{"id":"https://openalex.org/W2153160348","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a022470","title":"The Escherichia coli pldC Gene Encoding Lysophospholipase L1 Is Identical to the apeA and tesA Genes Encoding Protease I and Thioesterase I, Respectively","display_name":"The Escherichia coli pldC Gene Encoding Lysophospholipase L1 Is Identical to the apeA and tesA Genes Encoding Protease I and Thioesterase I, Respectively","publication_year":1999,"publication_date":"1999-08-01","ids":{"openalex":"https://openalex.org/W2153160348","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a022470","mag":"2153160348","pmid":"https://pubmed.ncbi.nlm.nih.gov/10423542"},"language":"en","primary_location":{"id":"doi:10.1093/oxfordjournals.jbchem.a022470","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a022470","is_oa":false,"landing_page_url":"https://doi.org/10.1093/oxfordjournals.jbchem.a022470","pdf_url":null,"source":{"id":"https://openalex.org/S184547178","display_name":"The Journal of Biochemistry","issn_l":"0021-924X","issn":["0021-924X","1756-2651"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pure.teikyo.jp/en/publications/a4e9c63c-bc1f-41fe-8902-ab9fc73444b1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110875081","display_name":"Ken Karasawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"K. Karasawa","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa, 199-0195, Japan. karasawa@pharm.teikyo-u.ac.jp","Faculty of Pharmaceutical Sciences, Teikyo UniversitySagamiko, Kanagawa 199-0195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa, 199-0195, Japan. karasawa@pharm.teikyo-u.ac.jp","institution_ids":["https://openalex.org/I87531838"]},{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Teikyo UniversitySagamiko, Kanagawa 199-0195","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027514076","display_name":"Kazuaki Yokoyama","orcid":"https://orcid.org/0000-0003-2407-5368","observed_orcids":["https://orcid.org/0000-0003-2407-5368"]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Yokoyama","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Teikyo University Sagamiko, Kanagawa 199-0195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Teikyo University Sagamiko, Kanagawa 199-0195","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111634673","display_name":"Morio Setaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Setaka","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Teikyo University Sagamiko, Kanagawa 199-0195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Teikyo University Sagamiko, Kanagawa 199-0195","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108529944","display_name":"S Nojima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S. Nojima","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Teikyo University Sagamiko, Kanagawa 199-0195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Teikyo University Sagamiko, Kanagawa 199-0195","institution_ids":["https://openalex.org/I87531838"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110875081"],"corresponding_institution_ids":["https://openalex.org/I87531838"],"apc_list":{"value":3276,"currency":"USD","value_usd":3276},"apc_paid":null,"fwci":0.1371,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.42566435,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"126","issue":"2","first_page":"445","last_page":"448"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.4909999966621399,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.4909999966621399,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.4214000105857849,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.053599998354911804,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8610000014305115},{"id":"https://openalex.org/keywords/gene-identity","display_name":"gene identity","score":0.5680000185966492},{"id":"https://openalex.org/keywords/amino-acid-sequence","display_name":"amino acid sequence","score":0.6620000004768372},{"id":"https://openalex.org/keywords/enzyme-purification","display_name":"enzyme purification","score":0.5040000081062317},{"id":"https://openalex.org/keywords/gene-overexpression","display_name":"gene overexpression","score":0.36500000953674316}],"concepts":[{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.788689374923706},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7249912023544312},{"id":"https://openalex.org/C2780622759","wikidata":"https://www.wikidata.org/wiki/Q76818446","display_name":"Thioesterase","level":4,"score":0.6907760500907898},{"id":"https://openalex.org/C2778530336","wikidata":"https://www.wikidata.org/wiki/Q3269791","display_name":"Lysophospholipase","level":4,"score":0.5668462514877319},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.42601609230041504},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4245443344116211},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.41917121410369873},{"id":"https://openalex.org/C125411270","wikidata":"https://www.wikidata.org/wiki/Q18653","display_name":"Encoding (memory)","level":2,"score":0.41752612590789795},{"id":"https://openalex.org/C2908821069","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli Proteins","level":4,"score":0.4111909866333008},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37305331230163574},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3135509490966797},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.25865083932876587},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.07779791951179504},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C12927208","wikidata":"https://www.wikidata.org/wiki/Q210430","display_name":"Phospholipase","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008245","descriptor_name":"Lysophospholipase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010170","descriptor_name":"Palmitoyl-CoA Hydrolase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D033903","descriptor_name":"Periplasmic Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/oxfordjournals.jbchem.a022470","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a022470","is_oa":false,"landing_page_url":"https://doi.org/10.1093/oxfordjournals.jbchem.a022470","pdf_url":null,"source":{"id":"https://openalex.org/S184547178","display_name":"The Journal of Biochemistry","issn_l":"0021-924X","issn":["0021-924X","1756-2651"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:10423542","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10423542","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:00953:0006733806","doi":null,"is_oa":true,"landing_page_url":"https://pure.teikyo.jp/en/publications/a4e9c63c-bc1f-41fe-8902-ab9fc73444b1","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Biochemistry","raw_type":"journal article"},{"id":"pmh:oai:irdb.nii.ac.jp:00953:0007493682","doi":null,"is_oa":false,"landing_page_url":"https://pure.teikyo.jp/en/publications/3b50166b-4b63-4812-9294-0ebf339e8e46","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JOURNAL OF BIOCHEMISTRY","raw_type":"journal article"}],"best_oa_location":{"id":"pmh:oai:irdb.nii.ac.jp:00953:0006733806","doi":null,"is_oa":true,"landing_page_url":"https://pure.teikyo.jp/en/publications/a4e9c63c-bc1f-41fe-8902-ab9fc73444b1","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Biochemistry","raw_type":"journal article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2107159689","https://openalex.org/W2972836971","https://openalex.org/W1934778525","https://openalex.org/W1896453590","https://openalex.org/W2079175458","https://openalex.org/W1596615238","https://openalex.org/W1903742525","https://openalex.org/W189360995","https://openalex.org/W2003513667","https://openalex.org/W1575071875"],"abstract_inverted_index":{"We":[0],"deduced":[1],"the":[2,13,17,48,57,62,73,77,85,99,102,109,116],"amino":[3,31,41],"acid":[4,32,42],"sequence":[5,15,38,75],"of":[6,16,39,47,61,76,84,101],"Escherichia":[7],"coli":[8,114],"lysophospholipase":[9],"L(1)":[10],"by":[11],"determining":[12],"nucleotide":[14,74],"pldC":[18,78,103,117],"gene":[19,79,104,118],"encoding":[20,90],"this":[21],"enzyme.":[22],"The":[23,44],"translated":[24],"protein":[25],"was":[26,52,80],"found":[27],"to":[28,82],"contain":[29],"208":[30],"residues":[33],"with":[34,56,98,105],"a":[35,68],"hydrophobic":[36],"leader":[37],"26":[40],"residues.":[43],"molecular":[45],"weight":[46],"purified":[49,111],"enzyme":[50,110],"(20,500)":[51],"in":[53],"good":[54],"agreement":[55],"predicted":[58],"size":[59],"(20,399)":[60],"processed":[63],"protein.":[64],"A":[65],"search":[66],"involving":[67],"data":[69],"bank":[70],"showed":[71,119],"that":[72],"identical":[81],"those":[83],"apeA":[86],"and":[87,93,123],"tesA":[88],"genes":[89],"protease":[91,121],"I":[92,122,125],"thioesterase":[94,124],"I,":[95],"respectively.":[96],"Consistent":[97],"identity":[100],"these":[106],"two":[107],"genes,":[108],"from":[112],"E.":[113],"overexpressing":[115],"both":[120],"activities.":[126]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}