{"id":"https://openalex.org/W2152802057","doi":"https://doi.org/10.1634/stemcells.2005-0457","title":"Murine Embryonic Stem Cells Secrete Cytokines/Growth Modulators That Enhance Cell Survival/Anti-Apoptosis and Stimulate Colony Formation of Murine Hematopoietic Progenitor Cells","display_name":"Murine Embryonic Stem Cells Secrete Cytokines/Growth Modulators That Enhance Cell Survival/Anti-Apoptosis and Stimulate Colony Formation of Murine Hematopoietic Progenitor Cells","publication_year":2005,"publication_date":"2005-12-09","ids":{"openalex":"https://openalex.org/W2152802057","doi":"https://doi.org/10.1634/stemcells.2005-0457","mag":"2152802057","pmid":"https://pubmed.ncbi.nlm.nih.gov/16339641"},"language":"en","primary_location":{"id":"doi:10.1634/stemcells.2005-0457","doi":"https://doi.org/10.1634/stemcells.2005-0457","is_oa":false,"landing_page_url":"https://doi.org/10.1634/stemcells.2005-0457","pdf_url":null,"source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100781913","display_name":"Ying Guo","orcid":"https://orcid.org/0000-0002-4423-113X","observed_orcids":["https://orcid.org/0000-0002-4423-113X"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Guo","raw_affiliation_strings":["Department of Microbiology/Immunology, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana, USA; Walther Cancer Institute, Indianapolis, Indiana, USA","Walther Cancer Institute, Indianapolis, Indiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology/Immunology, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana, USA; Walther Cancer Institute, Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Walther Cancer Institute, Indianapolis, Indiana, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073022518","display_name":"Barbara E. Graham-Evans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara Graham-Evans","raw_affiliation_strings":["Department of Microbiology/Immunology, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana, USA; Walther Cancer Institute, Indianapolis, Indiana, USA","Walther Cancer Institute, Indianapolis, Indiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology/Immunology, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana, USA; Walther Cancer Institute, Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Walther Cancer Institute, Indianapolis, Indiana, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038161052","display_name":"Hal E. Broxmeyer","orcid":"https://orcid.org/0000-0001-6575-0476","observed_orcids":["https://orcid.org/0000-0001-6575-0476"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hal E. Broxmeyer","raw_affiliation_strings":["Department of Microbiology/Immunology, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana, USA; Walther Cancer Institute, Indianapolis, Indiana, USA","Walther Cancer Institute, Indianapolis, Indiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology/Immunology, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana, USA; Walther Cancer Institute, Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Walther Cancer Institute, Indianapolis, Indiana, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5038161052"],"corresponding_institution_ids":["https://openalex.org/I4394709130"],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":1.6325,"has_fulltext":true,"cited_by_count":66,"citation_normalized_percentile":{"value":0.82168313,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"24","issue":"4","first_page":"850","last_page":"856"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.6371999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.6371999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.33180001378059387,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.020500000566244125,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mouse-embryonic-stem-cells","display_name":"mouse embryonic stem cells","score":0.9279999732971191},{"id":"https://openalex.org/keywords/conditioned-medium","display_name":"conditioned medium","score":0.8730000257492065},{"id":"https://openalex.org/keywords/hematopoietic-progenitor-cells","display_name":"hematopoietic progenitor cells","score":0.9430000185966492},{"id":"https://openalex.org/keywords/apoptosis-inhibition","display_name":"apoptosis inhibition","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cell-survival","display_name":"cell survival","score":0.7319999933242798},{"id":"https://openalex.org/keywords/leukemia-inhibitory-factor","display_name":"leukemia inhibitory factor","score":0.8349999785423279},{"id":"https://openalex.org/keywords/sdf-1-cxcl12","display_name":"SDF-1/CXCL12","score":0.8679999709129333},{"id":"https://openalex.org/keywords/interleukins","display_name":"interleukins","score":0.8600000143051147},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.8009999990463257},{"id":"https://openalex.org/keywords/stem-cell-factor","display_name":"stem cell factor","score":0.7049999833106995},{"id":"https://openalex.org/keywords/oncostatin-m","display_name":"oncostatin M","score":0.800000011920929},{"id":"https://openalex.org/keywords/macrophage-colony-stimulating-factor","display_name":"macrophage colony-stimulating factor","score":0.8199999928474426},{"id":"https://openalex.org/keywords/irradiation","display_name":"irradiation","score":0.5270000100135803},{"id":"https://openalex.org/keywords/hematopoietic-differentiation","display_name":"hematopoietic differentiation","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.763419508934021},{"id":"https://openalex.org/C2777667943","wikidata":"https://www.wikidata.org/wiki/Q909425","display_name":"Oncostatin M","level":4,"score":0.6302027702331543},{"id":"https://openalex.org/C27284151","wikidata":"https://www.wikidata.org/wiki/Q6534502","display_name":"Leukemia inhibitory factor","level":4,"score":0.6084059476852417},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5882099270820618},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5868995189666748},{"id":"https://openalex.org/C2022786","wikidata":"https://www.wikidata.org/wiki/Q909331","display_name":"Stem cell factor","level":4,"score":0.5731675028800964},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5461588501930237},{"id":"https://openalex.org/C131665280","wikidata":"https://www.wikidata.org/wiki/Q14866169","display_name":"Interleukin 3","level":5,"score":0.5370631814002991},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5258001685142517},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5047124624252319},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.48188549280166626},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.4696067273616791},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4219230115413666},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4019273519515991},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3948850929737091},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.30789875984191895},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.28133559226989746},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.12654578685760498},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.12471339106559753},{"id":"https://openalex.org/C11988809","wikidata":"https://www.wikidata.org/wiki/Q412889","display_name":"Interleukin 6","level":3,"score":0.12308165431022644},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06199672818183899},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003114","descriptor_name":"Colony-Forming Units Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039901","descriptor_name":"Totipotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D039901","descriptor_name":"Totipotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D039901","descriptor_name":"Totipotent Stem Cells","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1634/stemcells.2005-0457","doi":"https://doi.org/10.1634/stemcells.2005-0457","is_oa":false,"landing_page_url":"https://doi.org/10.1634/stemcells.2005-0457","pdf_url":null,"source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells","raw_type":"journal-article"},{"id":"pmid:16339641","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16339641","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cells (Dayton, Ohio)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W71511797","https://openalex.org/W1851300844","https://openalex.org/W1948275303","https://openalex.org/W1981541713","https://openalex.org/W1992160731","https://openalex.org/W2003307277","https://openalex.org/W2018855387","https://openalex.org/W2047227694","https://openalex.org/W2065266983","https://openalex.org/W2109538121","https://openalex.org/W2116695601","https://openalex.org/W2138403036","https://openalex.org/W2367771517","https://openalex.org/W2404894647","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2556945188","https://openalex.org/W2584133294","https://openalex.org/W2065266983","https://openalex.org/W2131877971","https://openalex.org/W1851300844","https://openalex.org/W2153532735","https://openalex.org/W2085122784","https://openalex.org/W1532964767","https://openalex.org/W2058839233","https://openalex.org/W2400629161"],"abstract_inverted_index":{"Stromal":[0],"cell-derived":[1],"factor":[2,35,66,88],"(SDF)-1/CXCL12,":[3],"released":[4],"by":[5],"murine":[6,18,25,56,74,159],"embryonic":[7],"stem":[8,92],"(ES)":[9],"cells,":[10],"enhances":[11],"survival,":[12],"chemotaxis,":[13],"and":[14,70,106,128,135,177],"hematopoietic":[15],"differentiation":[16],"of":[17,32,54,73,104,110,117,120,125,131,166,171,186],"ES":[19,26,41,50,79,121,145,149,160],"cells.":[20,78],"Conditioned":[21],"medium":[22],"(CM)":[23],"from":[24],"cells":[27,42,122,146,161],"growing":[28,162],"in":[29,44,68,163],"the":[30,40,164],"presence":[31,165],"leukemia":[33],"inhibitory":[34],"(LIF)":[36],"was":[37,142],"generated":[38],"while":[39],"were":[43,147],"an":[45],"undifferentiated":[46,158],"Oct-4":[47],"expressing":[48],"state.":[49],"cell-CM":[51],"enhanced":[52,123],"survival":[53],"normal":[55],"bone":[57,75],"marrow":[58,76],"myeloid":[59],"progenitors":[60],"(CFU-GM)":[61],"subjected":[62],"to":[63,114,140],"delayed":[64],"growth":[65,97,179],"addition":[67],"vitro":[69],"decreased":[71,129],"apoptosis":[72],"c-kit(+)lin-":[77],"CM":[80,151],"contained":[81],"interleukin":[82],"(IL)-1alpha,":[83],"IL-10,":[84],"IL-11,":[85],"macrophage-colony":[86],"stimulating":[87],"(CSF),":[89],"oncostatin":[90],"M,":[91],"cell":[93,150],"factor,":[94,98],"vascular":[95],"endothelial":[96],"as":[99,101],"well":[100],"a":[102,169],"number":[103,170],"chemokines":[105],"other":[107,178],"proteins,":[108,181],"some":[109,126],"which":[111,183],"are":[112],"known":[113],"enhance":[115],"survival/anti-apoptosis":[116],"progenitors.":[118],"Irradiation":[119],"release":[124,130],"proteins":[127],"others.":[132],"IL-6,":[133],"FGF-9,":[134],"TNF-alpha,":[136],"not":[137],"detected":[138],"prior":[139],"irradiation":[141],"found":[143],"after":[144],"irradiated.":[148],"also":[152],"stimulated":[153],"CFU-GM":[154],"colony":[155],"formation.":[156],"Thus,":[157],"LIF":[167],"produce/release":[168],"biologically":[172],"active":[173],"interleukins,":[174],"CSFs,":[175],"chemokines,":[176],"modulatory":[180],"results":[182],"may":[184],"be":[185],"physiological":[187],"and/or":[188],"practical":[189],"significance.":[190]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}