{"id":"https://openalex.org/W2153256992","doi":"https://doi.org/10.1111/j.1872-034x.2008.00426.x","title":"Plasma exchange in combination with online\u2010hemodiafiltration as a promising method for purifying the blood of fulminant hepatitis patients","display_name":"Plasma exchange in combination with online\u2010hemodiafiltration as a promising method for purifying the blood of fulminant hepatitis patients","publication_year":2008,"publication_date":"2008-11-01","ids":{"openalex":"https://openalex.org/W2153256992","doi":"https://doi.org/10.1111/j.1872-034x.2008.00426.x","mag":"2153256992","pmid":"https://pubmed.ncbi.nlm.nih.gov/19125952"},"language":"en","primary_location":{"id":"doi:10.1111/j.1872-034x.2008.00426.x","doi":"https://doi.org/10.1111/j.1872-034x.2008.00426.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1872-034x.2008.00426.x","pdf_url":null,"source":{"id":"https://openalex.org/S110399111","display_name":"Hepatology Research","issn_l":"1386-6346","issn":["1386-6346","1872-034X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109956225","display_name":"Kazuaki Inoue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156626","display_name":"SHOWA Medical University Fujigaoka Hospital","ror":"https://ror.org/0543mcr22","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210156626"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kazuaki Inoue","raw_affiliation_strings":["Division of Gastroenterology, Showa University Fujigaoka Hospital, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Showa University Fujigaoka Hospital, Yokohama, Japan","institution_ids":["https://openalex.org/I4210156626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024720308","display_name":"Akishi Kourin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156626","display_name":"SHOWA Medical University Fujigaoka Hospital","ror":"https://ror.org/0543mcr22","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210156626"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akishi Kourin","raw_affiliation_strings":["Division of Gastroenterology, Showa University Fujigaoka Hospital, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Showa University Fujigaoka Hospital, Yokohama, Japan","institution_ids":["https://openalex.org/I4210156626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086875352","display_name":"Tsunamasa Watanabe","orcid":"https://orcid.org/0000-0002-7659-914X","observed_orcids":["https://orcid.org/0000-0002-7659-914X"]},"institutions":[{"id":"https://openalex.org/I4210156626","display_name":"SHOWA Medical University Fujigaoka Hospital","ror":"https://ror.org/0543mcr22","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210156626"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsunamasa Watanabe","raw_affiliation_strings":["Division of Gastroenterology, Showa University Fujigaoka Hospital, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Showa University Fujigaoka Hospital, Yokohama, Japan","institution_ids":["https://openalex.org/I4210156626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113630466","display_name":"Masaya Yamada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156626","display_name":"SHOWA Medical University Fujigaoka Hospital","ror":"https://ror.org/0543mcr22","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210156626"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaya Yamada","raw_affiliation_strings":["Division of Gastroenterology, Showa University Fujigaoka Hospital, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Showa University Fujigaoka Hospital, Yokohama, Japan","institution_ids":["https://openalex.org/I4210156626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073161317","display_name":"Hiroshi Yasuda","orcid":"https://orcid.org/0000-0003-4547-5213","observed_orcids":["https://orcid.org/0000-0003-4547-5213"]},"institutions":[{"id":"https://openalex.org/I4210156626","display_name":"SHOWA Medical University Fujigaoka Hospital","ror":"https://ror.org/0543mcr22","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210156626"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Yasuda","raw_affiliation_strings":["Division of Gastroenterology, Showa University Fujigaoka Hospital, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Showa University Fujigaoka Hospital, Yokohama, Japan","institution_ids":["https://openalex.org/I4210156626"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110767556","display_name":"Makoto Yoshiba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156626","display_name":"SHOWA Medical University Fujigaoka Hospital","ror":"https://ror.org/0543mcr22","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210156626"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Yoshiba","raw_affiliation_strings":["Division of Gastroenterology, Showa University Fujigaoka Hospital, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Showa University Fujigaoka Hospital, Yokohama, Japan","institution_ids":["https://openalex.org/I4210156626"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109956225"],"corresponding_institution_ids":["https://openalex.org/I4210156626"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.26045057,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"38","issue":"s1","first_page":"S46","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fulminant-hepatitis","display_name":"fulminant hepatitis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/therapeutic-plasma-exchange","display_name":"plasma exchange","score":0.875},{"id":"https://openalex.org/keywords/online-hemodiafiltration","display_name":"online hemodiafiltration","score":0.9980000257492065},{"id":"https://openalex.org/keywords/artificial-liver-support","display_name":"artificial liver support","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hepatic-coma","display_name":"hepatic coma","score":0.902999997138977},{"id":"https://openalex.org/keywords/blood-purification","display_name":"blood purification","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8344191312789917},{"id":"https://openalex.org/C2993619895","wikidata":"https://www.wikidata.org/wiki/Q1353169","display_name":"Artificial liver","level":3,"score":0.7269832491874695},{"id":"https://openalex.org/C2994395758","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Fulminant hepatitis","level":3,"score":0.6977992057800293},{"id":"https://openalex.org/C2781107259","wikidata":"https://www.wikidata.org/wiki/Q5508364","display_name":"Fulminant","level":2,"score":0.6797831058502197},{"id":"https://openalex.org/C100136789","wikidata":"https://www.wikidata.org/wiki/Q1772448","display_name":"Coma (optics)","level":2,"score":0.6563281416893005},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.5668995976448059},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5374128818511963},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5122012495994568},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.4941425621509552},{"id":"https://openalex.org/C2911118192","wikidata":"https://www.wikidata.org/wiki/Q1192530","display_name":"Fulminant hepatic failure","level":4,"score":0.49082669615745544},{"id":"https://openalex.org/C2994427840","wikidata":"https://www.wikidata.org/wiki/Q970208","display_name":"Liver failure","level":2,"score":0.11785945296287537},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.06289193034172058},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1872-034x.2008.00426.x","doi":"https://doi.org/10.1111/j.1872-034x.2008.00426.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1872-034x.2008.00426.x","pdf_url":null,"source":{"id":"https://openalex.org/S110399111","display_name":"Hepatology Research","issn_l":"1386-6346","issn":["1386-6346","1872-034X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology Research","raw_type":"journal-article"},{"id":"pmid:19125952","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19125952","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology research : the official journal of the Japan Society of Hepatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W62142283","https://openalex.org/W378569729","https://openalex.org/W573559012","https://openalex.org/W1490740387","https://openalex.org/W1561086344","https://openalex.org/W1849025172","https://openalex.org/W1978073003","https://openalex.org/W1979776563","https://openalex.org/W1980288639","https://openalex.org/W1986353631","https://openalex.org/W2008047936","https://openalex.org/W2026555524","https://openalex.org/W2040944339","https://openalex.org/W2050083695","https://openalex.org/W2054594955","https://openalex.org/W2118142998","https://openalex.org/W2125611366","https://openalex.org/W2395417267","https://openalex.org/W4251590479"],"related_works":["https://openalex.org/W1998448136","https://openalex.org/W2026555524","https://openalex.org/W2397499714","https://openalex.org/W2393243668","https://openalex.org/W2008047936","https://openalex.org/W2895666602","https://openalex.org/W2048030398","https://openalex.org/W2324295625","https://openalex.org/W2328159614","https://openalex.org/W2410374032"],"abstract_inverted_index":{"BACKGROUND:":[0],"Fulminant":[1],"hepatitis":[2,43,94],"is":[3,16,171],"an":[4,74],"intractable":[5],"disease":[6,64],"caused":[7],"by":[8,145],"various":[9,90],"etiological":[10],"agents.":[11],"Artificial":[12],"liver":[13,147],"support":[14],"(ALS)":[15],"a":[17,172],"symptomatic":[18],"treatment":[19],"used":[20],"to":[21,47,160],"control":[22],"serious":[23],"symptoms,":[24],"such":[25],"as":[26],"bleeding":[27],"tendency,":[28],"hepatic":[29,134],"coma,":[30],"and":[31,55,81,97,107,125,174],"brain":[32],"edema.":[33],"METHODS:":[34],"The":[35,68,84,127,138,149],"present":[36],"study":[37],"involved":[38],"four":[39,59,69,120],"patients":[40,60,70,121,182],"with":[41,136,168,183],"fulminant":[42,93,184],"who":[44],"were":[45,61,71,111,142],"admitted":[46],"Showa":[48],"University":[49],"Fujigaoka":[50],"Hospital":[51],"between":[52],"January":[53],"2007":[54],"June":[56],"2007.":[57],"All":[58],"subacute":[62],"type":[63],"of":[65,86,92,100,118,153,181],"indeterminate":[66],"etiology.":[67],"placed":[72],"on":[73,89],"ALS":[75,88],"system":[76],"that":[77],"comprised":[78],"plasma":[79,105,139],"exchange":[80,165],"online":[82,169],"hemodiafiltration.":[83],"effect":[85],"the":[87,98,103,108,119,179],"symptoms":[91],"was":[95],"evaluated,":[96],"levels":[99,141],"glutamine":[101,140],"in":[102,166],"patients'":[104],"samples":[106],"discarded":[109],"buffer":[110],"assayed":[112],"using":[113],"automatic":[114],"analyser.":[115],"RESULTS:":[116],"Three":[117],"regained":[122],"full":[123],"consciousness":[124],"survived.":[126],"remaining":[128],"patient":[129],"died":[130],"despite":[131],"recovering":[132],"from":[133,157],"coma":[135],"ALS.":[137],"significantly":[143],"reduced":[144],"artificial":[146],"support.":[148],"estimated":[150],"distribution":[151],"volume":[152],"removed":[154],"Gln":[155],"ranged":[156],"30":[158],"L":[159],"60":[161],"L.":[162],"CONCLUSIONS:":[163],"Plasma":[164],"combination":[167],"hemodiafiltration":[170],"promising":[173],"effective":[175],"method":[176],"for":[177],"purifying":[178],"blood":[180],"hepatitis.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-08-27T14:10:00.468798","created_date":"2016-06-24T00:00:00"}
