{"id":"https://openalex.org/W2153227360","doi":"https://doi.org/10.1084/jem.20020234","title":"Protein Kinase C \u03b8 Affects Ca2+ Mobilization and NFAT Activation in Primary Mouse T Cells","display_name":"Protein Kinase C \u03b8 Affects Ca2+ Mobilization and NFAT Activation in Primary Mouse T Cells","publication_year":2003,"publication_date":"2003-06-02","ids":{"openalex":"https://openalex.org/W2153227360","doi":"https://doi.org/10.1084/jem.20020234","mag":"2153227360","pmid":"https://pubmed.ncbi.nlm.nih.gov/12782715","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2193906"},"language":"en","primary_location":{"id":"doi:10.1084/jem.20020234","doi":"https://doi.org/10.1084/jem.20020234","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.20020234","pdf_url":"https://rupress.org/jem/article-pdf/197/11/1525/1142942/jem197111525.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://rupress.org/jem/article-pdf/197/11/1525/1142942/jem197111525.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006347511","display_name":"Christa Pfeifhofer\u2010Obermair","orcid":"https://orcid.org/0000-0002-9942-6540","observed_orcids":["https://orcid.org/0000-0002-9942-6540"]},"institutions":[{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Christa Pfeifhofer","raw_affiliation_strings":["1Institute of Medical Biology and Human Genetics, University of Innsbruck, A-6020 Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute of Medical Biology and Human Genetics, University of Innsbruck, A-6020 Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072265568","display_name":"Kurt Kofler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Kurt Kofler","raw_affiliation_strings":["1Institute of Medical Biology and Human Genetics, University of Innsbruck, A-6020 Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute of Medical Biology and Human Genetics, University of Innsbruck, A-6020 Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041673676","display_name":"Thomas Gruber","orcid":"https://orcid.org/0000-0002-5796-7090","observed_orcids":["https://orcid.org/0000-0002-5796-7090"]},"institutions":[{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Thomas Gruber","raw_affiliation_strings":["1Institute of Medical Biology and Human Genetics, University of Innsbruck, A-6020 Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute of Medical Biology and Human Genetics, University of Innsbruck, A-6020 Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074497583","display_name":"Nassim Ghaffari\u2010Tabrizi\u2010Wizsy","orcid":"https://orcid.org/0000-0001-6696-8717","observed_orcids":["https://orcid.org/0000-0001-6696-8717"]},"institutions":[{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Nassim Ghaffari Tabrizi","raw_affiliation_strings":["1Institute of Medical Biology and Human Genetics, University of Innsbruck, A-6020 Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute of Medical Biology and Human Genetics, University of Innsbruck, A-6020 Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Christina Lutz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Christina Lutz","raw_affiliation_strings":["1Institute of Medical Biology and Human Genetics, University of Innsbruck, A-6020 Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute of Medical Biology and Human Genetics, University of Innsbruck, A-6020 Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111684268","display_name":"Karl Maly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Karl Maly","raw_affiliation_strings":["2Institute of Medical Biochemistry, University of Innsbruck, A-6020 Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Institute of Medical Biochemistry, University of Innsbruck, A-6020 Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067987771","display_name":"Michael Leitges","orcid":"https://orcid.org/0000-0003-4203-6995","observed_orcids":["https://orcid.org/0000-0003-4203-6995"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Leitges","raw_affiliation_strings":["3Max-Planck Institute for Experimental Endocrinology, D-30625 Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Max-Planck Institute for Experimental Endocrinology, D-30625 Hannover, Germany","institution_ids":["https://openalex.org/I149899117"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039033483","display_name":"Gottfried Baier","orcid":"https://orcid.org/0000-0002-2085-8325","observed_orcids":["https://orcid.org/0000-0002-2085-8325"]},"institutions":[{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Gottfried Baier","raw_affiliation_strings":["1Institute of Medical Biology and Human Genetics, University of Innsbruck, A-6020 Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute of Medical Biology and Human Genetics, University of Innsbruck, A-6020 Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039033483"],"corresponding_institution_ids":["https://openalex.org/I190249584"],"apc_list":null,"apc_paid":null,"fwci":7.3513,"has_fulltext":true,"cited_by_count":331,"citation_normalized_percentile":{"value":0.98560063,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"197","issue":"11","first_page":"1525","last_page":"1535"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-kinase-c-theta","display_name":"protein kinase C theta","score":0.9729999899864197},{"id":"https://openalex.org/keywords/nfat-activation","display_name":"NFAT activation","score":0.7400000095367432},{"id":"https://openalex.org/keywords/calcium-mobilization","display_name":"calcium mobilization","score":0.8510000109672546},{"id":"https://openalex.org/keywords/inositol-1-4-5-trisphosphate","display_name":"inositol 1,4,5-trisphosphate","score":0.9290000200271606},{"id":"https://openalex.org/keywords/t-cell-receptor-signaling","display_name":"T cell receptor signaling","score":0.7889999747276306},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.7409999966621399},{"id":"https://openalex.org/keywords/il-2-production","display_name":"IL-2 production","score":0.9399999976158142},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.984000027179718},{"id":"https://openalex.org/keywords/immunological-synapse","display_name":"immunological synapse","score":0.9459999799728394},{"id":"https://openalex.org/keywords/cd3-cd28-costimulation","display_name":"anti-CD3/CD28 stimulation","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C189938988","wikidata":"https://www.wikidata.org/wiki/Q24744925","display_name":"NFAT","level":4,"score":0.9012900590896606},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.7596886157989502},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7156640887260437},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5343498587608337},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5089066028594971},{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.4647331237792969},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.44051721692085266},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43523168563842773},{"id":"https://openalex.org/C148125776","wikidata":"https://www.wikidata.org/wiki/Q1622348","display_name":"CD28","level":4,"score":0.4293646514415741},{"id":"https://openalex.org/C9756297","wikidata":"https://www.wikidata.org/wiki/Q126223","display_name":"Immunological synapse","level":5,"score":0.41572606563568115},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.32915857434272766},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.2612617313861847},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2013823390007019},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15151914954185486},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13287058472633362},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.11018529534339905},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09439530968666077},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.09155920147895813}],"mesh":[{"descriptor_ui":"D000074121","descriptor_name":"Protein Kinase C-theta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017260","descriptor_name":"Receptor-CD3 Complex, Antigen, T-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050778","descriptor_name":"NFATC Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1084/jem.20020234","doi":"https://doi.org/10.1084/jem.20020234","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.20020234","pdf_url":"https://rupress.org/jem/article-pdf/197/11/1525/1142942/jem197111525.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},{"id":"pmid:12782715","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12782715","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2193906","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2193906/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.282.8928","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.282.8928","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/d5/12/J_Exp_Med_2003_Jun_2_197(11)_1525-1535.tar.gz","raw_type":"text"},{"id":"pmh:oai:edoc.mpg.de:112115","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mpg.de/112115","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Experimental Medicine, v.197, 1525-1535 (2003)","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1084/jem.20020234","doi":"https://doi.org/10.1084/jem.20020234","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.20020234","pdf_url":"https://rupress.org/jem/article-pdf/197/11/1525/1142942/jem197111525.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.766700029373169}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2153227360.pdf","grobid_xml":"https://content.openalex.org/works/W2153227360.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1481377618","https://openalex.org/W1497509454","https://openalex.org/W1794979908","https://openalex.org/W1927121266","https://openalex.org/W1977762182","https://openalex.org/W1978355305","https://openalex.org/W1989342624","https://openalex.org/W1991210089","https://openalex.org/W1995636937","https://openalex.org/W1996024251","https://openalex.org/W1999653497","https://openalex.org/W2001064691","https://openalex.org/W2010428440","https://openalex.org/W2011738951","https://openalex.org/W2012871894","https://openalex.org/W2013056080","https://openalex.org/W2015001083","https://openalex.org/W2016206413","https://openalex.org/W2021911222","https://openalex.org/W2025219269","https://openalex.org/W2027535477","https://openalex.org/W2039392072","https://openalex.org/W2044406741","https://openalex.org/W2053463045","https://openalex.org/W2058811157","https://openalex.org/W2068817531","https://openalex.org/W2080866951","https://openalex.org/W2082502466","https://openalex.org/W2085586163","https://openalex.org/W2086524338","https://openalex.org/W2096432487","https://openalex.org/W2099764547","https://openalex.org/W2106645663","https://openalex.org/W2111910803","https://openalex.org/W2118367937","https://openalex.org/W2138375420","https://openalex.org/W2141260882","https://openalex.org/W2141679273","https://openalex.org/W2144935474","https://openalex.org/W2163295981","https://openalex.org/W2166570978","https://openalex.org/W2327006078","https://openalex.org/W2461527170","https://openalex.org/W4243223027","https://openalex.org/W4253930413"],"related_works":["https://openalex.org/W7101014972","https://openalex.org/W4239168516","https://openalex.org/W2032896464","https://openalex.org/W2025924171","https://openalex.org/W7073891131","https://openalex.org/W2137154569","https://openalex.org/W2026123712","https://openalex.org/W1999653497","https://openalex.org/W1995636937","https://openalex.org/W2067084179"],"abstract_inverted_index":{"Protein":[0],"kinase":[1],"C":[2],"(PKC)theta":[3],"is":[4],"an":[5],"established":[6],"component":[7],"of":[8,19,28,67],"the":[9,17,25],"immunological":[10],"synapse":[11],"and":[12,21,46,94,106],"has":[13],"been":[14],"implicated":[15],"in":[16,40,54,109],"control":[18],"AP-1":[20],"NF-kappaB.":[22],"To":[23],"study":[24],"physiological":[26],"function":[27],"PKCtheta,":[29],"we":[30,60],"used":[31],"gene":[32],"targeting":[33],"to":[34,86,89],"generate":[35],"a":[36,104],"PKCtheta":[37,68,102],"null":[38],"allele":[39],"mice.":[41],"Consistently,":[42],"interleukin":[43],"2":[44],"production":[45],"T":[47,56,110],"cell":[48,111],"proliferative":[49],"responses":[50],"were":[51],"strongly":[52],"reduced":[53,90],"PKCtheta-deficient":[55],"cells.":[57],"Surprisingly,":[58],"however,":[59],"demonstrate":[61],"that":[62,101],"after":[63],"CD3/CD28":[64],"engagement,":[65],"deficiency":[66],"primarily":[69],"abrogates":[70],"NFAT":[71,82,113],"transactivation.":[72],"In":[73],"contrast,":[74],"NF-kappaB":[75],"activation":[76],"was":[77],"only":[78],"partially":[79],"reduced.":[80],"This":[81],"transactivation":[83],"defect":[84],"appears":[85],"be":[87],"secondary":[88],"inositol":[91],"1,4,5-trisphosphate":[92],"generation":[93],"intracellular":[95],"Ca2+":[96],"mobilization.":[97],"Our":[98],"finding":[99],"suggests":[100],"plays":[103],"critical":[105],"nonredundant":[107],"role":[108],"receptor-induced":[112],"activation.":[114]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":20}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}