{"id":"https://openalex.org/W2152934852","doi":"https://doi.org/10.1111/j.0300-9475.2004.01432.x","title":"Circulating Cytokines in Primary Sj\u00f6gren's Syndrome Determined by a Multiplex Cytokine Array System","display_name":"Circulating Cytokines in Primary Sj\u00f6gren's Syndrome Determined by a Multiplex Cytokine Array System","publication_year":2004,"publication_date":"2004-04-01","ids":{"openalex":"https://openalex.org/W2152934852","doi":"https://doi.org/10.1111/j.0300-9475.2004.01432.x","mag":"2152934852","pmid":"https://pubmed.ncbi.nlm.nih.gov/15182255"},"language":"en","primary_location":{"id":"doi:10.1111/j.0300-9475.2004.01432.x","doi":"https://doi.org/10.1111/j.0300-9475.2004.01432.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.0300-9475.2004.01432.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.0300-9475.2004.01432.x","source":{"id":"https://openalex.org/S79173686","display_name":"Scandinavian Journal of Immunology","issn_l":"0300-9475","issn":["0300-9475","1365-3083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.0300-9475.2004.01432.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013332149","display_name":"P\u00e9ter Szodoray","orcid":"https://orcid.org/0000-0003-4443-6159","observed_orcids":["https://orcid.org/0000-0003-4443-6159"]},"institutions":[{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"P. Szodoray","raw_affiliation_strings":["Broegelmann Research Laboratory, The Gade Institute, University of Bergen, Bergen, Norway. peter.szodoray@gades.uib.no","Broegelmann Research Laboratory, The Gade Institute, University of Bergen, Bergen, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broegelmann Research Laboratory, The Gade Institute, University of Bergen, Bergen, Norway. peter.szodoray@gades.uib.no","institution_ids":["https://openalex.org/I4432739"]},{"raw_affiliation_string":"Broegelmann Research Laboratory, The Gade Institute, University of Bergen, Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113606572","display_name":"Philip Alex","orcid":"https://orcid.org/0009-0006-1263-6315","observed_orcids":["https://orcid.org/0009-0006-1263-6315"]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Alex","raw_affiliation_strings":["Oklahoma Medical Research Foundation, Oklahoma City, OK, USA, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oklahoma Medical Research Foundation, Oklahoma City, OK, USA, and","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042881159","display_name":"Johan Gorgas Brun","orcid":"https://orcid.org/0000-0002-6004-3702","observed_orcids":["https://orcid.org/0000-0002-6004-3702"]},"institutions":[{"id":"https://openalex.org/I2800740805","display_name":"Haukeland University Hospital","ror":"https://ror.org/03np4e098","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2800740805"]},{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"J. G. Brun","raw_affiliation_strings":["Department of Rheumatology, Haukeland University Hospital, University of Bergen, Bergen, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Haukeland University Hospital, University of Bergen, Bergen, Norway","institution_ids":["https://openalex.org/I2800740805","https://openalex.org/I4432739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078634023","display_name":"Michael B Centola","orcid":"https://orcid.org/0009-0008-7000-9007","observed_orcids":["https://orcid.org/0009-0008-7000-9007"]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Centola","raw_affiliation_strings":["Oklahoma Medical Research Foundation, Oklahoma City, OK, USA, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oklahoma Medical Research Foundation, Oklahoma City, OK, USA, and","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070764431","display_name":"Roland Jonsson","orcid":"https://orcid.org/0000-0002-9588-0260","observed_orcids":["https://orcid.org/0000-0002-9588-0260"]},"institutions":[{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"R. Jonsson","raw_affiliation_strings":["Broegelmann Research Laboratory, The Gade Institute, University of Bergen, Bergen, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broegelmann Research Laboratory, The Gade Institute, University of Bergen, Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5013332149"],"corresponding_institution_ids":["https://openalex.org/I4432739"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":5.6037,"has_fulltext":false,"cited_by_count":171,"citation_normalized_percentile":{"value":0.96348091,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"59","issue":"6","first_page":"592","last_page":"599"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-sjogren-syndrome","display_name":"primary Sj\u00f6gren's syndrome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/plasma-cytokine-levels","display_name":"plasma cytokines","score":0.9700000286102295},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.7940000295639038},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.972000002861023},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.8640000224113464},{"id":"https://openalex.org/keywords/interleukin-12-p40","display_name":"interleukin-12p40","score":0.890999972820282},{"id":"https://openalex.org/keywords/il-15","display_name":"IL-15","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9869999885559082},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.9369999766349792},{"id":"https://openalex.org/keywords/extraglandular-manifestations","display_name":"extraglandular manifestations","score":0.859000027179718},{"id":"https://openalex.org/keywords/erythrocyte-sedimentation-rate","display_name":"erythrocyte sedimentation rate","score":0.9539999961853027},{"id":"https://openalex.org/keywords/igg","display_name":"IgG","score":0.8059999942779541},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.8569999933242798},{"id":"https://openalex.org/keywords/anti-cytokine-therapy","display_name":"anti-cytokine therapy","score":0.8410000205039978},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.7858861684799194},{"id":"https://openalex.org/C2780590879","wikidata":"https://www.wikidata.org/wiki/Q5009606","display_name":"CCL11","level":5,"score":0.7672579288482666},{"id":"https://openalex.org/C2777716647","wikidata":"https://www.wikidata.org/wiki/Q5381961","display_name":"Eotaxin","level":4,"score":0.7479761838912964},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6722184419631958},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.6630786061286926},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5734966993331909},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5668450593948364},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5575041770935059},{"id":"https://openalex.org/C2781188995","wikidata":"https://www.wikidata.org/wiki/Q6934982","display_name":"Multiplex","level":2,"score":0.49070942401885986},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4795936644077301},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29943418502807617},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2907176613807678},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.0877278745174408}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001799","descriptor_name":"Blood Sedimentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012859","descriptor_name":"Sjogren's Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012859","descriptor_name":"Sjogren's Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.0300-9475.2004.01432.x","doi":"https://doi.org/10.1111/j.0300-9475.2004.01432.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.0300-9475.2004.01432.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.0300-9475.2004.01432.x","source":{"id":"https://openalex.org/S79173686","display_name":"Scandinavian Journal of Immunology","issn_l":"0300-9475","issn":["0300-9475","1365-3083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:15182255","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15182255","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian journal of immunology","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1111/j.0300-9475.2004.01432.x","doi":"https://doi.org/10.1111/j.0300-9475.2004.01432.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.0300-9475.2004.01432.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.0300-9475.2004.01432.x","source":{"id":"https://openalex.org/S79173686","display_name":"Scandinavian Journal of Immunology","issn_l":"0300-9475","issn":["0300-9475","1365-3083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1112083259","display_name":"Oklahoma IDeA Network of Biomedical Research Excellence","funder_award_id":"P20RR016478","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G773184794","display_name":"Science in a Culture of Mentoring","funder_award_id":"P20RR015577","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2152934852.pdf"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W111972176","https://openalex.org/W1966903360","https://openalex.org/W1990141362","https://openalex.org/W1993886157","https://openalex.org/W2011994212","https://openalex.org/W2015081883","https://openalex.org/W2064531916","https://openalex.org/W2080554985","https://openalex.org/W2087559795","https://openalex.org/W2093350386","https://openalex.org/W2096234172","https://openalex.org/W2105683551","https://openalex.org/W2162710873","https://openalex.org/W2167385753","https://openalex.org/W2321306700","https://openalex.org/W2413863715","https://openalex.org/W2767842635","https://openalex.org/W3139807843"],"related_works":["https://openalex.org/W4383213646","https://openalex.org/W2326677341","https://openalex.org/W2321306700","https://openalex.org/W4283705434","https://openalex.org/W2556170007","https://openalex.org/W3093253948","https://openalex.org/W4238878916","https://openalex.org/W2096234172","https://openalex.org/W2151557366","https://openalex.org/W1501198020"],"abstract_inverted_index":{"Plasma":[0],"cytokines":[1,68,100,141],"play":[2],"an":[3],"important":[4],"role":[5],"in":[6,51,94,182,197],"the":[7,26,63,159,170,173,183,198],"pathogenesis":[8],"of":[9,25,35,65,69,98,140,163,188,200],"Sj\u00f6gren's":[10],"syndrome":[11],"(SS)":[12],"by":[13],"initiating":[14],"and":[15,19,37,43,74,87,126,135,156,185],"perpetuating":[16],"various":[17],"cellular":[18],"humoural":[20],"autoimmune":[21],"processes.":[22],"The":[23],"aim":[24],"present":[27],"study":[28],"was":[29,58,128],"to":[30,48,60,91,130,144],"describe":[31],"a":[32,194],"broad":[33],"spectrum":[34],"T-cell":[36],"B-cell":[38],"cytokines,":[39],"growth":[40,115],"factors,":[41],"chemokines":[42],"molecules":[44],"that":[45,172],"could":[46],"contribute":[47],"cell":[49],"death":[50],"SS.":[52,95,189],"A":[53,96],"novel":[54],"protein":[55],"array":[56,176],"system":[57,177],"utilized":[59,181],"measure":[61],"simultaneously":[62],"levels":[64,83,155],"25":[66],"plasma":[67,81,99],"patients":[70,134,147,157],"with":[71,84,148,158],"primary":[72],"SS":[73],"healthy":[75],"individuals.":[76],"Furthermore,":[77,190],"we":[78],"correlated":[79],"these":[80],"cytokine":[82,175],"potential":[85],"laboratory":[86],"clinical":[88],"parameters":[89],"related":[90],"disease":[92,186],"activity":[93],"subset":[97],"[e.g.":[101],"interleukin-1beta":[102],"(IL-1beta),":[103],"IL-6,":[104],"CXCL8":[105],"(IL-8),":[106],"IL-12":[107],"p40,":[108],"IL-15,":[109],"tumour":[110],"necrosis":[111],"factor-alpha":[112],"(TNF-alpha),":[113],"epidermal":[114],"factor,":[116],"CCL4":[117],"(MIP-1beta),":[118],"CCL2":[119],"(MCP-1),":[120],"CCL11":[121],"(Eotaxin),":[122],"CCL5":[123],"(RANTES),":[124],"TNF-RI":[125],"TNF-RII]":[127],"found":[129,143],"significantly":[131],"differ":[132],"between":[133,146],"controls.":[136],"Also,":[137],"distinct":[138],"populations":[139],"were":[142],"differentiate":[145],"normal":[149],"versus":[150],"elevated":[151],"ESR":[152],"or":[153,161],"IgG":[154],"presence":[160],"absence":[162],"extra-glandular":[164],"manifestations":[165],"(EGMs).":[166],"Our":[167],"results":[168],"support":[169],"assumption":[171],"multiplex":[174],"can":[178],"be":[179],"successfully":[180],"diagnosis":[184],"management":[187],"it":[191],"may":[192],"provide":[193],"powerful":[195],"tool":[196],"design":[199],"individualized":[201],"anticytokine":[202],"therapies.":[203]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
