{"id":"https://openalex.org/W2153182002","doi":"https://doi.org/10.3109/10731198309118815","title":"Evaluation of Collagen Crosslinking Techniques","display_name":"Evaluation of Collagen Crosslinking Techniques","publication_year":1983,"publication_date":"1983-01-01","ids":{"openalex":"https://openalex.org/W2153182002","doi":"https://doi.org/10.3109/10731198309118815","mag":"2153182002","pmid":"https://pubmed.ncbi.nlm.nih.gov/6091801"},"language":"en","primary_location":{"id":"doi:10.3109/10731198309118815","doi":"https://doi.org/10.3109/10731198309118815","is_oa":false,"landing_page_url":"https://doi.org/10.3109/10731198309118815","pdf_url":null,"source":{"id":"https://openalex.org/S4210240268","display_name":"Biomaterials Medical Devices and Artificial Organs","issn_l":"0090-5488","issn":["0090-5488"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315681","host_organization_name":"Marcel Dekker","host_organization_lineage":["https://openalex.org/P4310315681"],"host_organization_lineage_names":["Marcel Dekker"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials, Medical Devices, and Artificial Organs","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2153182002"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029680620","display_name":"Kevin S. Weadock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Weadock","raw_affiliation_strings":["Departments of Pathology and Surgery, Biomaterials Center, University of Medicine and Dentistry of New Jersey, Rutgers Medical School, Piscataway, New Jersey, 08854"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Surgery, Biomaterials Center, University of Medicine and Dentistry of New Jersey, Rutgers Medical School, Piscataway, New Jersey, 08854","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Robert M. Olson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M. Olson","raw_affiliation_strings":["Departments of Pathology and Surgery, Biomaterials Center, University of Medicine and Dentistry of New Jersey, Rutgers Medical School, Piscataway, New Jersey, 08854"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Surgery, Biomaterials Center, University of Medicine and Dentistry of New Jersey, Rutgers Medical School, Piscataway, New Jersey, 08854","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007354515","display_name":"Frederick H. Silver","orcid":"https://orcid.org/0000-0002-2480-9264","observed_orcids":["https://orcid.org/0000-0002-2480-9264"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick H. Silver","raw_affiliation_strings":["Departments of Pathology and Surgery, Biomaterials Center, University of Medicine and Dentistry of New Jersey, Rutgers Medical School, Piscataway, New Jersey, 08854"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Surgery, Biomaterials Center, University of Medicine and Dentistry of New Jersey, Rutgers Medical School, Piscataway, New Jersey, 08854","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2328,"has_fulltext":false,"cited_by_count":351,"citation_normalized_percentile":{"value":0.74895833,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"11","issue":"4","first_page":"293","last_page":"318"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12085","display_name":"Collagen: Extraction and Characterization","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12085","display_name":"Collagen: Extraction and Characterization","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11966","display_name":"Silk-based biomaterials and applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/collagen-cross-linking","display_name":"collagen cross-linking","score":0.9679999947547913},{"id":"https://openalex.org/keywords/collagen-films","display_name":"collagen films","score":0.9369999766349792},{"id":"https://openalex.org/keywords/glutaraldehyde","display_name":"glutaraldehyde","score":0.9409999847412109},{"id":"https://openalex.org/keywords/cyanamide","display_name":"cyanamide","score":0.8849999904632568},{"id":"https://openalex.org/keywords/uv-irradiation","display_name":"UV irradiation","score":0.7509999871253967},{"id":"https://openalex.org/keywords/dehydration","display_name":"dehydration","score":0.722000002861023},{"id":"https://openalex.org/keywords/collagenase-resistance","display_name":"collagenase resistance","score":0.8149999976158142},{"id":"https://openalex.org/keywords/swelling-ratio","display_name":"swelling ratio","score":0.6510000228881836},{"id":"https://openalex.org/keywords/elastic-modulus","display_name":"elastic modulus","score":0.7170000076293945},{"id":"https://openalex.org/keywords/tissue-ingrowth","display_name":"tissue ingrowth","score":0.8410000205039978},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.871999979019165},{"id":"https://openalex.org/keywords/collagen-biomaterials","display_name":"collagen-based biomaterials","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C2779606280","wikidata":"https://www.wikidata.org/wiki/Q414555","display_name":"Cyanamide","level":2,"score":0.8855724334716797},{"id":"https://openalex.org/C2777529624","wikidata":"https://www.wikidata.org/wiki/Q416475","display_name":"Glutaraldehyde","level":2,"score":0.8762960433959961},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.675508975982666},{"id":"https://openalex.org/C2778540859","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Swelling","level":2,"score":0.65004563331604},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.624934196472168},{"id":"https://openalex.org/C2778769901","wikidata":"https://www.wikidata.org/wiki/Q194290","display_name":"Dehydration","level":2,"score":0.6144416332244873},{"id":"https://openalex.org/C2780365088","wikidata":"https://www.wikidata.org/wiki/Q48318","display_name":"Urea","level":2,"score":0.5514711141586304},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.5147038102149963},{"id":"https://openalex.org/C2778394429","wikidata":"https://www.wikidata.org/wiki/Q304956","display_name":"Collagenase","level":3,"score":0.4950234293937683},{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.49349963665008545},{"id":"https://openalex.org/C2778414984","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biomaterial","level":2,"score":0.41130366921424866},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.36526209115982056},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.29571831226348877},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2796976566314697},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.1352868378162384},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13284331560134888},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003012","descriptor_name":"Microbial Collagenase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/10731198309118815","doi":"https://doi.org/10.3109/10731198309118815","is_oa":false,"landing_page_url":"https://doi.org/10.3109/10731198309118815","pdf_url":null,"source":{"id":"https://openalex.org/S4210240268","display_name":"Biomaterials Medical Devices and Artificial Organs","issn_l":"0090-5488","issn":["0090-5488"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315681","host_organization_name":"Marcel Dekker","host_organization_lineage":["https://openalex.org/P4310315681"],"host_organization_lineage_names":["Marcel Dekker"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials, Medical Devices, and Artificial Organs","raw_type":"journal-article"},{"id":"pmid:6091801","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6091801","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials, medical devices, and artificial organs","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W175628111","https://openalex.org/W601625487","https://openalex.org/W604002920","https://openalex.org/W1601346470","https://openalex.org/W1653038558","https://openalex.org/W1965995193","https://openalex.org/W2040176815","https://openalex.org/W2046317063","https://openalex.org/W2052660533","https://openalex.org/W2053537523","https://openalex.org/W2088884195","https://openalex.org/W2100837269","https://openalex.org/W2104669776","https://openalex.org/W2105465438","https://openalex.org/W2125240138","https://openalex.org/W2151869166","https://openalex.org/W2249129651","https://openalex.org/W2319445587","https://openalex.org/W2329501611","https://openalex.org/W4241521425"],"related_works":["https://openalex.org/W1993490033","https://openalex.org/W2080621574","https://openalex.org/W2033993336","https://openalex.org/W1971280448","https://openalex.org/W2602309809","https://openalex.org/W2242327641","https://openalex.org/W2100261886","https://openalex.org/W1966814265","https://openalex.org/W1967120924","https://openalex.org/W2093150067"],"abstract_inverted_index":{"The":[0],"properties":[1,15],"of":[2,16,42,48,57,60,67,101,153],"collagen":[3,43],"films":[4,17,44,53,78],"crosslinked":[5,18,79],"by":[6],"physical":[7],"and":[8,34,62,71,127],"chemical":[9],"techniques":[10,23,38],"were":[11],"compared":[12,111],"to":[13,27,55,73,77,112,135],"the":[14,150],"with":[19,80],"glutaraldehyde":[20],"(GTA).":[21],"Physical":[22],"studied":[24,39],"include":[25,40],"exposure":[26],"short":[28],"wave":[29],"(254":[30],"nm)":[31],"u.v.":[32],"irradiation":[33],"severe":[35,63,107,118],"dehydration.":[36],"Chemical":[37],"immersion":[41],"in":[45],"aqueous":[46,58],"solutions":[47,59],"cyanamide":[49,61,105,121],"or":[50,106,120],"GTA.":[51,81],"Collagen":[52],"exposed":[54],"combinations":[56],"dehydration":[64,108,119],"had":[65],"moduli":[66],"elasticity,":[68],"swelling":[69],"ratios":[70],"resistance":[72],"bacterial":[74],"collagenase":[75],"similar":[76],"Theoretical":[82],"calculations":[83],"based":[84],"on":[85,139],"amino":[86,96,126],"acid":[87,97],"composition":[88],"indicate":[89],"that":[90,163],"approximately":[91],"seven":[92],"times":[93],"as":[94,110],"many":[95],"residues":[98,129],"are":[99],"capable":[100],"forming":[102],"crosslinks":[103,123,146],"using":[104,117],"procedures":[109,134],"GTA":[113],"crosslinking.":[114],"In":[115],"addition,":[116],"forms":[122],"involving":[124],"both":[125],"carboxyl":[128],"which":[130],"may":[131,167],"allow":[132,168],"these":[133],"act":[136],"synergistically.":[137],"Based":[138],"our":[140],"studies":[141,161],"this":[142,154,164],"two-step":[143],"procedure":[144,166],"effectively":[145],"collagen-based":[147],"biomaterials":[148],"while":[149],"only":[151],"by-product":[152],"reaction":[155],"is":[156],"water-soluble":[157],"urea.":[158],"Preliminary":[159],"biocompatibility":[160],"suggest":[162],"crosslinking":[165],"for":[169],"pronounced":[170],"tissue":[171],"ingrowth.":[172]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}