{"id":"https://openalex.org/W2153289176","doi":"https://doi.org/10.1074/jbc.m310634200","title":"The Zinc Finger Transcription Factor Transforming Growth Factor \u03b2-Inducible Early Gene-1 Confers Myeloid-specific Activation of the Leukocyte Integrin CD11d Promoter","display_name":"The Zinc Finger Transcription Factor Transforming Growth Factor \u03b2-Inducible Early Gene-1 Confers Myeloid-specific Activation of the Leukocyte Integrin CD11d Promoter","publication_year":2004,"publication_date":"2004-06-01","ids":{"openalex":"https://openalex.org/W2153289176","doi":"https://doi.org/10.1074/jbc.m310634200","mag":"2153289176","pmid":"https://pubmed.ncbi.nlm.nih.gov/15087465"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m310634200","doi":"https://doi.org/10.1074/jbc.m310634200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m310634200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m310634200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055891747","display_name":"John D. Noti","orcid":"https://orcid.org/0000-0002-2927-9530","observed_orcids":["https://orcid.org/0000-0002-2927-9530"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"John D. Noti","raw_affiliation_strings":["Guthrie Research Institute, Sayre, Pennsylvania 18840, USA. noti_john@guthrie.org","Guthrie Research Institute, Sayre, Pennsylvania 18840"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guthrie Research Institute, Sayre, Pennsylvania 18840, USA. noti_john@guthrie.org","institution_ids":[]},{"raw_affiliation_string":"Guthrie Research Institute, Sayre, Pennsylvania 18840","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andrew K. Johnson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew K. Johnson","raw_affiliation_strings":["Guthrie Research Institute, Sayre, Pennsylvania 18840"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guthrie Research Institute, Sayre, Pennsylvania 18840","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004544314","display_name":"Jill D. Dillon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jill D. Dillon","raw_affiliation_strings":["Guthrie Research Institute, Sayre, Pennsylvania 18840"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guthrie Research Institute, Sayre, Pennsylvania 18840","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5055891747"],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.5791,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.80298121,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"279","issue":"26","first_page":"26948","last_page":"26958"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.02070000022649765,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tieg1","display_name":"TIEG1","score":0.949999988079071},{"id":"https://openalex.org/keywords/zinc-finger-transcription-factor","display_name":"zinc finger transcription factor","score":0.9319999814033508},{"id":"https://openalex.org/keywords/beta2-integrins","display_name":"beta2 integrins","score":0.8019999861717224},{"id":"https://openalex.org/keywords/promoter-regulation","display_name":"promoter regulation","score":0.8090000152587891},{"id":"https://openalex.org/keywords/sp1","display_name":"Sp1","score":0.8740000128746033},{"id":"https://openalex.org/keywords/sp3","display_name":"Sp3","score":0.9829999804496765},{"id":"https://openalex.org/keywords/myeloid-differentiation","display_name":"myeloid differentiation","score":0.8700000047683716},{"id":"https://openalex.org/keywords/promoter-binding","display_name":"promoter binding","score":0.6840000152587891},{"id":"https://openalex.org/keywords/phorbol-ester","display_name":"phorbol ester","score":0.8140000104904175}],"concepts":[{"id":"https://openalex.org/C24284526","wikidata":"https://www.wikidata.org/wiki/Q204785","display_name":"Zinc finger","level":4,"score":0.7038077712059021},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6232700347900391},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.606558084487915},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4658547043800354},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4616910219192505},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3783336877822876},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34166014194488525},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32690656185150146},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32461416721343994},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23482605814933777},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.13524213433265686}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016329","descriptor_name":"Sp1 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016335","descriptor_name":"Zinc Fingers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016335","descriptor_name":"Zinc Fingers","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018845","descriptor_name":"CD11 Antigens","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018845","descriptor_name":"CD11 Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020014","descriptor_name":"K562 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022423","descriptor_name":"Myeloid Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D022423","descriptor_name":"Myeloid Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022423","descriptor_name":"Myeloid Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051765","descriptor_name":"Early Growth Response Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m310634200","doi":"https://doi.org/10.1074/jbc.m310634200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m310634200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:15087465","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15087465","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m310634200","doi":"https://doi.org/10.1074/jbc.m310634200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m310634200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.766700029373169,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2428401612","display_name":"Molecular Mechanisms That Regulate CD11d Expression","funder_award_id":"R01HL063891","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W15592170","https://openalex.org/W1488543398","https://openalex.org/W1541937812","https://openalex.org/W1550039558","https://openalex.org/W1570271015","https://openalex.org/W1659855818","https://openalex.org/W1844478593","https://openalex.org/W1969356288","https://openalex.org/W1969870278","https://openalex.org/W1973053090","https://openalex.org/W1974446535","https://openalex.org/W1981571305","https://openalex.org/W1985725092","https://openalex.org/W1989653292","https://openalex.org/W1990918843","https://openalex.org/W2007996214","https://openalex.org/W2010745413","https://openalex.org/W2015831421","https://openalex.org/W2021951421","https://openalex.org/W2023318533","https://openalex.org/W2024320282","https://openalex.org/W2030688236","https://openalex.org/W2039971229","https://openalex.org/W2041574135","https://openalex.org/W2046783279","https://openalex.org/W2059592849","https://openalex.org/W2064129352","https://openalex.org/W2069025901","https://openalex.org/W2070188781","https://openalex.org/W2073028945","https://openalex.org/W2084940194","https://openalex.org/W2086652233","https://openalex.org/W2094860758","https://openalex.org/W2095268620","https://openalex.org/W2095564407","https://openalex.org/W2099675490","https://openalex.org/W2144955716","https://openalex.org/W2145837794","https://openalex.org/W2149627222","https://openalex.org/W2163361020","https://openalex.org/W2164870839","https://openalex.org/W2171195379","https://openalex.org/W2172473147","https://openalex.org/W2315471026","https://openalex.org/W4313377155"],"related_works":["https://openalex.org/W1998867320","https://openalex.org/W2144955716","https://openalex.org/W1969870278","https://openalex.org/W1990103617","https://openalex.org/W1541937812","https://openalex.org/W2041574135","https://openalex.org/W1985725092","https://openalex.org/W2300002192","https://openalex.org/W1548000107","https://openalex.org/W2051528622"],"abstract_inverted_index":{"CD11d":[0,28,35,59,90,145,167,181,196,220,237],"encodes":[1],"the":[2,21,27,34,52,58,71,89,144,166,180,236],"alpha(D)":[3],"subunit":[4],"for":[5,82,138],"a":[6,47,78],"leukocyte":[7],"integrin":[8],"that":[9,20,76,131,217],"is":[10,185,227],"expressed":[11,153],"on":[12],"myeloid":[13,94,155,174,190,225],"cells.":[14],"In":[15,110,172,201],"this":[16],"study":[17],"we":[18],"show":[19],"-100":[22,53],"to":[23,54,68,73,140,212,235],"-20":[24,55],"region":[25,56,75],"of":[26,33,57,86,98,108,125,165,179,189,195,219,224,232],"promoter":[29,60,91,168,182],"confers":[30],"myeloid-specific":[31],"activation":[32],"promoter.":[36,146,238],"Transforming":[37],"growth":[38],"factor":[39],"beta-inducible":[40],"early":[41],"gene-1":[42],"(TIEG1)":[43],"was":[44,66],"isolated":[45],"in":[46,93,143,154,208],"yeast":[48],"one-hybrid":[49],"screen":[50],"using":[51],"as":[61],"bait.":[62],"Purified":[63],"GST.TIEG1":[64],"protein":[65],"able":[67],"bind":[69],"within":[70],"-61":[72],"-45":[74],"overlaps":[77],"shorter":[79],"binding":[80,139,231,234],"site":[81],"Sp1.":[83,118],"Transient":[84],"overexpression":[85],"TIEG1":[87,99,103,112,132,148,184,198,205,233],"activated":[88],"specifically":[92],"cells,":[95,158,177],"whereas,":[96],"down-regulation":[97],"with":[100,117,134],"small":[101],"interfering":[102],"RNA":[104],"also":[105],"down-regulated":[106],"expression":[107,221],"CD11d.":[109],"vivo,":[111],"does":[113],"not":[114],"physically":[115],"interact":[116],"Cotransfection":[119],"and":[120,128,149,156,175,192],"electrophoretic":[121],"mobility":[122],"shift":[123],"analyses":[124],"TIEG1,":[126],"Sp1,":[127],"Sp3":[129],"revealed":[130,162],"competes":[133],"these":[135,170],"Sp":[136],"proteins":[137],"overlapping":[141],"sites":[142],"Although":[147],"Sp1":[150],"are":[151],"ubiquitously":[152],"non-myeloid":[157,176,209],"chromatin":[159],"immunoprecipitation":[160],"assays":[161],"differential":[163],"occupancy":[164,178,199,203],"by":[169,183,204],"factors.":[171],"undifferentiated":[173],"similar.":[186],"Upon":[187],"differentiation":[188,223],"cells":[191,210,226],"subsequent":[193],"up-regulation":[194,218],"expression,":[197],"increases.":[200],"contrast,":[202],"remains":[206],"low":[207],"exposed":[211],"phorbol":[213],"ester.":[214],"We":[215],"propose":[216],"following":[222],"mediated":[228],"through":[229],"increased":[230]},"counts_by_year":[{"year":2024,"cited_by_count":9},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}