{"id":"https://openalex.org/W2153176878","doi":"https://doi.org/10.1128/aac.00862-15","title":"Caspofungin Treatment of Aspergillus fumigatus Results in ChsG-Dependent Upregulation of Chitin Synthesis and the Formation of Chitin-Rich Microcolonies","display_name":"Caspofungin Treatment of Aspergillus fumigatus Results in ChsG-Dependent Upregulation of Chitin Synthesis and the Formation of Chitin-Rich Microcolonies","publication_year":2015,"publication_date":"2015-07-14","ids":{"openalex":"https://openalex.org/W2153176878","doi":"https://doi.org/10.1128/aac.00862-15","mag":"2153176878","pmid":"https://pubmed.ncbi.nlm.nih.gov/26169407","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4576100"},"language":"en","primary_location":{"id":"doi:10.1128/aac.00862-15","doi":"https://doi.org/10.1128/aac.00862-15","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.00862-15","pdf_url":"https://aac.asm.org/content/aac/59/10/5932.full.pdf","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://aac.asm.org/content/aac/59/10/5932.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047118089","display_name":"Louise A. Walker","orcid":"https://orcid.org/0000-0002-2236-8776","observed_orcids":["https://orcid.org/0000-0002-2236-8776"]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Louise A. Walker","raw_affiliation_strings":["Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom","institution_ids":["https://openalex.org/I195460627"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088449484","display_name":"Keunsook K. Lee","orcid":"https://orcid.org/0000-0002-0677-5320","observed_orcids":["https://orcid.org/0000-0002-0677-5320"]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Keunsook K. Lee","raw_affiliation_strings":["Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom","institution_ids":["https://openalex.org/I195460627"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053225241","display_name":"Carol A. Munro","orcid":"https://orcid.org/0000-0003-0761-1755","observed_orcids":["https://orcid.org/0000-0003-0761-1755"]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Carol A. Munro","raw_affiliation_strings":["Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom","institution_ids":["https://openalex.org/I195460627"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008227126","display_name":"Neil A. R. Gow","orcid":"https://orcid.org/0000-0002-2776-5850","observed_orcids":["https://orcid.org/0000-0002-2776-5850"]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Neil A. R. Gow","raw_affiliation_strings":["Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom","institution_ids":["https://openalex.org/I195460627"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5008227126"],"corresponding_institution_ids":["https://openalex.org/I195460627"],"apc_list":null,"apc_paid":null,"fwci":7.1546,"has_fulltext":true,"cited_by_count":94,"citation_normalized_percentile":{"value":0.97710947,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"59","issue":"10","first_page":"5932","last_page":"5941"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.5659000277519226,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.5659000277519226,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.4269999861717224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12683","display_name":"Studies on Chitinases and Chitosanases","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aspergillus-fumigatus","display_name":"Aspergillus fumigatus","score":0.9909999966621399},{"id":"https://openalex.org/keywords/caspofungin","display_name":"caspofungin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/echinocandins","display_name":"echinocandins","score":0.9290000200271606},{"id":"https://openalex.org/keywords/chitin-synthesis","display_name":"chitin synthesis","score":0.925000011920929},{"id":"https://openalex.org/keywords/chitin-synthase","display_name":"chitin synthase","score":0.7400000095367432},{"id":"https://openalex.org/keywords/microcolonies","display_name":"microcolonies","score":0.8799999952316284},{"id":"https://openalex.org/keywords/protein-kinase-c-signaling","display_name":"protein kinase C signaling","score":0.6880000233650208},{"id":"https://openalex.org/keywords/calcineurin-signaling","display_name":"calcineurin signaling","score":0.906000018119812},{"id":"https://openalex.org/keywords/nikkomycin-z","display_name":"nikkomycin Z","score":0.8069999814033508},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.6159999966621399},{"id":"https://openalex.org/keywords/hyphal-morphology","display_name":"hyphal morphology","score":0.5870000123977661},{"id":"https://openalex.org/keywords/breakthrough-infection","display_name":"breakthrough infection","score":0.5389999747276306},{"id":"https://openalex.org/keywords/antifungal-susceptibility","display_name":"antifungal susceptibility","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C2780402444","wikidata":"https://www.wikidata.org/wiki/Q420875","display_name":"Caspofungin","level":4,"score":0.9646884799003601},{"id":"https://openalex.org/C2781088250","wikidata":"https://www.wikidata.org/wiki/Q161219","display_name":"Chitin","level":3,"score":0.8480336666107178},{"id":"https://openalex.org/C2779320740","wikidata":"https://www.wikidata.org/wiki/Q3718510","display_name":"Echinocandin","level":4,"score":0.8188942670822144},{"id":"https://openalex.org/C2779787849","wikidata":"https://www.wikidata.org/wiki/Q134359","display_name":"Aspergillus fumigatus","level":2,"score":0.7976011633872986},{"id":"https://openalex.org/C2780992308","wikidata":"https://www.wikidata.org/wiki/Q24787583","display_name":"Chitin synthase","level":4,"score":0.6778460741043091},{"id":"https://openalex.org/C2910751997","wikidata":"https://www.wikidata.org/wiki/Q3718510","display_name":"Echinocandins","level":5,"score":0.6041924953460693},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5550247430801392},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5284892320632935},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44886860251426697},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.06936588883399963},{"id":"https://openalex.org/C2779629538","wikidata":"https://www.wikidata.org/wiki/Q412223","display_name":"Amphotericin B","level":3,"score":0.05568474531173706},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.0},{"id":"https://openalex.org/C2780651595","wikidata":"https://www.wikidata.org/wiki/Q411478","display_name":"Fluconazole","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077336","descriptor_name":"Caspofungin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000617","descriptor_name":"Aminoglycosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001232","descriptor_name":"Aspergillus fumigatus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001232","descriptor_name":"Aspergillus fumigatus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001232","descriptor_name":"Aspergillus fumigatus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D001232","descriptor_name":"Aspergillus fumigatus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001557","descriptor_name":"Benzenesulfonates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002122","descriptor_name":"Calcium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002473","descriptor_name":"Cell Wall","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002473","descriptor_name":"Cell Wall","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002686","descriptor_name":"Chitin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D002686","descriptor_name":"Chitin","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D002687","descriptor_name":"Chitin Synthase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D002687","descriptor_name":"Chitin Synthase","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D002687","descriptor_name":"Chitin Synthase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019703","descriptor_name":"Calcineurin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019703","descriptor_name":"Calcineurin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025301","descriptor_name":"Hyphae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D025301","descriptor_name":"Hyphae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025301","descriptor_name":"Hyphae","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054714","descriptor_name":"Echinocandins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D055666","descriptor_name":"Lipopeptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1128/aac.00862-15","doi":"https://doi.org/10.1128/aac.00862-15","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.00862-15","pdf_url":"https://aac.asm.org/content/aac/59/10/5932.full.pdf","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3551882","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4576100","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4576100","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4576100","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:26169407","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26169407","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.787.9212","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.787.9212","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/8e/11/zac5932.PMC4576100.pdf","raw_type":"text"},{"id":"pmh:oai:aura.abdn.ac.uk:2164/4935","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2164/4935","pdf_url":null,"source":{"id":"https://openalex.org/S4306400966","display_name":"Aberdeen University Research Archive (Aberdeen University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I195460627","host_organization_name":"University of Aberdeen","host_organization_lineage":["https://openalex.org/I195460627"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.1128/aac.00862-15","doi":"https://doi.org/10.1128/aac.00862-15","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.00862-15","pdf_url":"https://aac.asm.org/content/aac/59/10/5932.full.pdf","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1765893153","display_name":"Transmission electron microscopy with tomography for studies of cellular ultrastructure.","funder_award_id":"099215","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G3031113644","display_name":"Regulation of the biosynthesis of the cell wall skeleton of Candida albicans.","funder_award_id":"086827","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G4352492174","display_name":"Wellcome Strategic Award for Medical Mycology and Fungal Immunology","funder_award_id":"097377","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G467776361","display_name":"Making and breaking the cell walls of fungal pathogens.","funder_award_id":"101873","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G6435569997","display_name":"Candida albicans cell surface: regulation of the host-fungus interaction.","funder_award_id":"080088","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G8187263217","display_name":"Imaging the Morphogenesis, Cell Division and Growth of Microorganisms.","funder_award_id":"075470/Z/04/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2153176878.pdf","grobid_xml":"https://content.openalex.org/works/W2153176878.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1562615829","https://openalex.org/W1566200502","https://openalex.org/W1579605530","https://openalex.org/W1701541921","https://openalex.org/W1738685475","https://openalex.org/W1971198440","https://openalex.org/W1980422468","https://openalex.org/W1984710508","https://openalex.org/W1991203057","https://openalex.org/W1994237888","https://openalex.org/W1995932180","https://openalex.org/W1997941804","https://openalex.org/W2001579789","https://openalex.org/W2004503571","https://openalex.org/W2008815709","https://openalex.org/W2016405735","https://openalex.org/W2027546225","https://openalex.org/W2035029657","https://openalex.org/W2037327700","https://openalex.org/W2038204439","https://openalex.org/W2045454750","https://openalex.org/W2071880406","https://openalex.org/W2074866161","https://openalex.org/W2082568641","https://openalex.org/W2091164201","https://openalex.org/W2093276219","https://openalex.org/W2093862878","https://openalex.org/W2096833920","https://openalex.org/W2096857575","https://openalex.org/W2098898162","https://openalex.org/W2103317747","https://openalex.org/W2104743902","https://openalex.org/W2105069566","https://openalex.org/W2107794472","https://openalex.org/W2111169002","https://openalex.org/W2114215857","https://openalex.org/W2115522792","https://openalex.org/W2117555017","https://openalex.org/W2117926360","https://openalex.org/W2120004156","https://openalex.org/W2121243320","https://openalex.org/W2126957470","https://openalex.org/W2127911529","https://openalex.org/W2127993231","https://openalex.org/W2127997803","https://openalex.org/W2132121507","https://openalex.org/W2132497565","https://openalex.org/W2132684519","https://openalex.org/W2133000347","https://openalex.org/W2134432409","https://openalex.org/W2135256580","https://openalex.org/W2143321217","https://openalex.org/W2146611080","https://openalex.org/W2152485629","https://openalex.org/W2157068508","https://openalex.org/W2157350652","https://openalex.org/W2157921051","https://openalex.org/W2162906973","https://openalex.org/W2164252368","https://openalex.org/W2165227500","https://openalex.org/W2170090864","https://openalex.org/W2411276033","https://openalex.org/W2418108511","https://openalex.org/W2743041357"],"related_works":["https://openalex.org/W7098681777","https://openalex.org/W2126957470","https://openalex.org/W2625378674","https://openalex.org/W1995932180","https://openalex.org/W2550571967","https://openalex.org/W821690422","https://openalex.org/W7163583985","https://openalex.org/W2093276219","https://openalex.org/W2117555017","https://openalex.org/W7095340620"],"abstract_inverted_index":{"Treatment":[0],"of":[1,12,21,25,34,44,87,106,147,207,240],"Aspergillus":[2],"fumigatus":[3,55,227],"with":[4,57,115,130,144,167,186],"echinocandins":[5],"such":[6],"as":[7,253],"caspofungin":[8,35,134,168,188],"inhibits":[9],"the":[10,45,58,76,84,91,136,145,148,160,204,229,254],"synthesis":[11,27],"cell":[13,125],"wall":[14,126],"\u03b2-1,3-glucan,":[15],"which":[16,151],"triggers":[17],"a":[18],"compensatory":[19,85],"stimulation":[20],"chitin":[22,26,62,77,88,109,127,161,241],"synthesis.":[23,89,242],"Activation":[24],"can":[28],"occur":[29],"in":[30,111,124,135,191,203,215,221,235,248],"response":[31,70,112,216],"to":[32,37,71,74,96,113,133,154,159,217,231],"sub-MICs":[33],"and":[36,39,50,98,117,119,139,251],"CaCl2":[38,116],"calcofluor":[40],"white":[41],"(CFW),":[42],"agonists":[43,73],"protein":[46],"kinase":[47],"C":[48],"(PKC),":[49],"Ca(2+)-calcineurin":[51],"signaling":[52],"pathways.":[53],"A.":[54,226],"mutants":[56,102,142],"chs":[59],"gene":[60],"(encoding":[61],"synthase)":[63],"deleted":[64],"(\u0394Afchs)":[65],"were":[66,81,213],"tested":[67,103],"for":[68,83,256],"their":[69,108],"these":[72],"determine":[75],"synthase":[78,162],"enzymes":[79],"that":[80,172,184,199,225],"required":[82],"upregulation":[86,239],"Only":[90],"\u0394AfchsG":[92,149],"mutant":[93],"was":[94,173],"hypersensitive":[95],"caspofungin,":[97],"all":[99,140],"other":[100],"\u0394Afchs":[101,141],"remained":[104,152],"capable":[105],"increasing":[107],"content":[110,128],"treatment":[114,185,234],"CFW":[118],"caspofungin.":[120,155,208],"The":[121],"resulting":[122],"increase":[123],"correlated":[129],"reduced":[131],"susceptibility":[132],"wild":[137],"type":[138],"tested,":[143],"exception":[146],"mutant,":[150],"sensitive":[153],"In":[156,209],"vitro":[157,222],"exposure":[158],"inhibitor,":[163],"nikkomycin":[164],"Z,":[165],"along":[166],"demonstrated":[169,183],"synergistic":[170],"efficacy":[171],"again":[174],"AfChsG":[175],"dependent.":[176],"Dynamic":[177],"imaging":[178],"using":[179],"microfluidic":[180],"perfusion":[181],"chambers":[182],"sub-MIC":[187],"resulted":[189],"initially":[190],"hyphal":[192],"tip":[193],"lysis.":[194],"However,":[195],"thickened":[196],"hyphae":[197,212],"emerged":[198],"formed":[200,214],"aberrant":[201],"microcolonies":[202],"continued":[205],"presence":[206],"addition,":[210],"intrahyphal":[211],"echinocandin":[218,233],"treatment.":[219],"These":[220],"data":[223],"demonstrate":[224],"has":[228],"potential":[230],"survive":[232],"vivo":[236],"by":[237],"AfChsG-dependent":[238],"Chitin-rich":[243],"cells":[244],"may,":[245],"therefore,":[246],"persist":[247],"human":[249],"tissues":[250],"act":[252],"focus":[255],"breakthrough":[257],"infections.":[258]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}