{"id":"https://openalex.org/W2153246552","doi":"https://doi.org/10.4049/jimmunol.173.3.1711","title":"The Gads (GrpL) Adaptor Protein Regulates T Cell Homeostasis","display_name":"The Gads (GrpL) Adaptor Protein Regulates T Cell Homeostasis","publication_year":2004,"publication_date":"2004-08-01","ids":{"openalex":"https://openalex.org/W2153246552","doi":"https://doi.org/10.4049/jimmunol.173.3.1711","mag":"2153246552","pmid":"https://pubmed.ncbi.nlm.nih.gov/15265900"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.173.3.1711","doi":"https://doi.org/10.4049/jimmunol.173.3.1711","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.173.3.1711","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/173/3/1711/1185937/1711.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.aai.org/jimmunol/article-pdf/173/3/1711/1185937/1711.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000369032","display_name":"Thomas M. Yankee","orcid":"https://orcid.org/0000-0002-3907-4838","observed_orcids":["https://orcid.org/0000-0002-3907-4838"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas M Yankee","raw_affiliation_strings":["Department of Microbiology, University of Washington , Seattle, WA 98195","* Microbiology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Washington , Seattle, WA 98195","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"* Microbiology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000446895","display_name":"Theodore J. Yun","orcid":"https://orcid.org/0000-0002-5363-8409","observed_orcids":["https://orcid.org/0000-0002-5363-8409"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theodore J Yun","raw_affiliation_strings":["Department of Howard Hughes Medical Institute, University of Washington , Seattle, WA 98195","Department of Microbiology, University of Washington , Seattle, WA 98195","* Microbiology and","\u2021Howard Hughes Medical Institute, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Howard Hughes Medical Institute, University of Washington , Seattle, WA 98195","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Microbiology, University of Washington , Seattle, WA 98195","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"* Microbiology and","institution_ids":[]},{"raw_affiliation_string":"\u2021Howard Hughes Medical Institute, and","institution_ids":["https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015443347","display_name":"Kevin E. Draves","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin E Draves","raw_affiliation_strings":["Department of Microbiology, University of Washington , Seattle, WA 98195","* Microbiology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Washington , Seattle, WA 98195","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"* Microbiology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113529371","display_name":"Kolumam A. Ganesh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kolumam Ganesh","raw_affiliation_strings":["Department of Immunology, University of Washington , Seattle, WA 98195","\u2020Immunology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Washington , Seattle, WA 98195","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"\u2020Immunology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088675599","display_name":"Michael J. Bevan","orcid":"https://orcid.org/0000-0002-8222-3739","observed_orcids":["https://orcid.org/0000-0002-8222-3739"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J Bevan","raw_affiliation_strings":["Department of Howard Hughes Medical Institute, University of Washington , Seattle, WA 98195","Department of Immunology, University of Washington , Seattle, WA 98195","\u2020Immunology,","\u2021Howard Hughes Medical Institute, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Howard Hughes Medical Institute, University of Washington , Seattle, WA 98195","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Immunology, University of Washington , Seattle, WA 98195","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"\u2020Immunology,","institution_ids":[]},{"raw_affiliation_string":"\u2021Howard Hughes Medical Institute, and","institution_ids":["https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087887010","display_name":"Kaja Murali\u2010Krishna","orcid":"https://orcid.org/0000-0002-6275-1710","observed_orcids":["https://orcid.org/0000-0002-6275-1710"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaja Murali-Krishna","raw_affiliation_strings":["Department of Immunology, University of Washington , Seattle, WA 98195","Department of National Primate Research Center, University of Washington , Seattle, WA 98195","\u00a7National Primate Research Center, University of Washington, Seattle, WA 98195","\u2020Immunology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Washington , Seattle, WA 98195","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of National Primate Research Center, University of Washington , Seattle, WA 98195","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"\u00a7National Primate Research Center, University of Washington, Seattle, WA 98195","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"\u2020Immunology,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004809714","display_name":"Edward A. Clark","orcid":"https://orcid.org/0000-0001-8061-5475","observed_orcids":["https://orcid.org/0000-0001-8061-5475"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward A Clark","raw_affiliation_strings":["Department of Immunology, University of Washington , Seattle, WA 98195","Department of Microbiology, University of Washington , Seattle, WA 98195","Department of National Primate Research Center, University of Washington , Seattle, WA 98195","* Microbiology and","\u00a7National Primate Research Center, University of Washington, Seattle, WA 98195","\u2020Immunology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Washington , Seattle, WA 98195","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Microbiology, University of Washington , Seattle, WA 98195","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of National Primate Research Center, University of Washington , Seattle, WA 98195","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"* Microbiology and","institution_ids":[]},{"raw_affiliation_string":"\u00a7National Primate Research Center, University of Washington, Seattle, WA 98195","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"\u2020Immunology,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":0.4805,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.64904819,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"173","issue":"3","first_page":"1711","last_page":"1720"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-homeostasis","display_name":"T cell homeostasis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":1.0},{"id":"https://openalex.org/keywords/homeostatic-proliferation","display_name":"homeostatic proliferation","score":0.9340000152587891},{"id":"https://openalex.org/keywords/t-cell-apoptosis","display_name":"T cell apoptosis","score":0.5849999785423279},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.8790000081062317},{"id":"https://openalex.org/keywords/t-cell-survival","display_name":"T cell survival","score":0.6169999837875366},{"id":"https://openalex.org/keywords/interferon-gamma-production","display_name":"IFN-gamma production","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7232728004455566},{"id":"https://openalex.org/C183786373","wikidata":"https://www.wikidata.org/wiki/Q5964993","display_name":"Signal transducing adaptor protein","level":3,"score":0.6471174955368042},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5996389985084534},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5778385400772095},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.540761411190033},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5096895694732666},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44579625129699707},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42985376715660095},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3306368589401245},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2512291371822357},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19581279158592224},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15725737810134888},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13675367832183838}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008221","descriptor_name":"Lymphoid Tissue","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008221","descriptor_name":"Lymphoid Tissue","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D015723","descriptor_name":"Gene Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019014","descriptor_name":"fas Receptor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019264","descriptor_name":"Adoptive Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.173.3.1711","doi":"https://doi.org/10.4049/jimmunol.173.3.1711","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.173.3.1711","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/173/3/1711/1185937/1711.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:15265900","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15265900","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.4049/jimmunol.173.3.1711","doi":"https://doi.org/10.4049/jimmunol.173.3.1711","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.173.3.1711","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/173/3/1711/1185937/1711.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1686745415","display_name":null,"funder_award_id":"AI45088","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2361968156","display_name":null,"funder_award_id":"RR01666","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2872605252","display_name":null,"funder_award_id":"AI44257","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4409352853","display_name":null,"funder_award_id":"RR001 66","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4869829055","display_name":"Cytotoxic Response to Histocompatibility Antigens","funder_award_id":"R01AI019335","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6952987319","display_name":"National Primate Research Center","funder_award_id":"P51RR000166","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G7458741828","display_name":"Role of B cell activating factor (BAFF) in B cell responses and autoimmunity","funder_award_id":"R01AI044257","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8057550728","display_name":"ADAPTOR PROTEINS REGULATING B CELL MATURATION","funder_award_id":"R01AI045088","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000024207","display_name":null,"funder_award_id":"AI44257","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2153246552.pdf","grobid_xml":"https://content.openalex.org/works/W2153246552.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W66302031","https://openalex.org/W1491270159","https://openalex.org/W1508676807","https://openalex.org/W1513677920","https://openalex.org/W1537543309","https://openalex.org/W1804832985","https://openalex.org/W1804861156","https://openalex.org/W1910447160","https://openalex.org/W1948282121","https://openalex.org/W1967382031","https://openalex.org/W1979504241","https://openalex.org/W1982148376","https://openalex.org/W1990634604","https://openalex.org/W1992438206","https://openalex.org/W1994047471","https://openalex.org/W2002943653","https://openalex.org/W2003246773","https://openalex.org/W2010077156","https://openalex.org/W2010435020","https://openalex.org/W2016894208","https://openalex.org/W2020559949","https://openalex.org/W2030254950","https://openalex.org/W2034946023","https://openalex.org/W2039970092","https://openalex.org/W2041215937","https://openalex.org/W2043363499","https://openalex.org/W2044304932","https://openalex.org/W2053463045","https://openalex.org/W2053894639","https://openalex.org/W2061625698","https://openalex.org/W2070049656","https://openalex.org/W2072013743","https://openalex.org/W2076886801","https://openalex.org/W2081613818","https://openalex.org/W2087025778","https://openalex.org/W2100646106","https://openalex.org/W2106251488","https://openalex.org/W2106818686","https://openalex.org/W2107225522","https://openalex.org/W2109495864","https://openalex.org/W2119731343","https://openalex.org/W2136555968","https://openalex.org/W2152093499","https://openalex.org/W2153014356","https://openalex.org/W2158299560","https://openalex.org/W2169930621","https://openalex.org/W2400056554"],"related_works":["https://openalex.org/W2098434055","https://openalex.org/W1939782964","https://openalex.org/W4313387798","https://openalex.org/W843597071","https://openalex.org/W4313380773","https://openalex.org/W2137691375","https://openalex.org/W4313350020","https://openalex.org/W2023231208","https://openalex.org/W7171511580","https://openalex.org/W2010077156"],"abstract_inverted_index":{"Little":[0],"is":[1,166,195],"known":[2],"about":[3],"the":[4,7,23,46,158,191],"role":[5],"of":[6,25,122,137,144,161,199],"Gads":[8,26,192],"(GrpL)":[9],"adaptor":[10,193],"protein":[11,194],"in":[12,45,83,96,107,171,181],"mature":[13],"T":[14,33,40,66,78,88,111,126,131,164,185,201],"cell":[15,146,172],"populations.":[16],"In":[17],"this":[18],"study":[19],"we":[20],"show":[21],"that":[22,157,178],"effects":[24],"deficiency":[27],"on":[28],"murine":[29],"CD4(+)":[30,39,65,77,125,163,182,200],"and":[31,48,53,102,140,148,183,190],"CD8(+)":[32,87,130,184],"cells":[34,41,67,89,112,165,186],"are":[35,187],"markedly":[36,43],"different.":[37],"Gads(-/-)":[38,64,86,110,124,162],"were":[42,149],"deficient":[44],"spleen":[47],"had":[49,90,113,119,133],"an":[50],"activated":[51],"phenotype":[52],"a":[54,61,72,81,91,134,141,169],"rapid":[55,159],"turnover":[56,160],"rate.":[57],"When":[58],"transferred":[59],"into":[60],"wild-type":[62,76,108],"host,":[63],"continued":[68],"to":[69,98,152,168],"proliferate":[70],"at":[71],"higher":[73],"rate":[74,143],"than":[75],"cells,":[79,127,132],"demonstrating":[80],"defect":[82,170],"homeostatic":[84,105],"proliferation.":[85],"memory-like":[92],"phenotype,":[93],"produced":[94],"IFN-gamma":[95],"response":[97],"ex":[99],"vivo":[100],"stimulation,":[101],"underwent":[103],"normal":[104,120],"proliferation":[106,139],"hosts.":[109],"defective":[114],"TCR-mediated":[115,138],"calcium":[116],"responses,":[117],"but":[118,128],"activation":[121],"ERK.":[123],"not":[129],"severe":[135],"block":[136],"high":[142],"spontaneous":[145],"death":[147],"highly":[150],"susceptible":[151],"CD95-induced":[153],"apoptosis.":[154],"This":[155],"suggests":[156],"due":[167],"survival.":[173],"The":[174],"intracellular":[175],"signaling":[176],"pathways":[177],"regulate":[179],"homeostasis":[180,198],"clearly":[188],"different,":[189],"critical":[196],"for":[197],"cells.":[202]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}