{"id":"https://openalex.org/W215318713","doi":null,"title":"Neural melanocortin receptors are differentially expressed and regulated by stress in rat hypothalamic-pituitary-adrenal axis.","display_name":"Neural melanocortin receptors are differentially expressed and regulated by stress in rat hypothalamic-pituitary-adrenal axis.","publication_year":2004,"publication_date":"2004-09-01","ids":{"openalex":"https://openalex.org/W215318713","mag":"215318713","pmid":"https://pubmed.ncbi.nlm.nih.gov/15641161"},"language":"en","primary_location":{"id":"pmid:15641161","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15641161","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and molecular biology (Noisy-le-Grand, France)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045411150","display_name":"S J Wachira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83909951","display_name":"Morgan State University","ror":"https://ror.org/017d8gk22","country_code":"US","type":"education","lineage":["https://openalex.org/I83909951"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S J Wachira","raw_affiliation_strings":["Morgan State University, Department of Biology, Baltimore, Maryland 21251, USA. jwachir@morgan.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Morgan State University, Department of Biology, Baltimore, Maryland 21251, USA. jwachir@morgan.edu","institution_ids":["https://openalex.org/I83909951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012377585","display_name":"Cleo Hughes\u2010Darden","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C A Hughes-Darden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055103581","display_name":"H B Nicholas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H B Nicholas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"C V Taylor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C V Taylor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"T J Robinson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T J Robinson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2234,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.42301545,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"50","issue":"6","first_page":"703","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.6762999892234802,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.6762999892234802,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.18629999458789825,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.11330000311136246,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanocortin-receptors","display_name":"melanocortin receptors","score":0.9549999833106995},{"id":"https://openalex.org/keywords/melanocortin-3-receptor","display_name":"melanocortin 3 receptor","score":0.8410000205039978},{"id":"https://openalex.org/keywords/melanocortin-4-receptor","display_name":"melanocortin-4 receptor","score":1.0},{"id":"https://openalex.org/keywords/melanocortin-5-receptor","display_name":"MC5R","score":1.0},{"id":"https://openalex.org/keywords/proopiomelanocortin","display_name":"proopiomelanocortin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.9160000085830688},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.796999990940094},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6740000247955322},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.8479999899864197},{"id":"https://openalex.org/keywords/adrenal-gland","display_name":"adrenal gland","score":0.9819999933242798},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.902999997138977}],"concepts":[{"id":"https://openalex.org/C2779993316","wikidata":"https://www.wikidata.org/wiki/Q6591465","display_name":"Melanocortin","level":3,"score":0.9605684280395508},{"id":"https://openalex.org/C2781309135","wikidata":"https://www.wikidata.org/wiki/Q418896","display_name":"Proopiomelanocortin","level":3,"score":0.8853472471237183},{"id":"https://openalex.org/C43790157","wikidata":"https://www.wikidata.org/wiki/Q21118678","display_name":"Melanocortin 3 receptor","level":5,"score":0.7793594002723694},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7282776832580566},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7179760932922363},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6964282989501953},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.6444917321205139},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5816208124160767},{"id":"https://openalex.org/C2777241137","wikidata":"https://www.wikidata.org/wiki/Q24784850","display_name":"Melanocortin receptor","level":4,"score":0.5655230283737183},{"id":"https://openalex.org/C2780694816","wikidata":"https://www.wikidata.org/wiki/Q712294","display_name":"Adrenal gland","level":2,"score":0.4695601761341095},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.24638795852661133},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22290343046188354},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12162145972251892}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007030","descriptor_name":"Hypothalamo-Hypophyseal System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010913","descriptor_name":"Pituitary-Adrenal System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011333","descriptor_name":"Pro-Opiomelanocortin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011333","descriptor_name":"Pro-Opiomelanocortin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018043","descriptor_name":"Receptors, Corticotropin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018043","descriptor_name":"Receptors, Corticotropin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020187","descriptor_name":"REM Sleep Behavior Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020187","descriptor_name":"REM Sleep Behavior Disorder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044101","descriptor_name":"Receptors, Melanocortin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D044101","descriptor_name":"Receptors, Melanocortin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044101","descriptor_name":"Receptors, Melanocortin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044104","descriptor_name":"Receptor, Melanocortin, Type 3","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D044104","descriptor_name":"Receptor, Melanocortin, Type 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044104","descriptor_name":"Receptor, Melanocortin, Type 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044105","descriptor_name":"Receptor, Melanocortin, Type 4","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D044105","descriptor_name":"Receptor, Melanocortin, Type 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044105","descriptor_name":"Receptor, Melanocortin, Type 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15641161","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15641161","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and molecular biology (Noisy-le-Grand, France)","raw_type":"Journal Article"},{"id":"mag:215318713","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15641161","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1219338537","display_name":"MBRS SCORE Program at Morgan State University","funder_award_id":"S06GM051971","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4843981792","display_name":"Morgan State University Biomedical Research Center(RCMI)","funder_award_id":"G12RR017581","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G670182233","display_name":"Assisting Bioinformatics Efforts at Minority Schools","funder_award_id":"T36GM008789","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6837003917","display_name":"High Performance Computing for Biomedical Research","funder_award_id":"P41RR006009","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2068490946","https://openalex.org/W2064342896","https://openalex.org/W2233075382","https://openalex.org/W2951101553","https://openalex.org/W4306954825","https://openalex.org/W1982034861","https://openalex.org/W2948513891","https://openalex.org/W2011607277","https://openalex.org/W2801076365","https://openalex.org/W2156554178"],"abstract_inverted_index":{"Genetic":[0],"knockout":[1],"and":[2,21,31,56,64,86,105,145,147,169,183,193,199],"null":[3],"mutations":[4],"of":[5,38,59,78,99,132,153,178,206],"melanocortin":[6,41,126,180,201],"system":[7,42],"components":[8],"lead":[9],"to":[10,28,51,115,119],"phenotypes":[11],"that":[12,125,174],"recapitulate":[13],"the":[14,36,39,44,57,68,84,97,100,120,133,154,175,204],"metabolic":[15,30],"syndrome":[16],"such":[17],"as":[18],"obesity,":[19],"hypertension":[20],"insulin":[22],"resistance.":[23],"Since":[24],"stress":[25,45,55,207],"is":[26,123],"known":[27],"modify":[29],"cardiovascular":[32],"function,":[33],"we":[34],"hypothesized":[35],"involvement":[37],"neural":[40,179],"in":[43,67,83,96,109,129,166,203],"response.":[46],"Male":[47],"rats":[48],"were":[49,81,92],"subjected":[50],"rapid-eye-movement":[52],"sleep":[53],"deprivation":[54],"levels":[58,77],"proopiomelanocortin":[60],"(POMC),":[61],"MC3R,":[62,167],"MC4R":[63,113,146,168],"MC5R":[65,106],"transcripts":[66,80],"hypothalamic-pituitary-adrenal":[69],"axis":[70],"(HPA)":[71],"determined":[72,187],"by":[73,188],"real-time":[74],"PCR.":[75],"Increased":[76],"POMC":[79],"observed":[82],"hypothalamus":[85],"adrenal":[87],"gland":[88],"tissues":[89],"but":[90],"there":[91],"no":[93],"significant":[94],"changes":[95],"expression":[98],"receptors":[101,127,158],"genes.":[102],"Whereas":[103],"MC3R":[104,144,182],"are":[107,185],"expressed":[108],"all":[110],"HPA":[111],"tissues,":[112],"seems":[114],"be":[116],"restricted":[117],"mainly":[118],"hypothalamus.":[121],"It":[122],"possible":[124],"function":[128],"different":[130],"aspects":[131],"neuron.":[134],"In":[135],"vitro":[136],"studies":[137],"showed":[138],"similar":[139],"cellular":[140],"distribution":[141,191],"patterns":[142,192],"for":[143,197],"sequence":[148],"analyses":[149],"revealed":[150],"strong":[151],"conservation":[152],"putative":[155],"G-protein":[156],"coupled":[157],"(GPCR)":[159],"C-terminal":[160],"membrane":[161],"localization":[162],"signal,":[163],"EX(3-7)II/L":[164],"motif,":[165],"MC5R.":[170],"These":[171],"data":[172],"suggest":[173,194],"physiological":[176],"roles":[177],"receptors,":[181],"MC4R,":[184],"likely":[186],"distinct":[189],"tissue":[190],"a":[195],"role":[196],"hypothalamic":[198],"intra-adrenal":[200],"systems":[202],"manifestation":[205],"related":[208],"pathologies.":[209]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
