{"id":"https://openalex.org/W2153236178","doi":"https://doi.org/10.1586/erm.12.71","title":"Nucleic acid testing for tuberculosis at the point-of-care in high-burden countries","display_name":"Nucleic acid testing for tuberculosis at the point-of-care in high-burden countries","publication_year":2012,"publication_date":"2012-09-01","ids":{"openalex":"https://openalex.org/W2153236178","doi":"https://doi.org/10.1586/erm.12.71","mag":"2153236178","pmid":"https://pubmed.ncbi.nlm.nih.gov/23153237","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3740172"},"language":"en","primary_location":{"id":"doi:10.1586/erm.12.71","doi":"https://doi.org/10.1586/erm.12.71","is_oa":false,"landing_page_url":"https://doi.org/10.1586/erm.12.71","pdf_url":null,"source":{"id":"https://openalex.org/S124386304","display_name":"Expert Review of Molecular Diagnostics","issn_l":"1473-7159","issn":["1473-7159","1744-8352"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Molecular Diagnostics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3740172","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035475519","display_name":"Angelika Niemz","orcid":"https://orcid.org/0000-0001-7385-1541","observed_orcids":["https://orcid.org/0000-0001-7385-1541"]},"institutions":[{"id":"https://openalex.org/I90708416","display_name":"Keck Graduate Institute","ror":"https://ror.org/00f4jdp82","country_code":"US","type":"education","lineage":["https://openalex.org/I90708416"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angelika Niemz","raw_affiliation_strings":["Keck Graduate Institute of Applied Life Sciences, 535 Watson Drive, Claremont, CA 91711, USA","Keck Graduate Institute of Applied Life Sciences, 535 Watson Drive, Claremont, CA 91711, USA. aniemz@kgi.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Keck Graduate Institute of Applied Life Sciences, 535 Watson Drive, Claremont, CA 91711, USA","institution_ids":["https://openalex.org/I90708416"]},{"raw_affiliation_string":"Keck Graduate Institute of Applied Life Sciences, 535 Watson Drive, Claremont, CA 91711, USA. aniemz@kgi.edu","institution_ids":["https://openalex.org/I90708416"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103224060","display_name":"David S. Boyle","orcid":"https://orcid.org/0000-0003-4019-9037","observed_orcids":["https://orcid.org/0000-0003-4019-9037"]},"institutions":[{"id":"https://openalex.org/I1304598786","display_name":"Program for Appropriate Technology in Health","ror":"https://ror.org/02ycvrx49","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1304598786"]},{"id":"https://openalex.org/I4210099049","display_name":"Program for Appropriate Technology in Health","ror":"https://ror.org/0150cj610","country_code":"IN","type":"nonprofit","lineage":["https://openalex.org/I1304598786","https://openalex.org/I4210099049"]}],"countries":["IN","US"],"is_corresponding":false,"raw_author_name":"David S Boyle","raw_affiliation_strings":["Program for Appropriate Technology in Health, 2201 Westlake Ave, Suite 200, Seattle, WA 98121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program for Appropriate Technology in Health, 2201 Westlake Ave, Suite 200, Seattle, WA 98121, USA","institution_ids":["https://openalex.org/I1304598786","https://openalex.org/I4210099049"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.9656,"has_fulltext":false,"cited_by_count":74,"citation_normalized_percentile":{"value":0.96890621,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"12","issue":"7","first_page":"687","last_page":"701"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tuberculosis-diagnosis","display_name":"tuberculosis diagnosis","score":0.9259999990463257},{"id":"https://openalex.org/keywords/nucleic-acid-amplification-testing","display_name":"nucleic acid amplification tests","score":0.9440000057220459},{"id":"https://openalex.org/keywords/point-of-care-testing","display_name":"point-of-care testing","score":0.9729999899864197},{"id":"https://openalex.org/keywords/rapid-molecular-diagnostics","display_name":"rapid molecular diagnostics","score":0.7289999723434448},{"id":"https://openalex.org/keywords/isothermal-amplification","display_name":"isothermal amplification","score":0.7870000004768372},{"id":"https://openalex.org/keywords/pcr-based-assays","display_name":"PCR-based assays","score":0.6240000128746033},{"id":"https://openalex.org/keywords/drug-resistant-tuberculosis","display_name":"drug-resistant tuberculosis","score":0.9620000123977661},{"id":"https://openalex.org/keywords/hiv-coinfection","display_name":"HIV coinfection","score":0.7599999904632568},{"id":"https://openalex.org/keywords/pediatric-tuberculosis","display_name":"pediatric tuberculosis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/resource-limited-settings","display_name":"resource-limited settings","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.813329815864563},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6961701512336731},{"id":"https://openalex.org/C170130773","wikidata":"https://www.wikidata.org/wiki/Q216378","display_name":"Usability","level":2,"score":0.6147845387458801},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5466088652610779},{"id":"https://openalex.org/C51915194","wikidata":"https://www.wikidata.org/wiki/Q17075487","display_name":"Point of care","level":2,"score":0.5391412973403931},{"id":"https://openalex.org/C64841741","wikidata":"https://www.wikidata.org/wiki/Q491983","display_name":"Point-of-care testing","level":2,"score":0.5091528296470642},{"id":"https://openalex.org/C106436119","wikidata":"https://www.wikidata.org/wiki/Q836575","display_name":"Quality assurance","level":3,"score":0.49645429849624634},{"id":"https://openalex.org/C534262118","wikidata":"https://www.wikidata.org/wiki/Q177719","display_name":"Medical diagnosis","level":2,"score":0.4459378719329834},{"id":"https://openalex.org/C2780639635","wikidata":"https://www.wikidata.org/wiki/Q4888238","display_name":"Tuberculosis diagnosis","level":4,"score":0.4421547055244446},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42567822337150574},{"id":"https://openalex.org/C2909633786","wikidata":"https://www.wikidata.org/wiki/Q348667","display_name":"Nucleic Acid Amplification Tests","level":3,"score":0.42376819252967834},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.42263495922088623},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.3434617221355438},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23776322603225708},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2210141122341156},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.15847554802894592},{"id":"https://openalex.org/C2778618615","wikidata":"https://www.wikidata.org/wiki/Q4008393","display_name":"External quality assessment","level":2,"score":0.09815278649330139},{"id":"https://openalex.org/C107457646","wikidata":"https://www.wikidata.org/wiki/Q207434","display_name":"Human\u2013computer interaction","level":1,"score":0.0},{"id":"https://openalex.org/C2777391075","wikidata":"https://www.wikidata.org/wiki/Q131065","display_name":"Chlamydia trachomatis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003906","descriptor_name":"Developing Countries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D019095","descriptor_name":"Point-of-Care Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021141","descriptor_name":"Nucleic Acid Amplification Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1586/erm.12.71","doi":"https://doi.org/10.1586/erm.12.71","is_oa":false,"landing_page_url":"https://doi.org/10.1586/erm.12.71","pdf_url":null,"source":{"id":"https://openalex.org/S124386304","display_name":"Expert Review of Molecular Diagnostics","issn_l":"1473-7159","issn":["1473-7159","1744-8352"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Molecular Diagnostics","raw_type":"journal-article"},{"id":"pmid:23153237","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23153237","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert review of molecular diagnostics","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2752981","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3740172","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3740172","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3740172","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Expert Rev Mol Diagn","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2752981","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3740172","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.4399999976158142,"display_name":"Partnerships for the goals","id":"https://metadata.un.org/sdg/17"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2526889284","display_name":"Recombinase Polymerase Amplification for Point-of-Care Diagnosis of Infant HIV-1","funder_award_id":"R01AI097038","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4253122694","display_name":"Rapid Diagnosis of MDR TB from Sputum using a Small Fully Integrated Nucleic Acid","funder_award_id":"R01AI090831","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W71396311","https://openalex.org/W196907809","https://openalex.org/W300344787","https://openalex.org/W1502467014","https://openalex.org/W1684152776","https://openalex.org/W1748737970","https://openalex.org/W1907340751","https://openalex.org/W1976575734","https://openalex.org/W1977998612","https://openalex.org/W1979930182","https://openalex.org/W1982507912","https://openalex.org/W1983144055","https://openalex.org/W1998095407","https://openalex.org/W1999271936","https://openalex.org/W2001414564","https://openalex.org/W2012144531","https://openalex.org/W2012955978","https://openalex.org/W2016882071","https://openalex.org/W2036370347","https://openalex.org/W2041075648","https://openalex.org/W2041298534","https://openalex.org/W2045855653","https://openalex.org/W2048255163","https://openalex.org/W2049979497","https://openalex.org/W2050604127","https://openalex.org/W2057876450","https://openalex.org/W2061068281","https://openalex.org/W2064004679","https://openalex.org/W2066086624","https://openalex.org/W2073435936","https://openalex.org/W2073934376","https://openalex.org/W2074529500","https://openalex.org/W2079046645","https://openalex.org/W2084242120","https://openalex.org/W2089866381","https://openalex.org/W2095652241","https://openalex.org/W2101080794","https://openalex.org/W2101975077","https://openalex.org/W2103356891","https://openalex.org/W2105637323","https://openalex.org/W2107554560","https://openalex.org/W2109492080","https://openalex.org/W2109751189","https://openalex.org/W2112022845","https://openalex.org/W2113187661","https://openalex.org/W2114090343","https://openalex.org/W2122098181","https://openalex.org/W2124344963","https://openalex.org/W2124511060","https://openalex.org/W2128056123","https://openalex.org/W2132658179","https://openalex.org/W2133543850","https://openalex.org/W2135875946","https://openalex.org/W2145510128","https://openalex.org/W2153350094","https://openalex.org/W2154326381","https://openalex.org/W2160459224","https://openalex.org/W2162859059","https://openalex.org/W2162954064","https://openalex.org/W2165845866","https://openalex.org/W2165898417","https://openalex.org/W2166315112","https://openalex.org/W2167026482","https://openalex.org/W2168848141","https://openalex.org/W2170895924","https://openalex.org/W2437467664","https://openalex.org/W4255264726"],"related_works":["https://openalex.org/W2048255163","https://openalex.org/W2240486824","https://openalex.org/W3090882943","https://openalex.org/W4405326638","https://openalex.org/W1533255434","https://openalex.org/W1506943065","https://openalex.org/W1989719864","https://openalex.org/W3114554031","https://openalex.org/W4414304956","https://openalex.org/W4293112528"],"abstract_inverted_index":{"Early":[0],"diagnosis":[1,119],"of":[2,14,113],"tuberculosis":[3],"(TB)":[4],"facilitates":[5],"appropriate":[6],"treatment":[7],"initiation":[8],"and":[9,30,77,98,116,122],"can":[10],"limit":[11],"the":[12,63,111],"spread":[13],"this":[15],"highly":[16],"contagious":[17],"disease.":[18],"However,":[19],"commonly":[20],"used":[21],"TB":[22,36,58,115,118],"diagnostic":[23],"methods":[24,76],"are":[25,51,61,70,78],"slow,":[26],"often":[27],"insensitive,":[28],"cumbersome":[29],"inaccessible":[31],"to":[32],"most":[33],"patients":[34],"in":[35,62,100,120],"endemic":[37],"countries":[38],"that":[39,60],"lack":[40],"necessary":[41],"resources.":[42],"This":[43],"review":[44],"discusses":[45],"nucleic":[46],"acid":[47],"amplification":[48],"technologies,":[49],"which":[50],"being":[52],"developed":[53],"for":[54,110,117],"rapid":[55],"near":[56],"patient":[57],"diagnosis,":[59],"market":[64],"or":[65,74,83],"undergoing":[66],"clinical":[67,92],"evaluation.":[68],"They":[69],"based":[71],"on":[72],"PCR":[73],"isothermal":[75],"implemented":[79],"as":[80],"manual":[81],"assays":[82],"partially/fully":[84],"integrated":[85],"instrument":[86],"systems,":[87],"with":[88],"associated":[89],"tradeoffs":[90],"between":[91],"performance,":[93],"cost,":[94],"robustness,":[95],"quality":[96],"assurance":[97],"usability":[99],"remote":[101],"settings":[102],"by":[103],"minimally":[104],"trained":[105],"personnel.":[106],"Unmet":[107],"needs":[108],"prevail":[109],"identification":[112],"drug-resistant":[114],"HIV-positive":[121],"pediatric":[123],"patients.":[124]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":11}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
