex.org/W1996472388","https://openalex.org/W2014901738","https://openalex.org/W2027353671","https://openalex.org/W2029790299","https://openalex.org/W2048912827","https://openalex.org/W2057360439","https://openalex.org/W2146497768","https://openalex.org/W2160483166","https://openalex.org/W2161074777","https://openalex.org/W2414913214","https://openalex.org/W2418204411","https://openalex.org/W2424518921"],"related_works":["https://openalex.org/W7213437787","https://openalex.org/W185803695","https://openalex.org/W3098392","https://openalex.org/W4323340999","https://openalex.org/W2775740235","https://openalex.org/W3095974488","https://openalex.org/W2726959413","https://openalex.org/W48451113","https://openalex.org/W4390478412","https://openalex.org/W4389466640"],"abstract_inverted_index":{"PURPOSE:":[0],"Interleukins":[1],"may":[2,165],"stimulate":[3],"cancer":[4,75,100,134,155],"cells":[5],"growth":[6],"and":[7,18,40,46,68,96,125,135,156],"contribute":[8],"to":[9,24,77,150,157],"locoregional":[10],"relapse":[11],"as":[12,14,34],"well":[13],"metastasis.":[15],"Permanent":[16],"synthesis":[17],"release":[19],"of":[20,26,37,48,51,65,73,93,113,140],"these":[21],"cytokines":[22],"leads":[23],"augmentation":[25],"their":[27],"serum":[28,72,91,127],"concentration":[29,64],"that":[30,121,145],"might":[31],"be":[32,148],"utilized":[33],"a":[35,161],"marker":[36],"immunity":[38],"status":[39],"immune":[41],"system":[42],"activation":[43],"in":[44,57,70,98,102],"prognosis":[45,163],"monitoring":[47],"the":[49,58,63,83],"course":[50],"cancer.":[52,115],"MATERIAL":[53],"AND":[54],"METHODS:":[55],"Therefore,":[56],"present":[59,118],"study":[60,119],"we":[61],"assessed":[62],"IL-6,":[66,94,123],"IL-8":[67,95],"IL-10":[69,97,126],"blood":[71],"breast":[74,99,114,133,154],"patients":[76,101,159],"determine":[78],"whether":[79],"it":[80,146],"correlates":[81],"with":[82,104,110,132,137,153,160],"disease":[84],"progression.":[85],"RESULTS:":[86],"We":[87],"showed":[88],"statistically":[89],"higher":[90],"concentrations":[92],"comparison":[103],"healthy":[105],"women,":[106],"which":[107],"also":[108],"correlated":[109],"clinical":[111,138],"stage":[112,139],"CONCLUSIONS:":[116],"The":[117],"indicates":[120],"elevated":[122],"IL-8,":[124],"concentration,":[128],"are":[129],"strongly":[130],"associated":[131],"correlate":[136],"disease.":[141],"It":[142],"was":[143],"feasible":[144],"can":[147],"used":[149],"diagnose":[151],"women":[152],"identify":[158],"poor":[162],"who":[164],"benefit":[166],"from":[167],"more":[168],"aggressive":[169],"management.":[170]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":23},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}