{"id":"https://openalex.org/W2153302571","doi":"https://doi.org/10.1001/jama.283.6.779","title":"Oral Androstenedione Administration and Serum Testosterone Concentrations in Young Men","display_name":"Oral Androstenedione Administration and Serum Testosterone Concentrations in Young Men","publication_year":2000,"publication_date":"2000-02-09","ids":{"openalex":"https://openalex.org/W2153302571","doi":"https://doi.org/10.1001/jama.283.6.779","mag":"2153302571","pmid":"https://pubmed.ncbi.nlm.nih.gov/10683057"},"language":"en","primary_location":{"id":"doi:10.1001/jama.283.6.779","doi":"https://doi.org/10.1001/jama.283.6.779","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jama.283.6.779","pdf_url":null,"source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024994311","display_name":"Benjamin Z. Leder","orcid":"https://orcid.org/0000-0002-2051-0505","observed_orcids":["https://orcid.org/0000-0002-2051-0505"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Benjamin Z. Leder","raw_affiliation_strings":["Department of Medicine, Massachusetts General Hospital, Boston 02114, USA","Dept. of Medicine, Massachusetts General Hospital, Boston 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Massachusetts General Hospital, Boston 02114, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Dept. of Medicine, Massachusetts General Hospital, Boston 02114, USA","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5024994311"],"corresponding_institution_ids":["https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":9.0466,"has_fulltext":false,"cited_by_count":135,"citation_normalized_percentile":{"value":0.9847435,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"283","issue":"6","first_page":"779","last_page":"779"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12700","display_name":"Doping in Sports","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/3312","display_name":"Sociology and Political Science"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/androstenedione","display_name":"androstenedione","score":0.9869999885559082},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.7089999914169312},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9660000205039978},{"id":"https://openalex.org/keywords/estrone","display_name":"estrone","score":0.671999990940094},{"id":"https://openalex.org/keywords/young-men","display_name":"young men","score":0.574999988079071},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.4269999861717224},{"id":"https://openalex.org/keywords/over-the-counter-supplements","display_name":"over-the-counter supplements","score":0.5360000133514404},{"id":"https://openalex.org/keywords/anabolic-androgenic-steroids","display_name":"anabolic steroids","score":0.5260000228881836},{"id":"https://openalex.org/keywords/athletic-performance-enhancement","display_name":"athletic performance improvement","score":0.5370000004768372},{"id":"https://openalex.org/keywords/over-the-counter-drug-regulation","display_name":"over-the-counter drug regulation","score":0.38199999928474426}],"concepts":[{"id":"https://openalex.org/C2776683971","wikidata":"https://www.wikidata.org/wiki/Q411064","display_name":"Androstenedione","level":4,"score":0.9803791046142578},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.8603266477584839},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8251808285713196},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7137923836708069},{"id":"https://openalex.org/C2778656385","wikidata":"https://www.wikidata.org/wiki/Q414986","display_name":"Estrone","level":3,"score":0.691786527633667},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6578598022460938},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.4600868225097656},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.39440253376960754},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.36806046962738037}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000735","descriptor_name":"Androstenedione","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000735","descriptor_name":"Androstenedione","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000735","descriptor_name":"Androstenedione","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004970","descriptor_name":"Estrone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1001/jama.283.6.779","doi":"https://doi.org/10.1001/jama.283.6.779","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jama.283.6.779","pdf_url":null,"source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"journal-article"},{"id":"pmid:10683057","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10683057","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"Clinical Trial"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.611.1735","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.611.1735","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.bbszene.de/files/jci00000.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G3493866547","display_name":"General Clinical Research Center","funder_award_id":"M01RR001066","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5236900942","display_name":null,"funder_award_id":"5 R29 DK443341","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5484229421","display_name":null,"funder_award_id":"RR-1066","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G6353989759","display_name":"Effects of androgens, estrogens, and PTH on bone","funder_award_id":"K24DK002759","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W187717610","https://openalex.org/W1606414541","https://openalex.org/W1931521257","https://openalex.org/W1969903517","https://openalex.org/W1978998297","https://openalex.org/W1979948832","https://openalex.org/W1997184570","https://openalex.org/W2001431048","https://openalex.org/W2014087751","https://openalex.org/W2032143202","https://openalex.org/W2035354221","https://openalex.org/W2036781116","https://openalex.org/W2043450209","https://openalex.org/W2049275648","https://openalex.org/W2061438670","https://openalex.org/W2081922333","https://openalex.org/W2096331515","https://openalex.org/W2102231551","https://openalex.org/W2122119142","https://openalex.org/W2326289669","https://openalex.org/W2999510508"],"related_works":["https://openalex.org/W2157331893","https://openalex.org/W7097783191","https://openalex.org/W2083398119","https://openalex.org/W2157287637","https://openalex.org/W3108474990","https://openalex.org/W1984961194","https://openalex.org/W2429713300","https://openalex.org/W238432962","https://openalex.org/W2074961420","https://openalex.org/W2031419071"],"abstract_inverted_index":{"CONTEXT:":[0],"Androstenedione,":[1],"a":[2,65],"steroid":[3],"hormone":[4],"and":[5,15,21,56,116,150,159,219,228,253,288],"the":[6,126,135,138,154,168,171,179,186,208,223,237,240,243,250],"major":[7],"precursor":[8],"to":[9,18,75,82],"testosterone,":[10,113],"is":[11,16],"available":[12],"without":[13],"prescription":[14],"purported":[17],"increase":[19],"strength":[20],"athletic":[22],"performance.":[23],"The":[24],"hormonal":[25],"effects":[26],"of":[27,38,64,162,231,282],"androstenedione,":[28,114,163,232,277],"however,":[29],"are":[30],"unknown.":[31],"OBJECTIVE:":[32],"To":[33],"determine":[34],"if":[35],"oral":[36,84,276],"administration":[37],"androstenedione":[39,85,100,199],"increases":[40,285],"serum":[41,112,142,211,286],"testosterone":[42,143,174,193,287],"levels":[43],"in":[44,111,134,153,173,207,222,242,263,280,291],"healthy":[45,71,293],"men.":[46,294],"DESIGN:":[47],"Open-label":[48],"randomized":[49,81],"controlled":[50],"trial":[51],"conducted":[52],"between":[53],"October":[54],"1998":[55],"April":[57],"1999.":[58],"SETTING:":[59],"General":[60],"clinical":[61],"research":[62],"center":[63],"tertiary-care,":[66],"university-affiliated":[67],"hospital.":[68],"PARTICIPANTS:":[69],"Forty-two":[70],"men":[72],"aged":[73],"20":[74],"40":[76],"years.":[77],"INTERVENTION:":[78],"Subjects":[79],"were":[80,145,214],"receive":[83],"(either":[86],"100":[87],"mg/d":[88,94,161,230],"[n":[89,95],"=":[90,96,102,190,256],"15]":[91],"or":[92,98],"300":[93,160,229,283],"14])":[97],"no":[99],"(n":[101],"13)":[103],"for":[104,141,178,185,210,248,266],"7":[105],"days.":[106],"MAIN":[107],"OUTCOME":[108],"MEASURES:":[109],"Changes":[110],"estrone,":[115],"estradiol":[117,212,244,289],"levels,":[118,194],"measured":[119,268],"by":[120],"frequent":[121],"blood":[122],"sampling,":[123],"compared":[124,166,235],"among":[125],"3":[127],"treatment":[128],"groups.":[129,258],"RESULTS:":[130],"Mean":[131,204],"(SE)":[132,205],"changes":[133,206],"area":[136],"under":[137],"curve":[139],"(AUC)":[140],"concentrations":[144,213,290],"-2%":[146],"(7%),":[147],"-4%":[148],"(4%),":[149],"34%":[151],"(14%)":[152],"groups":[155,224],"receiving":[156,225],"0,":[157,226],"100,":[158,227],"respectively.":[164,233],"When":[165,234],"with":[167,236],"control":[169,238],"group,":[170,239],"change":[172,241],"AUC":[175,209,245],"was":[176,246,260],"significant":[177,247],"300-mg/d":[180,251],"group":[181,188],"(P<.001)":[182,252],"but":[183],"not":[184,202],"100-mg/d":[187,254],"(P":[189,255],".48).":[191],"Baseline":[192],"drawn":[195],"24":[196],"hours":[197],"after":[198],"administration,":[200],"did":[201],"change.":[203],"4%":[215],"(6%),":[216],"42%":[217],"(12%),":[218],"128%":[220],"(24%)":[221],"both":[249],".002)":[257],"There":[259],"marked":[261],"variability":[262],"individual":[264],"responses":[265],"all":[267],"sex":[269],"steroids.":[270],"CONCLUSIONS:":[271],"Our":[272],"data":[273],"suggest":[274],"that":[275],"when":[278],"given":[279],"dosages":[281],"mg/d,":[284],"some":[292]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}