{"id":"https://openalex.org/W2153184502","doi":"https://doi.org/10.2337/diabetes.53.12.3142","title":"Endogenous Ghrelin in Pancreatic Islets Restricts Insulin Release by Attenuating Ca2+ Signaling in \u03b2-Cells","display_name":"Endogenous Ghrelin in Pancreatic Islets Restricts Insulin Release by Attenuating Ca2+ Signaling in \u03b2-Cells","publication_year":2004,"publication_date":"2004-12-01","ids":{"openalex":"https://openalex.org/W2153184502","doi":"https://doi.org/10.2337/diabetes.53.12.3142","mag":"2153184502","pmid":"https://pubmed.ncbi.nlm.nih.gov/15561944"},"language":"en","primary_location":{"id":"doi:10.2337/diabetes.53.12.3142","doi":"https://doi.org/10.2337/diabetes.53.12.3142","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diabetes.53.12.3142","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081735051","display_name":"Katsuya Dezaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuya Dezaki","raw_affiliation_strings":["Department of Physiology, Division of Integrative Physiology, Jichi Medical School, Kawachi, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Division of Integrative Physiology, Jichi Medical School, Kawachi, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082727375","display_name":"Hiroshi Hosoda","orcid":"https://orcid.org/0000-0002-5215-551X","observed_orcids":["https://orcid.org/0000-0002-5215-551X"]},"institutions":[{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Hosoda","raw_affiliation_strings":["Department of Biochemistry, National Cardiovascular Center Research Institute, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, National Cardiovascular Center Research Institute, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041218978","display_name":"Masafumi Kakei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203765153","display_name":"Akita University","ror":"https://ror.org/03hv1ad10","country_code":"JP","type":"education","lineage":["https://openalex.org/I203765153"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masafumi Kakei","raw_affiliation_strings":["Department of Internal Medicine, Division of Endocrinology, Diabetes Geriatric Medicine, Akita University School of Medicine, Akita, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Endocrinology, Diabetes Geriatric Medicine, Akita University School of Medicine, Akita, Japan","institution_ids":["https://openalex.org/I203765153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008988594","display_name":"Suzuko Hashiguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107139324","display_name":"Kagoshima University","ror":"https://ror.org/03ss88z23","country_code":"JP","type":"education","lineage":["https://openalex.org/I107139324"]},{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Suzuko Hashiguchi","raw_affiliation_strings":["Department of Physiology, Division of Integrative Physiology, Jichi Medical School, Kawachi, Tochigi, Japan","Second Department of Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Division of Integrative Physiology, Jichi Medical School, Kawachi, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386"]},{"raw_affiliation_string":"Second Department of Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan","institution_ids":["https://openalex.org/I107139324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100844068","display_name":"Masatomo Watanabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masatomo Watanabe","raw_affiliation_strings":["Department of Physiology, Division of Integrative Physiology, Jichi Medical School, Kawachi, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Division of Integrative Physiology, Jichi Medical School, Kawachi, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068354355","display_name":"Kenji Kangawa","orcid":"https://orcid.org/0000-0003-4784-5599","observed_orcids":["https://orcid.org/0000-0003-4784-5599"]},"institutions":[{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Kangawa","raw_affiliation_strings":["Department of Biochemistry, National Cardiovascular Center Research Institute, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, National Cardiovascular Center Research Institute, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021448631","display_name":"Toshihiko Yada","orcid":"https://orcid.org/0000-0002-4160-2652","observed_orcids":["https://orcid.org/0000-0002-4160-2652"]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshihiko Yada","raw_affiliation_strings":["Department of Physiology, Division of Integrative Physiology, Jichi Medical School, Kawachi, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Division of Integrative Physiology, Jichi Medical School, Kawachi, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.2277,"has_fulltext":false,"cited_by_count":371,"citation_normalized_percentile":{"value":0.98078401,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"53","issue":"12","first_page":"3142","last_page":"3151"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ghrelin","display_name":"ghrelin","score":0.9819999933242798},{"id":"https://openalex.org/keywords/pancreatic-islets","display_name":"pancreatic islets","score":0.7990000247955322},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.8270000219345093},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.9649999737739563},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.8769999742507935},{"id":"https://openalex.org/keywords/growth-hormone-secretagogue-receptor","display_name":"growth hormone secretagogue receptor","score":0.7850000262260437},{"id":"https://openalex.org/keywords/acylated-ghrelin","display_name":"acylated ghrelin","score":0.8650000095367432},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.7570000290870667},{"id":"https://openalex.org/keywords/blood-glucose-regulation","display_name":"blood glucose regulation","score":0.7480000257492065},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8619999885559082},{"id":"https://openalex.org/keywords/energy-homeostasis","display_name":"energy homeostasis","score":0.9900000095367432}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.9294039607048035},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.9210331439971924},{"id":"https://openalex.org/C2779357093","wikidata":"https://www.wikidata.org/wiki/Q422269","display_name":"Ghrelin","level":3,"score":0.884211540222168},{"id":"https://openalex.org/C2780161494","wikidata":"https://www.wikidata.org/wiki/Q3510429","display_name":"Secretagogue","level":3,"score":0.8283361792564392},{"id":"https://openalex.org/C2779168441","wikidata":"https://www.wikidata.org/wiki/Q14914301","display_name":"Growth hormone secretagogue receptor","level":4,"score":0.7832921743392944},{"id":"https://openalex.org/C2779855799","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic islets","level":4,"score":0.5992261171340942},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5650278329849243},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.49625879526138306},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4595789313316345},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4103524088859558},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38522017002105713},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.33570611476898193},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2889094948768616},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15110495686531067}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005951","descriptor_name":"Glucose Tolerance Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D036361","descriptor_name":"Peptide Hormones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D036361","descriptor_name":"Peptide Hormones","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054439","descriptor_name":"Ghrelin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2337/diabetes.53.12.3142","doi":"https://doi.org/10.2337/diabetes.53.12.3142","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diabetes.53.12.3142","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmid:15561944","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15561944","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.872.9128","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.872.9128","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://diabetes.diabetesjournals.org/content/53/12/3142.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1547329911","https://openalex.org/W1616806865","https://openalex.org/W1973955359","https://openalex.org/W1995734405","https://openalex.org/W1996284417","https://openalex.org/W1997067449","https://openalex.org/W2003577251","https://openalex.org/W2006713761","https://openalex.org/W2009667219","https://openalex.org/W2011325404","https://openalex.org/W2012455440","https://openalex.org/W2033468788","https://openalex.org/W2035600501","https://openalex.org/W2048194663","https://openalex.org/W2053680491","https://openalex.org/W2073360655","https://openalex.org/W2079529427","https://openalex.org/W2087357268","https://openalex.org/W2090389952","https://openalex.org/W2105551719","https://openalex.org/W2105573142","https://openalex.org/W2106149108","https://openalex.org/W2111908554","https://openalex.org/W2115549108","https://openalex.org/W2119580431","https://openalex.org/W2127182681","https://openalex.org/W2134304063","https://openalex.org/W2135340140","https://openalex.org/W2137475680","https://openalex.org/W2162943132","https://openalex.org/W2163314855","https://openalex.org/W2163865122","https://openalex.org/W2167612522","https://openalex.org/W2335980015","https://openalex.org/W2793654547"],"related_works":["https://openalex.org/W7098595324","https://openalex.org/W145323646","https://openalex.org/W2033587570","https://openalex.org/W2132676982","https://openalex.org/W2073055216","https://openalex.org/W1978727573","https://openalex.org/W47964854","https://openalex.org/W1599926903","https://openalex.org/W2163314855","https://openalex.org/W2144648093"],"abstract_inverted_index":{"Ghrelin,":[0],"isolated":[1,151],"from":[2],"the":[3,9,13,28,60,72,76,81,111,143,146,198,252,273],"human":[4],"and":[5,46,65,106,129,157,169,193,202,243,267],"rat":[6],"stomach,":[7],"is":[8,20],"endogenous":[10,57,86,223],"ligand":[11],"for":[12],"growth":[14],"hormone":[15],"(GH)":[16],"secretagogue":[17,94,137,154,200],"receptor,":[18],"which":[19],"expressed":[21],"in":[22,59,68,80,166,203,216,225,251],"a":[23,53,177,204],"variety":[24],"of":[25,56,62,75,85,91,145,240,255,260,276],"tissues,":[26],"including":[27],"pancreatic":[29,82],"islets.":[30,83],"It":[31],"has":[32],"been":[33],"shown":[34],"that":[35,222,244,270],"low":[36],"plasma":[37,103,126],"ghrelin":[38,58,87,119,141,161,175,189,224,271],"levels":[39,45],"correlates":[40],"with":[41,263],"elevated":[42,121],"fasting":[43,99,122],"insulin":[44,63,108,131,147,167,184,233],"type":[47],"2":[48],"diabetes.":[49],"Here":[50],"we":[51],"show":[52],"physiological":[54],"role":[55],"regulation":[61,275],"release":[64,168,234,266],"blood":[66,256],"glucose":[67,100,104,112,123,127],"rodents.":[69],"Acylated":[70],"ghrelin,":[71,261],"active":[73],"form":[74],"peptide,":[77],"was":[78],"detected":[79],"Counteraction":[84],"by":[88],"intraperitoneal":[89,117],"injection":[90],"specific":[92],"GH":[93,136,153,199,265],"receptor":[95,138,155,201],"antagonists":[96],"markedly":[97,162],"lowered":[98],"concentrations,":[101,124],"attenuated":[102,130,190],"elevation,":[105,128],"enhanced":[107,125,163],"responses":[109,132],"during":[110,133],"tolerance":[113,148],"test":[114],"(GTT).":[115],"Conversely,":[116],"exogenous":[118],"GH-independently":[120],"GTT.":[134],"Neither":[135],"antagonist":[139],"nor":[140],"affected":[142],"profiles":[144],"test.":[149],"In":[150,186],"islets,":[152],"blockade":[156],"antiserum":[158],"against":[159],"acylated":[160],"glucose-induced":[164,191,232],"increases":[165,196],"intracellular":[170],"Ca2+":[171,241],"concentration":[172,180],"([Ca2+]i),":[173],"whereas":[174],"at":[176,235],"relatively":[178],"high":[179],"(10":[181],"nmol/l)":[182],"suppressed":[183],"release.":[185],"single":[187,217],"beta-cells,":[188],"first-phase":[192],"oscillatory":[194],"[Ca2+]i":[195],"via":[197,238],"pertussis":[205],"toxin-sensitive":[206],"manner.":[207],"Ghrelin":[208],"also":[209],"increased":[210],"tetraethylammonium-sensitive":[211],"delayed":[212],"outward":[213],"K+":[214],"currents":[215],"beta-cells.":[218],"These":[219],"findings":[220],"reveal":[221],"islets":[226],"acts":[227],"on":[228],"beta-cells":[229],"to":[230],"restrict":[231],"least":[236],"partly":[237],"attenuation":[239],"signaling,":[242],"this":[245],"insulinostatic":[246],"action":[247],"may":[248],"be":[249],"implicated":[250],"upward":[253],"control":[254],"glucose.":[257],"This":[258],"function":[259],"together":[262],"inducing":[264],"feeding,":[268],"suggests":[269],"underlies":[272],"integrative":[274],"energy":[277],"homeostasis.":[278]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":21},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":22},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":24},{"year":2012,"cited_by_count":27}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}