{"id":"https://openalex.org/W2153162183","doi":"https://doi.org/10.1530/eje-11-1072","title":"Fifteen years of GH replacement increases bone mineral density in hypopituitary patients with adult-onset GH deficiency","display_name":"Fifteen years of GH replacement increases bone mineral density in hypopituitary patients with adult-onset GH deficiency","publication_year":2012,"publication_date":"2012-02-08","ids":{"openalex":"https://openalex.org/W2153162183","doi":"https://doi.org/10.1530/eje-11-1072","mag":"2153162183","pmid":"https://pubmed.ncbi.nlm.nih.gov/22318746","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3341655"},"language":"en","primary_location":{"id":"doi:10.1530/eje-11-1072","doi":"https://doi.org/10.1530/eje-11-1072","is_oa":true,"landing_page_url":"https://doi.org/10.1530/eje-11-1072","pdf_url":"https://academic.oup.com/ejendo/article-pdf/166/5/787/46327185/787.pdf","source":{"id":"https://openalex.org/S4210218062","display_name":"European Journal of Endocrinology","issn_l":"0804-4643","issn":["0804-4643","1479-683X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/ejendo/article-pdf/166/5/787/46327185/787.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060309931","display_name":"Mariam Elbornsson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"M. Elbornsson","raw_affiliation_strings":["Department of Endocrinology, Institute of Medicine, Sahlgrenska Academy, Sahlgrenska University Hospital, University of Gothenburg, Gr\u00f6na Str\u00e5ket 8, SE-413 45 G\u00f6teborg, Sweden. mariam.elbornsson@medic.gu.se","Department of Endocrinology, Institute of Medicine, Sahlgrenska Academy, Sahlgrenska University Hospital, University of Gothenburg, Gr\u00f6na Str\u00e5ket 8, SE-413 45 G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Institute of Medicine, Sahlgrenska Academy, Sahlgrenska University Hospital, University of Gothenburg, Gr\u00f6na Str\u00e5ket 8, SE-413 45 G\u00f6teborg, Sweden. mariam.elbornsson@medic.gu.se","institution_ids":["https://openalex.org/I2801112325","https://openalex.org/I881427289"]},{"raw_affiliation_string":"Department of Endocrinology, Institute of Medicine, Sahlgrenska Academy, Sahlgrenska University Hospital, University of Gothenburg, Gr\u00f6na Str\u00e5ket 8, SE-413 45 G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I2801112325","https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045433633","display_name":"G. G\u00f6therstr\u00f6m","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"G. Gotherstrom","raw_affiliation_strings":["Department of Endocrinology, Institute of Medicine, Sahlgrenska Academy, Sahlgrenska University Hospital, University of Gothenburg, Gr\u00f6na Str\u00e5ket 8, SE-413 45 G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Institute of Medicine, Sahlgrenska Academy, Sahlgrenska University Hospital, University of Gothenburg, Gr\u00f6na Str\u00e5ket 8, SE-413 45 G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I2801112325","https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068522912","display_name":"Ingvar G. Bosaeus","orcid":"https://orcid.org/0000-0001-8287-6310","observed_orcids":["https://orcid.org/0000-0001-8287-6310"]},"institutions":[{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"I. Bosaeus","raw_affiliation_strings":["Department of Clinical Nutrition, Sahlgrenska University Hospital, SE-413 45 G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Nutrition, Sahlgrenska University Hospital, SE-413 45 G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I2801112325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112382408","display_name":"B.-\u00c5. Bengtsson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"B.-A. Bengtsson","raw_affiliation_strings":["Department of Endocrinology, Institute of Medicine, Sahlgrenska Academy, Sahlgrenska University Hospital, University of Gothenburg, Gr\u00f6na Str\u00e5ket 8, SE-413 45 G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Institute of Medicine, Sahlgrenska Academy, Sahlgrenska University Hospital, University of Gothenburg, Gr\u00f6na Str\u00e5ket 8, SE-413 45 G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I2801112325","https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051782257","display_name":"Gudmundur Johannsson","orcid":"https://orcid.org/0000-0003-3484-8440","observed_orcids":["https://orcid.org/0000-0003-3484-8440"]},"institutions":[{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"G. Johannsson","raw_affiliation_strings":["Department of Endocrinology, Institute of Medicine, Sahlgrenska Academy, Sahlgrenska University Hospital, University of Gothenburg, Gr\u00f6na Str\u00e5ket 8, SE-413 45 G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Institute of Medicine, Sahlgrenska Academy, Sahlgrenska University Hospital, University of Gothenburg, Gr\u00f6na Str\u00e5ket 8, SE-413 45 G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I2801112325","https://openalex.org/I881427289"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027918811","display_name":"Johan Svensson","orcid":"https://orcid.org/0000-0002-4487-6405","observed_orcids":["https://orcid.org/0000-0002-4487-6405"]},"institutions":[{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"J. Svensson","raw_affiliation_strings":["Department of Endocrinology, Institute of Medicine, Sahlgrenska Academy, Sahlgrenska University Hospital, University of Gothenburg, Gr\u00f6na Str\u00e5ket 8, SE-413 45 G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Institute of Medicine, Sahlgrenska Academy, Sahlgrenska University Hospital, University of Gothenburg, Gr\u00f6na Str\u00e5ket 8, SE-413 45 G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I2801112325","https://openalex.org/I881427289"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5060309931"],"corresponding_institution_ids":["https://openalex.org/I2801112325","https://openalex.org/I881427289"],"apc_list":{"value":3798,"currency":"EUR","value_usd":4292},"apc_paid":{"value":3798,"currency":"EUR","value_usd":4292},"fwci":7.6201,"has_fulltext":true,"cited_by_count":144,"citation_normalized_percentile":{"value":0.98044029,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"166","issue":"5","first_page":"787","last_page":"795"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/growth-hormone-replacement-therapy","display_name":"growth hormone replacement therapy","score":0.8939999938011169},{"id":"https://openalex.org/keywords/adult-onset-growth-hormone-deficiency","display_name":"adult-onset growth hormone deficiency","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hypopituitarism","display_name":"hypopituitarism","score":0.953000009059906},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.9959999918937683},{"id":"https://openalex.org/keywords/bone-mineral-content","display_name":"bone mineral content","score":0.9990000128746033},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.7599999904632568},{"id":"https://openalex.org/keywords/lumbar-spine","display_name":"lumbar spine","score":0.746999979019165},{"id":"https://openalex.org/keywords/femoral-neck","display_name":"femoral neck","score":0.9639999866485596},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9269999861717224}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8456524610519409},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8378098011016846},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6152203679084778},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.5604608058929443},{"id":"https://openalex.org/C2778491484","wikidata":"https://www.wikidata.org/wiki/Q922411","display_name":"Hypopituitarism","level":2,"score":0.4548954367637634},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.12936177849769592}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007018","descriptor_name":"Hypopituitarism","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D007018","descriptor_name":"Hypopituitarism","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015502","descriptor_name":"Absorptiometry, Photon","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D020249","descriptor_name":"Hormone Replacement Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1530/eje-11-1072","doi":"https://doi.org/10.1530/eje-11-1072","is_oa":true,"landing_page_url":"https://doi.org/10.1530/eje-11-1072","pdf_url":"https://academic.oup.com/ejendo/article-pdf/166/5/787/46327185/787.pdf","source":{"id":"https://openalex.org/S4210218062","display_name":"European Journal of Endocrinology","issn_l":"0804-4643","issn":["0804-4643","1479-683X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2352751","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3341655","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3341655","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3341655","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eur J Endocrinol","raw_type":"Text"},{"id":"pmid:22318746","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22318746","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of endocrinology","raw_type":"Clinical Trial"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.270.9569","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.270.9569","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/2c/9f/Eur_J_Endocrinol_2012_May_166(5)_787-795.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1530/eje-11-1072","doi":"https://doi.org/10.1530/eje-11-1072","is_oa":true,"landing_page_url":"https://doi.org/10.1530/eje-11-1072","pdf_url":"https://academic.oup.com/ejendo/article-pdf/166/5/787/46327185/787.pdf","source":{"id":"https://openalex.org/S4210218062","display_name":"European Journal of Endocrinology","issn_l":"0804-4643","issn":["0804-4643","1479-683X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320323421","display_name":"G\u00f6teborgs Universitet","ror":"https://ror.org/01tm6cn81"},{"id":"https://openalex.org/F4320335047","display_name":"Sahlgrenska Akademin","ror":"https://ror.org/01tm6cn81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2153162183.pdf","grobid_xml":"https://content.openalex.org/works/W2153162183.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W64800949","https://openalex.org/W363911213","https://openalex.org/W1565369626","https://openalex.org/W1965897913","https://openalex.org/W1971855331","https://openalex.org/W1975979596","https://openalex.org/W1978290157","https://openalex.org/W1978914649","https://openalex.org/W1979666189","https://openalex.org/W1979747206","https://openalex.org/W1982942836","https://openalex.org/W1988156838","https://openalex.org/W1991603023","https://openalex.org/W1993913510","https://openalex.org/W1996317901","https://openalex.org/W1998010040","https://openalex.org/W2002095519","https://openalex.org/W2004518714","https://openalex.org/W2007719997","https://openalex.org/W2010793737","https://openalex.org/W2018356665","https://openalex.org/W2020108509","https://openalex.org/W2023206717","https://openalex.org/W2036449739","https://openalex.org/W2037472576","https://openalex.org/W2044242260","https://openalex.org/W2045016320","https://openalex.org/W2046386459","https://openalex.org/W2050318024","https://openalex.org/W2051664779","https://openalex.org/W2052515706","https://openalex.org/W2057696296","https://openalex.org/W2059578141","https://openalex.org/W2065004245","https://openalex.org/W2071876386","https://openalex.org/W2075077585","https://openalex.org/W2076273192","https://openalex.org/W2077848651","https://openalex.org/W2080047197","https://openalex.org/W2084612579","https://openalex.org/W2090627812","https://openalex.org/W2095559222","https://openalex.org/W2102024055","https://openalex.org/W2109963649","https://openalex.org/W2112540452","https://openalex.org/W2117830565","https://openalex.org/W2119769535","https://openalex.org/W2124940928","https://openalex.org/W2127551329","https://openalex.org/W2129855350","https://openalex.org/W2135088291","https://openalex.org/W2136598250","https://openalex.org/W2138014802","https://openalex.org/W2140469927","https://openalex.org/W2142503581","https://openalex.org/W2144000500","https://openalex.org/W2145334647","https://openalex.org/W2148688487","https://openalex.org/W2157819450","https://openalex.org/W2158139052","https://openalex.org/W2172818901","https://openalex.org/W4235807144","https://openalex.org/W4242348489"],"related_works":["https://openalex.org/W7100882589","https://openalex.org/W4242348489","https://openalex.org/W2804147356","https://openalex.org/W2004820843","https://openalex.org/W1977867748","https://openalex.org/W2070835476","https://openalex.org/W2129855350","https://openalex.org/W2077581302","https://openalex.org/W2095559222","https://openalex.org/W2004518714"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Few":[1],"studies":[2],"have":[3],"determined":[4,52],"the":[5,34,72,75,113,183,194],"effects":[6,35],"of":[7,12,36,39,74,83,122,162],"more":[8,203],"than":[9,209],"5-10":[10],"years":[11,38,70,121,171,241],"GH":[13,40,61,81,123,207,213],"replacement":[14,41,124,208,214],"in":[15,53,129,158,215,222],"adults":[16,56,217],"on":[17,42],"bone":[18,23],"mineral":[19,24],"content":[20],"(BMC)":[21],"and":[22,44,135,147,160,164,225,230,236,242],"density":[25],"(BMD).":[26],"DESIGN/PATIENTS:":[27],"In":[28,152,197,232],"this":[29],"prospective,":[30],"single-centre,":[31],"open-label":[32],"study,":[33],"15":[37,96,120,175],"BMC":[43,132,142,159,179,229,235],"BMD,":[45],"measured":[46],"using":[47],"dual-energy":[48],"X-ray":[49],"absorptiometry,":[50],"were":[51],"126":[54],"hypopituitary":[55],"(72":[57],"men)":[58],"with":[59],"adult-onset":[60],"deficiency":[62],"(GHD).":[63],"Mean":[64],"age":[65],"was":[66,88,167,180],"49.4":[67],"(range":[68],"22-74)":[69],"at":[71,107,112,239],"initiation":[73],"study.":[76],"RESULTS:":[77],"The":[78,98,119],"mean":[79,99],"initial":[80],"dose":[82],"0.63":[84,110],"(s.e.m.":[85],"0.03)":[86],"mg/day":[87,94],"gradually":[89],"lowered":[90],"to":[91,109,193,206],"0.41":[92],"(0.01)":[93],"after":[95,169],"years.":[97],"serum":[100],"IGF1":[101],"SDS":[102],"increased":[103,143],"from":[104],"-1.69":[105],"(0.11)":[106],"baseline":[108,184,195,246],"(0.16)":[111],"study":[114],"end":[115],"(P<0.001":[116],"vs":[117],"baseline).":[118],"induced":[125,218],"a":[126,155,202,219],"sustained":[127,220],"increase":[128,157,221],"total":[130,223],"body":[131,224],"(+5%,":[133],"P<0.001)":[134],"BMD":[136,148,161,190,237],"(+2%,":[137],"P<0.001).":[138,173],"Lumbar":[139],"(L2-L4)":[140,227],"spine":[141,228],"by":[144,149],"9%":[145],"(P<0.001)":[146],"5%":[150,181],"(P<0.001).":[151],"femur":[153,177,188,233],"neck,":[154,234],"peak":[156],"7":[163,170,240],"3%,":[165],"respectively,":[166],"observed":[168],"(both":[172],"After":[174],"years,":[176],"neck":[178,189],"above":[182],"value":[185],"(P<0.01),":[186],"whereas":[187],"had":[191,201],"returned":[192],"level.":[196],"most":[198],"variables,":[199],"men":[200],"marked":[204],"response":[205],"women.":[210],"CONCLUSIONS:":[211],"Fifteen-year":[212],"GHD":[216],"lumbar":[226],"BMD.":[231],"peaked":[238],"then":[243],"decreased":[244],"towards":[245],"values.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}