{"id":"https://openalex.org/W2153159453","doi":"https://doi.org/10.1161/circgenetics.115.001129","title":"Characterization of Autosomal Dominant Hypercholesterolemia Caused by PCSK9 Gain of Function Mutations and Its Specific Treatment With Alirocumab, a PCSK9 Monoclonal Antibody","display_name":"Characterization of Autosomal Dominant Hypercholesterolemia Caused by PCSK9 Gain of Function Mutations and Its Specific Treatment With Alirocumab, a PCSK9 Monoclonal Antibody","publication_year":2015,"publication_date":"2015-12-01","ids":{"openalex":"https://openalex.org/W2153159453","doi":"https://doi.org/10.1161/circgenetics.115.001129","mag":"2153159453","pmid":"https://pubmed.ncbi.nlm.nih.gov/26374825","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5098466"},"language":"en","primary_location":{"id":"doi:10.1161/circgenetics.115.001129","doi":"https://doi.org/10.1161/circgenetics.115.001129","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circgenetics.115.001129","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCGENETICS.115.001129","source":{"id":"https://openalex.org/S103446830","display_name":"Circulation Cardiovascular Genetics","issn_l":"1942-3268","issn":["1942-3268","1942-325X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation: Cardiovascular Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCGENETICS.115.001129","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029779433","display_name":"Paul Nathan Hopkins","orcid":"https://orcid.org/0000-0002-9118-0427","observed_orcids":["https://orcid.org/0000-0002-9118-0427"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Paul N. Hopkins","raw_affiliation_strings":["Paul N. Hopkins"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paul N. Hopkins","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067704164","display_name":"Joep C. Defesche","orcid":"https://orcid.org/0000-0003-3707-8277","observed_orcids":["https://orcid.org/0000-0003-3707-8277"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joep Defesche","raw_affiliation_strings":["Joep Defesche"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joep Defesche","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084720714","display_name":"Sigrid W. Fouchier","orcid":"https://orcid.org/0000-0002-2996-2321","observed_orcids":["https://orcid.org/0000-0002-2996-2321"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sigrid W. Fouchier","raw_affiliation_strings":["Sigrid W. Fouchier"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sigrid W. Fouchier","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055596681","display_name":"\u00c9ric Bruckert","orcid":"https://orcid.org/0000-0002-4527-9629","observed_orcids":["https://orcid.org/0000-0002-4527-9629"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric Bruckert","raw_affiliation_strings":["Eric Bruckert"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eric Bruckert","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113631737","display_name":"G\u00e9rald Luc","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G\u00e9rald Luc","raw_affiliation_strings":["G\u00e9rald Luc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"G\u00e9rald Luc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004521406","display_name":"Bertrand Cariou","orcid":"https://orcid.org/0000-0002-1580-8040","observed_orcids":["https://orcid.org/0000-0002-1580-8040"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bertrand Cariou","raw_affiliation_strings":["Bertrand Cariou"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bertrand Cariou","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018875125","display_name":"Barbara Sjouke","orcid":"https://orcid.org/0000-0001-8162-9684","observed_orcids":["https://orcid.org/0000-0001-8162-9684"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barbara Sjouke","raw_affiliation_strings":["Barbara Sjouke"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barbara Sjouke","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025347732","display_name":"Trond P. Leren","orcid":"https://orcid.org/0000-0002-2324-8979","observed_orcids":["https://orcid.org/0000-0002-2324-8979"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Trond P. Leren","raw_affiliation_strings":["Trond P. Leren"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trond P. Leren","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028921297","display_name":"Mariko Harada\u2010Shiba","orcid":"https://orcid.org/0000-0002-7600-2059","observed_orcids":["https://orcid.org/0000-0002-7600-2059"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mariko Harada-Shiba","raw_affiliation_strings":["Mariko Harada-Shiba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mariko Harada-Shiba","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100871769","display_name":"Hiroshi Mabuchi","orcid":"https://orcid.org/0009-0002-4141-2872","observed_orcids":["https://orcid.org/0009-0002-4141-2872"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroshi Mabuchi","raw_affiliation_strings":["Hiroshi Mabuchi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hiroshi Mabuchi","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056986606","display_name":"Jean\u2010Pierre Rab\u00e8s","orcid":"https://orcid.org/0000-0002-1215-1493","observed_orcids":["https://orcid.org/0000-0002-1215-1493"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean-Pierre Rab\u00e8s","raw_affiliation_strings":["Jean-Pierre Rab\u00e8s"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jean-Pierre Rab\u00e8s","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107600104","display_name":"Alain Carri\u00e9","orcid":"https://orcid.org/0000-0003-4726-1171","observed_orcids":["https://orcid.org/0000-0003-4726-1171"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alain Carri\u00e9","raw_affiliation_strings":["Alain Carri\u00e9"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alain Carri\u00e9","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013516925","display_name":"Charles van Heyningen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles van Heyningen","raw_affiliation_strings":["Charles van Heyningen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles van Heyningen","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107392337","display_name":"Val\u00e9rie Carreau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Val\u00e9rie Carreau","raw_affiliation_strings":["Val\u00e9rie Carreau"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Val\u00e9rie Carreau","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037200495","display_name":"Michel Farnier","orcid":"https://orcid.org/0000-0002-0349-7978","observed_orcids":["https://orcid.org/0000-0002-0349-7978"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michel Farnier","raw_affiliation_strings":["Michel Farnier"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Michel Farnier","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111968325","display_name":"Yee Ping Teoh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yee P. Teoh","raw_affiliation_strings":["Yee P. Teoh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yee P. Teoh","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044113713","display_name":"Mafalda Bourbon","orcid":"https://orcid.org/0000-0001-8843-3799","observed_orcids":["https://orcid.org/0000-0001-8843-3799"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mafalda Bourbon","raw_affiliation_strings":["Mafalda Bourbon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mafalda Bourbon","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060616979","display_name":"Masa\u2010aki Kawashiri","orcid":"https://orcid.org/0000-0002-5759-1353","observed_orcids":["https://orcid.org/0000-0002-5759-1353"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masa-aki Kawashiri","raw_affiliation_strings":["Masa-aki Kawashiri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Masa-aki Kawashiri","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087125829","display_name":"Atsushi Nohara","orcid":"https://orcid.org/0000-0002-2586-5727","observed_orcids":["https://orcid.org/0000-0002-2586-5727"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Atsushi Nohara","raw_affiliation_strings":["Atsushi Nohara"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Atsushi Nohara","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002617335","display_name":"Handrean Soran","orcid":"https://orcid.org/0000-0003-1714-5014","observed_orcids":["https://orcid.org/0000-0003-1714-5014"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Handrean Soran","raw_affiliation_strings":["Handrean Soran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Handrean Soran","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035047137","display_name":"Adrian David Marais","orcid":"https://orcid.org/0000-0001-5678-5714","observed_orcids":["https://orcid.org/0000-0001-5678-5714"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. David Marais","raw_affiliation_strings":["A. David Marais"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A. David Marais","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103211583","display_name":"Hayato Tada","orcid":"https://orcid.org/0000-0002-3357-1809","observed_orcids":["https://orcid.org/0000-0002-3357-1809"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hayato Tada","raw_affiliation_strings":["Hayato Tada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hayato Tada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047514616","display_name":"Marianne Abifadel","orcid":"https://orcid.org/0000-0001-7645-8323","observed_orcids":["https://orcid.org/0000-0001-7645-8323"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marianne Abifadel","raw_affiliation_strings":["Marianne Abifadel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marianne Abifadel","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055519983","display_name":"Cath\u00e9rine Boileau","orcid":"https://orcid.org/0000-0002-0371-7539","observed_orcids":["https://orcid.org/0000-0002-0371-7539"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Catherine Boileau","raw_affiliation_strings":["Catherine Boileau"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Catherine Boileau","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105779561","display_name":"B. Chanu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bernard Chanu","raw_affiliation_strings":["Bernard Chanu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bernard Chanu","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075580025","display_name":"Shoji Katsuda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shoji Katsuda","raw_affiliation_strings":["Shoji Katsuda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shoji Katsuda","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002254054","display_name":"Ichiro Kishimoto","orcid":"https://orcid.org/0000-0002-8322-0230","observed_orcids":["https://orcid.org/0000-0002-8322-0230"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ichiro Kishimoto","raw_affiliation_strings":["Ichiro Kishimoto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ichiro Kishimoto","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000971455","display_name":"Gilles C. Lambert","orcid":"https://orcid.org/0000-0001-5632-0685","observed_orcids":["https://orcid.org/0000-0001-5632-0685"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gilles Lambert","raw_affiliation_strings":["Gilles Lambert"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gilles Lambert","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055879912","display_name":"Hisashi Makino","orcid":"https://orcid.org/0000-0001-9953-3736","observed_orcids":["https://orcid.org/0000-0001-9953-3736"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hisashi Makino","raw_affiliation_strings":["Hisashi Makino"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hisashi Makino","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064352051","display_name":"Yoshihiro Miyamoto","orcid":"https://orcid.org/0000-0002-1337-0508","observed_orcids":["https://orcid.org/0000-0002-1337-0508"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshihiro Miyamoto","raw_affiliation_strings":["Yoshihiro Miyamoto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yoshihiro Miyamoto","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075686624","display_name":"Matthieu Pichelin","orcid":"https://orcid.org/0000-0002-6822-6132","observed_orcids":["https://orcid.org/0000-0002-6822-6132"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthieu Pichelin","raw_affiliation_strings":["Matthieu Pichelin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Matthieu Pichelin","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025214510","display_name":"Kunimasa Yagi","orcid":"https://orcid.org/0000-0002-6805-6428","observed_orcids":["https://orcid.org/0000-0002-6805-6428"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kunimasa Yagi","raw_affiliation_strings":["Kunimasa Yagi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kunimasa Yagi","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101502157","display_name":"Masakazu Yamagishi","orcid":"https://orcid.org/0000-0003-4201-5094","observed_orcids":["https://orcid.org/0000-0003-4201-5094"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masakazu Yamagishi","raw_affiliation_strings":["Masakazu Yamagishi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Masakazu Yamagishi","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108128917","display_name":"Yassine Za\u00efr","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yassine Zair","raw_affiliation_strings":["Yassine Zair"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yassine Zair","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038455658","display_name":"Scott J. Mellis","orcid":"https://orcid.org/0009-0008-3991-2177","observed_orcids":["https://orcid.org/0009-0008-3991-2177"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott Mellis","raw_affiliation_strings":["Scott Mellis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scott Mellis","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085672493","display_name":"George D. Yancopoulos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George D. Yancopoulos","raw_affiliation_strings":["George D. Yancopoulos"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"George D. Yancopoulos","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083524146","display_name":"Neil Stahl","orcid":"https://orcid.org/0000-0001-7265-2575","observed_orcids":["https://orcid.org/0000-0001-7265-2575"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neil Stahl","raw_affiliation_strings":["Neil Stahl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neil Stahl","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Johanna Mendoza","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johanna Mendoza","raw_affiliation_strings":["Johanna Mendoza"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johanna Mendoza","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109073167","display_name":"Yunling E. Du","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yunling Du","raw_affiliation_strings":["Yunling Du"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yunling Du","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019163181","display_name":"Sara Hamon","orcid":"https://orcid.org/0000-0002-2413-2302","observed_orcids":["https://orcid.org/0000-0002-2413-2302"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sara Hamon","raw_affiliation_strings":["Sara Hamon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sara Hamon","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043484813","display_name":"Michel Krempf","orcid":"https://orcid.org/0000-0002-4353-9511","observed_orcids":["https://orcid.org/0000-0002-4353-9511"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michel Krempf","raw_affiliation_strings":["Michel Krempf"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Michel Krempf","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045041660","display_name":"Gary D. Swergold","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary D. Swergold","raw_affiliation_strings":["Gary D. Swergold"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gary D. Swergold","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5029779433"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.0371,"has_fulltext":true,"cited_by_count":122,"citation_normalized_percentile":{"value":0.98776197,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"8","issue":"6","first_page":"823","last_page":"831"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autosomal-dominant-hypercholesterolemia","display_name":"autosomal dominant hypercholesterolemia","score":0.9549999833106995},{"id":"https://openalex.org/keywords/alirocumab","display_name":"alirocumab","score":0.9810000061988831},{"id":"https://openalex.org/keywords/pcsk9-monoclonal-antibodies","display_name":"PCSK9 monoclonal antibodies","score":0.9909999966621399},{"id":"https://openalex.org/keywords/ldl-cholesterol-lowering","display_name":"LDL cholesterol lowering","score":0.878000020980835},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.9120000004768372},{"id":"https://openalex.org/keywords/premature-cardiovascular-disease","display_name":"premature cardiovascular disease","score":0.7670000195503235},{"id":"https://openalex.org/keywords/pcsk9-inhibitors","display_name":"PCSK9 inhibitors","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C2780948078","wikidata":"https://www.wikidata.org/wiki/Q21130010","display_name":"PCSK9","level":5,"score":0.9714404344558716},{"id":"https://openalex.org/C2780902209","wikidata":"https://www.wikidata.org/wiki/Q4726914","display_name":"Alirocumab","level":5,"score":0.9389281868934631},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7133793234825134},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6671762466430664},{"id":"https://openalex.org/C2779120738","wikidata":"https://www.wikidata.org/wiki/Q2711291","display_name":"Familial hypercholesterolemia","level":3,"score":0.5199426412582397},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5169588923454285},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.5057487487792969},{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.4473362863063812},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.42582160234451294},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4208952486515045},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.3729386627674103},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3573918640613556},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3300834894180298},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1490684449672699},{"id":"https://openalex.org/C2780745583","wikidata":"https://www.wikidata.org/wiki/Q1316030","display_name":"Apolipoprotein A1","level":4,"score":0.07184627652168274},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071449","descriptor_name":"Proprotein Convertase 9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006938","descriptor_name":"Hyperlipoproteinemia Type II","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006938","descriptor_name":"Hyperlipoproteinemia Type II","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006938","descriptor_name":"Hyperlipoproteinemia Type II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043484","descriptor_name":"Proprotein Convertases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D043484","descriptor_name":"Proprotein Convertases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D043484","descriptor_name":"Proprotein Convertases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1161/circgenetics.115.001129","doi":"https://doi.org/10.1161/circgenetics.115.001129","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circgenetics.115.001129","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCGENETICS.115.001129","source":{"id":"https://openalex.org/S103446830","display_name":"Circulation Cardiovascular Genetics","issn_l":"1942-3268","issn":["1942-3268","1942-325X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation: Cardiovascular Genetics","raw_type":"journal-article"},{"id":"pmid:26374825","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26374825","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation. Cardiovascular genetics","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:5098466","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5098466/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circ Cardiovasc Genet","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-01830975v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-01830975","pdf_url":"https://hal.science/hal-01830975v1/file/823.full.pdf","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Circulation: Genomic and Precision Medecine, 2015, Equipe 5, 8 (6), pp.823--831. &#x27E8;10.1161/CIRCGENETICS.115.001129&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/4dd0ea52-508a-4a16-9e88-e06bbd34dc45","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/characterization-of-autosomal-dominant-hypercholesterolemia-caused-by-pcsk9-gain-of-function-mutations-and-its-specific-treatment-with-alirocumab-a-pcsk9-monoclonal-antibody(4dd0ea52-508a-4a16-9e88-e06bbd34dc45).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Circulation. Cardiovascular genetics, 8(6), 823 - 831. Lippincott Williams and Wilkins","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/c5f46a04-c9cf-4f0f-9095-f6fcd00d74a4","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/files/160787824/Characterization-of-autosomal-dominant-hypercholesterolemia-caused-by-pcsk9-gain-of-function-mutations-and-its-specific-.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repositorio.insa.pt:10400.18/3173","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10400.18/3173","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1161/circgenetics.115.001129","doi":"https://doi.org/10.1161/circgenetics.115.001129","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circgenetics.115.001129","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCGENETICS.115.001129","source":{"id":"https://openalex.org/S103446830","display_name":"Circulation Cardiovascular Genetics","issn_l":"1942-3268","issn":["1942-3268","1942-325X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation: Cardiovascular Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5225638054","display_name":"ANGPTL8 function and development of coronary artery disease","funder_award_id":"26461359","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G788065149","display_name":null,"funder_award_id":"U1148","funder_id":"https://openalex.org/F4320320893","funder_display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale"}],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320310065","display_name":"Danone","ror":"https://ror.org/00aj77a24"},{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320310319","display_name":"Central Manchester University Hospitals NHS Foundation Trust","ror":"https://ror.org/00he80998"},{"id":"https://openalex.org/F4320311600","display_name":"Regeneron Pharmaceuticals","ror":"https://ror.org/02f51rf24"},{"id":"https://openalex.org/F4320316137","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938"},{"id":"https://openalex.org/F4320316238","display_name":"Kowa Company","ror":"https://ror.org/009z2z347"},{"id":"https://openalex.org/F4320316982","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38"},{"id":"https://openalex.org/F4320318231","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320322561","display_name":"Saint Joseph University","ror":"https://ror.org/044fxjq88"},{"id":"https://openalex.org/F4320323024","display_name":"Astellas Pharma","ror":"https://ror.org/01cjash87"},{"id":"https://openalex.org/F4320323400","display_name":"Universit\u00e9 Pierre et Marie Curie","ror":"https://ror.org/02en5vm52"},{"id":"https://openalex.org/F4320323424","display_name":"Universidade de Lisboa","ror":"https://ror.org/01c27hj86"},{"id":"https://openalex.org/F4320324164","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79"},{"id":"https://openalex.org/F4320324271","display_name":"Astellas Foundation for Research on Metabolic Disorders","ror":"https://ror.org/01cjash87"},{"id":"https://openalex.org/F4320325719","display_name":"Universit\u00e9 de Nantes","ror":"https://ror.org/03gnr7b55"},{"id":"https://openalex.org/F4320326049","display_name":"Assistance publique-H\u00f4pitaux de Paris","ror":null},{"id":"https://openalex.org/F4320331144","display_name":"Universit\u00e9 de Versailles Saint-Quentin-en-Yvelines","ror":"https://ror.org/03mkjjy25"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2153159453.pdf","grobid_xml":"https://content.openalex.org/works/W2153159453.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1523379588","https://openalex.org/W1966101029","https://openalex.org/W1969417111","https://openalex.org/W1974078996","https://openalex.org/W1980786839","https://openalex.org/W1989730880","https://openalex.org/W2000338246","https://openalex.org/W2030060743","https://openalex.org/W2040612932","https://openalex.org/W2043461445","https://openalex.org/W2051679035","https://openalex.org/W2054749768","https://openalex.org/W2056411372","https://openalex.org/W2057968913","https://openalex.org/W2094826099","https://openalex.org/W2099136586","https://openalex.org/W2099654648","https://openalex.org/W2103487568","https://openalex.org/W2106285889","https://openalex.org/W2108956796","https://openalex.org/W2116970126","https://openalex.org/W2118868005","https://openalex.org/W2123717499","https://openalex.org/W2128030263","https://openalex.org/W2141227482","https://openalex.org/W2142627469","https://openalex.org/W2146660254","https://openalex.org/W2149360857","https://openalex.org/W2155766749","https://openalex.org/W2164409290","https://openalex.org/W2165624352","https://openalex.org/W2166203308","https://openalex.org/W2170601708"],"related_works":["https://openalex.org/W2996849495","https://openalex.org/W3171058285","https://openalex.org/W2981743498","https://openalex.org/W2889458515","https://openalex.org/W2751933740","https://openalex.org/W2756698192","https://openalex.org/W2035882075","https://openalex.org/W2767163800","https://openalex.org/W2191078666","https://openalex.org/W4402762653"],"abstract_inverted_index":{"BACKGROUND:":[0],"Patients":[1],"with":[2,85,115,141,182],"PCSK9":[3,48,82,106,158,184,210,229],"gene":[4,112],"gain":[5],"of":[6,14,47,67,118,130,144,198,223],"function":[7],"(GOF)":[8],"mutations":[9,84,108,145],"have":[10,214],"a":[11,53,62,228],"rare":[12],"form":[13],"autosomal":[15],"dominant":[16],"hypercholesterolemia.":[17],"However,":[18],"data":[19],"examining":[20],"their":[21,93],"clinical":[22,45],"characteristics":[23,46],"and":[24,134,218,235],"geographic":[25],"distribution":[26],"are":[27,219],"lacking.":[28],"Furthermore,":[29],"no":[30],"randomized":[31,63],"treatment":[32],"study":[33,66],"in":[34,52,146,157,170,241],"this":[35],"population":[36],"has":[37],"been":[38],"reported.":[39],"METHODS":[40],"AND":[41],"RESULTS:":[42],"We":[43,59],"compiled":[44],"GOF":[49,83,107,159,185,211],"mutation":[50,160,186,212],"carriers":[51,143,213],"multinational":[54],"retrospective,":[55],"cross-sectional,":[56],"observational":[57],"study.":[58],"then":[60],"performed":[61],"placebo-phase,":[64],"double-blind":[65],"alirocumab":[68,199],"150":[69],"mg":[70],"administered":[71],"subcutaneously":[72],"every":[73],"2":[74,173],"weeks":[75,174,197],"to":[76,164,237],"13":[77],"patients":[78,161,187],"representing":[79],"4":[80],"different":[81,105],"low-density":[86],"lipoprotein":[87],"cholesterol":[88],"(LDL-C)":[89],"\u226570":[90],"mg/dL":[91],"on":[92],"current":[94],"lipid-lowering":[95],"therapies":[96],"at":[97,172,220],"baseline.":[98],"Observational":[99],"study:":[100,156],"among":[101],"164":[102],"patients,":[103],"16":[104],"distributed":[109],"throughout":[110],"the":[111,147],"were":[113,138],"associated":[114],"varying":[116],"severity":[117],"untreated":[119,135],"LDL-C":[120,136,171,201,216,233],"levels.":[121],"Coronary":[122],"artery":[123],"disease":[124],"was":[125,175,202],"common":[126],"(33%;":[127],"average":[128],"age":[129],"onset,":[131],"49.4":[132],"years),":[133],"concentrations":[137],"higher":[139],"compared":[140,181],"matched":[142],"LDLR":[148],"(n=2126)":[149],"or":[150],"apolipoprotein":[151],"B":[152],"(n=470)":[153],"genes.":[154],"Intervention":[155],"randomly":[162],"assigned":[163],"receive":[165],"alirocumab,":[166],"mean":[167],"percent":[168],"reduction":[169],"62.5%":[176],"(P<0.0001)":[177],"from":[178,206],"baseline,":[179],"53.7%":[180],"placebo-treated":[183],"(P=0.0009;":[188],"primary":[189],"end":[190],"point).":[191],"After":[192],"all":[193],"subjects":[194],"received":[195],"8":[196],"treatment,":[200],"reduced":[203],"by":[204],"73%":[205],"baseline":[207],"(P<0.0001).":[208],"CONCLUSIONS:":[209],"elevated":[215],"levels":[217,234],"high":[221],"risk":[222],"premature":[224],"cardiovascular":[225],"disease.":[226],"Alirocumab,":[227],"antibody,":[230],"markedly":[231],"lowers":[232],"seems":[236],"be":[238],"well":[239],"tolerated":[240],"these":[242],"patients.":[243],"CLINICAL":[244],"TRIAL":[245],"REGISTRATION:":[246],"URL:":[247],"http://www.clinicaltrials.gov.":[248],"Unique":[249],"Identifier:":[250],"NCT01604824.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
