{"id":"https://openalex.org/W2153308987","doi":"https://doi.org/10.1523/jneurosci.2323-09.2009","title":"Astrocytic Dysfunction in Epileptogenesis: Consequence of Altered Potassium and Glutamate Homeostasis?","display_name":"Astrocytic Dysfunction in Epileptogenesis: Consequence of Altered Potassium and Glutamate Homeostasis?","publication_year":2009,"publication_date":"2009-08-26","ids":{"openalex":"https://openalex.org/W2153308987","doi":"https://doi.org/10.1523/jneurosci.2323-09.2009","mag":"2153308987","pmid":"https://pubmed.ncbi.nlm.nih.gov/19710312","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2875068"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.2323-09.2009","doi":"https://doi.org/10.1523/jneurosci.2323-09.2009","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.2323-09.2009","pdf_url":"https://www.jneurosci.org/content/jneuro/29/34/10588.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2153308987"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/29/34/10588.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028987999","display_name":"Yaron David","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Yaron David","raw_affiliation_strings":["Department of Physiology, Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel","Neurosurgery, Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel","institution_ids":["https://openalex.org/I124227911"]},{"raw_affiliation_string":"Neurosurgery, Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel,","institution_ids":["https://openalex.org/I124227911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051237501","display_name":"Luisa P. Cacheaux","orcid":"https://orcid.org/0000-0001-7428-3355","observed_orcids":["https://orcid.org/0000-0001-7428-3355"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luisa P. Cacheaux","raw_affiliation_strings":["Helen Wills Neuroscience Institute and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helen Wills Neuroscience Institute and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043761324","display_name":"Sebastian Ivens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268531","display_name":"NeuroCure Cluster of Excellence","ror":"https://ror.org/0188nsq50","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4405268531"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sebastian Ivens","raw_affiliation_strings":["Institute of Neurophysiology, Neurocure Research Center, Charite \u00b4Universita \u00a8tsmedizin, 10117 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurophysiology, Neurocure Research Center, Charite \u00b4Universita \u00a8tsmedizin, 10117 Berlin, Germany","institution_ids":["https://openalex.org/I4405268531","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018946767","display_name":"Ezequiel Lapilover","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268531","display_name":"NeuroCure Cluster of Excellence","ror":"https://ror.org/0188nsq50","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4405268531"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ezequiel Lapilover","raw_affiliation_strings":["Institute of Neurophysiology, Neurocure Research Center, Charite \u00b4Universita \u00a8tsmedizin, 10117 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurophysiology, Neurocure Research Center, Charite \u00b4Universita \u00a8tsmedizin, 10117 Berlin, Germany","institution_ids":["https://openalex.org/I4405268531","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091270897","display_name":"Uwe Heinemann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268531","display_name":"NeuroCure Cluster of Excellence","ror":"https://ror.org/0188nsq50","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4405268531"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Uwe Heinemann","raw_affiliation_strings":["Institute of Neurophysiology, Neurocure Research Center, Charite \u00b4Universita \u00a8tsmedizin, 10117 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurophysiology, Neurocure Research Center, Charite \u00b4Universita \u00a8tsmedizin, 10117 Berlin, Germany","institution_ids":["https://openalex.org/I4405268531","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044952192","display_name":"Daniela Kaufer","orcid":"https://orcid.org/0000-0002-3830-5999","observed_orcids":["https://orcid.org/0000-0002-3830-5999"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniela Kaufer","raw_affiliation_strings":["Department of Integrative Biology, University of California, Berkeley, Berkeley, California 94720-3140, and","Helen Wills Neuroscience Institute and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology, University of California, Berkeley, Berkeley, California 94720-3140, and","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Helen Wills Neuroscience Institute and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003585109","display_name":"Alon Friedman","orcid":"https://orcid.org/0000-0003-4780-8456","observed_orcids":["https://orcid.org/0000-0003-4780-8456","https://orcid.org/0000-0001-6907-1040"]},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]},{"id":"https://openalex.org/I4405268531","display_name":"NeuroCure Cluster of Excellence","ror":"https://ror.org/0188nsq50","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4405268531"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","IL"],"is_corresponding":true,"raw_author_name":"Alon Friedman","raw_affiliation_strings":["Departments of Physiology and Neurosurgery, Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel","Institute of Neurophysiology, Neurocure Research Center, Charit\u00e9 Universit\u00e4tsmedizin, Berlin, Germany","Institute of Neurophysiology, Neurocure Research Center, Charite \u00b4Universita \u00a8tsmedizin, 10117 Berlin, Germany","Neurosurgery, Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Physiology and Neurosurgery, Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel","institution_ids":["https://openalex.org/I124227911"]},{"raw_affiliation_string":"Institute of Neurophysiology, Neurocure Research Center, Charit\u00e9 Universit\u00e4tsmedizin, Berlin, Germany","institution_ids":["https://openalex.org/I4405268531","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Institute of Neurophysiology, Neurocure Research Center, Charite \u00b4Universita \u00a8tsmedizin, 10117 Berlin, Germany","institution_ids":["https://openalex.org/I4405268531","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Neurosurgery, Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel,","institution_ids":["https://openalex.org/I124227911"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5003585109"],"corresponding_institution_ids":["https://openalex.org/I124227911","https://openalex.org/I4405268531","https://openalex.org/I7877124"],"apc_list":null,"apc_paid":null,"fwci":14.9773,"has_fulltext":true,"cited_by_count":343,"citation_normalized_percentile":{"value":0.99420606,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"29","issue":"34","first_page":"10588","last_page":"10599"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epileptogenesis","display_name":"epileptogenesis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9869999885559082},{"id":"https://openalex.org/keywords/blood-brain-barrier-disruption","display_name":"blood-brain barrier disruption","score":0.9020000100135803},{"id":"https://openalex.org/keywords/albumin","display_name":"albumin","score":0.5590000152587891},{"id":"https://openalex.org/keywords/deoxycholic-acid","display_name":"deoxycholic acid","score":0.9430000185966492},{"id":"https://openalex.org/keywords/glutamate-clearance","display_name":"glutamate clearance","score":0.8399999737739563},{"id":"https://openalex.org/keywords/potassium-clearance","display_name":"potassium clearance","score":0.9039999842643738},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.6230000257492065},{"id":"https://openalex.org/keywords/synaptic-facilitation","display_name":"synaptic facilitation","score":0.8569999933242798},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.7519999742507935},{"id":"https://openalex.org/keywords/neuronal-hyperexcitability","display_name":"neuronal hyperexcitability","score":0.9129999876022339},{"id":"https://openalex.org/keywords/network-synchronization","display_name":"network synchronization","score":0.6959999799728394},{"id":"https://openalex.org/keywords/focal-epilepsy","display_name":"focal epilepsy","score":0.7639999985694885},{"id":"https://openalex.org/keywords/seizure-like-activity","display_name":"seizure-like activity","score":0.7149999737739563},{"id":"https://openalex.org/keywords/neocortex","display_name":"neocortex","score":0.7689999938011169}],"concepts":[{"id":"https://openalex.org/C57236427","wikidata":"https://www.wikidata.org/wiki/Q5382987","display_name":"Epileptogenesis","level":3,"score":0.9525620937347412},{"id":"https://openalex.org/C2777222312","wikidata":"https://www.wikidata.org/wiki/Q726562","display_name":"Neocortex","level":2,"score":0.8523706197738647},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.715327262878418},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6304072141647339},{"id":"https://openalex.org/C2780495277","wikidata":"https://www.wikidata.org/wiki/Q905442","display_name":"Glial fibrillary acidic protein","level":3,"score":0.5202825665473938},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.5008783340454102},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.44890114665031433},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.4350467324256897},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42775362730026245},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.35946470499038696},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3162820339202881},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2409130334854126},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20305997133255005},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09425613284111023},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.08308053016662598},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003840","descriptor_name":"Deoxycholic Acid","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005904","descriptor_name":"Glial Fibrillary Acidic Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018690","descriptor_name":"Excitatory Amino Acid Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019579","descriptor_name":"Neocortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019706","descriptor_name":"Excitatory Postsynaptic Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019706","descriptor_name":"Excitatory Postsynaptic Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1523/jneurosci.2323-09.2009","doi":"https://doi.org/10.1523/jneurosci.2323-09.2009","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.2323-09.2009","pdf_url":"https://www.jneurosci.org/content/jneuro/29/34/10588.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmid:19710312","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19710312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2875068","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2875068/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Neurosci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.2323-09.2009","doi":"https://doi.org/10.1523/jneurosci.2323-09.2009","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.2323-09.2009","pdf_url":"https://www.jneurosci.org/content/jneuro/29/34/10588.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1723231957","display_name":null,"funder_award_id":"566/07","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"},{"id":"https://openalex.org/G847701470","display_name":"TGF-beta Mediated Inflammatory Signaling: a Critical Role in Epileptogenesis","funder_award_id":"R01NS066005","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320320878","display_name":"Minerva Foundation","ror":"https://ror.org/02rxjts25"},{"id":"https://openalex.org/F4320320950","display_name":"United States-Israel Binational Science Foundation","ror":"https://ror.org/00j8z2m73"},{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2153308987.pdf","grobid_xml":"https://content.openalex.org/works/W2153308987.grobid-xml"},"referenced_works_count":97,"referenced_works":["https://openalex.org/W94310332","https://openalex.org/W1575357711","https://openalex.org/W1787988090","https://openalex.org/W1797368996","https://openalex.org/W1844740521","https://openalex.org/W1888014295","https://openalex.org/W1965377078","https://openalex.org/W1971586375","https://openalex.org/W1971639674","https://openalex.org/W1971775352","https://openalex.org/W1973804595","https://openalex.org/W1974436068","https://openalex.org/W1975165380","https://openalex.org/W1980979304","https://openalex.org/W1988900265","https://openalex.org/W1989539506","https://openalex.org/W1992758695","https://openalex.org/W1993718011","https://openalex.org/W1994416969","https://openalex.org/W1996589674","https://openalex.org/W1998347917","https://openalex.org/W2000108988","https://openalex.org/W2003410399","https://openalex.org/W2004115145","https://openalex.org/W2009771635","https://openalex.org/W2011101653","https://openalex.org/W2013227602","https://openalex.org/W2013479315","https://openalex.org/W2013752437","https://openalex.org/W2015541518","https://openalex.org/W2020753680","https://openalex.org/W2024400996","https://openalex.org/W2024964894","https://openalex.org/W2025528474","https://openalex.org/W2027814920","https://openalex.org/W2029291080","https://openalex.org/W2030352252","https://openalex.org/W2034457899","https://openalex.org/W2036495604","https://openalex.org/W2036537324","https://openalex.org/W2036838450","https://openalex.org/W2039280124","https://openalex.org/W2042393720","https://openalex.org/W2045458651","https://openalex.org/W2045694752","https://openalex.org/W2048371307","https://openalex.org/W2050706464","https://openalex.org/W2053789318","https://openalex.org/W2054536949","https://openalex.org/W2056326370","https://openalex.org/W2059347766","https://openalex.org/W2064186318","https://openalex.org/W2065748172","https://openalex.org/W2069963369","https://openalex.org/W2074077310","https://openalex.org/W2074792377","https://openalex.org/W2078412655","https://openalex.org/W2079031049","https://openalex.org/W2080728354","https://openalex.org/W2083165258","https://openalex.org/W2083971880","https://openalex.org/W2085379136","https://openalex.org/W2090794044","https://openalex.org/W2094089753","https://openalex.org/W2096961422","https://openalex.org/W2097833693","https://openalex.org/W2099249565","https://openalex.org/W2106013244","https://openalex.org/W2109205784","https://openalex.org/W2109350218","https://openalex.org/W2112937635","https://openalex.org/W2115810166","https://openalex.org/W2116573581","https://openalex.org/W2117120818","https://openalex.org/W2119774379","https://openalex.org/W2123001230","https://openalex.org/W2124940469","https://openalex.org/W2124963616","https://openalex.org/W2126033464","https://openalex.org/W2127338217","https://openalex.org/W2133100820","https://openalex.org/W2133280661","https://openalex.org/W2133315293","https://openalex.org/W2135328571","https://openalex.org/W2135827569","https://openalex.org/W2143674877","https://openalex.org/W2150454711","https://openalex.org/W2157853053","https://openalex.org/W2160644313","https://openalex.org/W2163161737","https://openalex.org/W2169759057","https://openalex.org/W2169931873","https://openalex.org/W2408313473","https://openalex.org/W2408807018","https://openalex.org/W4236260798","https://openalex.org/W4237588596","https://openalex.org/W4238401914"],"related_works":["https://openalex.org/W2078412655","https://openalex.org/W1566431026","https://openalex.org/W1605156812","https://openalex.org/W2072166960","https://openalex.org/W2040958998","https://openalex.org/W1972795959","https://openalex.org/W3094399095","https://openalex.org/W175475767","https://openalex.org/W1939354665","https://openalex.org/W4306322293"],"abstract_inverted_index":{"Focal":[0],"epilepsy":[1],"often":[2],"develops":[3],"following":[4,108,147],"traumatic,":[5],"ischemic,":[6],"or":[7,45,115],"infectious":[8],"brain":[9,18],"injury.":[10],"While":[11],"the":[12,16,22,35,41,49,59,80,87,104,134,158,174,227,231],"electrical":[13],"activity":[14],"of":[15,40,48,58,74,82,92,137,140,160,164,176,186,233],"epileptic":[17,76],"is":[19,178],"well":[20],"characterized,":[21],"mechanisms":[23],"underlying":[24],"epileptogenesis":[25,85,205],"are":[26],"poorly":[27],"understood.":[28],"We":[29,78,94,151,224],"have":[30],"recently":[31],"shown":[32],"that":[33,173,226],"in":[34,84,86,99,103,131,230],"rat":[36],"neocortex,":[37],"long-lasting":[38],"breakdown":[39],"blood-brain":[42],"barrier":[43],"(BBB)":[44],"direct":[46],"exposure":[47,148],"neocortex":[50,105],"to":[51,55,149,156,192,211],"serum-derived":[52],"albumin":[53,90],"leads":[54,191],"rapid":[56],"upregulation":[57],"astrocytic":[60,100,162,219],"marker":[61],"GFAP":[62],"(glial":[63],"fibrillary":[64],"acidic":[65],"protein),":[66],"followed":[67],"by":[68],"delayed":[69],"(within":[70],"4-7":[71],"d)":[72],"development":[73],"an":[75],"focus.":[77],"investigated":[79],"role":[81],"astrocytes":[83],"BBB-breakdown":[88],"and":[89,127,143,166,196,240],"models":[91],"epileptogenesis.":[93,223],"found":[95],"similar,":[96],"robust":[97],"changes":[98,118],"gene":[101],"expression":[102],"within":[106],"hours":[107],"treatment":[109],"with":[110,180],"deoxycholic":[111],"acid":[112],"(BBB":[113],"breakdown)":[114],"albumin.":[116,150],"These":[117],"predict":[119],"reduced":[120,135,161],"clearance":[121,136,232],"capacity":[122],"for":[123],"both":[124,141],"extracellular":[125,234],"glutamate":[126,144,167,177],"potassium.":[128],"Electrophysiological":[129],"recordings":[130,203],"vitro":[132,201],"confirmed":[133,206],"activity-dependent":[138],"accumulation":[139,175,190],"potassium":[142,165,189,235],"24":[145],"h":[146],"used":[152],"a":[153,217],"NEURON":[154],"model":[155,171],"simulate":[157],"consequences":[159],"uptake":[163],"on":[168],"EPSPs.":[169],"The":[170],"predicted":[172],"associated":[179],"frequency-dependent":[181,193,207,237],"(>100":[182],"Hz)":[183,195],"decreased":[184],"facilitation":[185,209],"EPSPs,":[187],"while":[188],"(10-50":[194],"NMDA-dependent":[197],"synaptic":[198,208],"facilitation.":[199],"In":[200],"electrophysiological":[202],"during":[204,222],"leading":[210],"seizure-like":[212],"activity.":[213],"Our":[214],"data":[215],"indicate":[216],"transcription-mediated":[218],"transformation":[220],"early":[221],"suggest":[225],"resulting":[228],"reduction":[229],"underlies":[236],"neuronal":[238],"hyperexcitability":[239],"network":[241],"synchronization.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":23},{"year":2024,"cited_by_count":26},{"year":2023,"cited_by_count":28},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":23},{"year":2016,"cited_by_count":20},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":27},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":34}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}