{"id":"https://openalex.org/W2153159055","doi":"https://doi.org/10.2337/diacare.26.7.2216-a","title":"Association Between Endothelial Nitric Oxide Synthase Glu298Asp Polymorphism and Postchallenge Insulin Levels in Nondiabetic Japanese Subjects","display_name":"Association Between Endothelial Nitric Oxide Synthase Glu298Asp Polymorphism and Postchallenge Insulin Levels in Nondiabetic Japanese Subjects","publication_year":2003,"publication_date":"2003-07-01","ids":{"openalex":"https://openalex.org/W2153159055","doi":"https://doi.org/10.2337/diacare.26.7.2216-a","mag":"2153159055","pmid":"https://pubmed.ncbi.nlm.nih.gov/12832346"},"language":"en","primary_location":{"id":"doi:10.2337/diacare.26.7.2216-a","doi":"https://doi.org/10.2337/diacare.26.7.2216-a","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diacare.26.7.2216-a","pdf_url":null,"source":{"id":"https://openalex.org/S49878492","display_name":"Diabetes Care","issn_l":"0149-5992","issn":["0149-5992","1935-5548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084788318","display_name":"Noriko Maruyama","orcid":"https://orcid.org/0000-0002-4487-4936","observed_orcids":["https://orcid.org/0000-0002-4487-4936"]},"institutions":[{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noriko Maruyama","raw_affiliation_strings":["Third Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, Japan","institution_ids":["https://openalex.org/I178574317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004508919","display_name":"Yutaka Yano","orcid":"https://orcid.org/0000-0003-0234-1207","observed_orcids":["https://orcid.org/0000-0003-0234-1207"]},"institutions":[{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yutaka Yano","raw_affiliation_strings":["Third Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, Japan","institution_ids":["https://openalex.org/I178574317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062744464","display_name":"Esteban Cesar Gabazza","orcid":"https://orcid.org/0000-0001-5748-1499","observed_orcids":["https://orcid.org/0000-0001-5748-1499"]},"institutions":[{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Esteban C. Gabazza","raw_affiliation_strings":["Third Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, Japan","institution_ids":["https://openalex.org/I178574317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007685233","display_name":"Rika Araki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Rika Araki","raw_affiliation_strings":["Third Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, Japan","institution_ids":["https://openalex.org/I178574317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076503722","display_name":"Akira Katsuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Katsuki","raw_affiliation_strings":["Third Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, Japan","institution_ids":["https://openalex.org/I178574317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052295114","display_name":"Yasuko Hori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuko Hori","raw_affiliation_strings":["Third Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, Japan","institution_ids":["https://openalex.org/I178574317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027464317","display_name":"Kaname Nakatani","orcid":"https://orcid.org/0000-0001-6709-541X","observed_orcids":["https://orcid.org/0000-0001-6709-541X"]},"institutions":[{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kaname Nakatani","raw_affiliation_strings":["Department of Laboratory Medicine, Mie University School of Medicine, Tsu, Mie, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Mie University School of Medicine, Tsu, Mie, Japan","institution_ids":["https://openalex.org/I178574317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051495874","display_name":"Yasuhiro Sumida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiro Sumida","raw_affiliation_strings":["Third Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, Japan","institution_ids":["https://openalex.org/I178574317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110700048","display_name":"Yukihiko Adachi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukihiko Adachi","raw_affiliation_strings":["Third Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, Japan","institution_ids":["https://openalex.org/I178574317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5004508919"],"corresponding_institution_ids":["https://openalex.org/I178574317"],"apc_list":null,"apc_paid":null,"fwci":0.1898,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.5722132,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"26","issue":"7","first_page":"2216","last_page":"2218"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.7163000106811523,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.7163000106811523,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.11800000071525574,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.10509999841451645,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/enos-glu298asp-polymorphism","display_name":"eNOS Glu298Asp polymorphism","score":0.953000009059906},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.7229999899864197},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.675000011920929},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.5979999899864197},{"id":"https://openalex.org/keywords/skeletal-muscle-glucose-uptake","display_name":"skeletal muscle glucose uptake","score":0.902999997138977},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.5199999809265137}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8713890314102173},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8422218561172485},{"id":"https://openalex.org/C2778326061","wikidata":"https://www.wikidata.org/wiki/Q1761022","display_name":"Enos","level":4,"score":0.8019239902496338},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6968281865119934},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5238718390464783},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.5200626254081726},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.4674226939678192},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.4475362300872803},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.44639432430267334},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.445487380027771},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42952868342399597},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.40247929096221924}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005951","descriptor_name":"Glucose Tolerance Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052250","descriptor_name":"Nitric Oxide Synthase Type III","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2337/diacare.26.7.2216-a","doi":"https://doi.org/10.2337/diacare.26.7.2216-a","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diacare.26.7.2216-a","pdf_url":null,"source":{"id":"https://openalex.org/S49878492","display_name":"Diabetes Care","issn_l":"0149-5992","issn":["0149-5992","1935-5548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"journal-article"},{"id":"pmid:12832346","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12832346","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes care","raw_type":"Letter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9074000120162964,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1928175618","https://openalex.org/W1972561326","https://openalex.org/W1976851726","https://openalex.org/W1983844941","https://openalex.org/W1998500745","https://openalex.org/W2065501573","https://openalex.org/W2114289687","https://openalex.org/W2121790250","https://openalex.org/W2132806782","https://openalex.org/W2141719916","https://openalex.org/W2141757949","https://openalex.org/W2345903479","https://openalex.org/W2405570732","https://openalex.org/W4233562854"],"related_works":["https://openalex.org/W1983844941","https://openalex.org/W1566230955","https://openalex.org/W2064113295","https://openalex.org/W1994269627","https://openalex.org/W1984210838","https://openalex.org/W1591464427","https://openalex.org/W1979902898","https://openalex.org/W2014583505","https://openalex.org/W1970403847","https://openalex.org/W2043422603"],"abstract_inverted_index":{"Endothelial":[0],"nitric":[1],"oxide":[2],"synthase":[3],"(eNOS)":[4],"catalyzes":[5],"NO":[6,13,56],"production":[7,54],"in":[8,57,70,83,90,93,105,115,123],"vascular":[9],"endothelial":[10],"cells,":[11],"and":[12,42,67,131,151,161,183,186],"regulates":[14],"local":[15],"blood":[16,33,65,149],"flow":[17,66,150],"by":[18,38,44,141,166],"inducing":[19],"vasodilation":[20],"(1).":[21],"Enhancement":[22],"of":[23,31,55,63,86,109,134,139,147,178],"skeletal":[24],"muscle":[25,32],"glucose":[26,68,88,152,169,185],"uptake":[27,69,89],"occurs":[28],"during":[29],"elevation":[30],"flow,":[34],"which":[35],"is":[36],"induced":[37],"increased":[39],"eNOS":[40,58,78,94,140],"expression":[41],"activated":[43],"insulin":[45,159,187],"stimulation":[46],"(2\u20134).":[47],"It":[48,154],"was":[49,155],"previously":[50],"reported":[51],"that":[52,77,158],"low":[53],"knockout":[59],"mice":[60],"causes":[61],"reduction":[62,146],"insulin-induced":[64,87,148],"whole":[71,91],"body":[72],"(5).":[73],"These":[74],"findings":[75],"suggest":[76],"plays":[79],"an":[80],"important":[81],"role":[82],"the":[84,127,176],"regulation":[85],"body.\n\nPolymorphism":[92],"exon":[95],"7":[96],"with":[97,181],"G\u2192T":[98],"conversion":[99],"at":[100],"nucleotide":[101],"position":[102],"894":[103],"results":[104],"amino":[106,116],"acid":[107,111,114,117],"substitution":[108],"glutamic":[110],"for":[112],"aspartic":[113],"residue":[118],"298":[119],"(Glu298Asp).":[120],"Structural":[121],"alteration":[122],"this":[124,135,142,179],"variant":[125],"affects":[126],"susceptibility":[128],"to":[129],"cleavage":[130],"reduces":[132],"activity":[133],"enzyme":[136],"(6,7).":[137],"Dysfunction":[138],"polymorphism":[143,180],"may":[144],"cause":[145],"uptake.":[153],"recently":[156],"demonstrated":[157],"secretion":[160],"sensitivity":[162],"could":[163],"be":[164],"assessed":[165],"75-g":[167],"oral":[168],"tolerance":[170],"test":[171],"(8,9).":[172],"Therefore,":[173],"we":[174],"examined":[175],"association":[177],"fasting":[182],"postchallenge":[184],"levels":[188],"\u2026":[189]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
