{"id":"https://openalex.org/W2152735985","doi":null,"title":"MYC messenger RNA expression predicts survival outcome in childhood primitive neuroectodermal tumor/medulloblastoma.","display_name":"MYC messenger RNA expression predicts survival outcome in childhood primitive neuroectodermal tumor/medulloblastoma.","publication_year":2001,"publication_date":"2001-08-01","ids":{"openalex":"https://openalex.org/W2152735985","mag":"2152735985","pmid":"https://pubmed.ncbi.nlm.nih.gov/11489822"},"language":"en","primary_location":{"id":"pmid:11489822","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11489822","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020920424","display_name":"Michael Andreas Grotzer","orcid":"https://orcid.org/0000-0002-1154-2732","observed_orcids":["https://orcid.org/0000-0002-1154-2732"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M A Grotzer","raw_affiliation_strings":["Division of Oncology, The Children's Hospital of Philadelphia, PA 19104, USA. Michael.Grotzer@kispi.unizh.ch"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, The Children's Hospital of Philadelphia, PA 19104, USA. Michael.Grotzer@kispi.unizh.ch","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045426069","display_name":"Michael D. Hogarty","orcid":"https://orcid.org/0000-0002-9221-4852","observed_orcids":["https://orcid.org/0000-0002-9221-4852"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M D Hogarty","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018873651","display_name":"Anna J. Janss","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A J Janss","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100651992","display_name":"Xueyuan Liu","orcid":"https://orcid.org/0000-0002-2093-4201","observed_orcids":["https://orcid.org/0000-0002-2093-4201","https://orcid.org/0009-0005-4627-5610"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"X Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"H Zhao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059343286","display_name":"Angelika Eggert","orcid":"https://orcid.org/0000-0003-3476-8184","observed_orcids":["https://orcid.org/0000-0003-3476-8184"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Eggert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108424497","display_name":"Leslie N. Sutton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L N Sutton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108374257","display_name":"LUCY BALIAN RORKE","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L B Rorke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004950779","display_name":"Garrett M. Brodeur","orcid":"https://orcid.org/0000-0002-6721-122X","observed_orcids":["https://orcid.org/0000-0002-6721-122X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G M Brodeur","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101920170","display_name":"Peter C. Phillips\u2225","orcid":"https://orcid.org/0000-0001-5565-8326","observed_orcids":["https://orcid.org/0000-0001-5565-8326"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P C Phillips","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.6823,"has_fulltext":false,"cited_by_count":168,"citation_normalized_percentile":{"value":0.97930539,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"7","issue":"8","first_page":"2425","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primitive-neuroectodermal-tumor","display_name":"primitive neuroectodermal tumor","score":0.9269999861717224},{"id":"https://openalex.org/keywords/medulloblastoma","display_name":"medulloblastoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pediatric-brain-tumors","display_name":"pediatric brain tumors","score":0.7850000262260437},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8399999737739563},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9850000143051147},{"id":"https://openalex.org/keywords/myc-amplification","display_name":"MYC amplification","score":0.9110000133514404},{"id":"https://openalex.org/keywords/radiotherapy-avoidance","display_name":"radiotherapy avoidance","score":0.6570000052452087},{"id":"https://openalex.org/keywords/treatment-intensity-reduction","display_name":"treatment intensity reduction","score":0.7689999938011169}],"concepts":[{"id":"https://openalex.org/C2780789225","wikidata":"https://www.wikidata.org/wiki/Q1333608","display_name":"Medulloblastoma","level":2,"score":0.8914068937301636},{"id":"https://openalex.org/C2776891213","wikidata":"https://www.wikidata.org/wiki/Q618660","display_name":"Primitive neuroectodermal tumor","level":3,"score":0.5732741355895996},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5292937755584717},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5080130100250244},{"id":"https://openalex.org/C4692481","wikidata":"https://www.wikidata.org/wiki/Q169526","display_name":"Reverse transcription polymerase chain reaction","level":4,"score":0.4421636462211609},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43555986881256104},{"id":"https://openalex.org/C2775842971","wikidata":"https://www.wikidata.org/wiki/Q3542016","display_name":"Neuroectodermal tumor","level":3,"score":0.4273703694343567},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.42355582118034363},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4224490225315094},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4135507047176361},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.4108082354068756},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.38033586740493774},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3465231657028198},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.333631694316864},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20589247345924377},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07590582966804504}],"mesh":[{"descriptor_ui":"D002528","descriptor_name":"Cerebellar Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002528","descriptor_name":"Cerebellar Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008527","descriptor_name":"Medulloblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008527","descriptor_name":"Medulloblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016259","descriptor_name":"Genes, myc","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018242","descriptor_name":"Neuroectodermal Tumors, Primitive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018242","descriptor_name":"Neuroectodermal Tumors, Primitive","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020812","descriptor_name":"Receptor, trkC","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11489822","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11489822","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"mag:2152735985","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11489822","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G545014352","display_name":"PRIMITIVE NEUROECTODERMAL TUMORS OF CHILDHOOD","funder_award_id":"P01NS034514","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W53915367","https://openalex.org/W161464813","https://openalex.org/W246770661","https://openalex.org/W1509850974","https://openalex.org/W1520596966","https://openalex.org/W1553178519","https://openalex.org/W1580788756","https://openalex.org/W1590195146","https://openalex.org/W1593929630","https://openalex.org/W1765636564","https://openalex.org/W1783699960","https://openalex.org/W1830677466","https://openalex.org/W1911329365","https://openalex.org/W1926885922","https://openalex.org/W1947312736","https://openalex.org/W1958993671","https://openalex.org/W1974965723","https://openalex.org/W1979300931","https://openalex.org/W1980348698","https://openalex.org/W1990588284","https://openalex.org/W2002404925","https://openalex.org/W2003862789","https://openalex.org/W2010111403","https://openalex.org/W2016855149","https://openalex.org/W2017289800","https://openalex.org/W2024247791","https://openalex.org/W2024280594","https://openalex.org/W2025047211","https://openalex.org/W2026691962","https://openalex.org/W2034622647","https://openalex.org/W2036371914","https://openalex.org/W2038252730","https://openalex.org/W2039576264","https://openalex.org/W2044864159","https://openalex.org/W2046648130","https://openalex.org/W2048242881","https://openalex.org/W2056120923","https://openalex.org/W2060127845","https://openalex.org/W2062451107","https://openalex.org/W2064772366","https://openalex.org/W2073840747","https://openalex.org/W2076695313","https://openalex.org/W2081455238","https://openalex.org/W2083471473","https://openalex.org/W2085357449","https://openalex.org/W2090138737","https://openalex.org/W2093960008","https://openalex.org/W2100140863","https://openalex.org/W2112160426","https://openalex.org/W2115732593","https://openalex.org/W2124394191","https://openalex.org/W2132604294","https://openalex.org/W2137684281","https://openalex.org/W2138189723","https://openalex.org/W2147423434","https://openalex.org/W2155076622","https://openalex.org/W2156773545","https://openalex.org/W2156978104","https://openalex.org/W2157636873","https://openalex.org/W2162966612","https://openalex.org/W2168649383","https://openalex.org/W2267860343","https://openalex.org/W2320732213","https://openalex.org/W2322711897","https://openalex.org/W2328777842","https://openalex.org/W2330923897","https://openalex.org/W2334615503","https://openalex.org/W2405545490","https://openalex.org/W2406511889","https://openalex.org/W2411341602","https://openalex.org/W2417217560","https://openalex.org/W2470793218","https://openalex.org/W4296216171"],"related_works":["https://openalex.org/W1765636564","https://openalex.org/W7096638339","https://openalex.org/W2073840747","https://openalex.org/W2020301883","https://openalex.org/W2514619758","https://openalex.org/W2794517877","https://openalex.org/W1968825318","https://openalex.org/W2414191959","https://openalex.org/W2158063808","https://openalex.org/W1899313383"],"abstract_inverted_index":{"PURPOSE":[0],"AND":[1],"EXPERIMENTAL":[2],"DESIGN:":[3],"Cerebellar":[4],"primitive":[5],"neuroectodermal":[6],"tumors/medulloblastomas":[7],"(PNET/MB)":[8],"are":[9],"the":[10,43,79],"most":[11],"common":[12],"malignant":[13],"brain":[14],"tumors":[15],"in":[16,38,49,67,175,188,195,207],"childhood.":[17],"To":[18],"identify":[19],"PNET/MB":[20,56,69,131,190,201],"biological":[21],"prognostic":[22,99],"factors":[23],"that":[24],"define":[25],"a":[26,30,36,71,75,126,141,167],"patient":[27],"group":[28,129],"with":[29,74,88,136,200],"sufficiently":[31],"good":[32,127,155],"prognosis":[33],"to":[34,193],"permit":[35],"reduction":[37],"treatment":[39,196],"intensity,":[40],"we":[41],"determined":[42],"expression":[44,65,94,119,124,165],"levels":[45,66,181],"of":[46,115,130,145,152,171,178,204],"MYC":[47,63,89,92,117,163,179],"mRNA":[48,64,93,118,123,164,180],"fresh":[50],"frozen":[51],"tumor":[52],"samples":[53],"from":[54],"26":[55],"patients":[57,132,157,199],"using":[58],"semiquantitative":[59],"reverse":[60],"transcription-PCR.":[61],"RESULTS:":[62],"primary":[68],"showed":[70],"wide":[72],"range":[73],"22-fold":[76],"difference":[77],"between":[78],"highest":[80],"and":[81,84,105,120,184],"lowest":[82],"values":[83],"did":[85],"not":[86],"correlate":[87],"gene":[90],"amplification.":[91],"was":[95,106],"an":[96],"independent":[97,169],"significant":[98],"factor":[100],"for":[101,198],"progression-free":[102,138],"survival":[103,139],"outcome":[104,128,156,174],"more":[107],"predictive":[108],"than":[109],"standard":[110],"clinical":[111,173,191],"factors.":[112],"The":[113],"combination":[114],"low":[116],"high":[121],"TrkC":[122],"identified":[125],"(n":[133],"=":[134],"7)":[135],"100%":[137],"after":[140],"median":[142],"follow-up":[143],"time":[144],"55":[146],"months":[147],"(range,":[148],"15-91":[149],"months).":[150],"Three":[151],"these":[153],"seven":[154],"survived":[158],"without":[159],"radiotherapy.":[160],"CONCLUSIONS:":[161],"Low":[162],"is":[166,182],"powerful":[168],"predictor":[170],"favorable":[172],"PNET/MB.":[176],"Assessment":[177],"feasible":[183],"may":[185],"be":[186],"incorporated":[187],"prospective":[189],"trials":[192],"aid":[194],"planning":[197],"on":[202],"confirmation":[203],"our":[205],"results":[206],"larger":[208],"studies.":[209]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
