{"id":"https://openalex.org/W2152913697","doi":"https://doi.org/10.1158/1055-9965.epi-09-0372","title":"Obesity and Cancer: The Role of Dysfunctional Adipose Tissue","display_name":"Obesity and Cancer: The Role of Dysfunctional Adipose Tissue","publication_year":2009,"publication_date":"2009-10-01","ids":{"openalex":"https://openalex.org/W2152913697","doi":"https://doi.org/10.1158/1055-9965.epi-09-0372","mag":"2152913697","pmid":"https://pubmed.ncbi.nlm.nih.gov/19755644"},"language":"en","primary_location":{"id":"doi:10.1158/1055-9965.epi-09-0372","doi":"https://doi.org/10.1158/1055-9965.epi-09-0372","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1055-9965.epi-09-0372","pdf_url":null,"source":{"id":"https://openalex.org/S8391440","display_name":"Cancer Epidemiology Biomarkers & Prevention","issn_l":"1055-9965","issn":["1055-9965","1538-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Epidemiology, Biomarkers &amp; Prevention","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011418634","display_name":"Rob C.M. van Kruijsdijk","orcid":"https://orcid.org/0000-0002-3399-6604","observed_orcids":["https://orcid.org/0000-0002-3399-6604"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Rob C.M. van Kruijsdijk","raw_affiliation_strings":["Departments of 1Vascular Medicine and 2Pathology and Medical Oncology, University Medical Center Utrecht, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Vascular Medicine and 2Pathology and Medical Oncology, University Medical Center Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090786009","display_name":"Elsken van der Wall","orcid":"https://orcid.org/0000-0003-2568-6937","observed_orcids":["https://orcid.org/0000-0003-2568-6937"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Elsken van der Wall","raw_affiliation_strings":["Departments of 1Vascular Medicine and 2Pathology and Medical Oncology, University Medical Center Utrecht, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Vascular Medicine and 2Pathology and Medical Oncology, University Medical Center Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073320977","display_name":"Frank L.J. Visseren","orcid":"https://orcid.org/0000-0003-3951-5223","observed_orcids":["https://orcid.org/0000-0003-3951-5223"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Frank L.J. Visseren","raw_affiliation_strings":["Departments of 1Vascular Medicine and 2Pathology and Medical Oncology, University Medical Center Utrecht, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Vascular Medicine and 2Pathology and Medical Oncology, University Medical Center Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5073320977"],"corresponding_institution_ids":["https://openalex.org/I3018483916"],"apc_list":null,"apc_paid":null,"fwci":4.4445,"has_fulltext":false,"cited_by_count":733,"citation_normalized_percentile":{"value":0.98086124,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"18","issue":"10","first_page":"2569","last_page":"2578"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.82669997215271,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.82669997215271,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.15690000355243683,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.5820000171661377},{"id":"https://openalex.org/keywords/adipose-tissue-dysfunction","display_name":"adipose tissue dysfunction","score":0.9779999852180481},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9589999914169312},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.9980000257492065},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.9319999814033508},{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.9649999737739563},{"id":"https://openalex.org/keywords/sex-steroids","display_name":"sex steroids","score":0.8220000267028809},{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.972000002861023},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7960000038146973},{"id":"https://openalex.org/keywords/overweight-prevention","display_name":"overweight prevention","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C2776782570","wikidata":"https://www.wikidata.org/wiki/Q357439","display_name":"Adiponectin","level":4,"score":0.8005620241165161},{"id":"https://openalex.org/C194832188","wikidata":"https://www.wikidata.org/wiki/Q2638593","display_name":"Adipokine","level":4,"score":0.7694211602210999},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.7472319602966309},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.6794134378433228},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6773562431335449},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.6701444387435913},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6501325964927673},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.5772261023521423},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5606938600540161},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5369467735290527},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4937768876552582},{"id":"https://openalex.org/C2780586474","wikidata":"https://www.wikidata.org/wiki/Q332428","display_name":"Overweight","level":3,"score":0.4619686007499695},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.45908230543136597},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4364657998085022},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4180793762207031},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.37613001465797424},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18619155883789062}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1158/1055-9965.epi-09-0372","doi":"https://doi.org/10.1158/1055-9965.epi-09-0372","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1055-9965.epi-09-0372","pdf_url":null,"source":{"id":"https://openalex.org/S8391440","display_name":"Cancer Epidemiology Biomarkers & Prevention","issn_l":"1055-9965","issn":["1055-9965","1538-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Epidemiology, Biomarkers &amp; Prevention","raw_type":"journal-article"},{"id":"pmid:19755644","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19755644","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":158,"referenced_works":["https://openalex.org/W332185995","https://openalex.org/W1511930757","https://openalex.org/W1543891416","https://openalex.org/W1562891630","https://openalex.org/W1576403695","https://openalex.org/W1587875569","https://openalex.org/W1675602016","https://openalex.org/W1807656740","https://openalex.org/W1864871585","https://openalex.org/W1898391394","https://openalex.org/W1965037168","https://openalex.org/W1967563637","https://openalex.org/W1971377850","https://openalex.org/W1974033843","https://openalex.org/W1975070422","https://openalex.org/W1976552085","https://openalex.org/W1976844022","https://openalex.org/W1977524333","https://openalex.org/W1978281808","https://openalex.org/W1979999673","https://openalex.org/W1980087218","https://openalex.org/W1981261500","https://openalex.org/W1984077508","https://openalex.org/W1984634800","https://openalex.org/W1985416534","https://openalex.org/W1986423215","https://openalex.org/W1986878490","https://openalex.org/W1987949508","https://openalex.org/W1993959456","https://openalex.org/W1994423670","https://openalex.org/W1996831894","https://openalex.org/W1999229158","https://openalex.org/W2000033816","https://openalex.org/W2001568034","https://openalex.org/W2003500892","https://openalex.org/W2003699768","https://openalex.org/W2004239490","https://openalex.org/W2004516503","https://openalex.org/W2008431672","https://openalex.org/W2008869160","https://openalex.org/W2012037560","https://openalex.org/W2012167887","https://openalex.org/W2016246684","https://openalex.org/W2021765303","https://openalex.org/W2022279920","https://openalex.org/W2025193872","https://openalex.org/W2025710049","https://openalex.org/W2027837629","https://openalex.org/W2028313225","https://openalex.org/W2029066152","https://openalex.org/W2034773448","https://openalex.org/W2039063847","https://openalex.org/W2042706232","https://openalex.org/W2042893069","https://openalex.org/W2045632404","https://openalex.org/W2047108227","https://openalex.org/W2050131271","https://openalex.org/W2050604034","https://openalex.org/W2050795981","https://openalex.org/W2051180209","https://openalex.org/W2053249023","https://openalex.org/W2054154194","https://openalex.org/W2057110290","https://openalex.org/W2057123987","https://openalex.org/W2057418848","https://openalex.org/W2060350507","https://openalex.org/W2062637797","https://openalex.org/W2066340025","https://openalex.org/W2066809635","https://openalex.org/W2070001214","https://openalex.org/W2070861981","https://openalex.org/W2071342389","https://openalex.org/W2072380594","https://openalex.org/W2072382749","https://openalex.org/W2081341888","https://openalex.org/W2083461110","https://openalex.org/W2085351616","https://openalex.org/W2086840459","https://openalex.org/W2087016879","https://openalex.org/W2088623150","https://openalex.org/W2090086221","https://openalex.org/W2091321756","https://openalex.org/W2091725413","https://openalex.org/W2092509345","https://openalex.org/W2093332642","https://openalex.org/W2094835614","https://openalex.org/W2095847870","https://openalex.org/W2096492292","https://openalex.org/W2097733438","https://openalex.org/W2098049779","https://openalex.org/W2100784798","https://openalex.org/W2102119534","https://openalex.org/W2103761194","https://openalex.org/W2104340251","https://openalex.org/W2105702970","https://openalex.org/W2107550410","https://openalex.org/W2108881204","https://openalex.org/W2110713453","https://openalex.org/W2112338443","https://openalex.org/W2113017183","https://openalex.org/W2117503386","https://openalex.org/W2118131350","https://openalex.org/W2119519672","https://openalex.org/W2119541125","https://openalex.org/W2120613477","https://openalex.org/W2121527286","https://openalex.org/W2126034108","https://openalex.org/W2126035635","https://openalex.org/W2126071318","https://openalex.org/W2126317966","https://openalex.org/W2126924946","https://openalex.org/W2127543909","https://openalex.org/W2127645314","https://openalex.org/W2128380182","https://openalex.org/W2130219349","https://openalex.org/W2130766522","https://openalex.org/W2132577252","https://openalex.org/W2132655440","https://openalex.org/W2136024338","https://openalex.org/W2138220577","https://openalex.org/W2138555254","https://openalex.org/W2138792619","https://openalex.org/W2141550792","https://openalex.org/W2141662760","https://openalex.org/W2144420811","https://openalex.org/W2144545612","https://openalex.org/W2144737008","https://openalex.org/W2144888610","https://openalex.org/W2145724381","https://openalex.org/W2149060937","https://openalex.org/W2150776809","https://openalex.org/W2153383900","https://openalex.org/W2153388523","https://openalex.org/W2154902011","https://openalex.org/W2155243001","https://openalex.org/W2160822634","https://openalex.org/W2161966331","https://openalex.org/W2167342921","https://openalex.org/W2167543957","https://openalex.org/W2167596697","https://openalex.org/W2168536185","https://openalex.org/W2169159364","https://openalex.org/W2169519360","https://openalex.org/W2171370241","https://openalex.org/W2171594703","https://openalex.org/W2174415873","https://openalex.org/W2181009182","https://openalex.org/W2184009762","https://openalex.org/W2323202746","https://openalex.org/W2917806833","https://openalex.org/W3138780921","https://openalex.org/W4238251256","https://openalex.org/W4249825849","https://openalex.org/W4252851641","https://openalex.org/W6634367828","https://openalex.org/W6637374581","https://openalex.org/W6677609281","https://openalex.org/W6685214338"],"related_works":["https://openalex.org/W1560008238","https://openalex.org/W2944339347","https://openalex.org/W2564261821","https://openalex.org/W2119036906","https://openalex.org/W1958804953","https://openalex.org/W2561806934","https://openalex.org/W2183647087","https://openalex.org/W2121878894","https://openalex.org/W7134238330","https://openalex.org/W2164035507"],"abstract_inverted_index":{"Overweight":[0],"and":[1,17,48,68,76,83,108,116],"obesity":[2,107,117],"are":[3,79],"health":[4],"problems":[5],"of":[6,14,24,27,39,51,54,63,74,103],"epidemic":[7],"proportions,":[8],"increasing":[9],"the":[10,36,104],"risk":[11],"not":[12],"only":[13],"cardiovascular":[15],"disease":[16],"type":[18],"2":[19],"diabetes":[20],"mellitus":[21],"but":[22],"also":[23],"various":[25],"types":[26],"cancer.":[28],"Obesity":[29],"is":[30],"strongly":[31],"associated":[32],"with":[33],"changes":[34],"in":[35,81],"physiological":[37],"function":[38],"adipose":[40,93],"tissue,":[41],"leading":[42],"to":[43],"insulin":[44,59],"resistance,":[45,60],"chronic":[46,77],"inflammation,":[47,78],"altered":[49],"secretion":[50],"adipokines.":[52],"Several":[53],"these":[55,89],"factors,":[56],"such":[57],"as":[58,96],"increased":[61],"levels":[62,73],"leptin,":[64],"plasminogen":[65],"activator":[66],"inhibitor-1,":[67],"endogenous":[69],"sex":[70],"steroids,":[71],"decreased":[72],"adiponectin,":[75],"involved":[80],"carcinogenesis":[82],"cancer":[84,109],"progression.":[85],"This":[86],"article":[87],"reviews":[88],"mechanisms,":[90],"focusing":[91],"on":[92],"tissue":[94],"dysfunction":[95],"a":[97],"unifying":[98],"causal":[99],"factor.":[100],"Although":[101],"understanding":[102],"link":[105],"between":[106],"might":[110],"provide":[111],"therapeutic":[112],"targets,":[113],"preventing":[114],"overweight":[115],"still":[118],"remains":[119],"number":[120],"one":[121],"priority.":[122]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":21},{"year":2024,"cited_by_count":26},{"year":2023,"cited_by_count":35},{"year":2022,"cited_by_count":39},{"year":2021,"cited_by_count":48},{"year":2020,"cited_by_count":36},{"year":2019,"cited_by_count":53},{"year":2018,"cited_by_count":52},{"year":2017,"cited_by_count":58},{"year":2016,"cited_by_count":41},{"year":2015,"cited_by_count":69},{"year":2014,"cited_by_count":56},{"year":2013,"cited_by_count":72},{"year":2012,"cited_by_count":51}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
