{"id":"https://openalex.org/W2153292644","doi":"https://doi.org/10.1128/jvi.73.8.6680-6690.1999","title":"Patterns of Chemokine Receptor Fusion Cofactor Utilization by Human Immunodeficiency Virus Type 1 Variants from the Lungs and Blood","display_name":"Patterns of Chemokine Receptor Fusion Cofactor Utilization by Human Immunodeficiency Virus Type 1 Variants from the Lungs and Blood","publication_year":1999,"publication_date":"1999-08-01","ids":{"openalex":"https://openalex.org/W2153292644","doi":"https://doi.org/10.1128/jvi.73.8.6680-6690.1999","mag":"2153292644","pmid":"https://pubmed.ncbi.nlm.nih.gov/10400765","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/112752"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.73.8.6680-6690.1999","doi":"https://doi.org/10.1128/jvi.73.8.6680-6690.1999","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.73.8.6680-6690.1999","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/112752","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100737412","display_name":"Anjali Singh","orcid":"https://orcid.org/0000-0002-3185-2949","observed_orcids":["https://orcid.org/0000-0002-3185-2949"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anjali Singh","raw_affiliation_strings":["<!--label omitted: 1-->Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6060","Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6060"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6060","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6060","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Gideon Besson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gideon Besson","raw_affiliation_strings":["<!--label omitted: 1-->Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6060","Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6060"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6060","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6060","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001626654","display_name":"Azin Mobasher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Azin Mobasher","raw_affiliation_strings":["<!--label omitted: 1-->Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6060","Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6060"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6060","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6060","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074582058","display_name":"Ronald G. Collman","orcid":"https://orcid.org/0000-0002-0508-3701","observed_orcids":["https://orcid.org/0000-0002-0508-3701"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald G. Collman","raw_affiliation_strings":["<!--label omitted: 1-->Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6060","Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6060"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6060","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6060","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":2.23,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.88270319,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"73","issue":"8","first_page":"6680","last_page":"6690"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.968999981880188},{"id":"https://openalex.org/keywords/ccr5","display_name":"CCR5","score":0.7440000176429749},{"id":"https://openalex.org/keywords/cxcr4","display_name":"CXCR4","score":1.0},{"id":"https://openalex.org/keywords/apelin-receptor","display_name":"apelin receptor","score":0.6859999895095825},{"id":"https://openalex.org/keywords/us28","display_name":"US28","score":0.8230000138282776},{"id":"https://openalex.org/keywords/ccr2b","display_name":"CCR2b","score":0.8679999709129333},{"id":"https://openalex.org/keywords/ccr3","display_name":"CCR3","score":0.9739999771118164},{"id":"https://openalex.org/keywords/ccr8","display_name":"CCR8","score":0.996999979019165},{"id":"https://openalex.org/keywords/cx3cr1","display_name":"CX3CR1","score":1.0},{"id":"https://openalex.org/keywords/gpr1","display_name":"GPR1","score":0.8809999823570251},{"id":"https://openalex.org/keywords/gpr15","display_name":"GPR15","score":0.9929999709129333},{"id":"https://openalex.org/keywords/virus-entry","display_name":"viral entry","score":0.5339999794960022},{"id":"https://openalex.org/keywords/tissue-compartmentalization","display_name":"tissue compartmentalization","score":0.8320000171661377},{"id":"https://openalex.org/keywords/viral-quasispecies","display_name":"viral quasispecies","score":0.7799999713897705},{"id":"https://openalex.org/keywords/productive-infection","display_name":"productive infection","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9142237901687622},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.6840939521789551},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6074271202087402},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5640604496002197},{"id":"https://openalex.org/C45635710","wikidata":"https://www.wikidata.org/wiki/Q418404","display_name":"Chemokine receptor CCR5","level":5,"score":0.504552960395813},{"id":"https://openalex.org/C129470790","wikidata":"https://www.wikidata.org/wiki/Q415718","display_name":"CXCR4","level":4,"score":0.4922410547733307},{"id":"https://openalex.org/C2779690655","wikidata":"https://www.wikidata.org/wiki/Q374232","display_name":"Lentivirus","level":4,"score":0.42078879475593567},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.39872217178344727},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3919026553630829},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34168076515197754},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26956290006637573},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.17286807298660278}],"mesh":[{"descriptor_ui":"D000075744","descriptor_name":"Receptors, CXCR6","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006679","descriptor_name":"HIV Seropositivity","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006679","descriptor_name":"HIV Seropositivity","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006679","descriptor_name":"HIV Seropositivity","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011991","descriptor_name":"Receptors, Virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015728","descriptor_name":"Receptors, HIV","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015752","descriptor_name":"Genes, env","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018000","descriptor_name":"Receptors, Peptide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018121","descriptor_name":"Receptors, Cytokine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018123","descriptor_name":"Receptors, Interleukin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019707","descriptor_name":"Receptors, Chemokine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019713","descriptor_name":"Receptors, CCR5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019718","descriptor_name":"Receptors, CXCR4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D023062","descriptor_name":"Receptors, Interleukin-8A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054390","descriptor_name":"Receptors, CCR2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054397","descriptor_name":"Receptors, CCR3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054401","descriptor_name":"Receptors, CCR8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/jvi.73.8.6680-6690.1999","doi":"https://doi.org/10.1128/jvi.73.8.6680-6690.1999","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.73.8.6680-6690.1999","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:112752","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/112752","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:10400765","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10400765","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:112752","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/112752","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4531152939","display_name":"HIV ACTIVATION &REGULATION IN LUNG--VIRAL DETERMINANTS","funder_award_id":"R01HL058004","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W94921626","https://openalex.org/W177323295","https://openalex.org/W1500985028","https://openalex.org/W1540165068","https://openalex.org/W1602599521","https://openalex.org/W1623426438","https://openalex.org/W1642524132","https://openalex.org/W1648071921","https://openalex.org/W1664573657","https://openalex.org/W1723922714","https://openalex.org/W1731073298","https://openalex.org/W1881691580","https://openalex.org/W1963855922","https://openalex.org/W1965019797","https://openalex.org/W1979834302","https://openalex.org/W1981440980","https://openalex.org/W1992119514","https://openalex.org/W1992987846","https://openalex.org/W1993678833","https://openalex.org/W1996403683","https://openalex.org/W2000884295","https://openalex.org/W2001950566","https://openalex.org/W2004290834","https://openalex.org/W2008669330","https://openalex.org/W2008697584","https://openalex.org/W2018982364","https://openalex.org/W2019600619","https://openalex.org/W2026328689","https://openalex.org/W2026444780","https://openalex.org/W2034430377","https://openalex.org/W2045039139","https://openalex.org/W2052392655","https://openalex.org/W2056488073","https://openalex.org/W2066121768","https://openalex.org/W2067714902","https://openalex.org/W2069775700","https://openalex.org/W2080359089","https://openalex.org/W2090630729","https://openalex.org/W2091893741","https://openalex.org/W2094361364","https://openalex.org/W2098127393","https://openalex.org/W2098217581","https://openalex.org/W2100146195","https://openalex.org/W2108256128","https://openalex.org/W2113222286","https://openalex.org/W2116296362","https://openalex.org/W2124846613","https://openalex.org/W2125080468","https://openalex.org/W2126255146","https://openalex.org/W2131376910","https://openalex.org/W2136602493","https://openalex.org/W2142179027","https://openalex.org/W2143584481","https://openalex.org/W2149864650","https://openalex.org/W2152003330","https://openalex.org/W2155691564","https://openalex.org/W2155989561","https://openalex.org/W2156694786","https://openalex.org/W2159017912","https://openalex.org/W2163611230","https://openalex.org/W2223571138","https://openalex.org/W2282756759","https://openalex.org/W2307505398","https://openalex.org/W2435141031"],"related_works":["https://openalex.org/W1817018401","https://openalex.org/W1664573657","https://openalex.org/W2098885135","https://openalex.org/W2170119258","https://openalex.org/W1996845333","https://openalex.org/W2116296362","https://openalex.org/W7096324285","https://openalex.org/W1978812453","https://openalex.org/W2169186537","https://openalex.org/W165793546"],"abstract_inverted_index":{"Human":[0],"immunodeficiency":[1],"virus":[2],"type":[3],"1":[4],"(HIV-1)":[5],"infection":[6],"is":[7],"highly":[8],"compartmentalized,":[9],"with":[10,24,166],"distinct":[11,243],"viral":[12],"genotypes":[13],"being":[14],"found":[15],"in":[16,42,47,200,236,257],"the":[17,30,53,59,75,88,140,147,185,213,226,237,255,266],"lungs,":[18],"brain,":[19],"and":[20,27,34,58,77,83,92,134,153,155,160,164,197,239,244,265,273],"other":[21,38,186],"organs":[22],"compared":[23],"blood.":[25],"CCR5":[26,104,114],"CXCR4":[28,116],"are":[29,49,241],"principal":[31],"HIV-1":[32,234],"coreceptors,":[33,64],"a":[35,283],"number":[36],"of":[37,62,79,87,175,212,228,268,286],"molecules":[39],"support":[40],"entry":[41,63],"vitro":[43],"but":[44,105,137,178],"their":[45,85],"roles":[46],"vivo":[48],"uncertain.":[50],"To":[51],"address":[52],"relationship":[54],"between":[55,195,271],"tissue":[56],"compartmentalization":[57],"selective":[60,279],"use":[61,86,180],"we":[65],"generated":[66],"functional":[67],"env":[68,171,182],"clones":[69,172,183,261],"from":[70,74,100,110,131,173,184,262],"primary":[71],"isolates":[72,174],"derived":[73],"lungs":[76,238],"blood":[78,111,133,196,240],"three":[80],"infected":[81],"individuals":[82],"analyzed":[84],"principal,":[89],"secondary,":[90],"orphan,":[91],"virus-encoded":[93],"coreceptors":[94,149],"for":[95,126],"fusion.":[96],"All":[97],"Env":[98,129,275],"proteins":[99,130,276],"lung":[101,135,198],"viruses":[102,112,199],"used":[103,113,125,139],"not":[106],"CXCR4,":[107],"while":[108],"those":[109],"or":[115,117,202,215],"both.":[118],"The":[119],"orphan":[120,156,203,216],"receptor":[121,142],"APJ":[122],"was":[123,162,191],"widely":[124],"fusion":[127,205],"by":[128,146,170,181],"both":[132],"viruses,":[136],"none":[138,211],"cytomegalovirus-encoded":[141],"US28.":[143],"Fusion":[144],"mediated":[145],"secondary":[148,201,214],"CCR2b,":[150],"CCR3,":[151],"CCR8,":[152],"CX3CR1":[154],"receptors":[157,217],"GPR1,":[158],"GPR15,":[159],"STRL33":[161],"variable":[163],"heterogeneous,":[165],"relatively":[167],"broad":[168],"utilization":[169,259,281],"one":[176],"subject":[177],"limited":[179],"two":[187],"subjects.":[188],"However,":[189,254],"there":[190],"no":[192],"clear":[193,269],"distinction":[194,270],"coreceptor":[204,258,280],"patterns.":[206],"In":[207],"contrast":[208],"to":[209],"fusion,":[210],"enabled":[218],"efficient":[219],"productive":[220],"infection.":[221],"These":[222],"results":[223],"confirm,":[224],"at":[225],"level":[227],"cofactor":[229],"utilization,":[230],"previous":[231],"observations":[232],"that":[233],"populations":[235],"biologically":[242],"demonstrate":[245],"diversity":[246],"within":[247],"lung-derived":[248],"as":[249,251,282],"well":[250],"blood-derived":[252,274],"quasispecies.":[253],"heterogeneity":[256],"among":[260],"each":[263],"isolate":[264],"lack":[267],"lung-":[272],"argue":[277],"against":[278],"major":[284],"determinant":[285],"compartmentalization.":[287]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}