{"id":"https://openalex.org/W2152907264","doi":null,"title":"The pharmaco-economics of peri-operative beta-blocker and statin therapy in South Africa.","display_name":"The pharmaco-economics of peri-operative beta-blocker and statin therapy in South Africa.","publication_year":2006,"publication_date":"2006-11-01","ids":{"openalex":"https://openalex.org/W2152907264","mag":"2152907264","pmid":"https://pubmed.ncbi.nlm.nih.gov/17167708"},"language":"en","primary_location":{"id":"pmid:17167708","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17167708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066903887","display_name":"Bruce McClure Biccard","orcid":"https://orcid.org/0000-0001-5872-8369","observed_orcids":["https://orcid.org/0000-0001-5872-8369"]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"B M Biccard","raw_affiliation_strings":["Nuffield Department of Anaesthetics, Oxford University, John Radcliffe Hospital, Headington, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Anaesthetics, Oxford University, John Radcliffe Hospital, Headington, Oxford, UK","institution_ids":["https://openalex.org/I2802742124","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111907445","display_name":"John William Sear","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J W Sear","raw_affiliation_strings":["Nuffield Department of Anaesthetics, Oxford University, John Radcliffe Hospital, Headington, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Anaesthetics, Oxford University, John Radcliffe Hospital, Headington, Oxford, UK","institution_ids":["https://openalex.org/I2802742124","https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109059177","display_name":"Pierre Fo\u00ebx","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P Fo\u00ebx","raw_affiliation_strings":["Nuffield Department of Anaesthetics, Oxford University, John Radcliffe Hospital, Headington, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Anaesthetics, Oxford University, John Radcliffe Hospital, Headington, Oxford, UK","institution_ids":["https://openalex.org/I2802742124","https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9043,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.77190244,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"96","issue":"11","first_page":"1199","last_page":"202"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11930","display_name":"Cardiac, Anesthesia and Surgical Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11930","display_name":"Cardiac, Anesthesia and Surgical Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.8610000014305115},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.9959999918937683},{"id":"https://openalex.org/keywords/perioperative-medication","display_name":"perioperative drug therapy","score":0.7229999899864197},{"id":"https://openalex.org/keywords/elective-noncardiac-surgery","display_name":"elective non-cardiac surgery","score":0.878000020980835},{"id":"https://openalex.org/keywords/perioperative-cardiovascular-complications","display_name":"perioperative cardiovascular complications","score":0.9259999990463257},{"id":"https://openalex.org/keywords/cost-reduction","display_name":"cost reduction","score":0.6790000200271606},{"id":"https://openalex.org/keywords/south-africa","display_name":"South Africa","score":0.625}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9767564535140991},{"id":"https://openalex.org/C31174226","wikidata":"https://www.wikidata.org/wiki/Q64855140","display_name":"Perioperative","level":2,"score":0.8324457406997681},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.6767953634262085},{"id":"https://openalex.org/C2778742482","wikidata":"https://www.wikidata.org/wiki/Q816759","display_name":"Beta blocker","level":3,"score":0.5179466605186462},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.5177992582321167},{"id":"https://openalex.org/C2781312054","wikidata":"https://www.wikidata.org/wiki/Q5354947","display_name":"Elective surgery","level":2,"score":0.5148636102676392},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.4940684139728546},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.4346504211425781},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3731279969215393},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3265417218208313},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3246139585971832},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28224584460258484},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.10480383038520813},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D003365","descriptor_name":"Costs and Cost Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007431","descriptor_name":"Intraoperative Complications","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013019","descriptor_name":"South Africa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017850","descriptor_name":"Economics, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019990","descriptor_name":"Perioperative Care","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:17167708","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17167708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde","raw_type":"Journal Article"},{"id":"mag:2152907264","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17167708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W274148713","https://openalex.org/W1596428716","https://openalex.org/W1981591620","https://openalex.org/W1994235921","https://openalex.org/W2000211370","https://openalex.org/W2006638045","https://openalex.org/W2007742842","https://openalex.org/W2015413151","https://openalex.org/W2017202497","https://openalex.org/W2021202706","https://openalex.org/W2025851046","https://openalex.org/W2026737066","https://openalex.org/W2027494068","https://openalex.org/W2030475349","https://openalex.org/W2035938418","https://openalex.org/W2039449300","https://openalex.org/W2044017515","https://openalex.org/W2068822701","https://openalex.org/W2070568974","https://openalex.org/W2097674540","https://openalex.org/W2135740385","https://openalex.org/W2165636891","https://openalex.org/W2317607797","https://openalex.org/W2330628369"],"related_works":["https://openalex.org/W2044017515","https://openalex.org/W2035938418","https://openalex.org/W2792474247","https://openalex.org/W1509524613","https://openalex.org/W2619615795","https://openalex.org/W4244827204","https://openalex.org/W1572435451","https://openalex.org/W2262548690","https://openalex.org/W2069363529","https://openalex.org/W2043348646"],"abstract_inverted_index":{"We":[0],"conducted":[1],"a":[2,41,45],"pharmaco-economic":[3],"analysis":[4,29],"of":[5,10,71,80],"the":[6,21,78,89],"prospective":[7],"peri-operative":[8,33,57],"studies":[9],"beta-blocker":[11],"and":[12,35],"statin":[13,36],"administration":[14],"for":[15,26],"major":[16,48,58,66,84],"elective":[17,65],"non-cardiac":[18,67],"surgery,":[19],"using":[20],"Discovery":[22],"Health":[23],"claims":[24],"costs":[25],"2004.":[27],"This":[28],"shows":[30],"that":[31],"acute":[32],"beta-blockade":[34],"therapy":[37],"could":[38],"result":[39],"in":[40,47,52,88,97],"cost":[42],"saving":[43],"through":[44],"reduction":[46],"perioperative":[49],"cardiovascular":[50,59,81],"complications":[51,82],"patients":[53],"with":[54],"an":[55],"expected":[56],"complication":[60],"rate":[61],"exceeding":[62],"10%":[63],"following":[64,83],"surgery.":[68],"The":[69],"validity":[70],"these":[72],"findings":[73],"is":[74,92],"dependent":[75],"on":[76],"whether":[77],"incidence":[79],"noncardiac":[85],"surgery":[86],"reported":[87],"international":[90],"literature":[91],"found":[93],"to":[94],"be":[95],"similar":[96],"South":[98],"Africa.":[99]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}