{"id":"https://openalex.org/W2153255593","doi":"https://doi.org/10.1051/medsci/20052110849","title":"Le complexe GIT-PIX : Une plate-forme de r\u00e9gulation des GTPases ARF et Rac/Cdc42","display_name":"Le complexe GIT-PIX : Une plate-forme de r\u00e9gulation des GTPases ARF et Rac/Cdc42","publication_year":2005,"publication_date":"2005-10-01","ids":{"openalex":"https://openalex.org/W2153255593","doi":"https://doi.org/10.1051/medsci/20052110849","mag":"2153255593","pmid":"https://pubmed.ncbi.nlm.nih.gov/16197902"},"language":"fr","primary_location":{"id":"doi:10.1051/medsci/20052110849","doi":"https://doi.org/10.1051/medsci/20052110849","is_oa":true,"landing_page_url":"https://doi.org/10.1051/medsci/20052110849","pdf_url":"https://www.medecinesciences.org/articles/medsci/pdf/2005/08/medsci20052110p849.pdf","source":{"id":"https://openalex.org/S20253135","display_name":"m\u00e9decine/sciences","issn_l":"0767-0974","issn":["0767-0974","1958-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319748","host_organization_name":"EDP Sciences","host_organization_lineage":["https://openalex.org/P4310319748","https://openalex.org/P4310319982"],"host_organization_lineage_names":["EDP Sciences","Science Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"m\u00e9decine/sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.medecinesciences.org/articles/medsci/pdf/2005/08/medsci20052110p849.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036788309","display_name":"Maria Zeniou","orcid":"https://orcid.org/0000-0002-3237-0263","observed_orcids":["https://orcid.org/0000-0002-3237-0263"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Maria Zeniou-Meyer","raw_affiliation_strings":["CNRS UPR-2356, Neurotransmission et s\u00e9cr\u00e9tion neuroendocrine, Centre de neurochimie, Strasbourg, France","CNRS UPR-2356, Neurotransmission et s\u00e9cr\u00e9tion neuroendocrine, Centre de neurochimie, 5 rue Blaise Pascal 67084 Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS UPR-2356, Neurotransmission et s\u00e9cr\u00e9tion neuroendocrine, Centre de neurochimie, Strasbourg, France","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"CNRS UPR-2356, Neurotransmission et s\u00e9cr\u00e9tion neuroendocrine, Centre de neurochimie, 5 rue Blaise Pascal 67084 Strasbourg, France","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007070901","display_name":"Jean\u2010Paul Borg","orcid":"https://orcid.org/0000-0001-8418-3382","observed_orcids":["https://orcid.org/0000-0001-8418-3382"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210150365","display_name":"Institut Paoli-Calmettes","ror":"https://ror.org/04s3t1g37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210150365"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Paul Borg","raw_affiliation_strings":["Pharmacologie mol\u00e9culaire, Institut de canc\u00e9rologie de Marseille, UMR 599, Inserm, Institut Paoli-Calmettes, 27, boulevard Le\u00ef Roure, 13009 Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacologie mol\u00e9culaire, Institut de canc\u00e9rologie de Marseille, UMR 599, Inserm, Institut Paoli-Calmettes, 27, boulevard Le\u00ef Roure, 13009 Marseille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210150365"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038071498","display_name":"Nicolas Vitale","orcid":"https://orcid.org/0000-0002-4752-4907","observed_orcids":["https://orcid.org/0000-0002-4752-4907"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Nicolas Vitale","raw_affiliation_strings":["CNRS UPR-2356, Neurotransmission et s\u00e9cr\u00e9tion neuroendocrine, Centre de neurochimie, 5 rue Blaise Pascal 67084 Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS UPR-2356, Neurotransmission et s\u00e9cr\u00e9tion neuroendocrine, Centre de neurochimie, 5 rue Blaise Pascal 67084 Strasbourg, France","institution_ids":["https://openalex.org/I1294671590"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5038071498"],"corresponding_institution_ids":["https://openalex.org/I1294671590"],"apc_list":{"value":1650,"currency":"EUR","value_usd":1865},"apc_paid":null,"fwci":0.1034,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.36954346,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"21","issue":"10","first_page":"849","last_page":"853"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9150000214576721,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9150000214576721,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.08320000022649765,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arf-gtpases","display_name":"Arf GTPases","score":0.9539999961853027},{"id":"https://openalex.org/keywords/gtpase-activating-protein","display_name":"GTPase-activating protein","score":0.5889999866485596},{"id":"https://openalex.org/keywords/cytoskeleton-organization","display_name":"cytoskeletal organization","score":0.8270000219345093},{"id":"https://openalex.org/keywords/membrane-dynamics","display_name":"membrane dynamics","score":0.9779999852180481},{"id":"https://openalex.org/keywords/tumor-suppressor-signaling","display_name":"tumor suppressor signaling","score":0.7929999828338623},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.8769999742507935}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6139560341835022},{"id":"https://openalex.org/C2780040266","wikidata":"https://www.wikidata.org/wiki/Q15311701","display_name":"CDC42","level":3,"score":0.5558359622955322},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.5498731136322021},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5324270129203796},{"id":"https://openalex.org/C163181125","wikidata":"https://www.wikidata.org/wiki/Q408592","display_name":"GTPase-activating protein","level":4,"score":0.421579509973526},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.35545212030410767},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2271847426891327},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.2040175497531891},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.19080719351768494},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.1433119773864746},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10524958372116089}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020662","descriptor_name":"Guanine Nucleotide Exchange Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020662","descriptor_name":"Guanine Nucleotide Exchange Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064067","descriptor_name":"Rho Guanine Nucleotide Exchange Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1051/medsci/20052110849","doi":"https://doi.org/10.1051/medsci/20052110849","is_oa":true,"landing_page_url":"https://doi.org/10.1051/medsci/20052110849","pdf_url":"https://www.medecinesciences.org/articles/medsci/pdf/2005/08/medsci20052110p849.pdf","source":{"id":"https://openalex.org/S20253135","display_name":"m\u00e9decine/sciences","issn_l":"0767-0974","issn":["0767-0974","1958-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319748","host_organization_name":"EDP Sciences","host_organization_lineage":["https://openalex.org/P4310319748","https://openalex.org/P4310319982"],"host_organization_lineage_names":["EDP Sciences","Science Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"m\u00e9decine/sciences","raw_type":"journal-article"},{"id":"pmid:16197902","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16197902","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medecine sciences : M/S","raw_type":"English Abstract"},{"id":"pmh:oai:edpsciences.org:dkey/10.1051/medsci/20052110849","doi":null,"is_oa":false,"landing_page_url":"https://www.medecinesciences.org/10.1051/medsci/20052110849/pdf","pdf_url":"https://www.medecinesciences.org/10.1051/medsci/20052110849/pdf","source":{"id":"https://openalex.org/S4306400744","display_name":"Springer Link (Chiba Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8488066","host_organization_name":"Chiba Institute of Technology","host_organization_lineage":["https://openalex.org/I8488066"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://doi.org/10.1051/medsci/20052110849","raw_type":"Text"},{"id":"pmh:oai:erudit.org:011586ar","doi":null,"is_oa":false,"landing_page_url":"http://id.erudit.org/iderudit/011586ar","pdf_url":null,"source":{"id":"https://openalex.org/S4377196102","display_name":"\u00c9rudit (Universit\u00e9 de Montr\u00e9al)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I70931966","host_organization_name":"Universit\u00e9 de Montr\u00e9al","host_organization_lineage":["https://openalex.org/I70931966"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"mag:2126019228","doi":null,"is_oa":false,"landing_page_url":"https://medecinesciences.org/articles/medsci/pdf/2005/08/medsci20052110p849.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1051/medsci/20052110849","doi":"https://doi.org/10.1051/medsci/20052110849","is_oa":true,"landing_page_url":"https://doi.org/10.1051/medsci/20052110849","pdf_url":"https://www.medecinesciences.org/articles/medsci/pdf/2005/08/medsci20052110p849.pdf","source":{"id":"https://openalex.org/S20253135","display_name":"m\u00e9decine/sciences","issn_l":"0767-0974","issn":["0767-0974","1958-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319748","host_organization_name":"EDP Sciences","host_organization_lineage":["https://openalex.org/P4310319748","https://openalex.org/P4310319982"],"host_organization_lineage_names":["EDP Sciences","Science Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"m\u00e9decine/sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2153255593.pdf","grobid_xml":"https://content.openalex.org/works/W2153255593.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1506345236","https://openalex.org/W1936721474","https://openalex.org/W1964024918","https://openalex.org/W1977831677","https://openalex.org/W1984967137","https://openalex.org/W2007101096","https://openalex.org/W2019581551","https://openalex.org/W2030648310","https://openalex.org/W2035595951","https://openalex.org/W2038317844","https://openalex.org/W2038333370","https://openalex.org/W2047362862","https://openalex.org/W2055267037","https://openalex.org/W2062803349","https://openalex.org/W2067363611","https://openalex.org/W2080064173","https://openalex.org/W2081898060","https://openalex.org/W2082365601","https://openalex.org/W2086405676","https://openalex.org/W2109910885","https://openalex.org/W2120337721","https://openalex.org/W2133508703","https://openalex.org/W2144646304","https://openalex.org/W2145573546","https://openalex.org/W2152568000"],"related_works":["https://openalex.org/W2382722815","https://openalex.org/W92363708","https://openalex.org/W2318452950","https://openalex.org/W1521414432","https://openalex.org/W2047362862","https://openalex.org/W1982886435","https://openalex.org/W2034507509","https://openalex.org/W2061006256","https://openalex.org/W2126019228","https://openalex.org/W7019165070"],"abstract_inverted_index":{"Les":[0],"prot\u00e9ines":[1,31,55,85,103,107],"G":[2,56,86,104],"sont":[3],"des":[4,54,102,106,191,201,206,223],"commutateurs":[5],"mol\u00e9culaires":[6],"contr\u00f4lant":[7],"divers":[8],"aspects":[9],"de":[10,27,43,98,134,182,203,208],"la":[11,16,20,66,118,178,189,195],"vie":[12],"cellulaire":[13],"tels":[14],"que":[15,83],"transduction":[17],"du":[18,22,68,74,186],"signal,":[19],"r\u00e9organisation":[21],"cytosquelette":[23,187],"et":[24,37,51,93,143,157,188],"les":[25,34,84,94,132,137,163,172],"m\u00e9canismes":[26],"transport":[28],"v\u00e9siculaire.":[29],"Ces":[30,210],"fixent":[32],"alternativement":[33],"nucl\u00e9otides":[35],"GDP":[36,69],"GTP,":[38],"ce":[39,216],"qui":[40,64],"leur":[41],"permet":[42],"transiter":[44],"entre":[45,131],"deux":[46],"conformations":[47],"structurelles,":[48],"respectivement":[49],"inactive":[50,120],"active.":[52],"L\u2019activation":[53],"r\u00e9sulte":[57],"d\u2019une":[58],"interaction":[59],"avec":[60,90],"un":[61,115,152,168],"facteur":[62,153],"d\u2019\u00e9change":[63,154],"stimule":[65],"dissociation":[67],"pour":[70,155,162,180],"le":[71,221],"remplacer":[72],"par":[73,105,177],"GTP.":[75],"C\u2019est":[76],"sous":[77],"cette":[78],"forme":[79,119],"li\u00e9e":[80,121],"au":[81,122],"GTP":[82],"vont":[87],"pouvoir":[88],"interagir":[89],"leurs":[91],"effecteurs":[92],"activer.":[95],"La":[96,145],"stimulation":[97],"l\u2019activit\u00e9":[99],"intrins\u00e8que":[100],"d\u2019hydrolyse":[101],"GAP":[108,161],"(GTPase":[109],"activating":[110],"protein)":[111],"va":[112],"conduire":[113],"\u00e0":[114,200,214],"retour":[116],"vers":[117],"GDP.":[123],"De":[124,193],"nombreuses":[125],"\u00e9tudes":[126],"ont":[127],"montr\u00e9":[128],"l\u2019existence":[129],"d\u2019interconnexions":[130],"voies":[133],"signalisation":[135,204],"impliquant":[136],"GTPases":[138],"ARF":[139],"(ADP":[140],"ribosylation":[141],"factor)":[142],"Rac/Cdc42.":[144],"d\u00e9couverte":[146],"d\u2019un":[147],"complexe":[148,217],"prot\u00e9ique":[149],"comprenant":[150,205],"PIX,":[151],"Rac/Cdc42":[156],"GIT1,":[158],"une":[159],"prot\u00e9ine":[160],"ARF,":[164],"a":[165],"r\u00e9cemment":[166],"donn\u00e9":[167],"nouvel":[169],"\u00e9clairage":[170],"sur":[171],"moyens":[173],"mis":[174],"en":[175,218],"oeuvre":[176],"cellule":[179],"r\u00e9guler":[181],"fa\u00e7on":[183],"\u00e9troite":[184],"l\u2019agencement":[185],"dynamique":[190],"membranes.":[192],"plus,":[194],"plate-forme":[196],"PIX-GIT1":[197],"est":[198],"associ\u00e9e":[199],"r\u00e9seaux":[202],"suppresseurs":[207],"tumeur.":[209],"donn\u00e9es":[211],"r\u00e9centes":[212],"incitent":[213],"prendre":[215],"consid\u00e9ration":[219],"dans":[220],"contexte":[222],"pathologies":[224],"canc\u00e9reuses.":[225]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
