{"id":"https://openalex.org/W2153269370","doi":"https://doi.org/10.1126/scitranslmed.3000522","title":"Brief Suppression of Abcc8 Prevents Autodestruction of Spinal Cord After Trauma","display_name":"Brief Suppression of Abcc8 Prevents Autodestruction of Spinal Cord After Trauma","publication_year":2010,"publication_date":"2010-04-21","ids":{"openalex":"https://openalex.org/W2153269370","doi":"https://doi.org/10.1126/scitranslmed.3000522","mag":"2153269370","pmid":"https://pubmed.ncbi.nlm.nih.gov/20410530","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2903041"},"language":"en","primary_location":{"id":"doi:10.1126/scitranslmed.3000522","doi":"https://doi.org/10.1126/scitranslmed.3000522","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scitranslmed.3000522","pdf_url":null,"source":{"id":"https://openalex.org/S24207032","display_name":"Science Translational Medicine","issn_l":"1946-6234","issn":["1946-6234","1946-6242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2903041","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073844022","display_name":"J. Marc Simard","orcid":"https://orcid.org/0000-0002-5373-1988","observed_orcids":["https://orcid.org/0000-0002-5373-1988","https://orcid.org/0000-0003-1161-3729"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. Marc Simard","raw_affiliation_strings":["Department of Neurosurgery, University of Maryland School of Medicine, 22 South Greene Street, Suite S12D, Baltimore, MD 21201\u20131595, USA","Department of Pathology, University of Maryland School of Medicine, Baltimore MD 21201, USA","Department of Physiology, University of Maryland School of Medicine, Baltimore MD 21201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Maryland School of Medicine, 22 South Greene Street, Suite S12D, Baltimore, MD 21201\u20131595, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Department of Pathology, University of Maryland School of Medicine, Baltimore MD 21201, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Department of Physiology, University of Maryland School of Medicine, Baltimore MD 21201, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S. Kyoon Woo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Kyoon Woo","raw_affiliation_strings":["Department of Neurosurgery, University of Maryland School of Medicine, 22 South Greene Street, Suite S12D, Baltimore, MD 21201\u20131595, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Maryland School of Medicine, 22 South Greene Street, Suite S12D, Baltimore, MD 21201\u20131595, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111990004","display_name":"Michael D. Norenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael D. Norenberg","raw_affiliation_strings":["Department of Pathology, University of Miami School of Medicine, Miami, FL 33101, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Miami School of Medicine, Miami, FL 33101, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111779173","display_name":"\u00c7i\u011fdem Tosun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cigdem Tosun","raw_affiliation_strings":["Department of Neurosurgery, University of Maryland School of Medicine, 22 South Greene Street, Suite S12D, Baltimore, MD 21201\u20131595, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Maryland School of Medicine, 22 South Greene Street, Suite S12D, Baltimore, MD 21201\u20131595, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zheng Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zheng Chen","raw_affiliation_strings":["Department of Neurosurgery, University of Maryland School of Medicine, 22 South Greene Street, Suite S12D, Baltimore, MD 21201\u20131595, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Maryland School of Medicine, 22 South Greene Street, Suite S12D, Baltimore, MD 21201\u20131595, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046677689","display_name":"Svetlana Ivanova","orcid":"https://orcid.org/0000-0002-4999-8401","observed_orcids":["https://orcid.org/0000-0002-4999-8401"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Svetlana Ivanova","raw_affiliation_strings":["Department of Neurosurgery, University of Maryland School of Medicine, 22 South Greene Street, Suite S12D, Baltimore, MD 21201\u20131595, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Maryland School of Medicine, 22 South Greene Street, Suite S12D, Baltimore, MD 21201\u20131595, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055663115","display_name":"Orest Tsymbalyuk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Orest Tsymbalyuk","raw_affiliation_strings":["Department of Neurosurgery, University of Maryland School of Medicine, 22 South Greene Street, Suite S12D, Baltimore, MD 21201\u20131595, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Maryland School of Medicine, 22 South Greene Street, Suite S12D, Baltimore, MD 21201\u20131595, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086767351","display_name":"Joseph Bryan","orcid":"https://orcid.org/0000-0003-3476-858X","observed_orcids":["https://orcid.org/0000-0003-3476-858X"]},"institutions":[{"id":"https://openalex.org/I1286936699","display_name":"Pacific Northwest Research Institute","ror":"https://ror.org/03x0d4x24","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1286936699"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Bryan","raw_affiliation_strings":["Pacific Northwest Diabetes Research Institute, 720 Broadway, Seattle, WA 98122, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pacific Northwest Diabetes Research Institute, 720 Broadway, Seattle, WA 98122, USA","institution_ids":["https://openalex.org/I1286936699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056800721","display_name":"Douglas Landsman","orcid":"https://orcid.org/0000-0002-3614-9283","observed_orcids":["https://orcid.org/0000-0002-3614-9283"]},"institutions":[{"id":"https://openalex.org/I2800380144","display_name":"Christopher and Dana Reeve Foundation","ror":"https://ror.org/0430rna51","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800380144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas Landsman","raw_affiliation_strings":["Christopher and Dana Reeve Foundation, 636 Morris Turnpike, Suite 3A, Short Hills, NJ 07078, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Christopher and Dana Reeve Foundation, 636 Morris Turnpike, Suite 3A, Short Hills, NJ 07078, USA","institution_ids":["https://openalex.org/I2800380144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039689256","display_name":"Volodymyr Gerzanich","orcid":"https://orcid.org/0000-0002-6714-1946","observed_orcids":["https://orcid.org/0000-0002-6714-1946"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Volodymyr Gerzanich","raw_affiliation_strings":["Department of Neurosurgery, University of Maryland School of Medicine, 22 South Greene Street, Suite S12D, Baltimore, MD 21201\u20131595, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Maryland School of Medicine, 22 South Greene Street, Suite S12D, Baltimore, MD 21201\u20131595, USA","institution_ids":["https://openalex.org/I126744593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5073844022"],"corresponding_institution_ids":["https://openalex.org/I126744593"],"apc_list":null,"apc_paid":null,"fwci":4.6337,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.9536185,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"2","issue":"28","first_page":"28ra29","last_page":"28ra29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12249","display_name":"Veterinary Orthopedics and Neurology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spinal-cord-injury","display_name":"spinal cord injury","score":0.9490000009536743},{"id":"https://openalex.org/keywords/abcc8","display_name":"ABCC8","score":0.9459999799728394},{"id":"https://openalex.org/keywords/sulfonylurea-receptor-1","display_name":"SUR1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/secondary-injury","display_name":"secondary injury","score":0.6330000162124634},{"id":"https://openalex.org/keywords/hemorrhagic-necrosis","display_name":"hemorrhagic necrosis","score":0.9419999718666077},{"id":"https://openalex.org/keywords/antisense-oligodeoxynucleotides","display_name":"antisense oligodeoxynucleotides","score":0.8529999852180481},{"id":"https://openalex.org/keywords/gene-suppression","display_name":"gene suppression","score":0.6060000061988831},{"id":"https://openalex.org/keywords/neurological-function","display_name":"neurological function","score":0.6079999804496765},{"id":"https://openalex.org/keywords/hemorrhagic-contusion","display_name":"hemorrhagic contusion","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C2994329924","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal trauma","level":3,"score":0.7640672326087952},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.649418830871582},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.5669691562652588},{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.4902375340461731},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.40132686495780945},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.11439061164855957}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005905","descriptor_name":"Glyburide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011955","descriptor_name":"Receptors, Drug","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D011955","descriptor_name":"Receptors, Drug","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011955","descriptor_name":"Receptors, Drug","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D016329","descriptor_name":"Sp1 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016372","descriptor_name":"RNA, Antisense","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024661","descriptor_name":"Potassium Channels, Inwardly Rectifying","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D024661","descriptor_name":"Potassium Channels, Inwardly Rectifying","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024661","descriptor_name":"Potassium Channels, Inwardly Rectifying","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064233","descriptor_name":"Sulfonylurea Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1126/scitranslmed.3000522","doi":"https://doi.org/10.1126/scitranslmed.3000522","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scitranslmed.3000522","pdf_url":null,"source":{"id":"https://openalex.org/S24207032","display_name":"Science Translational Medicine","issn_l":"1946-6234","issn":["1946-6234","1946-6242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Translational Medicine","raw_type":"journal-article"},{"id":"pmid:20410530","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20410530","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science translational medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2903041","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2903041","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Sci Transl Med","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2903041","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2903041","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Sci Transl Med","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5360641798","display_name":"Astrocyte regulation of the blood-brain barrier in intracerebral hemorrhage","funder_award_id":"R01HL082517","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7337410801","display_name":"TrpM4 channel in spinal cord injury","funder_award_id":"R01NS061934","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8925550715","display_name":"Spinal cord injury, progressive hemorrhagic necrosis and the NC(Ca-ATP) channel","funder_award_id":"R01NS060801","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G961501906","display_name":"Pathological role of the SUR1-regulated NC(Ca-ATP) channel in cortex after subara","funder_award_id":"R01NS061808","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W120465808","https://openalex.org/W1561824693","https://openalex.org/W1902460967","https://openalex.org/W1967503662","https://openalex.org/W1972817664","https://openalex.org/W1975644972","https://openalex.org/W1975724680","https://openalex.org/W1977944550","https://openalex.org/W1978669570","https://openalex.org/W1983325630","https://openalex.org/W1988042413","https://openalex.org/W1988868629","https://openalex.org/W1998384354","https://openalex.org/W2005554057","https://openalex.org/W2028899000","https://openalex.org/W2036465941","https://openalex.org/W2039548797","https://openalex.org/W2039809192","https://openalex.org/W2047747930","https://openalex.org/W2055923019","https://openalex.org/W2061905525","https://openalex.org/W2067208808","https://openalex.org/W2073855304","https://openalex.org/W2087640478","https://openalex.org/W2091358578","https://openalex.org/W2094484227","https://openalex.org/W2104214122","https://openalex.org/W2105443363","https://openalex.org/W2107565079","https://openalex.org/W2117339662","https://openalex.org/W2124365637","https://openalex.org/W2129338507","https://openalex.org/W2157399468","https://openalex.org/W2160353065","https://openalex.org/W2161951762","https://openalex.org/W2162016919","https://openalex.org/W2166505057","https://openalex.org/W2167037697","https://openalex.org/W2170645579","https://openalex.org/W2208036780","https://openalex.org/W2248632371"],"related_works":["https://openalex.org/W2036465941","https://openalex.org/W3045518274","https://openalex.org/W4388364423","https://openalex.org/W2126766857","https://openalex.org/W2765219868","https://openalex.org/W4312561593","https://openalex.org/W1142363128","https://openalex.org/W4241603005","https://openalex.org/W2506729121","https://openalex.org/W7095805227"],"abstract_inverted_index":{"Spinal":[0],"cord":[1],"injury":[2,16],"(SCI)":[3],"is":[4],"typically":[5],"complicated":[6],"by":[7,18],"progressive":[8,19,45,82],"hemorrhagic":[9,23,46,83],"necrosis,":[10,84],"an":[11,133],"autodestructive":[12],"process":[13],"of":[14,21,36,59,61,68,101,109,116,120,125,140],"secondary":[15],"characterized":[17],"enlargement":[20],"a":[22],"contusion":[24],"during":[25],"the":[26,34,99,137],"first":[27],"several":[28],"hours":[29],"after":[30,130],"trauma.":[31],"We":[32],"assessed":[33],"role":[35],"Abcc8,":[37],"which":[38],"encodes":[39],"sulfonylurea":[40],"receptor":[41],"1":[42],"(SUR1),":[43],"in":[44,70,74,92,103],"necrosis.":[47],"After":[48],"SCI,":[49],"humans":[50],"and":[51,56,63,73,90],"rodents":[52],"exhibited":[53],"similar":[54],"regional":[55],"cellular":[57],"patterns":[58],"up-regulation":[60],"SUR1":[62,69],"Abcc8":[64,80,110,126],"messenger":[65],"RNA.":[66],"Elimination":[67],"Abcc8(-/-)":[71],"mice":[72],"rats":[75],"given":[76],"antisense":[77,128],"oligodeoxynucleotide":[78,129],"against":[79],"prevented":[81],"yielded":[85],"significantly":[86],"better":[87],"neurological":[88],"function,":[89],"resulted":[91],"lesions":[93],"that":[94],"were":[95,112],"one-fourth":[96],"to":[97],"one-third":[98],"size":[100],"those":[102],"control":[104],"animals.":[105],"The":[106],"beneficial":[107],"effects":[108],"suppression":[111],"associated":[113],"with":[114,127],"prevention":[115],"oncotic":[117],"(necrotic)":[118],"death":[119],"capillary":[121],"endothelial":[122],"cells.":[123],"Suppression":[124],"SCI":[131],"presents":[132],"opportunity":[134],"for":[135],"reducing":[136],"devastating":[138],"sequelae":[139],"SCI.":[141]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}