{"id":"https://openalex.org/W2152777071","doi":null,"title":"Genetic and Vascular Risk Factors for Cognitive Decline and Cerebral Small-Vessel Disease","display_name":"Genetic and Vascular Risk Factors for Cognitive Decline and Cerebral Small-Vessel Disease","publication_year":2006,"publication_date":"2006-12-14","ids":{"openalex":"https://openalex.org/W2152777071","mag":"2152777071"},"language":"en","primary_location":{"id":"pmh:eur:oai:pure.eur.nl:publications/4d31f31f-eae7-44b8-853b-a98c517435b5","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/4d31f31f-eae7-44b8-853b-a98c517435b5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pure.eur.nl/en/publications/4d31f31f-eae7-44b8-853b-a98c517435b5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047423137","display_name":"Christiane Reitz","orcid":"https://orcid.org/0000-0001-8757-7889","observed_orcids":["https://orcid.org/0000-0001-8757-7889"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Christiane Reitz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8757-7889","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5047423137"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8628000020980835,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8628000020980835,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13648","display_name":"Cerebrovascular and genetic disorders","score":0.07800000160932541,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.05090000107884407,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cerebral-small-vessel-disease","display_name":"cerebral small vessel disease","score":0.9269999861717224},{"id":"https://openalex.org/keywords/vascular-risk-factors","display_name":"vascular risk factors","score":0.9679999947547913},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.8790000081062317},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.9079999923706055},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9750000238418579},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.9110000133514404},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cerebrovascular-disease","display_name":"cerebrovascular disease","score":0.7960000038146973},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.7979999780654907},{"id":"https://openalex.org/keywords/white-matter-lesions","display_name":"white matter lesions","score":0.8610000014305115},{"id":"https://openalex.org/keywords/lacunar-infarction","display_name":"lacunar infarction","score":0.9179999828338623},{"id":"https://openalex.org/keywords/post-stroke-dementia","display_name":"post-stroke dementia","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.9291042685508728},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.6217977404594421},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5695697665214539},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5426403284072876},{"id":"https://openalex.org/C2777952318","wikidata":"https://www.wikidata.org/wiki/Q583908","display_name":"Vascular dementia","level":4,"score":0.526427149772644},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5096018314361572},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4651639759540558},{"id":"https://openalex.org/C2779504383","wikidata":"https://www.wikidata.org/wiki/Q41482","display_name":"Autopsy","level":2,"score":0.4609525799751282},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.44477155804634094},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3857463300228119},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36312687397003174},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.34847667813301086},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.339580774307251},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.32016563415527344},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:eur:oai:pure.eur.nl:publications/4d31f31f-eae7-44b8-853b-a98c517435b5","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/4d31f31f-eae7-44b8-853b-a98c517435b5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:eur:oai:repub.eur.nl:13309","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1765/13309","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:oai:repub.eur.nl:13309","doi":null,"is_oa":true,"landing_page_url":"http://repub.eur.nl/pub/13309","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2152777071","doi":null,"is_oa":false,"landing_page_url":"https://repub.eur.nl/pub/13309/061214_Christiane Reitz.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:eur:oai:pure.eur.nl:publications/4d31f31f-eae7-44b8-853b-a98c517435b5","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/4d31f31f-eae7-44b8-853b-a98c517435b5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W1528057257","https://openalex.org/W1552103637","https://openalex.org/W1555463606","https://openalex.org/W1965334291","https://openalex.org/W1966113865","https://openalex.org/W1973725374","https://openalex.org/W1976541189","https://openalex.org/W1981746777","https://openalex.org/W1989083293","https://openalex.org/W1989255295","https://openalex.org/W1990163817","https://openalex.org/W1990427131","https://openalex.org/W1991758163","https://openalex.org/W1992903980","https://openalex.org/W1993079921","https://openalex.org/W1998432608","https://openalex.org/W2001206122","https://openalex.org/W2009869050","https://openalex.org/W2018775727","https://openalex.org/W2022648887","https://openalex.org/W2023224182","https://openalex.org/W2025774809","https://openalex.org/W2028037111","https://openalex.org/W2028436804","https://openalex.org/W2029324012","https://openalex.org/W2034664059","https://openalex.org/W2034897558","https://openalex.org/W2045777597","https://openalex.org/W2049733019","https://openalex.org/W2054162453","https://openalex.org/W2058610272","https://openalex.org/W2061202327","https://openalex.org/W2070385947","https://openalex.org/W2071772648","https://openalex.org/W2072150523","https://openalex.org/W2072656254","https://openalex.org/W2072753569","https://openalex.org/W2086582799","https://openalex.org/W2089118067","https://openalex.org/W2090295661","https://openalex.org/W2093813371","https://openalex.org/W2097326214","https://openalex.org/W2098621361","https://openalex.org/W2100419955","https://openalex.org/W2104855192","https://openalex.org/W2107191158","https://openalex.org/W2109642048","https://openalex.org/W2113708991","https://openalex.org/W2114175246","https://openalex.org/W2116287283","https://openalex.org/W2118592618","https://openalex.org/W2126701762","https://openalex.org/W2134768056","https://openalex.org/W2135070546","https://openalex.org/W2136239752","https://openalex.org/W2138034817","https://openalex.org/W2149486086","https://openalex.org/W2150142809","https://openalex.org/W2152708848","https://openalex.org/W2152888111","https://openalex.org/W2153669770","https://openalex.org/W2154916799","https://openalex.org/W2160643135","https://openalex.org/W2160776746","https://openalex.org/W2167215352","https://openalex.org/W2167591919","https://openalex.org/W2168565032","https://openalex.org/W2171053760","https://openalex.org/W2218853927","https://openalex.org/W2749375914","https://openalex.org/W4296941341"],"related_works":["https://openalex.org/W2888087653","https://openalex.org/W2538375767","https://openalex.org/W1596528066","https://openalex.org/W2725106266","https://openalex.org/W2966749056","https://openalex.org/W1974317715","https://openalex.org/W1967893324","https://openalex.org/W2094011216","https://openalex.org/W2435370254","https://openalex.org/W2502471382"],"abstract_inverted_index":{"One":[0],"of":[1,24,28,33,49,65,94,103,124,163,166,183,196,209,214,216,227,268],"the":[2,14,29,63,90,99,105,164,207,266],"earliest":[3],"known":[4],"written":[5],"reports":[6],"on":[7,254],"dementia":[8,114,174,228],"is":[9,115,236,249],"attributed":[10],"to":[11,204,223,262],"Pythagoras":[12],"in":[13,62,132,143],"7th\\ncentury":[15],"BC,":[16],"who":[17,71,169],"described":[18],"old":[19,69],"age":[20],"as":[21,239],"a":[22,40,66,116,180,191,221,250],"period":[23],"decline":[25,156],"and":[26,43,85,120,127,137,154,157,186,243,248],"decay":[27],"human":[30],"body":[31],"and\\nregression":[32],"mental":[34],"capacities.":[35],"In":[36,159],"1907,":[37],"Alois":[38],"Alzheimer,":[39],"german":[41],"psychiatrist":[42],"scientist,\\nobserved":[44],"at":[45,51],"necropsy":[46],"an":[47],"overload":[48],"-":[50,56],"that":[52,113,121],"time":[53],"still":[54],"unknown":[55],"amyloid":[57,83,126,184],"plaques":[58,84,185],"and\\nneurofi":[59],"brillary":[60],"tangles":[61,189],"brain":[64,246,255],"51":[67],"year":[68],"woman":[70],"had":[72,170,177],"suff":[73],"ered":[74],"during":[75],"her":[76],"life\\ncourse":[77],"from":[78],"progressive":[79],"cognitive":[80,155],"decline.":[81],"Nowadays,":[82],"neurofi":[86,128,187],"brillary\\ntangles":[87],"are":[88],"considered":[89],"main":[91],"neuropathological":[92],"hallmarks":[93],"Alzheimer\u2019s":[95],"disease,":[96,139,234],"which":[97,235],"is\\nregarded":[98],"most":[100],"frequent":[101],"subtype":[102],"dementia.\\nOver":[104],"past":[106],"two":[107],"decades":[108],"evidence":[109],"has":[110,259],"been":[111,171,260],"accumulating":[112],"heterogeneous\\nand":[117],"multifactorial":[118],"disorder,":[119],"besides":[122],"accumulation":[123],"beta":[125],"brillary\\ntangles,":[129],"other":[130],"factors,":[131],"particular":[133],"vascular":[134,151],"risk":[135,152,208,226,267],"factors":[136,153],"cerebrovascular":[138,199],"may\\nbe":[140],"involved,":[141],"especially":[142],"late-onset":[144],"dementia.":[145,158,269],"Observational":[146],"studies":[147],"reported":[148,203,261],"associations\\nbetween":[149],"several":[150],"autopsy":[160],"studies,\\nabout":[161],"35%":[162],"brains":[165],"elderly":[167],"persons,":[168,258],"diagnosed":[172],"with":[173,211],"during\\ntheir":[175],"lifetime,":[176],"not":[178],"only":[179],"higher":[181],"burden":[182],"brillar":[188],"but\\nrather":[190],"mixed":[192],"pathology":[193],"also":[194],"consisting":[195],"signifi":[197],"cant":[198],"disease.":[200],"Stroke":[201],"has\\nbeen":[202],"considerably":[205],"increase":[206],"dementia,":[210],"prevalence":[212],"rates":[213],"poststroke\\ndementia":[215],"about":[217],"30%,":[218],"refl":[219],"ecting":[220],"3.6":[222],"5.8-fold":[224],"increased":[225],"compared\\nto":[229],"stroke-free":[230],"subjects.":[231],"Cerebral":[232],"small-vessel":[233],"defi":[237],"ned":[238],"cerebral":[240],"white":[241],"matter\\nlesions":[242],"asymptomatic":[244],"lacunar":[245],"infarcts":[247],"common":[251],"fi":[252],"nding":[253],"scans":[256],"of\\nelderly":[257],"more":[263],"than":[264],"double":[265]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
