{"id":"https://openalex.org/W2153138245","doi":"https://doi.org/10.1517/14656566.3.6.755","title":"Paclitaxel in cancer therapy","display_name":"Paclitaxel in cancer therapy","publication_year":2002,"publication_date":"2002-06-01","ids":{"openalex":"https://openalex.org/W2153138245","doi":"https://doi.org/10.1517/14656566.3.6.755","mag":"2153138245","pmid":"https://pubmed.ncbi.nlm.nih.gov/12036415"},"language":"en","primary_location":{"id":"doi:10.1517/14656566.3.6.755","doi":"https://doi.org/10.1517/14656566.3.6.755","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14656566.3.6.755","pdf_url":null,"source":{"id":"https://openalex.org/S52020611","display_name":"Expert Opinion on Pharmacotherapy","issn_l":"1465-6566","issn":["1465-6566","1744-7666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110182324","display_name":"Maurie Markman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maurie Markman","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA. mekhait@ccf.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA. mekhait@ccf.org","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111567764","display_name":"Tarek M. Mekhail","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tarek M Mekhail","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. Mekhait@ccf.org","Department of Hematology and Medical Oncology, Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, OH 44195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. Mekhait@ccf.org","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, OH 44195, USA","institution_ids":["https://openalex.org/I1316902750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1316902750"],"apc_list":null,"apc_paid":null,"fwci":0.247,"has_fulltext":false,"cited_by_count":377,"citation_normalized_percentile":{"value":0.30211817,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"3","issue":"6","first_page":"755","last_page":"766"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":1.0},{"id":"https://openalex.org/keywords/microtubule-polymerization","display_name":"microtubule assembly","score":0.7789999842643738},{"id":"https://openalex.org/keywords/microtubule-dynamics","display_name":"microtubule dynamics","score":0.9860000014305115},{"id":"https://openalex.org/keywords/acquired-drug-resistance","display_name":"acquired drug resistance","score":0.8669999837875366},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.7720000147819519},{"id":"https://openalex.org/keywords/drug-efflux-pumps","display_name":"drug efflux pumps","score":0.8999999761581421},{"id":"https://openalex.org/keywords/hypersensitivity","display_name":"hypersensitivity","score":0.7870000004768372},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.984000027179718},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7670000195503235},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.7039999961853027},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":0.9440000057220459},{"id":"https://openalex.org/keywords/lymphoma","display_name":"lymphoma","score":0.8820000290870667},{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":0.9919999837875366},{"id":"https://openalex.org/keywords/kaposi-sarcoma","display_name":"Kaposi's sarcoma","score":0.8270000219345093},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.3179999887943268}],"concepts":[{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.922110915184021},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8473685383796692},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5478935837745667},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5135416984558105},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.456351101398468},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45020973682403564},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.44110748171806335},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42461633682250977},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40053799748420715},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3627379238605499}],"mesh":[{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1517/14656566.3.6.755","doi":"https://doi.org/10.1517/14656566.3.6.755","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14656566.3.6.755","pdf_url":null,"source":{"id":"https://openalex.org/S52020611","display_name":"Expert Opinion on Pharmacotherapy","issn_l":"1465-6566","issn":["1465-6566","1744-7666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Pharmacotherapy","raw_type":"journal-article"},{"id":"pmid:12036415","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12036415","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on pharmacotherapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":99,"referenced_works":["https://openalex.org/W370487","https://openalex.org/W57954726","https://openalex.org/W120771606","https://openalex.org/W121883304","https://openalex.org/W132905495","https://openalex.org/W1262485082","https://openalex.org/W1547132539","https://openalex.org/W1562190372","https://openalex.org/W1570441204","https://openalex.org/W1749876465","https://openalex.org/W1781345619","https://openalex.org/W1783154753","https://openalex.org/W1828224642","https://openalex.org/W1830813972","https://openalex.org/W1835347798","https://openalex.org/W1837236202","https://openalex.org/W1845622004","https://openalex.org/W1854639282","https://openalex.org/W1863225814","https://openalex.org/W1868450210","https://openalex.org/W1880426265","https://openalex.org/W1881209172","https://openalex.org/W1883854830","https://openalex.org/W1894009312","https://openalex.org/W1900284273","https://openalex.org/W1960713055","https://openalex.org/W1976033985","https://openalex.org/W1981534406","https://openalex.org/W1982141224","https://openalex.org/W1995973757","https://openalex.org/W1998276910","https://openalex.org/W2003362694","https://openalex.org/W2013907429","https://openalex.org/W2015167754","https://openalex.org/W2017330771","https://openalex.org/W2027975261","https://openalex.org/W2036475994","https://openalex.org/W2037139573","https://openalex.org/W2037490361","https://openalex.org/W2037605675","https://openalex.org/W2043061492","https://openalex.org/W2043750157","https://openalex.org/W2046471046","https://openalex.org/W2057157978","https://openalex.org/W2059453596","https://openalex.org/W2067299834","https://openalex.org/W2069200256","https://openalex.org/W2080155235","https://openalex.org/W2081406767","https://openalex.org/W2084092457","https://openalex.org/W2097105130","https://openalex.org/W2103498979","https://openalex.org/W2117771496","https://openalex.org/W2117995467","https://openalex.org/W2118873545","https://openalex.org/W2128069055","https://openalex.org/W2130787156","https://openalex.org/W2131524935","https://openalex.org/W2133635118","https://openalex.org/W2134979684","https://openalex.org/W2135427853","https://openalex.org/W2135459504","https://openalex.org/W2137597770","https://openalex.org/W2141258764","https://openalex.org/W2145555831","https://openalex.org/W2148078311","https://openalex.org/W2154084738","https://openalex.org/W2157227537","https://openalex.org/W2159027140","https://openalex.org/W2159256537","https://openalex.org/W2162960688","https://openalex.org/W2165982968","https://openalex.org/W2167527499","https://openalex.org/W2169073956","https://openalex.org/W2170912376","https://openalex.org/W2181611844","https://openalex.org/W2213012239","https://openalex.org/W2242824667","https://openalex.org/W2248741218","https://openalex.org/W2262251960","https://openalex.org/W2270346008","https://openalex.org/W2318605753","https://openalex.org/W2328421677","https://openalex.org/W2335667890","https://openalex.org/W2403580394","https://openalex.org/W2411032314","https://openalex.org/W2412318818","https://openalex.org/W2414469356","https://openalex.org/W2414643639","https://openalex.org/W2418898383","https://openalex.org/W2419662862","https://openalex.org/W2504684570","https://openalex.org/W2618306484","https://openalex.org/W2797611163","https://openalex.org/W2992820193","https://openalex.org/W3010717707","https://openalex.org/W3143077989","https://openalex.org/W4210704032","https://openalex.org/W4233628679"],"related_works":["https://openalex.org/W3206612685","https://openalex.org/W2181548792","https://openalex.org/W7100690690","https://openalex.org/W7167788017","https://openalex.org/W4210983938","https://openalex.org/W2071309482","https://openalex.org/W2069059514","https://openalex.org/W2154054522","https://openalex.org/W2054361195","https://openalex.org/W2412495131"],"abstract_inverted_index":{"The":[0],"last":[1],"decade":[2],"witnessed":[3],"the":[4,18,24,34,58],"introduction":[5],"of":[6,17,26,47,54,60,93],"exciting":[7],"new":[8],"chemotherapeutic":[9],"agents.":[10],"Among":[11],"these,":[12],"paclitaxel":[13,51,71],"emerged":[14],"as":[15,65],"one":[16],"most":[19],"powerful":[20],"compounds.":[21],"Paclitaxel":[22,86,104,134],"promotes":[23],"polymerisation":[25],"tubulin,":[27],"thereby":[28],"causing":[29],"cell":[30,40,122,132],"death":[31],"by":[32],"disrupting":[33],"normal":[35],"microtubule":[36],"dynamics":[37],"required":[38],"for":[39],"division":[41],"and":[42,57,76,84,101,120,125,130],"vital":[43],"interphase":[44],"processes.":[45],"Mechanisms":[46],"acquired":[48],"resistance":[49],"to":[50,114],"include":[52,72],"alterations":[53],"tubulin":[55],"structure":[56],"amplification":[59],"membrane":[61],"phosphoglycoproteins":[62],"that":[63,111],"function":[64],"drug-efflux":[66],"pumps.":[67],"Toxicities":[68,79],"associated":[69],"with":[70],"hypersensitivity":[73],"reaction,":[74],"neurotoxicity":[75],"haematological":[77],"toxicities.":[78],"may":[80],"be":[81],"both":[82],"dose-":[83],"schedule-dependent.":[85],"has":[87,106],"activity":[88,107],"against":[89,138],"a":[90],"broad":[91],"band":[92],"tumour":[94],"types,":[95],"including":[96,117],"breast,":[97],"ovarian,":[98],"lung,":[99],"head":[100],"neck":[102],"cancers.":[103],"also":[105,136],"in":[108],"other":[109],"malignancies":[110],"are":[112],"refractory":[113],"conventional":[115],"chemotherapy,":[116],"previously-treated":[118],"lymphoma":[119],"small":[121],"lung":[123],"cancers":[124],"oesophageal,":[126],"gastric":[127],"endometrial,":[128],"bladder":[129],"germ":[131],"tumours.":[133],"is":[135],"active":[137],"AIDS-associated":[139],"Kaposi's":[140],"sarcoma.":[141]},"counts_by_year":[{"year":2026,"cited_by_count":18},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":24},{"year":2023,"cited_by_count":33},{"year":2022,"cited_by_count":33},{"year":2021,"cited_by_count":31},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
