{"id":"https://openalex.org/W2153304763","doi":"https://doi.org/10.1265/jjh.49.797","title":"Effects of Aging on Urinary Secretion of 3-Hydroxyproline and its Importance for Cancer Screening in The Elderly with ROC Analysis.","display_name":"Effects of Aging on Urinary Secretion of 3-Hydroxyproline and its Importance for Cancer Screening in The Elderly with ROC Analysis.","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W2153304763","doi":"https://doi.org/10.1265/jjh.49.797","mag":"2153304763","pmid":"https://pubmed.ncbi.nlm.nih.gov/7807707"},"language":"ja","primary_location":{"id":"doi:10.1265/jjh.49.797","doi":"https://doi.org/10.1265/jjh.49.797","is_oa":true,"landing_page_url":"https://doi.org/10.1265/jjh.49.797","pdf_url":"https://www.jstage.jst.go.jp/article/jjh1946/49/4/49_4_797/_pdf","source":{"id":"https://openalex.org/S2755265425","display_name":"Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)","issn_l":"0021-5082","issn":["0021-5082","1882-6482"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4364118889","host_organization_name":"The Japanese Society for Hygiene","host_organization_lineage":["https://openalex.org/P4364118889"],"host_organization_lineage_names":["The Japanese Society for Hygiene"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/jjh1946/49/4/49_4_797/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078062809","display_name":"\u00c2ngelo Jos\u00e9 Gon\u00e7alves B\u00f3s","orcid":"https://orcid.org/0000-0003-4901-3155","observed_orcids":["https://orcid.org/0000-0003-4901-3155"]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Angelo J. G. BOS","raw_affiliation_strings":["Department of Community Health, Division of Community Health and Environmental Medicine, School of Medicine, University of Tokai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Community Health, Division of Community Health and Environmental Medicine, School of Medicine, University of Tokai","institution_ids":["https://openalex.org/I1314466530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009438700","display_name":"Ping Yuan","orcid":"https://orcid.org/0000-0001-5557-7964","observed_orcids":["https://orcid.org/0000-0001-5557-7964"]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ping YUAN","raw_affiliation_strings":["Department of Community Health, Division of Community Health and Environmental Medicine, School of Medicine, University of Tokai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Community Health, Division of Community Health and Environmental Medicine, School of Medicine, University of Tokai","institution_ids":["https://openalex.org/I1314466530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072129074","display_name":"Akie Maruta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akie MARUTA","raw_affiliation_strings":["Central Research Laboratory, National Defense Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Research Laboratory, National Defense Medical College","institution_ids":["https://openalex.org/I53888640"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shigeo MATSUYAMA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeo MATSUYAMA","raw_affiliation_strings":["Central Research Laboratory, National Defense Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Research Laboratory, National Defense Medical College","institution_ids":["https://openalex.org/I53888640"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Masao ARAI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masao ARAI","raw_affiliation_strings":["Department of Community Health, Division of Community Health and Environmental Medicine, School of Medicine, University of Tokai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Community Health, Division of Community Health and Environmental Medicine, School of Medicine, University of Tokai","institution_ids":["https://openalex.org/I1314466530"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040381217","display_name":"Isao Okazaki","orcid":"https://orcid.org/0000-0002-9825-496X","observed_orcids":["https://orcid.org/0000-0002-9825-496X"]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Isao OKAZAKI","raw_affiliation_strings":["Department of Community Health, Division of Community Health and Environmental Medicine, School of Medicine, University of Tokai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Community Health, Division of Community Health and Environmental Medicine, School of Medicine, University of Tokai","institution_ids":["https://openalex.org/I1314466530"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.19160105,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"49","issue":"4","first_page":"797","last_page":"806"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.08269999921321869,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.08269999921321869,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.0575999990105629,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12379","display_name":"Cancer Diagnosis and Treatment","score":0.05590000003576279,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/3-hydroxyproline","display_name":"3-hydroxyproline","score":0.9769999980926514},{"id":"https://openalex.org/keywords/urinary-biomarkers","display_name":"urinary biomarkers","score":0.8109999895095825},{"id":"https://openalex.org/keywords/tumor-screening","display_name":"cancer screening","score":0.7870000004768372},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9769999980926514},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.8970000147819519},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.6769999861717224},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.7170000076293945},{"id":"https://openalex.org/keywords/cutoff-values","display_name":"cut-off values","score":0.6169999837875366},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C2779797417","wikidata":"https://www.wikidata.org/wiki/Q12460151","display_name":"Hydroxyproline","level":2,"score":0.7437251806259155},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.5583474636077881},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5034562945365906},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5029868483543396},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.40329509973526},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36532533168792725}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006909","descriptor_name":"Hydroxyproline","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008403","descriptor_name":"Mass Screening","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1265/jjh.49.797","doi":"https://doi.org/10.1265/jjh.49.797","is_oa":true,"landing_page_url":"https://doi.org/10.1265/jjh.49.797","pdf_url":"https://www.jstage.jst.go.jp/article/jjh1946/49/4/49_4_797/_pdf","source":{"id":"https://openalex.org/S2755265425","display_name":"Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)","issn_l":"0021-5082","issn":["0021-5082","1882-6482"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4364118889","host_organization_name":"The Japanese Society for Hygiene","host_organization_lineage":["https://openalex.org/P4364118889"],"host_organization_lineage_names":["The Japanese Society for Hygiene"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)","raw_type":"journal-article"},{"id":"pmid:7807707","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7807707","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon eiseigaku zasshi. Japanese journal of hygiene","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1265/jjh.49.797","doi":"https://doi.org/10.1265/jjh.49.797","is_oa":true,"landing_page_url":"https://doi.org/10.1265/jjh.49.797","pdf_url":"https://www.jstage.jst.go.jp/article/jjh1946/49/4/49_4_797/_pdf","source":{"id":"https://openalex.org/S2755265425","display_name":"Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)","issn_l":"0021-5082","issn":["0021-5082","1882-6482"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4364118889","host_organization_name":"The Japanese Society for Hygiene","host_organization_lineage":["https://openalex.org/P4364118889"],"host_organization_lineage_names":["The Japanese Society for Hygiene"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2153304763.pdf","grobid_xml":"https://content.openalex.org/works/W2153304763.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W118315802","https://openalex.org/W586168735","https://openalex.org/W1536719366","https://openalex.org/W1840399502","https://openalex.org/W1968114652","https://openalex.org/W1983963079","https://openalex.org/W2006782555","https://openalex.org/W2030430985","https://openalex.org/W2032643234","https://openalex.org/W2068816912","https://openalex.org/W2144854800","https://openalex.org/W2157171253","https://openalex.org/W2157825442","https://openalex.org/W2227151305","https://openalex.org/W2399536901","https://openalex.org/W2415138847","https://openalex.org/W2428571797","https://openalex.org/W2467013287","https://openalex.org/W6600804206"],"related_works":["https://openalex.org/W118315802","https://openalex.org/W2733242271","https://openalex.org/W3011234226","https://openalex.org/W3004094344","https://openalex.org/W2034129081","https://openalex.org/W2061286710","https://openalex.org/W2168722640","https://openalex.org/W4254756882","https://openalex.org/W2793368779","https://openalex.org/W2048700534"],"abstract_inverted_index":{"OBJECTIVE:":[0],"to":[1,77,82,148,309],"observe":[2],"the":[3,22,27,42,46,51,55,101,145,150,163,195,244,251,265,274,314,320],"influence":[4],"of":[5,10,24,29,44,48,54,122,166,175,183,204,219,223,231,281,318,322],"aging":[6,25,161],"on":[7,26],"urinary":[8,30,125,164,184,205,224,285,323],"secretion":[9,165],"3-hydroxyproline":[11],"(3-Hyp)":[12],"in":[13,17,50,71,129,144,168,186,194,213,264,273,294,329,334],"normal":[14,130,169,196],"subjects":[15,131],"and":[16,20,59,85,89,115,124,132,136,207,233,272,276,306,316,333],"cancer":[18,35,63,92,133,189,214,248,262,292,302,327],"patients":[19,61,187],"study":[21],"effects":[23],"accuracy":[28,260],"3-Hyp":[31,49,126,167,185,206,225,257,286,324],"as":[32],"a":[33,172,330,335],"general-purpose":[34],"screening":[36,263,293,328],"test.":[37],"DESIGN:":[38],"We":[39,158],"reanalyzed,":[40],"from":[41],"aspect":[43],"gerontology,":[45],"amounts":[47],"urine":[52],"samples":[53],"211":[56],"healthy":[57],"persons":[58,227,238,296],"94":[60],"with":[62,111,171,188],"reported":[64],"earlier.":[65],"The":[66,91,120,180,201,216,284,311],"two":[67],"groups":[68,147],"were":[69,138,190,243],"divided":[70],"3":[72,97],"age":[73,123,208,232],"subgroups:":[74],"adult,":[75],"30":[76],"44":[78],"years,":[79,84],"middle-aged,":[80],"45":[81],"64":[83],"aged,":[86],"65":[87,229,239],"years":[88,230,240,298],"older.":[90],"stage":[93,99,103,107,116],"was":[94,127,209,288],"separated":[95],"into":[96],"categories:":[98],"1,":[100],"early":[102,279],"without":[104],"any":[105],"invasion,":[106],"2,":[108],"locally":[109],"invasive":[110],"no":[112],"distant":[113],"metastasis,":[114],"3,":[117],"advanced":[118],"cancer.":[119,282],"correlation":[121,173,202],"analyzed":[128],"patients.":[134,215],"Sensitivity":[135],"specificity":[137],"calculated":[139],"for":[140,226,237,247,261,268,278,291,325],"different":[141],"cutoff":[142,217],"points":[143,218],"diverse":[146],"construct":[149],"receiver":[151],"operating":[152],"characteristic":[153],"(ROC)":[154],"curves.":[155],"MAIN":[156],"RESULTS:":[157],"observed":[159,255],"that":[160,256],"decreases":[162],"subjects,":[170,197],"coefficient":[174,203],"-0.250":[176],"(p":[177],"<":[178],"0.001).":[179],"mean":[181],"levels":[182],"significantly":[191],"higher":[192,259],"than":[193],"p":[198],"=":[199],"0.005.":[200],"not":[210],"significant":[211],"(0.100)":[212],"0.800":[220],"mg/g":[221,235],"creatinine":[222,236],"under":[228],"0.600":[234],"or":[241,299],"older":[242],"best":[245],"thresholds":[246],"screening.":[249],"In":[250],"ROC":[252],"analyses,":[253],"we":[254],"has":[258],"aged":[266,275],"group":[267],"all":[269],"stages":[270,280],"together":[271],"middle-aged":[277],"CONCLUSIONS:":[283],"test":[287],"more":[289,304,307],"effective":[290],"old":[295],"(65":[297],"older),":[300],"where":[301],"is":[303],"frequent":[305],"difficult":[308],"discover.":[310],"authors":[312],"stress":[313],"necessity":[315],"importance":[317],"verifying":[319],"effectiveness":[321],"general":[326],"larger":[331],"population":[332],"community":[336],"set.":[337]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}